| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesse E Hanson, Daniel V Madiso. Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 15. 2007-05-03. PMID:17428978. |
whole-cell recordings from individual pairs of presynaptic and postsynaptic neurons in organotypic hippocampal slices were used to probe the cell-autonomous effects of fmr1 genotype in mosaic networks. |
2007-05-03 |
2023-08-12 |
mouse |
| Aaron W Grossman, Nicholas M Elisseou, Brandon C McKinney, William T Greenoug. Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines. Brain research. vol 1084. issue 1. 2006-08-10. PMID:16574084. |
examination of golgi-stained pyramidal cells in hippocampal subfield ca1 of adult fmr1 knockout mice reveals longer spines than controls and a morphology profile that, while essentially opposite of that described in the fmr1 knockout neocortex, appears similarly immature. |
2006-08-10 |
2023-08-12 |
mouse |
| Michael D Greicius, Jesse M Boyett-Anderson, Vinod Menon, Allan L Reis. Reduced basal forebrain and hippocampal activation during memory encoding in girls with fragile X syndrome. Neuroreport. vol 15. issue 10. 2004-10-01. PMID:15232287. |
the fragile x gene (fmr1) is prominently transcribed in two regions critical to memory encoding and attention: the hippocampus and the basal forebrain. |
2004-10-01 |
2023-08-12 |
human |
| Laura N Antar, Rownak Afroz, Jason B Dictenberg, Reed C Carroll, Gary J Bassel. Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 11. 2004-05-28. PMID:15028757. |
using high-resolution fluorescence and digital imaging microscopy in cultured hippocampal neurons, fmrp and fmr1 mrna were localized in granules throughout dendrites and within spines. |
2004-05-28 |
2023-08-12 |
Not clear |
| Menahem Segal, Ute Kreher, Varda Greenberger, Katharina Brau. Is fragile X mental retardation protein involved in activity-induced plasticity of dendritic spines? Brain research. vol 972. issue 1-2. 2003-07-11. PMID:12711073. |
these experiments indicate that fmr1 is not likely to be an essential factor in activity-modulated morphological plasticity of dendritic spines in cultured hippocampal neurons. |
2003-07-11 |
2023-08-12 |
mouse |
| Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castré. BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus. Neurobiology of disease. vol 11. issue 1. 2003-01-23. PMID:12460560. |
exposure of cultured hippocampal neurons to bdnf, but not to nt-3, reduced fmr1 mrna levels to 84.8% of control at 4 h and the levels were back to baseline by 24 h or 4 days. |
2003-01-23 |
2023-08-12 |
mouse |
| Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castré. BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus. Neurobiology of disease. vol 11. issue 1. 2003-01-23. PMID:12460560. |
furthermore, expression of fmr1 mrna was reduced (82.4% of control) in vivo in the hippocampus of transgenic mice overexpressing trkb receptors, and a small but significant (5.1%) decrease was also detected in fmrp protein levels. |
2003-01-23 |
2023-08-12 |
mouse |
| Jianxue Li, Marc R Pelletier, Jose-Luis Perez Velazquez, Peter L Carle. Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency. Molecular and cellular neurosciences. vol 19. issue 2. 2002-04-25. PMID:11860268. |
here we report that the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit, glur1, was decreased in the cortical synapses, but not in the hippocampus or cerebellum, of fmr1 gene knockout mice. |
2002-04-25 |
2023-08-12 |
mouse |
| G Valentine, S Chakravarty, J Sarvey, C Bramham, M Herkenha. Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression. Brain research. Molecular brain research. vol 75. issue 2. 2000-04-21. PMID:10686356. |
in situ hybridization of fmr1 mrna in hippocampus of rats given ltp in vivo showed no change in fmr1 mrna levels relative to control. |
2000-04-21 |
2023-08-12 |
rat |
| B Bardoni, A Schenck, J L Mande. A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Human molecular genetics. vol 8. issue 13. 2000-01-24. PMID:10556305. |
nufip mrna expression is strikingly similar to that of the fmr1 gene in neurones of cortex, hippocampus and cerebellum. |
2000-01-24 |
2023-08-12 |
Not clear |
| J M Godfraind, E Reyniers, K De Boulle, R D'Hooge, P P De Deyn, C E Bakker, B A Oostra, R F Kooy, P J Willem. Long-term potentiation in the hippocampus of fragile X knockout mice. American journal of medical genetics. vol 64. issue 2. 1996-12-13. PMID:8844057. |
as malperformance in the morris water maze test has been associated with impaired long-term potentiation (ltp), electrophysiological studies were performed in hippocampal slices of fmr1 knockout mice to check for the presence of ltp. |
1996-12-13 |
2023-08-12 |
mouse |
| J M Godfraind, E Reyniers, K De Boulle, R D'Hooge, P P De Deyn, C E Bakker, B A Oostra, R F Kooy, P J Willem. Long-term potentiation in the hippocampus of fragile X knockout mice. American journal of medical genetics. vol 64. issue 2. 1996-12-13. PMID:8844057. |
judged by field extracellular excitatory postsynaptic potential recordings in the ca1 hippocampal area, fmr1 knockout mice express ltp to a similar extent as their wild type littermates during the first 1-2 hr after high frequency stimulation. |
1996-12-13 |
2023-08-12 |
mouse |