| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tue G Banke, Andres Barri. Transient Enhanced GluA2 Expression in Young Hippocampal Neurons of a Fragile X Mouse Model. Frontiers in synaptic neuroscience. vol 12. 2020-12-22. PMID:33343326. |
here, we have investigated the development of ampar-mediated synaptic transmission in the hippocampus of the fmr1 knock-out (ko) mouse, a widely used model of fragile x syndrome (fxs). |
2020-12-22 |
2023-08-13 |
mouse |
| Jonas Feuge, Franziska Scharkowski, Kristin Michaelsen-Preusse, Martin Kort. FMRP Modulates Activity-Dependent Spine Plasticity by Binding Cofilin1 mRNA and Regulating Localization and Local Translation. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 12. 2020-11-04. PMID:30953439. |
here, we provide evidence that structural and functional plasticity are severely impaired after nmdar-dependent ltp in the hippocampus of fmr1 ko mice. |
2020-11-04 |
2023-08-13 |
mouse |
| Malan Zhang, Xin Li, Du Xiao, Tao Lu, Bing Qin, Zhigang Zheng, Yonggen Zhang, Yi Liu, Tiebin Yan, Xinjia Ha. Identification of differentially expressed microRNAs and their target genes in the hippocampal tissues of Fmr1 knockout mice. American journal of translational research. vol 12. issue 3. 2020-09-28. PMID:32269714. |
identification of differentially expressed micrornas and their target genes in the hippocampal tissues of fmr1 knockout mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Malan Zhang, Xin Li, Du Xiao, Tao Lu, Bing Qin, Zhigang Zheng, Yonggen Zhang, Yi Liu, Tiebin Yan, Xinjia Ha. Identification of differentially expressed microRNAs and their target genes in the hippocampal tissues of Fmr1 knockout mice. American journal of translational research. vol 12. issue 3. 2020-09-28. PMID:32269714. |
to uncover the possible role of micrornas (mirnas) in fxs and their relationship with fmrp, we used microarray analysis to investigate the mirna expression profiles in the hippocampal tissues of fmr1 knockout (fmr1-ko) mice and wild type (wt) mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. |
effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from fmr1 knockout mice. |
2020-06-11 |
2023-08-13 |
mouse |
| Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. |
synaptic plasticity, protein synthesis, and cellular growth pathways have been studied extensively in hippocampal slices from a mouse model of fxs (fmr1 ko). |
2020-06-11 |
2023-08-13 |
mouse |
| Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. |
we asked if this non-physiological condition could have effects on fmr1 ko phenotypes reported in hippocampal slices. |
2020-06-11 |
2023-08-13 |
mouse |
| Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. |
in the absence of amino acids, we replicate many of the reported findings in fmr1 ko hippocampal slices, but in the more physiological condition of inclusion of amino acids in the medium, we did not find evidence of enhanced mglur5-dependent ltd. activation of mglur5 increased protein synthesis in both wild type and fmr1 ko. |
2020-06-11 |
2023-08-13 |
mouse |
| Sarah M Reinhard, Maham Rais, Sonia Afroz, Yasmien Hanania, Kasim Pendi, Katherine Espinoza, Robert Rosenthal, Devin K Binder, Iryna M Ethell, Khaleel A Raza. Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory. Neurobiology of learning and memory. vol 164. 2020-04-08. PMID:31326533. |
we tested this hypothesis by quantifying pv and pnn expression in the amygdala, hippocampus and auditory cortex of fmr1 ko mice following fear conditioning. |
2020-04-08 |
2023-08-13 |
mouse |
| Sarah M Reinhard, Maham Rais, Sonia Afroz, Yasmien Hanania, Kasim Pendi, Katherine Espinoza, Robert Rosenthal, Devin K Binder, Iryna M Ethell, Khaleel A Raza. Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory. Neurobiology of learning and memory. vol 164. 2020-04-08. PMID:31326533. |
we also found reduced pnn density in the amygdala and auditory cortex of fmr1 ko mice in all conditions, as well as reduced pnn intensity in ca2 hippocampus. |
2020-04-08 |
2023-08-13 |
mouse |
| Maria I Alvarez-Mora, Petar Podlesniy, Ellen Gelpi, Renate Hukema, Irene Madrigal, Javier Pagonabarraga, Ramon Trullas, Montserrat Mila, Laia Rodriguez-Reveng. Fragile X-associated tremor/ataxia syndrome: Regional decrease of mitochondrial DNA copy number relates to clinical manifestations. Genes, brain, and behavior. vol 18. issue 5. 2019-12-30. PMID:30887649. |
