| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
ibu-am5 inhibited the binding of [3h]-cp55,940 to rat brain cb1 and human cb2 cannabinoid receptors more potently than ibuprofen, but the increase in potency was less than the corresponding increase in potency seen for inhibition of faah activity. |
2007-07-26 |
2023-08-12 |
human |
| Matthew N Hill, Eda S Karacabeyli, Boris B Gorzalk. Estrogen recruits the endocannabinoid system to modulate emotionality. Psychoneuroendocrinology. vol 32. issue 4. 2007-07-03. PMID:17391861. |
fatty acid amide hydrolase (faah), the enzyme which degrades the endocannabinoid anandamide, has been shown to be regulated by estrogen. |
2007-07-03 |
2023-08-12 |
human |
| Matthew N Hill, Eda S Karacabeyli, Boris B Gorzalk. Estrogen recruits the endocannabinoid system to modulate emotionality. Psychoneuroendocrinology. vol 32. issue 4. 2007-07-03. PMID:17391861. |
collectively, these data demonstrate that estrogen may elicit changes in emotional behavior through an endocannabinoid mechanism, and suggest that inhibition of faah represents a therapeutic target for anxiety and depression in women. |
2007-07-03 |
2023-08-12 |
human |
| Francis F Y Lam, Phoebe W S Luk, Ethel S K N. Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. Life sciences. vol 80. issue 16. 2007-06-28. PMID:17275857. |
these findings suggest the vasodilator action of anandamide in the rat knee joint involved hydrolysis of the compound by faah, production of cox-derived eicosanoid(s), activation of trpv1 receptors, and a small component involved activation of endothelial anandamide/abnormal-cannabidiol receptors; a minor delayed dilator response was mediated by activation of conventional cannabinoid receptors. |
2007-06-28 |
2023-08-12 |
rat |
| Karen L Kage, Paul L Richardson, Linda Traphagen, Jean Severin, Ana Pereda-Lopez, Thomas Lubben, Rachel Davis-Taber, Melissa H Vos, Diane Bartley, Karl Walter, John Harlan, Larry Solomon, Usha Warrior, Thomas F Holzman, Connie Faltynek, Carol S Surowy, Victoria E Scot. A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase. Journal of neuroscience methods. vol 161. issue 1. 2007-06-21. PMID:17083980. |
fatty acid amide hydrolase (faah) is the enzyme responsible for the rapid degradation of fatty acid amides such as the endocannabinoid anandamide. |
2007-06-21 |
2023-08-12 |
human |
| Stephen A Varvel, Laura E Wise, Floride Niyuhire, Benjamin F Cravatt, Aron H Lichtma. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 5. 2007-06-05. PMID:17047668. |
here, we test the hypothesis that elevating brain levels of the endogenous cannabinoid anandamide through either genetic deletion or pharmacological inhibition of its primary catabolic enzyme fatty-acid amide hydrolase (faah) will potentiate extinction in a fixed platform water maze task. |
2007-06-05 |
2023-08-12 |
mouse |
| Janet Hoenicka, Guillermo Ponce, Miguel A Jiménez-Arriero, Israel Ampuero, Roberto Rodríguez-Jiménez, Gabriel Rubio, Maria Aragüés, Jose A Ramos, Tomás Palom. Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3' region of the DRD2 gene. Neurotoxicity research. vol 11. issue 1. 2007-05-22. PMID:17449448. |
association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the cnr1 and faah endocannabinoid genes, and the 3' region of the drd2 gene. |
2007-05-22 |
2023-08-12 |
Not clear |
| Marcello Solinas, Gianluigi Tanda, Zuzana Justinova, Carrie E Wertheim, Sevil Yasar, Daniele Piomelli, Subramanian K Vadivel, Alexandros Makriyannis, Steven R Goldber. The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17210800. |
the endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. |
2007-05-14 |
2023-08-12 |
rat |
| Amy K Dickason-Chesterfield, Stephanie R Kidd, Steven A Moore, John M Schaus, Bin Liu, George G Nomikos, Christian C Felde. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16736384. |
pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. |
2007-04-24 |
2023-08-12 |
Not clear |
| Amy K Dickason-Chesterfield, Stephanie R Kidd, Steven A Moore, John M Schaus, Bin Liu, George G Nomikos, Christian C Felde. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16736384. |
