All Relations between fmr1 and hippocampus

Publication Sentence Publish Date Extraction Date Species
Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from fmr1 knockout mice. 2020-06-11 2023-08-13 mouse
Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. synaptic plasticity, protein synthesis, and cellular growth pathways have been studied extensively in hippocampal slices from a mouse model of fxs (fmr1 ko). 2020-06-11 2023-08-13 mouse
Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. we asked if this non-physiological condition could have effects on fmr1 ko phenotypes reported in hippocampal slices. 2020-06-11 2023-08-13 mouse
Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. in the absence of amino acids, we replicate many of the reported findings in fmr1 ko hippocampal slices, but in the more physiological condition of inclusion of amino acids in the medium, we did not find evidence of enhanced mglur5-dependent ltd. activation of mglur5 increased protein synthesis in both wild type and fmr1 ko. 2020-06-11 2023-08-13 mouse
Sarah M Reinhard, Maham Rais, Sonia Afroz, Yasmien Hanania, Kasim Pendi, Katherine Espinoza, Robert Rosenthal, Devin K Binder, Iryna M Ethell, Khaleel A Raza. Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory. Neurobiology of learning and memory. vol 164. 2020-04-08. PMID:31326533. we tested this hypothesis by quantifying pv and pnn expression in the amygdala, hippocampus and auditory cortex of fmr1 ko mice following fear conditioning. 2020-04-08 2023-08-13 mouse
Sarah M Reinhard, Maham Rais, Sonia Afroz, Yasmien Hanania, Kasim Pendi, Katherine Espinoza, Robert Rosenthal, Devin K Binder, Iryna M Ethell, Khaleel A Raza. Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory. Neurobiology of learning and memory. vol 164. 2020-04-08. PMID:31326533. we also found reduced pnn density in the amygdala and auditory cortex of fmr1 ko mice in all conditions, as well as reduced pnn intensity in ca2 hippocampus. 2020-04-08 2023-08-13 mouse
Maria I Alvarez-Mora, Petar Podlesniy, Ellen Gelpi, Renate Hukema, Irene Madrigal, Javier Pagonabarraga, Ramon Trullas, Montserrat Mila, Laia Rodriguez-Reveng. Fragile X-associated tremor/ataxia syndrome: Regional decrease of mitochondrial DNA copy number relates to clinical manifestations. Genes, brain, and behavior. vol 18. issue 5. 2019-12-30. PMID:30887649. in human brain samples, mtdna levels were measured in the cerebellar vermis, dentate nucleus, parietal and temporal cortex, thalamus, caudate nucleus and hippocampus from a female fxtas patient, a fmr1 premutation male carrier without fxtas and from three male controls. 2019-12-30 2023-08-13 mouse
Botao Liu, Gemma Molinaro, Huan Shu, Emily E Stackpole, Kimberly M Huber, Joel D Richte. Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice. Nucleic acids research. vol 47. issue 5. 2019-10-11. PMID:30590705. using hippocampal tissue from wide type and fragile x mental retardation 1 (fmr1) knockout mice, we show that variable rnase digestion can lead to significant sample batch effects. 2019-10-11 2023-08-13 mouse
S Y Yau, Luis Bettio, M Vetrici, A Truesdell, C Chiu, J Chiu, E Truesdell, B R Christi. Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Neurobiology of disease. vol 113. 2019-09-06. PMID:29367010. chronic minocycline treatment improves hippocampal neuronal structure, nmda receptor function, and memory processing in fmr1 knockout mice. 2019-09-06 2023-08-13 mouse
Tara Arbab, Francesco P Battaglia, Cyriel M A Pennartz, Conrado A Bosma. Abnormal hippocampal theta and gamma hypersynchrony produces network and spike timing disturbances in the Fmr1-KO mouse model of Fragile X syndrome. Neurobiology of disease. vol 114. 2019-09-06. PMID:29486296. here, we investigated how neuronal network synchronization in the mouse hippocampus is compromised by the fmr1 mutation that causes fxs (santos et al., 2014), relating recently observed single-cell level impairments (arbab et al., 2017) to neuronal network aberrations. 2019-09-06 2023-08-13 mouse
