| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adam J Iliff, Abigail J Renoux, Amy Krans, Karen Usdin, Michael A Sutton, Peter K Tod. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Human molecular genetics. vol 22. issue 6. 2013-08-30. PMID:23250915. |
electrophysiological analysis reveals enhanced mglur-mediated long-term depression (mglur-ltd) at ca3-ca1 synapses in acute hippocampal slices prepared from cgg ki mice relative to wild-type littermates, similar to fmr1 knockout mice. |
2013-08-30 |
2023-08-12 |
mouse |
| Lara Costa, Michela Spatuzza, Simona D'Antoni, Carmela M Bonaccorso, Chiara Trovato, Sebastiano A Musumeci, Marcello Leopoldo, Enza Lacivita, Maria V Catania, Lucia Cirann. Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome. Biological psychiatry. vol 72. issue 11. 2013-04-23. PMID:22817866. |
fmr1 knockout (fmr1 ko) mice, an animal model of fxs, exhibit spatial memory impairment and synapse malfunctioning in the hippocampus, with abnormal enhancement of long-term depression mediated by metabotropic glutamate receptors (mglur-ltd). |
2013-04-23 |
2023-08-12 |
mouse |
| Snigdha Roy, Nick Watkins, Detlef Hec. Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits. PloS one. vol 7. issue 9. 2013-03-12. PMID:22984567. |
absence of fmrp in fragile x patients as well as in fmr1 knockout (ko) mice results, among other changes, in abnormal dendritic spine formation and altered synaptic plasticity in the neocortex and hippocampus. |
2013-03-12 |
2023-08-12 |
mouse |
| Orly Lazarov, Michael P Demars, Kai Da Tommy Zhao, Haroon M Ali, Vanessa Grauzas, Adam Kney, John Larso. Impaired survival of neural progenitor cells in dentate gyrus of adult mice lacking fMRP. Hippocampus. vol 22. issue 6. 2013-03-11. PMID:22128095. |
interestingly, recent evidence suggests that conditional knockout of fmr1 in neural progenitor cells in mice impairs hippocampal neurogenesis, which in turn contributes to learning impairments. |
2013-03-11 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
longitudinal in vivo developmental changes of metabolites in the hippocampus of fmr1 knockout mice. |
2013-02-14 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
in this study, magnetic resonance imaging (mri) and (1) h magnetic resonance spectroscopy (mrs) were used to determine in vivo longitudinal changes in volume and metabolites in the hippocampus during the critical period of early myelination and synaptogenesis at post-natal days (pnd) 18, 21, and 30 in fmr1 ko mice compared with wild-type (wt) controls. |
2013-02-14 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
mri demonstrated an increase in volume of the hippocampus in the fmr1 ko mouse compared with controls. |
2013-02-14 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
mrs revealed significant developmental changes in the ratios of hippocampal metabolites n-acetylaspartate (naa), myo-inositol (ins), and taurine to total creatine (tcr) in fmr1 ko mice compared with wt controls. |
2013-02-14 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
an imbalance of brain metabolites in the hippocampus of fmr1 ko mice during the critical developmental period of synaptogenesis and early myelination could have long-lasting effects that adversely affect brain development and contribute to ongoing alterations in brain function. |
2013-02-14 |
2023-08-12 |
mouse |
| Eitan S Kaplan, Zhengyu Cao, Susan Hulsizer, Flora Tassone, Robert F Berman, Paul J Hagerman, Isaac N Pessa. Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. Journal of neurochemistry. vol 123. issue 4. 2012-12-21. PMID:22924671. |
early mitochondrial abnormalities in hippocampal neurons cultured from fmr1 pre-mutation mouse model. |
2012-12-21 |
2023-08-12 |
mouse |
| Eitan S Kaplan, Zhengyu Cao, Susan Hulsizer, Flora Tassone, Robert F Berman, Paul J Hagerman, Isaac N Pessa. Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. Journal of neurochemistry. vol 123. issue 4. 2012-12-21. PMID:22924671. |
in this study, we show that dissociated hippocampal neuronal culture from pre-cgg ki mice (average 170 cgg repeats) express 42.6% of the fmrp levels and 3.8-fold higher fmr1 mrna than that measured in wild-type neurons at 4 days in vitro. |
