| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jee-Yeon Hwang, Hannah R Monday, Jingqi Yan, Andrea Gompers, Adina R Buxbaum, Kirsty J Sawicka, Robert H Singer, Pablo E Castillo, R Suzanne Zuki. CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X. Cell reports. vol 39. issue 10. 2022-06-08. PMID:35675768. |
using single-molecule mrna detection, we show that mrna encoding the ampar subunit glua2 (but not glua1) is elevated in dendrites and at transcription sites of hippocampal neurons of fmr1 ko mice, indicating elevated glua2 transcription. |
2022-06-08 |
2023-08-14 |
mouse |
| Anna Delprato, Emily Xiao, Devika Mano. Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment. Behavioral and brain functions : BBF. vol 18. issue 1. 2022-05-19. PMID:35590332. |
in this systematic review we examine the roles of the dcx, comt and fmr1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. |
2022-05-19 |
2023-08-13 |
Not clear |
| Sahar Javadi, Yue Li, Jie Sheng, Lucy Zhao, Yao Fu, Daifeng Wang, Xinyu Zha. Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome. BMC medicine. vol 20. issue 1. 2022-05-13. PMID:35549943. |
we have previously shown that fmr1 represses the levels and activities of ubiquitin ligase mdm2 in young adult fmr1-deficient mice, and treatment by a mdm2 inhibitor nutlin-3 rescues both hippocampal neurogenic and cognitive deficits in fmr1-deficient mice when analyzed shortly after the administration. |
2022-05-13 |
2023-08-13 |
mouse |
| Jessica L Armstrong, Clinton E Cana. Targeting 5-HT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554052. |
for example, we show significantly decreased pnn density in hippocampal ca2 in juvenile fmr1 knockout (ko) mice, a neural system critical for social memory, compared to wild-type (wt) mice (p=0.0043, n=8 and 7, respectively). |
2022-05-13 |
2023-08-13 |
mouse |
| Shivaprasad H Sathyanarayana, Jasmine A Saunders, Jacob Slaughter, Kamran Tariq, Rajarshi Chakrabarti, Madhumala K Sadanandappa, Bryan W Luikart, Giovanni Bosc. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-18. PMID:35394871. |
genetic studies of hippocampal granule neuron development have been used to elucidate cellular functions of pten and fmr1. |
2022-04-18 |
2023-08-16 |
mouse |
| Rohini Subrahmanyam, Deepanjali Dwivedi, Zubin Rashid, Katherine Bonnycastle, Michael A Cousin, Sumantra Chattarj. Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors. Journal of neurochemistry. vol 158. issue 5. 2021-11-17. PMID:34327719. |
here we combined electrophysiological and fluorescence imaging analyses on primary hippocampal cultures prepared from an fmr1 knockout (ko) rat model. |
2021-11-17 |
2023-08-13 |
rat |
| Kami Koldewyn, David Hessl, John Adams, Flora Tassone, Paul J Hagerman, Randi J Hagerman, Susan M River. Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation. Brain imaging and behavior. vol 2. issue 2. 2021-10-20. PMID:19430586. |
reduced hippocampal activation during recall is associated with elevated fmr1 mrna and psychiatric symptoms in men with the fragile x premutation. |
2021-10-20 |
2023-08-12 |
Not clear |
| Kami Koldewyn, David Hessl, John Adams, Flora Tassone, Paul J Hagerman, Randi J Hagerman, Susan M River. Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation. Brain imaging and behavior. vol 2. issue 2. 2021-10-20. PMID:19430586. |
left hippocampal activation was negatively correlated with both fmr1 mrna level and psychiatric symptomology in the premutation group. |
2021-10-20 |
2023-08-12 |
Not clear |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
electrophysiology studies in fmr1 knockout (ko) mice, a murine model of fragile x syndrome, have demonstrated alterations of synaptic plasticity, with exaggerated long-term depression induced by activation of metabotropic glutamate receptors (mglur-ltd) in fmr1 ko hippocampus. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
we have previously demonstrated that activation of serotonin 5-ht7 receptors reverses mglur-ltd in the hippocampus of wild-type and fmr1 ko mice, thus correcting a synaptic dysfunction typically observed in this disease model. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
