| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ivan Tubert-Brohman, Orlando Acevedo, William L Jorgense. Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations. Journal of the American Chemical Society. vol 128. issue 51. 2007-02-20. PMID:17177441. |
fatty acid amide hydrolase (faah) is a serine hydrolase that degrades anandamide, an endocannabinoid, and oleamide, a sleep-inducing lipid, and has potential applications as a therapeutic target for neurological disorders. |
2007-02-20 |
2023-08-12 |
Not clear |
| Bela Szabo, Michal J Urbanski, Tiziana Bisogno, Vincenzo Di Marzo, Aitziber Mendiguren, Wolfram U Baer, Ilka Freima. Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. The Journal of physiology. vol 577. issue Pt 1. 2007-01-23. PMID:16973696. |
thus, three kinds of observations identified 2-ag as the endocannabinoid involved in dsi in the mouse cerebellum: dsi was abolished by diacylglycerol lipase inhibitors; dsi was potentiated by a monoglyceride lipase inhibitor; and dsi was not changed by an inhibitor of fatty acid amide hydrolase. |
2007-01-23 |
2023-08-12 |
mouse |
| Ben Paylor, Sandra Holt, Christopher J Fowle. The potency of the fatty acid amide hydrolase inhibitor URB597 is dependent upon the assay pH. Pharmacological research. vol 54. issue 6. 2007-01-23. PMID:16997568. |
inhibitors of the enzyme fatty acid amide hydrolase (faah), the principal enzyme involved in the metabolism of the endogenous cannabinoid anandamide, have potential utility in the treatment of disorders including inflammation and inflammatory pain. |
2007-01-23 |
2023-08-12 |
rat |
| Jason R Clapper, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Daniele Piomell. The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues. Pharmacological research. vol 54. issue 5. 2007-01-10. PMID:16935521. |
the o-arylcarbamate urb597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester; also referred to as kds-4103) is a potent inhibitor of fatty-acid amide hydrolase (faah), an intracellular serine hydrolase responsible for the inactivation of the endogenous cannabinoid anandamide. |
2007-01-10 |
2023-08-12 |
mouse |
| Matthias Blüher, Stefan Engeli, Nora Klöting, Janin Berndt, Mathias Fasshauer, Sándor Bátkai, Pál Pacher, Michael R Schön, Jens Jordan, Michael Stumvol. Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes. vol 55. issue 11. 2007-01-04. PMID:17065342. |
we further measured expression of the cannabinoid type 1 (cb(1)) receptor and fatty acid amide hydrolase (faah) genes in paired samples of subcutaneous and visceral adipose tissue in all 60 subjects. |
2007-01-04 |
2023-08-12 |
human |
| Angelo Jayamanne, Ruth Greenwood, Vanessa A Mitchell, Sevda Aslan, Daniele Piomelli, Christopher W Vaugha. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. British journal of pharmacology. vol 147. issue 3. 2006-12-26. PMID:16331291. |
these findings suggest that the faah inhibitor urb597 produces cannabinoid cb1 and cb2 receptor-mediated analgesia in inflammatory pain states, without causing the undesirable side effects associated with cannabinoid receptor activation. |
2006-12-26 |
2023-08-12 |
rat |
| Josée Guindon, Jesse LoVerme, André De Léan, Daniele Piomelli, Pierre Beaulie. Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? European journal of pharmacology. vol 550. issue 1-3. 2006-12-15. PMID:17027744. |
nonsteroidal anti-inflammatory drugs (nsaids) inhibit fatty-acid amide hydrolase (faah), the enzyme responsible for the metabolism of anandamide, an endocannabinoid. |
2006-12-15 |
2023-08-12 |
Not clear |
| Magdalena Zaniewska, Andrew C McCreary, Edmund Przegaliński, Małgorzata Fili. Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. European journal of pharmacology. vol 540. issue 1-3. 2006-12-11. PMID:16730696. |
during test sessions the following drugs were coadministered with saline (substitution studies) or nicotine (0.025-0.4 mg/kg; combination studies): the alpha4beta2 nicotinic acetylcholine receptor subtype antagonist dihydro-beta-erythroidine (dhbetae), the non-selective nicotinic acetylcholine receptor subtype antagonist mecamylamine, the alpha7 nicotinic acetylcholine receptor subtype antagonist methyllycaconitine (mla), the alpha4beta2 nicotinic acetylcholine receptor subtype agonist 5-iodo-3-(2(s)-azetidinylmethoxy)pyridine (5-ia), the cannabinoid cb1 receptor antagonist/partial agonist rimonabant, the cannabinoid cb2 receptor antagonist n-[(1s)-endo-1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl]5-(4-chloro-3-methyl-phenyl)-1-(4-methybenzyl)pyrazole-3-carboxamide (sr 144528), the cannabinoid cb1/2 receptor agonists (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)-phenyl]-trans-4-(3-hydroxy-propyl)cyclohexanol (cp 55,940) or r(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]-pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-(1-naphthalenyl)-methanone mesylate (win 55,212-2), the endogenous cannabinoid agonist and non-competitive alpha7 nicotinic acetylcholine receptor subtype antagonist anandamide, the anandamide uptake and fatty acid amide hydrolase inhibitor n-(4-hydroxyphenyl)-5z,8z,11z,14z-eicosatetraenamide (am-404), the fatty acid amide hydrolase inhibitor cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (urb 597), am-404+anandamide or urb 597+anandamide. |
2006-12-11 |
2023-08-12 |
rat |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16956707. |
