| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rhidaya Shrestha, Sang-chul Kim, John M Dyer, Richard A Dixon, Kent D Chapma. Plant fatty acid (ethanol) amide hydrolases. Biochimica et biophysica acta. vol 1761. issue 3. 2006-07-17. PMID:16624618. |
fatty acid amide hydrolase (faah) plays a central role in modulating endogenous n-acylethanolamine (nae) levels in vertebrates, and, in part, constitutes an "endocannabinoid" signaling pathway that regulates diverse physiological and behavioral processes in animals. |
2006-07-17 |
2023-08-12 |
rat |
| Kent-Olov Jonsson, Sandra Holt, Christopher J Fowle. The endocannabinoid system: current pharmacological research and therapeutic possibilities. Basic & clinical pharmacology & toxicology. vol 98. issue 2. 2006-07-07. PMID:16445584. |
the main topics covered are: the mechanism of action of cannabinoid(2) receptor agonists; identification of the endocannabinoid(s) involved in retrograde signalling; the elusive mechanism(s) of endocannabinoid uptake; therapeutic possibilities for fatty acid amide hydrolase inhibitors; and the cyclooxygenase-2 and lipoxygenase-derived biologically active metabolites of the endocannabinoids. |
2006-07-07 |
2023-08-12 |
Not clear |
| Josée Guindon, André De Léan, Pierre Beaulie. Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. Pain. vol 121. issue 1-2. 2006-06-02. PMID:16480822. |
anandamide, an endocannabinoid, is degraded by the enzyme fatty acid amide hydrolase which can be inhibited by nonsteroidal anti-inflammatory drugs (nsaids). |
2006-06-02 |
2023-08-12 |
rat |
| Lynsey G Bilsland, James R T Dick, Gareth Pryce, Stefania Petrosino, Vincenzo Di Marzo, David Baker, Linda Greensmit. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16571781. |
furthermore, genetic ablation of the faah enzyme, which results in raised levels of the endocannabinoid anandamide, prevented the appearance of disease signs in 90-day-old sod1g93a mice. |
2006-06-01 |
2023-08-12 |
mouse |
| Lynsey G Bilsland, James R T Dick, Gareth Pryce, Stefania Petrosino, Vincenzo Di Marzo, David Baker, Linda Greensmit. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16571781. |
surprisingly, elevation of cannabinoid levels with either win55,212-2 or faah ablation had no effect on life span. |
2006-06-01 |
2023-08-12 |
mouse |
| Tiziana Bisogno, Maria Grazia Cascio, Bijali Saha, Anu Mahadevan, Paolo Urbani, Alberto Minassi, Giovanni Appendino, Carmela Saturnino, Billy Martin, Raj Razdan, Vincenzo Di Marz. Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochimica et biophysica acta. vol 1761. issue 2. 2006-05-31. PMID:16466961. |
apart from being almost inactive on magl, these two compounds showed high selectivity over rat liver triacylglycerol lipase, rat n-acylphosphatidyl-ethanolamine-selective phospholipase d (involved in anandamide biosynthesis), rat fatty acid amide hydrolase and human recombinant cannabinoid cb1 and cb2 receptors. |
2006-05-31 |
2023-08-12 |
human |
| John M McPartland, Isabel Matias, Vincenzo Di Marzo, Michelle Glas. Evolutionary origins of the endocannabinoid system. Gene. vol 370. 2006-05-26. PMID:16434153. |
within this limited number of twelve organisms, the endocannabinoid genes exhibited heterogeneous evolutionary trajectories, with functional orthologs limited to mammals (trpv1 and gpr55), or vertebrates (cb2 and daglbeta), or chordates (magl and cox2), or animals (daglalpha and cb1-like receptors), or opisthokonta (animals and fungi, nape-pld), or eukaryotes (faah). |
2006-05-26 |
2023-08-12 |
mouse |
| Filomena Fezza, Natalia Battista, Monica Bari, Mauro Maccarron. Methods to assay anandamide hydrolysis and transport in synaptosomes. Methods in molecular medicine. vol 123. 2006-05-26. PMID:16506407. |
the biological activity of aea at cannabinoid and noncannabinoid receptors depends on its life span in the extracellular space, which is regulated by a rapid cellular uptake, followed by intracellular degradation by the enzyme aea hydrolase (fatty acid amide hydrolase). |
2006-05-26 |
2023-08-12 |
Not clear |
| Stephen A Varvel, Benjamin F Cravatt, April E Engram, Aron H Lichtma. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16352706. |
more generally, faah may represent a novel therapeutic target that circumvents the undesirable cognitive side effects commonly associated with direct-acting cannabinoid agonists. |
2006-05-25 |
2023-08-12 |
mouse |
| Mauro Maccarrone, Anna Fiori, Monica Bari, Filippo Granata, Valeria Gasperi, M Egle De Stefano, Alessandro Finazzi-Agrò, Roberto Stro. Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. Thrombosis and haemostasis. vol 95. issue 1. 2006-04-27. PMID:16543970. |