in human brain samples, mtdna levels were measured in the cerebellar vermis, dentate nucleus, parietal and temporal cortex, thalamus, caudate nucleus and hippocampus from a female fxtas patient, a fmr1 premutation male carrier without fxtas and from three male controls. |
2019-12-30 |
2023-08-13 |
mouse |
| Botao Liu, Gemma Molinaro, Huan Shu, Emily E Stackpole, Kimberly M Huber, Joel D Richte. Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice. Nucleic acids research. vol 47. issue 5. 2019-10-11. PMID:30590705. |
using hippocampal tissue from wide type and fragile x mental retardation 1 (fmr1) knockout mice, we show that variable rnase digestion can lead to significant sample batch effects. |
2019-10-11 |
2023-08-13 |
mouse |
| S Y Yau, Luis Bettio, M Vetrici, A Truesdell, C Chiu, J Chiu, E Truesdell, B R Christi. Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Neurobiology of disease. vol 113. 2019-09-06. PMID:29367010. |
chronic minocycline treatment improves hippocampal neuronal structure, nmda receptor function, and memory processing in fmr1 knockout mice. |
2019-09-06 |
2023-08-13 |
mouse |
| Tara Arbab, Francesco P Battaglia, Cyriel M A Pennartz, Conrado A Bosma. Abnormal hippocampal theta and gamma hypersynchrony produces network and spike timing disturbances in the Fmr1-KO mouse model of Fragile X syndrome. Neurobiology of disease. vol 114. 2019-09-06. PMID:29486296. |
here, we investigated how neuronal network synchronization in the mouse hippocampus is compromised by the fmr1 mutation that causes fxs (santos et al., 2014), relating recently observed single-cell level impairments (arbab et al., 2017) to neuronal network aberrations. |
2019-09-06 |
2023-08-13 |
mouse |
| Patrick J Mulholland, Tara L Teppen, Kelsey M Miller, Hannah G Sexton, Subhash C Pandey, H Scott Swartzwelde. Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. Alcoholism, clinical and experimental research. vol 42. issue 4. 2019-08-12. PMID:29336496. |
donepezil reverses dendritic spine morphology adaptations and fmr1 epigenetic modifications in hippocampus of adult rats after adolescent alcohol exposure. |
2019-08-12 |
2023-08-13 |
rat |
| Patrick J Mulholland, Tara L Teppen, Kelsey M Miller, Hannah G Sexton, Subhash C Pandey, H Scott Swartzwelde. Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. Alcoholism, clinical and experimental research. vol 42. issue 4. 2019-08-12. PMID:29336496. |
because of the known relationship between dendritic spine density and morphology with the fragile x mental retardation 1 (fmr1) gene, we also assessed fmr1 expression and its epigenetic regulation in hippocampus after aie and donepezil pretreatment. |
2019-08-12 |
2023-08-13 |
rat |
| Kimberly P Keil, Sunjay Sethi, Machelle D Wilson, Jill L Silverman, Isaac N Pessah, Pamela J Lei. Genetic mutations in Ca Genes, brain, and behavior. vol 18. issue 1. 2019-03-21. PMID:30311737. |
the dendritic morphology of pyramidal neurons in ca1 hippocampus and somatosensory cortex was quantified in golgi-stained brain sections from juvenile mice of both sexes expressing either a human gain-of-function mutation in ryanodine receptor 1 (t4826i-ryr1), a human cgg repeat expansion (170-200 cgg repeats) in the fragile x mental retardation gene 1 (fmr1 premutation), both mutations (double mutation; dm), or wildtype mice. |
2019-03-21 |
2023-08-13 |
mouse |
| Kimberly P Keil, Sunjay Sethi, Machelle D Wilson, Jill L Silverman, Isaac N Pessah, Pamela J Lei. Genetic mutations in Ca Genes, brain, and behavior. vol 18. issue 1. 2019-03-21. PMID:30311737. |
in hippocampal neurons, increased dendritic arborization was observed in male t4826i-ryr1 and, to a lesser extent, male fmr1 premutation neurons. |
2019-03-21 |
2023-08-13 |
mouse |
| Kwan Young Lee, Kathryn A Jewett, Hee Jung Chung, Nien-Pei Tsa. Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2. Human molecular genetics. vol 27. issue 16. 2019-03-08. PMID:29771335. |
here, we showed that the homeostatic synaptic downscaling is absent in the hippocampal neurons of fmr1 ko mice, the mouse model of the most common inherited autism, fragile x syndrome (fxs). |
2019-03-08 |
2023-08-13 |
mouse |
| L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. |
as in humans, fmr1 ko mice lacking fmrp display autistic-like behaviors and deformities of actin-rich synaptic structures in addition to impaired hippocampal learning and synaptic plasticity. |
2019-02-26 |
2023-08-13 |
mouse |