| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Liu, Rui-Ping Wan, Ling-Jia Tang, Shu-Jing Liu, Hai-Jun Li, Qi-Hua Zhao, Wei-Ping Liao, Xiao-Fang Sun, Yong-Hong Yi, Yue-Sheng Lon. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24906954. |
mirna microarray analysis showed that the levels of 38 mirnas showed a significant increase with about 15 ~ 250-folds and the levels of 26 mirnas showed a significant decrease with only about 2 ~ 4-folds in the hippocampus of p7 fmr1 knockout (ko) mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Ting Liu, Rui-Ping Wan, Ling-Jia Tang, Shu-Jing Liu, Hai-Jun Li, Qi-Hua Zhao, Wei-Ping Liao, Xiao-Fang Sun, Yong-Hong Yi, Yue-Sheng Lon. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24906954. |
we further demonstrated that a set of protein-coding mrnas, potentially targeted by the nine mirnas, were down-regulated in the hippocampus of fmr1 ko mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Julie C Lauterborn, Matiar Jafari, Alex H Babayan, Christine M Gal. Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 2. 2015-08-31. PMID:24046080. |
fragile x syndrome (fxs) and the fmr1 knockout (ko) mouse model of this disorder exhibit abnormal dendritic spines in neocortex, but the degree of spine disturbances in hippocampus is not clear. |
2015-08-31 |
2023-08-12 |
mouse |
| Marius F Ifrim, Kathryn R Williams, Gary J Bassel. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 18. 2015-07-24. PMID:25948262. |
the basal translation rates of venus-psd-95 mrna was increased in cultured hippocampal neurons from fmr1 ko mice compared with wt neurons, which correlated with a transient elevation of endogenous psd-95 within dendrites. |
2015-07-24 |
2023-08-13 |
mouse |
| Marius F Ifrim, Kathryn R Williams, Gary J Bassel. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 18. 2015-07-24. PMID:25948262. |
following mglur stimulation with (s)-3,5-dihydroxyphenylglycine, the rate of venus-psd-95 mrna translation increased rapidly in dendrites of wt hippocampal neurons, but not in those of fmr1 ko neurons or when the binding site of mir125a, previously shown to bind psd-95 3'utr, was mutated. |
2015-07-24 |
2023-08-13 |
mouse |
| Ronald R Seese, Kathleen Wang, Yue Qin Yao, Gary Lynch, Christine M Gal. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 47. 2015-04-20. PMID:25385607. |
spacing also rescued training-induced activation of synaptic erk1/2 in dorsal hippocampus of fmr1 ko mice. |
2015-04-20 |
2023-08-13 |
mouse |
| Lara Costa, Lara M Sardone, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome. Frontiers in behavioral neuroscience. vol 9. 2015-03-27. PMID:25814945. |
novel agonists for serotonin 5-ht7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and fmr1 ko mice, a model of fragile x syndrome. |
2015-03-27 |
2023-08-13 |
mouse |
| Tao Chen, Jing-Shan Lu, Qian Song, Ming-Gang Liu, Kohei Koga, Giannina Descalzi, Yun-Qing Li, Min Zhu. Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24553731. |
in the hippocampus of fmr1 knockout mice (ko), long-term depression is enhanced whereas long-term potentiation (ltp) including late-phase ltp (l-ltp) is reduced or unaffected. |
2015-02-12 |
2023-08-12 |
mouse |
| Qin Xu, Zhiwei Zhu, Jialu Xu, Weizhong Gu, Zhengyan Zha. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 12. 2014-11-12. PMID:23033162. |
depressed nnos expression during spine transition in the developing hippocampus of fmr1 ko mice. |
2014-11-12 |
2023-08-12 |
mouse |
| Qin Xu, Zhiwei Zhu, Jialu Xu, Weizhong Gu, Zhengyan Zha. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 12. 2014-11-12. PMID:23033162. |
the objective of this research was to investigate and compare changes of postnatal neuronal nos (nnos) expression in the hippocampus of male fragile x mental retardation 1 gene knockout mice (fmr1 ko mice, the animal model of fxs) and male wild-type mice (wt) at postnatal day 7 (p7), p14, p21, and p28. |
2014-11-12 |
2023-08-12 |
mouse |
| Anahita Amiri, Efrain Sanchez-Ortiz, Woosung Cho, Shari G Birnbaum, Jing Xu, Renée M McKay, Luis F Parad. Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus. Autism research : official journal of the International Society for Autism Research. vol 7. issue 1. 2014-10-28. PMID:24408886. |
