| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha L Hodges, Suzanne O Nolan, Joseph H Taube, Joaquin N Lug. Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. Neuroreport. vol 28. issue 18. 2018-06-27. PMID:28915148. |
this study examined whether fmr1 knockout (ko) and wild-type mice on a fvb/nj background strain had altered cytokine expression at baseline levels in the hippocampus. |
2018-06-27 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Joseph H Taube, Joaquin N Lug. Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. Neuroreport. vol 28. issue 18. 2018-06-27. PMID:28915148. |
results showed fmr1 ko mice to have decreased proinflammatory cytokine hippocampal mrna expression, specifically interleukin (il)-6 and tumor necrosis factor-α, compared with wild-type mice. |
2018-06-27 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Joseph H Taube, Joaquin N Lug. Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. Neuroreport. vol 28. issue 18. 2018-06-27. PMID:28915148. |
further investigation of the immune profile of the fmr1 ko mouse is critical to understand whether this deficiency of cytokines in the hippocampus is indicative of a broader immunologic deficit associated with fxs. |
2018-06-27 |
2023-08-13 |
mouse |
| Victor Sabanov, Sien Braat, Laura D'Andrea, Rob Willemsen, Shimriet Zeidler, Liesbeth Rooms, Claudia Bagni, R Frank Kooy, Detlef Balschu. Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice. Neuropharmacology. vol 116. 2018-05-09. PMID:28012946. |
impaired gabaergic inhibition in the hippocampus of fmr1 knockout mice. |
2018-05-09 |
2023-08-13 |
mouse |
| Elisabetta Aloisi, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias Georg Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe-Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Fric. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature communications. vol 8. issue 1. 2018-04-27. PMID:29062097. |
using single-molecule tracking, we found that mglur5 was significantly more mobile at synapses in hippocampal fmr1 ko neurons, causing an increased synaptic surface co-clustering of mglur5 and nmdar. |
2018-04-27 |
2023-08-13 |
mouse |
| S Y Yau, C A Bostrom, J Chiu, C J Fontaine, S Sawchuk, A Meconi, R C Wortman, E Truesdell, A Truesdell, C Chiu, B N Hryciw, B D Eadie, M Ghilan, B R Christi. Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of disease. vol 96. 2018-02-09. PMID:27659109. |
we, and others, have recently reported that there is significant impairment in n-methyl-d-aspartate receptor (nmdar)-dependent long-term potentiation (ltp) and long-term depression (ltd) in the hippocampal dentate gyrus (dg) of male fmr1 knock out mice. |
2018-02-09 |
2023-08-13 |
mouse |
| Kirsty Sawicka, Alexander Pyronneau, Miranda Chao, Michael V L Bennett, R Suzanne Zuki. Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27663742. |
the fmr1 ko mouse, a model of fxs, exhibits elevated translation in the hippocampus and the cortex. |
2018-01-30 |
2023-08-13 |
mouse |
| Magdalena Jasińska, Jacek Miłek, Iwona A Cymerman, Szymon Łęski, Leszek Kaczmarek, Magdalena Dziembowsk. miR-132 Regulates Dendritic Spine Structure by Direct Targeting of Matrix Metalloproteinase 9 mRNA. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26319558. |
furthermore, we demonstrate that the overexpression of mir-132 in the cultured hippocampal neurons from fmr1 ko mice that have increased synaptic mmp-9 level provokes enlargement of the dendritic spine heads, a process previously implicated in enhanced synaptic plasticity. |
2018-01-16 |
2023-08-13 |
mouse |
| Lin-Tao Zhou, Shun-Hua Ye, Hai-Xuan Yang, Yong-Ting Zhou, Qi-Hua Zhao, Wei-Wen Sun, Mei-Mei Gao, Yong-Hong Yi, Yue-Sheng Lon. A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14. Neuroscience. vol 349. 2018-01-16. PMID:28257890. |
we show that the relative skipping/inclusion ratio of the micro-exon l in the protrudin gene and exon 10 in the tau gene decreased in the hippocampus of fmr1 knockout (ko) mice. |
2018-01-16 |
2023-08-13 |
mouse |
| Gaëlle Robin, José R López, Glenda M Espinal, Susan Hulsizer, Paul J Hagerman, Isaac N Pessa. Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. Human molecular genetics. vol 26. issue 14. 2018-01-11. PMID:28444183. |
in a mouse that harbors a premutation cgg expansion (precgg), cortical and hippocampal fmrp expression is moderately reduced from birth through adulthood, with greater fmrp reductions in the soma than in the neurite, despite several-fold elevation of fmr1 mrna levels. |
2018-01-11 |
