| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Angeles Real, M Pilar Simón, Raúl Heredia, Yolanda de Diego, Salvador Guirad. Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice. The Journal of comparative neurology. vol 519. issue 13. 2011-11-15. PMID:21491426. |
phenotypic changes in calbindin d28k immunoreactivity in the hippocampus of fmr1 knockout mice. |
2011-11-15 |
2023-08-12 |
mouse |
| M Angeles Real, M Pilar Simón, Raúl Heredia, Yolanda de Diego, Salvador Guirad. Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice. The Journal of comparative neurology. vol 519. issue 13. 2011-11-15. PMID:21491426. |
here we analyze the immunohistochemical expression of the calbindin d28k protein in the hippocampus of fmr1 knockout (ko) mice and compare it with that of their wildtype (wt) littermates. |
2011-11-15 |
2023-08-12 |
mouse |
| Josien Levenga, Femke M S de Vrij, Ronald A M Buijsen, Tracy Li, Ingeborg M Nieuwenhuizen, Andreea Pop, Ben A Oostra, Rob Willemse. Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice. Neurobiology of learning and memory. vol 95. issue 4. 2011-10-14. PMID:21371563. |
subregion-specific dendritic spine abnormalities in the hippocampus of fmr1 ko mice. |
2011-10-14 |
2023-08-12 |
mouse |
| Josien Levenga, Femke M S de Vrij, Ronald A M Buijsen, Tracy Li, Ingeborg M Nieuwenhuizen, Andreea Pop, Ben A Oostra, Rob Willemse. Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice. Neurobiology of learning and memory. vol 95. issue 4. 2011-10-14. PMID:21371563. |
we investigated hippocampal protrusion morphology in adult fmr1 knockout mice. |
2011-10-14 |
2023-08-12 |
mouse |
| Pan-Yue Deng, David Sojka, Vitaly A Klyachk. Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795546. |
here we report marked presynaptic abnormalities at excitatory hippocampal synapses in fmr1 knock-out (ko) mice leading to defects in stp and information processing. |
2011-10-07 |
2023-08-12 |
mouse |
| Pan-Yue Deng, David Sojka, Vitaly A Klyachk. Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795546. |
fmr1 ko mice also exhibited abnormal synaptic processing of natural stimulus trains, specifically excessive enhancement during the high-frequency spike discharges associated with hippocampal place fields. |
2011-10-07 |
2023-08-12 |
mouse |
| Zhi-Wei Zhu, Qin Xu, Zheng-Yan Zhao, Wei-Zhong Gu, Ding-Wen W. Spatiotemporal expression of PSD-95 in Fmr1 knockout mice brain. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 3. 2011-09-22. PMID:21092061. |
to investigate and compare the spatial and temporal expression of post-synaptic density-95 (psd-95) in fmr1 knockout mice (the animal model of fragile x syndrome, fxs) and wild-type mice brain, on postnatal day 7 (p7), p14, p21, p28 and p90, mice from each group were decapitated, and three principal brain regions (cerebral cortex, hippocampus and cerebellum) were obtained and stored for later experiments. |
2011-09-22 |
2023-08-12 |
mouse |
| Zhi-Wei Zhu, Qin Xu, Zheng-Yan Zhao, Wei-Zhong Gu, Ding-Wen W. Spatiotemporal expression of PSD-95 in Fmr1 knockout mice brain. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 3. 2011-09-22. PMID:21092061. |
moreover, it was found that psd-95 mrna and protein in the hippocampus were significantly decreased in fmr1 knockout mice during the developmental period (p7, p14, p21 and p28) as well as at adulthood (p90) (p < 0.05, and p < 0.01, respectively). |
2011-09-22 |
2023-08-12 |
mouse |
| Josien Levenga, Shigemi Hayashi, Femke M S de Vrij, Sebastiaan K Koekkoek, Herma C van der Linde, Ingeborg Nieuwenhuizen, Cheng Song, Ronald A M Buijsen, Andreea S Pop, Baltazar Gomezmancilla, David L Nelson, Rob Willemsen, Fabrizio Gasparini, Ben A Oostr. AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21316452. |
we also studied the effect of afq056 on cultured fmr1 ko hippocampal neurons; untreated neurons showed elongated spines and treatment resulted in shortened spines. |
2011-08-23 |
2023-08-12 |
mouse |
| Steven A Connor, Charles A Hoeffer, Eric Klann, Peter V Nguye. Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 4. 2011-07-13. PMID:21430043. |
to determine if enhanced heterosynaptic ltp in fmr1 ko mouse hippocampus requires protein synthesis, we applied a translation inhibitor, emetine (eme). |
2011-07-13 |
2023-08-12 |
mouse |