type-1 and type-2 cannabinoid receptors (cb1r and cb2r), a selective aea membrane transporter (amt), an aea-degrading fatty acid amide hydrolase, and the aea-synthesizing enzymes n-acyltransferase and n-acyl-phosphatidylethanolamines-specific phospholipase d. we also show that activation of cb1r enhances amt activity through increased nitric oxide synthase (nos) activity and subsequent increase of no production. |
2006-04-27 |
2023-08-12 |
cattle |
| Sandra Holt, Francesca Comelli, Barbara Costa, Christopher J Fowle. Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors. British journal of pharmacology. vol 146. issue 3. 2006-04-25. PMID:16100529. |
inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors. |
2006-04-25 |
2023-08-12 |
mouse |
| J Fernández-Ruiz, S Gonzále. Cannabinoid control of motor function at the basal ganglia. Handbook of experimental pharmacology. issue 168. 2006-04-19. PMID:16596785. |
this three-fold evidence has provided support to the idea that cannabinoid-based compounds, which act at key steps of the endocannabinoid transmission [receptors, transporter, fatty acid amide hydrolase (faah)], might be of interest because of their potential ability to alleviate motor symptoms and/or provide neuroprotection in a variety of neurological pathologies directly affecting basal ganglia structures, such as parkinson's disease and huntington's chorea, or indirectly, such as multiple sclerosis and alzheimer's disease. |
2006-04-19 |
2023-08-12 |
Not clear |
| Sherrye T Glaser, S John Gatley, Andrew N Giffor. Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16278311. |
these data indicate faah activity generates heterogeneous regional accumulation of [3h]anandamide and metabolites, and they suggest the modulation of endocannabinoid tone by faah inhibitors depends upon not only the dose and compound used but also on the degree of faah expression in the brain regions examined. |
2006-04-13 |
2023-08-12 |
mouse |
| Sabatino Maione, Tiziana Bisogno, Vito de Novellis, Enza Palazzo, Luigia Cristino, Marta Valenti, Stefania Petrosino, Vittorio Guglielmotti, Francesco Rossi, Vincenzo Di Marz. Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16284279. |
elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. |
2006-04-13 |
2023-08-12 |
rat |
| Sabatino Maione, Tiziana Bisogno, Vito de Novellis, Enza Palazzo, Luigia Cristino, Marta Valenti, Stefania Petrosino, Vittorio Guglielmotti, Francesco Rossi, Vincenzo Di Marz. Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16284279. |
we studied in healthy rats the effect of elevation of pag endocannabinoid [anandamide and 2-arachidonoylglycerol (2-ag)] levels produced by intra-pag injections of the inhibitor of fatty acid amide hydrolase urb597 [cyclohexylcarbamic acid-3'-carbamoyl-biphenyl-3-yl ester] on 1) nociception in the "plantar test" and 2) spontaneous and tail-flick-related activities of rvm neurons. |
2006-04-13 |
2023-08-12 |
rat |
| Sherrye T Glaser, Dale G Deutsch, Keith M Studholme, Sarah Zimov, Stephen Yazull. Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide. Visual neuroscience. vol 22. issue 6. 2006-04-04. PMID:16469181. |
here we focused on one endocannabinoid, anandamide (aea), and its major hydrolyzing enzyme, fatty acid amide hydrolase (faah), in the goldfish retina. |
2006-04-04 |
2023-08-12 |
rat |
| Gustav Schelling, Daniela Hauer, Shahnaz Christina Azad, Martin Schmoelz, Alexander Chouker, Michael Schmidt, Cyrill Hornuss, Markus Rippberger, Josef Briegel, Manfred Thiel, Michael Vogese. Effects of general anesthesia on anandamide blood levels in humans. Anesthesiology. vol 104. issue 2. 2006-03-21. PMID:16436846. |
the endocannabinoid system includes g-protein-coupled cannabinoid receptors, the endocannabinoids n-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol, and multiple enzymes involved in the biosynthesis and degradation of endocannabinoids, including the anandamide metabolizing enzyme fatty acid amide hydrolase. |
2006-03-21 |
2023-08-12 |
Not clear |
| David A Karanian, Queenie B Brown, Alexandros Makriyannis, Therese A Kosten, Ben A Bah. Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 34. 2006-03-03. PMID:16120783. |
dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. |
2006-03-03 |
2023-08-12 |
Not clear |
| David A Karanian, Queenie B Brown, Alexandros Makriyannis, Therese A Kosten, Ben A Bah. Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 34. 2006-03-03. PMID:16120783. |
besides direct activation with cb1 receptor agonists, cannabinergic signaling can be modulated through inhibition of endocannabinoid transport and fatty acid amide hydrolase (faah), two mechanisms of endocannabinoid inactivation. |
2006-03-03 |
2023-08-12 |
Not clear |
| Jessica P Alexander, Benjamin F Cravat. Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chemistry & biology. vol 12. issue 11. 2006-03-02. PMID:16298297. |
fatty acid amide hydrolase (faah) regulates a large class of signaling lipids, including the endocannabinoid anandamide. |
2006-03-02 |
2023-08-12 |
Not clear |