a subset of compounds reported in the literature were tested in our laboratory under common assay conditions to measure their ability to (a) inhibit [(14)c]-anandamide uptake in cells containing (rbl-2h3) or cells lacking (hela) faah, (b) inhibit purified faah hydrolytic activity, and (c) inhibit binding to a putative binding site involved in endocannabinoid transport in both rbl and hela cell membranes. |
2007-04-24 |
2023-08-12 |
Not clear |
| Amy K Dickason-Chesterfield, Stephanie R Kidd, Steven A Moore, John M Schaus, Bin Liu, George G Nomikos, Christian C Felde. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16736384. |
a more direct comparison of multiple inhibitors could be made in these three assay systems performed in the same laboratory, revealing more information about the selectivity of these compounds and the relationship between the putative endocannabinoid transport protein and faah. |
2007-04-24 |
2023-08-12 |
Not clear |
| Laura E Wise, Christopher C Shelton, Benjamin F Cravatt, Billy R Martin, Aron H Lichtma. Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. European journal of pharmacology. vol 557. issue 1. 2007-04-12. PMID:17217945. |
assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid cb1 receptors. |
2007-04-12 |
2023-08-12 |
mouse |
| Laura E Wise, Christopher C Shelton, Benjamin F Cravatt, Billy R Martin, Aron H Lichtma. Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. European journal of pharmacology. vol 557. issue 1. 2007-04-12. PMID:17217945. |
the behavioral effects of anandamide were evaluated in mice that lacked both fatty acid amide hydrolase (faah) and cannabinoid cb(1) receptors (dko) as compared to faah (-/-), cannabinoid cb(1) (-/-), and wild type mice. |
2007-04-12 |
2023-08-12 |
mouse |
| Gianna Rossi, Valeria Gasperi, Rita Paro, Daniela Barsacchi, Sandra Cecconi, Mauro Maccarron. Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. Endocrinology. vol 148. issue 3. 2007-04-04. PMID:17110429. |
altogether these data suggest that faah is the only target of fsh among the elements of the endocannabinoid system, and that its regulation by pka and aromatase-dependent pathways impacts sertoli cell proliferation. |
2007-04-04 |
2023-08-12 |
mouse |
| Haibin Wang, Huirong Xie, Xiaofei Sun, Philip J Kingsley, Lawrence J Marnett, Benjamin F Cravatt, Sudhansu K De. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins & other lipid mediators. vol 83. issue 1-2. 2007-03-29. PMID:17259073. |
we also provide evidence that region- and stage-specific uterine expression of n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and sn-1-diacylglycerol (dag) lipase alpha (daglalpha) and monoacylglycerol lipase (magl) for synthesis and hydrolysis of anandamide and 2-ag, respectively, creates endocannabinoid gradients conducive to implantation. |
2007-03-29 |
2023-08-12 |
mouse |
| Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. |
cannabinoid cb1 and cb2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. |
2007-03-19 |
2023-08-12 |
human |
| Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. |
however, most experimental data come from animal models of ms. we investigated the status of cannabinoid cb1 and cb2 receptors and fatty acid amide hydrolase (faah) enzyme in brain tissue samples obtained from ms patients. |
2007-03-19 |
2023-08-12 |
human |
| Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. |
as seen for other neuroinflammatory conditions, selective glial expression of cannabinoid cb1 and cb2 receptors and faah enzyme is induced in ms, thus supporting a role for the endocannabinoid system in the pathogenesis and/or evolution of this disease. |
2007-03-19 |
2023-08-12 |
human |
| Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kan. Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267577. |
in contrast, inhibitors of other endocannabinoid hydrolyzing enzymes, fatty acid amide hydrolase and cyclooxygenase-2, had no effect on the 2-ag-induced ipsc suppression. |
2007-03-16 |
2023-08-12 |
Not clear |
| Alessio Lodola, Marco Mor, Jolanta Zurek, Giorgio Tarzia, Daniele Piomelli, Jeremy N Harvey, Adrian J Mulhollan. Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase. Biophysical journal. vol 92. issue 2. 2007-02-28. PMID:17098788. |
this unusual finding has important implications for fatty acid amide hydrolase, a key enzyme in the endocannabinoid system. |
2007-02-28 |
2023-08-12 |
Not clear |