here we show that pharmacological inhibition of cyclin-dependent kinase 5 (cdk5, a signaling molecule recently shown to be a modulator of brain synaptic plasticity) enhanced mglur-ltd in wild-type hippocampal neurons, which became comparable to exaggerated mglur-ltd observed in fmr1 ko neurons. |
2021-08-18 |
2023-08-13 |
mouse |
| Kathleen C Schmidt, Inna Loutaev, Zenaide Quezado, Carrie Sheeler, Carolyn Beebe Smit. Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1- Neurobiology of disease. vol 143. 2021-08-05. PMID:32569795. |
in accord with this hypothesis, we have previously reported increased rates of cerebral protein synthesis (rcps) in the fmr1 knockout mouse model of fxs and others have reported similar effects in hippocampal slices. |
2021-08-05 |
2023-08-13 |
mouse |
| Alexandra Marsillo, Lovena David, Bishoy Gerges, Daniel Kerr, Rodina Sadek, Vitaliy Lasiychuk, David Salame, Youstina Soliman, Silvia Menkes, Aheli Chatterjee, Andrew Mancuso, Probal Banerje. PKC epsilon as a neonatal target to correct FXS-linked AMPA receptor translocation in the hippocampus, boost PVN oxytocin expression, and normalize adult behavior in Fmr1 knockout mice. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 4. 2021-07-02. PMID:33359697. |
pkc epsilon as a neonatal target to correct fxs-linked ampa receptor translocation in the hippocampus, boost pvn oxytocin expression, and normalize adult behavior in fmr1 knockout mice. |
2021-07-02 |
2023-08-13 |
mouse |
| Dušica Briševac, Ralf Scholz, Dan Du, Mohammad Nael Elagabani, Georg Köhr, Hans-Christian Korna. The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33125726. |
here, we determined the fraction of active, gtp-bound arf6 in cortical neuron cultures and synaptoneurosomes from fmr1 knockout mice, measured actin polymerization in neurons expressing arf6 mutants with variant gtp- or gdp-binding properties, and recorded hippocampal long-term depression induced by metabotropic glutamate receptors (mglur-ltd) in acute brain slices. |
2021-06-21 |
2023-08-13 |
mouse |
| Dušica Briševac, Ralf Scholz, Dan Du, Mohammad Nael Elagabani, Georg Köhr, Hans-Christian Korna. The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33125726. |
targeted deletion of iqsec1 in hippocampal neurons of 3-week-old mice interfered with mglur-ltd in wild-type, but not in fmr1 knockout mice. |
2021-06-21 |
2023-08-13 |
mouse |
| Bumwhee Lee, Shree Panda, Hye Young Le. Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome. Stem cell reports. vol 15. issue 2. 2021-06-02. PMID:32735823. |
here, we found that the number of primary cilia in fmr1 ko mice is reduced, specifically in the dg of the hippocampus. |
2021-06-02 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
in response to lps, fmr1 ko mice had elevated hippocampal il-1β and il-6 mrna levels 4 h post-treatment compared to wt mice, with no differences detected in any cytokines at baseline or between genotypes 24 h post-lps administration. |
2021-03-04 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
fmr1 ko mice also had upregulated hippocampal bdnf gene expression 4 h post-treatment compared to wt mice, which was not dependent on lps administration. |
2021-03-04 |
2023-08-13 |
mouse |
| Ronald R Seese, Aliza A Le, Kathleen Wang, Conor D Cox, Gary Lynch, Christine M Gal. A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability. Neurobiology of disease. vol 134. 2021-01-13. PMID:31494285. |
relatedly, hippocampal long-term potentiation (ltp) is impaired in the fmr1 knockout (ko) mouse model of fxs. |
2021-01-13 |
2023-08-13 |
mouse |
| Ronald R Seese, Aliza A Le, Kathleen Wang, Conor D Cox, Gary Lynch, Christine M Gal. A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability. Neurobiology of disease. vol 134. 2021-01-13. PMID:31494285. |
in hippocampal slices, bath infusion of the trkb agonist 7,8-dihydroxyflavone (7,8-dhf) completely restored otherwise impaired hippocampal field ca1 ltp of fmr1 kos without effect in wild types (wts). |
2021-01-13 |
2023-08-13 |
mouse |