2023-08-13 |
mouse |
| Connie Cheng, Sally K M Lau, Laurie C Doerin. Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model. Molecular brain. vol 9. issue 1. 2017-11-17. PMID:27485117. |
correspondingly, fmr1 ko hippocampal neurons exhibited morphological deficits in dendritic spines and alterations in excitatory synapse formation following long-term culture. |
2017-11-17 |
2023-08-13 |
mouse |
| M Angeles Luque, Pablo Beltran-Matas, M Carmen Marin, Blas Torres, Luis Herrer. Excitability is increased in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. PloS one. vol 12. issue 9. 2017-10-17. PMID:28931075. |
with a view to determining the effects of the absence of fmrp on cell excitability, we studied rheobase, action potential duration, firing frequency-current intensity relationship and action potential after-hyperpolarization (ahp) in ca1 pyramidal cells of the hippocampus of wild type (wt) and fmr1 ko male mice. |
2017-10-17 |
2023-08-13 |
mouse |
| Sally M Till, Antonis Asiminas, Adam D Jackson, Danai Katsanevaki, Stephanie A Barnes, Emily K Osterweil, Mark F Bear, Sumantra Chattarji, Emma R Wood, David J A Wyllie, Peter C Kin. Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Human molecular genetics. vol 24. issue 21. 2016-08-02. PMID:26243794. |
using a new rat model of fragile x syndrome, we report that fmr1 knockout (ko) rats exhibit elevated basal protein synthesis and an increase in mglur-dependent long-term depression in ca1 of the hippocampus that is independent of new protein synthesis. |
2016-08-02 |
2023-08-13 |
mouse |
| Artuela Çaku, David Pellerin, Paméla Bouvier, Emilie Riou, Francois Corbi. Effect of lovastatin on behavior in children and adults with fragile X syndrome: an open-label study. American journal of medical genetics. Part A. vol 164A. issue 11. 2016-05-16. PMID:25258112. |
recent work in fmr1 knockout mice has shown that lovastatin, an inhibitor of ras-erk1/2, normalized hippocampus protein synthesis. |
2016-05-16 |
2023-08-13 |
mouse |
| Yan Li, Aicha Abdourahman, Joseph A Tamm, Alan L Pehrson, Connie Sánchez, Maria Gulinell. Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice. Pharmacology, biochemistry, and behavior. vol 135. 2016-04-12. PMID:26046533. |
vortioxetine, but not fluoxetine, increased hippocampal expression of several neuroplasticity-related genes in middle-aged mice (e.g., nfkb1, fos, fmr1, camk2a, arc, shank1, nlgn2, and rab3a). |
2016-04-12 |
2023-08-13 |
mouse |
| Ting Liu, Rui-Ping Wan, Ling-Jia Tang, Shu-Jing Liu, Hai-Jun Li, Qi-Hua Zhao, Wei-Ping Liao, Xiao-Fang Sun, Yong-Hong Yi, Yue-Sheng Lon. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24906954. |
here, we found a development-dependant dynamic expression of fmr1 gene (encoding fmrp) in mouse hippocampus with a small peak at postnatal day 7 (p7). |
2016-02-12 |
2023-08-13 |
mouse |
| Ting Liu, Rui-Ping Wan, Ling-Jia Tang, Shu-Jing Liu, Hai-Jun Li, Qi-Hua Zhao, Wei-Ping Liao, Xiao-Fang Sun, Yong-Hong Yi, Yue-Sheng Lon. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24906954. |
mirna microarray analysis showed that the levels of 38 mirnas showed a significant increase with about 15 ~ 250-folds and the levels of 26 mirnas showed a significant decrease with only about 2 ~ 4-folds in the hippocampus of p7 fmr1 knockout (ko) mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Ting Liu, Rui-Ping Wan, Ling-Jia Tang, Shu-Jing Liu, Hai-Jun Li, Qi-Hua Zhao, Wei-Ping Liao, Xiao-Fang Sun, Yong-Hong Yi, Yue-Sheng Lon. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24906954. |
we further demonstrated that a set of protein-coding mrnas, potentially targeted by the nine mirnas, were down-regulated in the hippocampus of fmr1 ko mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Julie C Lauterborn, Matiar Jafari, Alex H Babayan, Christine M Gal. Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 2. 2015-08-31. PMID:24046080. |
fragile x syndrome (fxs) and the fmr1 knockout (ko) mouse model of this disorder exhibit abnormal dendritic spines in neocortex, but the degree of spine disturbances in hippocampus is not clear. |
2015-08-31 |
2023-08-12 |
mouse |
| Marius F Ifrim, Kathryn R Williams, Gary J Bassel. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 18. 2015-07-24. PMID:25948262. |
the basal translation rates of venus-psd-95 mrna was increased in cultured hippocampal neurons from fmr1 ko mice compared with wt neurons, which correlated with a transient elevation of endogenous psd-95 within dendrites. |
2015-07-24 |
2023-08-13 |
mouse |