Patrick J Mulholland, Tara L Teppen, Kelsey M Miller, Hannah G Sexton, Subhash C Pandey, H Scott Swartzwelde. Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. Alcoholism, clinical and experimental research. vol 42. issue 4. 2019-08-12. PMID:29336496. donepezil reverses dendritic spine morphology adaptations and fmr1 epigenetic modifications in hippocampus of adult rats after adolescent alcohol exposure. 2019-08-12 2023-08-13 rat
Patrick J Mulholland, Tara L Teppen, Kelsey M Miller, Hannah G Sexton, Subhash C Pandey, H Scott Swartzwelde. Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. Alcoholism, clinical and experimental research. vol 42. issue 4. 2019-08-12. PMID:29336496. because of the known relationship between dendritic spine density and morphology with the fragile x mental retardation 1 (fmr1) gene, we also assessed fmr1 expression and its epigenetic regulation in hippocampus after aie and donepezil pretreatment. 2019-08-12 2023-08-13 rat
Kimberly P Keil, Sunjay Sethi, Machelle D Wilson, Jill L Silverman, Isaac N Pessah, Pamela J Lei. Genetic mutations in Ca Genes, brain, and behavior. vol 18. issue 1. 2019-03-21. PMID:30311737. the dendritic morphology of pyramidal neurons in ca1 hippocampus and somatosensory cortex was quantified in golgi-stained brain sections from juvenile mice of both sexes expressing either a human gain-of-function mutation in ryanodine receptor 1 (t4826i-ryr1), a human cgg repeat expansion (170-200 cgg repeats) in the fragile x mental retardation gene 1 (fmr1 premutation), both mutations (double mutation; dm), or wildtype mice. 2019-03-21 2023-08-13 mouse
Kimberly P Keil, Sunjay Sethi, Machelle D Wilson, Jill L Silverman, Isaac N Pessah, Pamela J Lei. Genetic mutations in Ca Genes, brain, and behavior. vol 18. issue 1. 2019-03-21. PMID:30311737. in hippocampal neurons, increased dendritic arborization was observed in male t4826i-ryr1 and, to a lesser extent, male fmr1 premutation neurons. 2019-03-21 2023-08-13 mouse
Kwan Young Lee, Kathryn A Jewett, Hee Jung Chung, Nien-Pei Tsa. Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2. Human molecular genetics. vol 27. issue 16. 2019-03-08. PMID:29771335. here, we showed that the homeostatic synaptic downscaling is absent in the hippocampal neurons of fmr1 ko mice, the mouse model of the most common inherited autism, fragile x syndrome (fxs). 2019-03-08 2023-08-13 mouse
L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. as in humans, fmr1 ko mice lacking fmrp display autistic-like behaviors and deformities of actin-rich synaptic structures in addition to impaired hippocampal learning and synaptic plasticity. 2019-02-26 2023-08-13 mouse
L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. herein, we report that fmr1 ko mouse hippocampus exhibits increased levels of membrane-bound rac1, which may prevent proper learning-induced synaptic changes. 2019-02-26 2023-08-13 mouse
L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. we also determine that increasing training intensity during fear conditioning (fc) training restores contextual memory in fmr1 ko mice and reduces membrane-bound rac1 in fmr1 ko hippocampus. 2019-02-26 2023-08-13 mouse
L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. increased training intensity also results in normalized long-term potentiation in hippocampal slices taken from fmr1 ko mice. 2019-02-26 2023-08-13 mouse
Samantha L Hodges, Suzanne O Nolan, Joseph H Taube, Joaquin N Lug. Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. Neuroreport. vol 28. issue 18. 2018-06-27. PMID:28915148. adult fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. 2018-06-27 2023-08-13 mouse