several studies suggest that some organophosphorus toxicants can potentially modify cannabinergic signaling by direct binding to cannabinoid receptors and inhibition of enzymes responsible for cannabinoid degradation (i.e., fatty acid amide hydrolase and monoacylglycerol lipase). |
2006-11-29 |
2023-08-12 |
rat |
| Anke M Mulder, Benjamin F Cravat. Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. Biochemistry. vol 45. issue 38. 2006-11-08. PMID:16981687. |
endocannabinoid metabolism in the absence of fatty acid amide hydrolase (faah): discovery of phosphorylcholine derivatives of n-acyl ethanolamines. |
2006-11-08 |
2023-08-12 |
mouse |
| Anke M Mulder, Benjamin F Cravat. Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. Biochemistry. vol 45. issue 38. 2006-11-08. PMID:16981687. |
termination of the activity of the n-acyl ethanolamine (nae) class of lipid-signaling molecules, including the endocannabinoid anandamide (aea), is principally mediated by the integral membrane enzyme fatty acid amide hydrolase (faah) in vivo. |
2006-11-08 |
2023-08-12 |
mouse |
| Josée Guindon, Pierre Beaulie. Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. Neuropharmacology. vol 50. issue 7. 2006-10-06. PMID:16442133. |
nonsteroidal anti-inflammatory drugs (nsaids) inhibit fatty acid amidohydrolase (faah), the enzyme responsible for the metabolism of anandamide, an endocannabinoid. |
2006-10-06 |
2023-08-12 |
rat |
| Haibin Wang, Huirong Xie, Yong Guo, Hao Zhang, Toshifumi Takahashi, Philip J Kingsley, Lawrence J Marnett, Sanjoy K Das, Benjamin F Cravatt, Sudhansu K De. Fatty acid amide hydrolase deficiency limits early pregnancy events. The Journal of clinical investigation. vol 116. issue 8. 2006-09-14. PMID:16886060. |
faah inactivation yielding higher anandamide or experimentally induced higher cannabinoid [(-)-delta9-tetrahydrocannabinol] levels constrain preimplantation embryo development with aberrant expression of cdx2, nanog, and oct3/4, genes known to direct lineage specification. |
2006-09-14 |
2023-08-12 |
mouse |
| Daniele Piomelli, Giorgio Tarzia, Andrea Duranti, Andrea Tontini, Marco Mor, Timothy R Compton, Olivier Dasse, Edward P Monaghan, Jeff A Parrott, David Putma. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS drug reviews. vol 12. issue 1. 2006-09-08. PMID:16834756. |
in the present article, we review the pharmacological properties of kds-4103 (urb597), a highly potent and selective inhibitor of the enzyme fatty-acid amide hydrolase (faah), which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide. |
2006-09-08 |
2023-08-12 |
mouse |
| Alan Saghatelian, Michele K McKinney, Michael Bandell, Ardem Patapoutian, Benjamin F Cravat. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. vol 45. issue 30. 2006-09-05. PMID:16866345. |
most of the physiological substrates of faah characterized to date belong to the n-acyl ethanolamine (nae) class of fatty acid amides, including the endocannabinoid anandamide, the anti-inflammatory lipid n-palmitoyl ethanolamine, and the satiating factor n-oleoyl ethanolamine. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanna M Saario, Antti Poso, Risto O Juvonen, Tomi Järvinen, Outi M H Salo-Ahe. Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. Journal of medicinal chemistry. vol 49. issue 15. 2006-08-31. PMID:16854070. |
fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. |
2006-08-31 |
2023-08-12 |
human |
| Susanna M Saario, Antti Poso, Risto O Juvonen, Tomi Järvinen, Outi M H Salo-Ahe. Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. Journal of medicinal chemistry. vol 49. issue 15. 2006-08-31. PMID:16854070. |
the endocannabinoid system consists of two cannabinoid receptors (cb1 and cb2), endogenous ligands (endocannabinoids), and the enzymes involved in the metabolism of the endocannabinoids, including fatty acid amide hydrolase (faah) and monoglyceride lipase (mgl). |
2006-08-31 |
2023-08-12 |
human |
| Marcello Solinas, Zuzana Justinova, Steven R Goldberg, Gianluigi Tand. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. Journal of neurochemistry. vol 98. issue 2. 2006-08-18. PMID:16805835. |
anandamide produced two distinctly different effects on dopamine levels: (1) a rapid, transient increase that was blocked by the cannabinoid cb1 receptor antagonist rimonabant, but not by the vanilloid vr1 receptor antagonist capsazepine, and was magnified and prolonged by the fatty acid amide hydrolase (faah) enzyme inhibitor, urb597; (2) a smaller delayed and long-lasting increase, not sensitive to cb1, vr1 or faah blockade. |
2006-08-18 |
2023-08-12 |
rat |
| Gilda Cobellis, Giovanna Cacciola, Donatella Scarpa, Rosaria Meccariello, Rosanna Chianese, Maria Fosca Franzoni, Ken Mackie, Riccardo Pierantoni, Silvia Fasan. Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. Biology of reproduction. vol 75. issue 1. 2006-08-10. PMID:16611862. |
endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. |
2006-08-10 |
2023-08-12 |
mouse |
| Gilda Cobellis, Giovanna Cacciola, Donatella Scarpa, Rosaria Meccariello, Rosanna Chianese, Maria Fosca Franzoni, Ken Mackie, Riccardo Pierantoni, Silvia Fasan. Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. Biology of reproduction. vol 75. issue 1. 2006-08-10. PMID:16611862. |
here we provide direct evidence on the presence of the "endocannabinoid system," constituted by type-1 cannabinoid receptor (cnr1) and fatty acid amide hydrolase (faah), in the frog rana esculenta testis demonstrating its expression in tubular compartment. |
2006-08-10 |
2023-08-12 |
mouse |