| Christopher L Cunningham, Verónica Martínez Cerdeño, Eliecer Navarro Porras, Anish N Prakash, James M Angelastro, Rob Willemsen, Paul J Hagerman, Isaac N Pessah, Robert F Berman, Stephen C Nocto. Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Human molecular genetics. vol 20. issue 1. 2011-05-24. PMID:20935171. |
recent work with cultured hippocampal neurons from a premutation (fmr1 cgg knock-in) mouse model revealed impaired development of early postnatal neurons, consistent with the developmental clinical involvement of premutation carriers. |
2011-05-24 |
2023-08-12 |
mouse |
| Emily K Osterweil, Dilja D Krueger, Kimberly Reinhold, Mark F Bea. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084617. |
here, we use an in vitro assay of protein synthesis in the hippocampus of male fmr1 knock-out (ko) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. |
2010-12-23 |
2023-08-12 |
mouse |
| B D Eadie, W N Zhang, F Boehme, J Gil-Mohapel, L Kainer, J M Simpson, B R Christi. Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Neurobiology of disease. vol 36. issue 2. 2010-06-03. PMID:19666116. |
the process of neurogenesis appears abnormal in young adult fmr1 ko mice, with significantly fewer bromodeoxyuridine-positive cells surviving for at least 4 weeks in the ventral subregion of the dentate gyrus (dg), a hippocampal subregion more closely associated with emotion than the dorsal dg. |
2010-06-03 |
2023-08-12 |
mouse |
| B D Eadie, W N Zhang, F Boehme, J Gil-Mohapel, L Kainer, J M Simpson, B R Christi. Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Neurobiology of disease. vol 36. issue 2. 2010-06-03. PMID:19666116. |
this work indicates that loss of fmr1 expression can alter anxiety-related behaviors in mice as well as produce region-specific alterations in hippocampal adult neurogenesis. |
2010-06-03 |
2023-08-12 |
mouse |
| Brad E Pfeiffer, Tong Zang, Julia R Wilkerson, Makoto Taniguchi, Marina A Maksimova, Laura N Smith, Christopher W Cowan, Kimberly M Hube. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. vol 66. issue 2. 2010-05-25. PMID:20434996. |
here, we demonstrate that mef2 activation fails to eliminate functional or structural excitatory synapses in hippocampal neurons from fmr1 ko mice. |
2010-05-25 |
2023-08-12 |
mouse |
| Yucui Chen, Flora Tassone, Robert F Berman, Paul J Hagerman, Randi J Hagerman, Rob Willemsen, Isaac N Pessa. Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Human molecular genetics. vol 19. issue 1. 2010-03-09. PMID:19846466. |
murine hippocampal neurons expressing fmr1 gene premutations show early developmental deficits and late degeneration. |
2010-03-09 |
2023-08-12 |
mouse |
| Ali Sharma, Charles A Hoeffer, Yukihiro Takayasu, Takahiro Miyawaki, Sean M McBride, Eric Klann, R Suzanne Zuki. Dysregulation of mTOR signaling in fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 2. 2010-02-01. PMID:20071534. |
here we show that mtor phosphorylation and activity are elevated in hippocampus of juvenile fmr1 knock-out mice by four functional readouts: (1) association of mtor with regulatory associated protein of mtor; (2) mtor kinase activity; (3) phosphorylation of mtor downstream targets s6 kinase and 4e-binding protein; and (4) formation of eukaryotic initiation factor complex 4f, a critical first step in cap-dependent translation. |
2010-02-01 |
2023-08-12 |
mouse |
| Christopher J Yuskaitis, Marjelo A Mines, Margaret K King, J David Sweatt, Courtney A Miller, Richard S Jop. Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome. Biochemical pharmacology. vol 79. issue 4. 2010-01-19. PMID:19799873. |
inhibitory serine-phosphorylation of gsk3 was lower in fmr1 knockout, than wild-type, mouse brain regions and was increased by acute or chronic lithium treatment, which also increased hippocampal brain-derived neurotrophic factor levels. |
2010-01-19 |
2023-08-12 |
mouse |
| Yuze Shang, Hansen Wang, Valentina Mercaldo, Xiangyao Li, Tao Chen, Min Zhu. Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19659572. |
however, results for synaptic long-term potentiation (ltp), a key cellular model for learning and memory, remain inconclusive in the hippocampus of fmr1 knockout mice. |
2009-11-06 |
2023-08-12 |
mouse |
| Jing Zhang, Lingfei Hou, Eric Klann, David L Nelso. Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models. Journal of neurophysiology. vol 101. issue 5. 2009-06-04. PMID:19244359. |
altered hippocampal synaptic plasticity in the fmr1 gene family knockout mouse models. |
2009-06-04 |
2023-08-12 |
mouse |