2012-12-21 |
2023-08-12 |
mouse |
| Zhengyu Cao, Susan Hulsizer, Flora Tassone, Hiu-tung Tang, Randi J Hagerman, Michael A Rogawski, Paul J Hagerman, Isaac N Pessa. Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone. Human molecular genetics. vol 21. issue 13. 2012-12-13. PMID:22466801. |
clustered burst firing in fmr1 premutation hippocampal neurons: amelioration with allopregnanolone. |
2012-12-13 |
2023-08-12 |
mouse |
| M Uutela, J Lindholm, V Louhivuori, H Wei, L M Louhivuori, A Pertovaara, K Akerman, E Castrén, M L Castré. Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22435671. |
fmr1 ko mice showed age-dependent alterations in hippocampal bdnf expression that declined after the age of 4 months compared to wild-type controls. |
2012-11-20 |
2023-08-12 |
mouse |
| John M Wang, Kami Koldewyn, Ryu-Ichiro Hashimoto, Andrea Schneider, Lien Le, Flora Tassone, Katherine Cheung, Paul Hagerman, David Hessl, Susan M River. Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding. Frontiers in human neuroscience. vol 6. 2012-11-02. PMID:23115550. |
previous functional mri (fmri) studies have shown that fragile x mental retardation 1 (fmr1) fragile x premutation allele carriers (fxpcs) exhibit decreased hippocampal activation during a recall task and lower inferior frontal activation during a working memory task compared to matched controls. |
2012-11-02 |
2023-08-12 |
Not clear |
| Weixiang Guo, Adeline C Murthy, Li Zhang, Eric B Johnson, Eric G Schaller, Andrea M Allan, Xinyu Zha. Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Human molecular genetics. vol 21. issue 3. 2012-08-30. PMID:22048960. |
since fmrp is known to play an important role in adult hippocampal neurogenesis and hippocampus-dependent learning and fmrp regulates the adult neural stem cell fate through the translational regulation of glycogen synthase kinase 3β (gsk3β), we investigated the effects of a gsk3β inhibitor, sb216763, on fmr1 knockout mice (fmr1 ko). |
2012-08-30 |
2023-08-12 |
mouse |
| Weixiang Guo, Adeline C Murthy, Li Zhang, Eric B Johnson, Eric G Schaller, Andrea M Allan, Xinyu Zha. Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Human molecular genetics. vol 21. issue 3. 2012-08-30. PMID:22048960. |
we found that the inhibition of gsk3β could reverse the hippocampus-dependent learning deficits and rescue adult hippocampal neurogenesis at multiple stages in fmr1 ko mice. |
2012-08-30 |
2023-08-12 |
mouse |
| Brennan D Eadie, Jesse Cushman, Timal S Kannangara, Michael S Fanselow, Brian R Christi. NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21049485. |
here we report that fmr1 knockout mice exhibit impaired bidirectional synaptic plasticity in the dentate gyrus (dg) of the hippocampus. |
2012-05-14 |
2023-08-12 |
mouse |
| Scott M Paluszkiewicz, Brandon S Martin, Molly M Huntsma. Fragile X syndrome: the GABAergic system and circuit dysfunction. Developmental neuroscience. vol 33. issue 5. 2012-04-16. PMID:21934270. |
while alterations in excitatory synapse function and plasticity are well-established in fmr1 knockout (ko) mouse models of fxs, a number of recent electrophysiological and molecular studies now identify prominent defects in inhibitory gabaergic transmission in behaviorally relevant forebrain regions such as the amygdala, cortex, and hippocampus. |
2012-04-16 |
2023-08-12 |
mouse |
| Benjamin D Auerbach, Emily K Osterweil, Mark F Bea. Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature. vol 480. issue 7375. 2012-02-23. PMID:22113615. |
using electrophysiological and biochemical assays of neuronal protein synthesis in the hippocampus of tsc2(+/-) and fmr1(-/y) mice, here we show that synaptic dysfunction caused by these mutations actually falls at opposite ends of a physiological spectrum. |
2012-02-23 |
2023-08-12 |
mouse |
| Hye Young Lee, Woo-Ping Ge, Wendy Huang, Ye He, Gordon X Wang, Ashley Rowson-Baldwin, Stephen J Smith, Yuh Nung Jan, Lily Yeh Ja. Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron. vol 72. issue 4. 2012-01-12. PMID:22099464. |
moreover, treating hippocampal slices from fmr1 ko mice with kv4 channel blocker restores long-term potentiation induced by moderate stimuli. |
2012-01-12 |
2023-08-12 |
mouse |