analysis of fmr1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus. |
2014-10-28 |
2023-08-12 |
mouse |
| Anahita Amiri, Efrain Sanchez-Ortiz, Woosung Cho, Shari G Birnbaum, Jing Xu, Renée M McKay, Luis F Parad. Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus. Autism research : official journal of the International Society for Autism Research. vol 7. issue 1. 2014-10-28. PMID:24408886. |
we show that ablating fmr1 in differentiated neurons of hippocampus and cortex results in dendritic alterations and changes in synaptic marker intensity that are brain region specific. |
2014-10-28 |
2023-08-12 |
mouse |
| Marko Uutela, Jesse Lindholm, Tomi Rantamäki, Juzoh Umemori, Kerri Hunter, Vootele Võikar, Maija L Castré. Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Frontiers in cellular neuroscience. vol 8. 2014-06-06. PMID:24904293. |
reduced brain-derived neurotrophic factor (bdnf) and increased trkb receptor expression levels in the hippocampus of fmr1 ko mice associated with inappropriate coping responses under stressful condition and abolished antidepressant activity of fluoxetine. |
2014-06-06 |
2023-08-13 |
mouse |
| Marko Uutela, Jesse Lindholm, Tomi Rantamäki, Juzoh Umemori, Kerri Hunter, Vootele Võikar, Maija L Castré. Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Frontiers in cellular neuroscience. vol 8. 2014-06-06. PMID:24904293. |
fluoxetine response in the cell proliferation was also missing in the hippocampus of fmr1 ko mice when compared with wild-type controls. |
2014-06-06 |
2023-08-13 |
mouse |
| Ying Cheng, Joshua G Corbin, Richard J Lev. Programmed cell death is impaired in the developing brain of FMR1 mutants. Developmental neuroscience. vol 35. issue 4. 2014-03-19. PMID:23900139. |
both fmr1 mutant strains demonstrated decreased apoptosis in neocortex, hippocampus, and basolateral amygdala, impaired cytochrome c and procaspase-9 release from mitochondria despite intact bax translocation, increased expression of the antiapoptotic protein, bcl-xl, and increased number of neurons. |
2014-03-19 |
2023-08-12 |
mouse |
| L E Dansie, K Phommahaxay, A G Okusanya, J Uwadia, M Huang, S E Rotschafer, K A Razak, D W Ethell, I M Ethel. Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice. Neuroscience. vol 246. 2014-02-24. PMID:23660195. |
we previously reported that minocycline promotes the maturation of dendritic spines - postsynaptic sites for excitatory synapses - in the developing hippocampus of fmr1 ko mice, which may underlie the beneficial effects of minocycline on anxiolytic behavior in young fmr1 ko mice. |
2014-02-24 |
2023-08-12 |
mouse |
| Tsuyoshi Udagawa, Natalie G Farny, Mira Jakovcevski, Hanoch Kaphzan, Juan Marcos Alarcon, Shobha Anilkumar, Maria Ivshina, Jessica A Hurt, Kentaro Nagaoka, Vijayalaxmi C Nalavadi, Lori J Lorenz, Gary J Bassell, Schahram Akbarian, Sumantra Chattarji, Eric Klann, Joel D Richte. Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nature medicine. vol 19. issue 11. 2014-01-23. PMID:24141422. |
acute depletion of cpeb1 in the hippocampus of adult fmr1(-/y) mice rescued working memory deficits, demonstrating reversal of this fxs phenotype. |
2014-01-23 |
2023-08-12 |
mouse |
| Alex Straiker, Kyung-Tai Min, Ken Macki. Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. Neurobiology of disease. vol 56. 2014-01-10. PMID:23578490. |
fmr1 deletion enhances and ultimately desensitizes cb(1) signaling in autaptic hippocampal neurons. |
2014-01-10 |
2023-08-12 |
mouse |
| Alex Straiker, Kyung-Tai Min, Ken Macki. Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. Neurobiology of disease. vol 56. 2014-01-10. PMID:23578490. |
a recent report found that mglur5-dependent endogenous cannabinoid signaling is enhanced in hippocampal slices from fmr1 knockout mice, suggesting a link between fxs and cannabinoid signaling. |
2014-01-10 |
2023-08-12 |
mouse |
| Alex Straiker, Kyung-Tai Min, Ken Macki. Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. Neurobiology of disease. vol 56. 2014-01-10. PMID:23578490. |
we have used autaptic hippocampal neurons cultured from fmr1 knockout mice to further explore the interaction between endocannabinoid signaling and fmrp. |
2014-01-10 |
2023-08-12 |
mouse |