| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryan J McLaughlin, Matthew N Hill, Anna C Morrish, Boris B Gorzalk. Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762511. |
systemic administration of direct cannabinoid cb1 receptor agonists and inhibitors of the hydrolytic enzyme fatty acid amide hydrolase have been shown to elicit antidepressant effects. |
2007-10-23 |
2023-08-12 |
rat |
| Ryan J McLaughlin, Matthew N Hill, Anna C Morrish, Boris B Gorzalk. Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762511. |
male sprague-dawley rats were bilaterally implanted with cannulae directed at the dentate gyrus of the dorsal hippocampus and subsequently received three infusions of either the cannabinoid cb1 receptor agonist hu-210 (1 and 2.5 microg), the fatty acid amide hydrolase inhibitor urb597 (0.5 and 1 microg), the cannabinoid cb1 receptor antagonist am251 (1 and 2.5 microg), or vehicle (dimethyl sulfoxide) and were assessed in the forced swim test. |
2007-10-23 |
2023-08-12 |
rat |
| G Murdolo, K Kempf, A Hammarstedt, C Herder, U Smith, P-A Jansso. Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals. Journal of endocrinological investigation. vol 30. issue 8. 2007-10-23. PMID:17923791. |
the aim of this study was to elucidate the acute in vivo effects of insulin on gene expression of the cannabinoid type 1 (cb-1) and type 2 (cb-2) receptors, as well as of the fatty acid amide hydrolase (faah) in the sc abdominal adipose tissue (scaat). |
2007-10-23 |
2023-08-12 |
human |
| John Williams, JodiAnne Wood, Lakshmipathi Pandarinathan, David A Karanian, Ben A Bahr, Paul Vouros, Alexandros Makriyanni. Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS. Analytical chemistry. vol 79. issue 15. 2007-10-02. PMID:17600384. |
we have obtained an endocannabinoid profile specifically for the frontal cortex of the rat brain and have determined anandamide level differences following the administration of the fatty acid amide hydrolase inhibitor am374. |
2007-10-02 |
2023-08-12 |
rat |
| Geoffray Labar, Catherine Michau. Fatty acid amide hydrolase: from characterization to therapeutics. Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712824. |
fatty acid amide hydrolase (faah) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. |
2007-09-28 |
2023-08-12 |
Not clear |
| Kazuhito Tsuboi, Naoko Takezaki, Natsuo Ued. The N-acylethanolamine-hydrolyzing acid amidase (NAAA). Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712833. |
bioactive n-acylethanolamines, including the endocannabinoid anandamide and anti-inflammatory n-palmitoylethanolamine, are hydrolyzed to fatty acids and ethanolamine in animal tissues by the catalysis of fatty acid amide hydrolase (faah). |
2007-09-28 |
2023-08-12 |
mouse |
| Jessica P Alexander, Benjamin F Cravat. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Journal of the American Chemical Society. vol 128. issue 30. 2007-09-21. PMID:16866524. |
the putative endocannabinoid transport blocker ly2183240 is a potent inhibitor of faah and several other brain serine hydrolases. |
2007-09-21 |
2023-08-12 |
Not clear |
| Sándor Bátkai, Mohanraj Rajesh, Partha Mukhopadhyay, György Haskó, Lucas Liaudet, Benjamin F Cravatt, Anna Csiszár, Zoltan Ungvári, Pál Pache. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. American journal of physiology. Heart and circulatory physiology. vol 293. issue 2. 2007-09-18. PMID:17434980. |
inhibition of the endocannabinoid anandamide metabolizing enzyme, the fatty acid amide hydrolase (faah), is emerging as a promising novel approach for the treatment of various inflammatory disorders. |
2007-09-18 |
2023-08-12 |
mouse |
| Sándor Bátkai, Mohanraj Rajesh, Partha Mukhopadhyay, György Haskó, Lucas Liaudet, Benjamin F Cravatt, Anna Csiszár, Zoltan Ungvári, Pál Pache. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. American journal of physiology. Heart and circulatory physiology. vol 293. issue 2. 2007-09-18. PMID:17434980. |
there was no difference in the myocardial cannabinoid cb(1) and cb(2) receptor gene expression between young and aging faah(-/-) and faah(+/+) mice. |
2007-09-18 |
2023-08-12 |
mouse |
| Shinya Iwasaki, Hiroki Ishiguro, Susumu Higuchi, Emmanuel S Onaivi, Tadao Arinam. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. Psychiatric genetics. vol 17. issue 4. 2007-09-17. PMID:17621164. |
association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a japanese population. |
2007-09-17 |
2023-08-12 |
Not clear |
| Shinya Iwasaki, Hiroki Ishiguro, Susumu Higuchi, Emmanuel S Onaivi, Tadao Arinam. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. Psychiatric genetics. vol 17. issue 4. 2007-09-17. PMID:17621164. |
fatty acid amide hydrolase (faah) and monoglyceride lipase (mgll) are the major endocannabinoid metabolic enzymes. |
2007-09-17 |
2023-08-12 |
Not clear |
| Shinya Iwasaki, Hiroki Ishiguro, Susumu Higuchi, Emmanuel S Onaivi, Tadao Arinam. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. Psychiatric genetics. vol 17. issue 4. 2007-09-17. PMID:17621164. |
owing to the importance of endocannabinoid system in addiction, the pro129thr polymorphism in the faah gene has reportedly been associated with substance abuse and dependence in a caucasian population. |
2007-09-17 |
2023-08-12 |
Not clear |
| Shoichiro Tsuyama, Daichi Oikawa, Yasuko Yamasaki, Sayuri Takagi, Hironori Ando, Mitsuhiro Furus. Expression of endocannabinoid synthetic enzyme mRnas is correlated with cannabinoid 1 receptor mRNA in the mouse brain. Nutritional neuroscience. vol 10. issue 1-2. 2007-09-12. PMID:17539482. |
phospholipase d (pld), fatty acid amide hydrolase (faah), diacyl-glycerol lipase (dagl), monoacyl-glycerol lipase (magl) and cannabinoid 1 (cb1) receptor mrna expressions were determined in the whole brain. |
2007-09-12 |
2023-08-12 |
mouse |
| Natalia Battista, Monica Bari, Alessia Tarditi, Caterina Mariotti, Anne-Catherine Bachoud-Lévi, Chiara Zuccato, Alessandro Finazzi-Agrò, Silvia Genitrini, Marc Peschanski, Stefano Di Donato, Elena Cattaneo, Mauro Maccarron. Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes. Neurobiology of disease. vol 27. issue 1. 2007-09-06. PMID:17553686. |
we assayed peripheral lymphocytes from hd patients and healthy controls, and found that the activity of the fatty acid amide hydrolase (faah), the enzyme that degrades the endocannabinoid anandamide (aea), was dramatically decreased (down to less than 10%) in hd compared to healthy subjects. |
2007-09-06 |
2023-08-12 |
human |
| Rachel F Tyndale, Jennifer I Payne, Alexandra L Gerber, Jack C Sip. The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 5. 2007-08-30. PMID:17290447. |
faah is a mammalian enzyme that inactivates neuromodulatory-signaling lipids including the endogenous cannabinoid 1 receptor agonist anandamide. |
2007-08-30 |
2023-08-12 |
human |
| Roberto Russo, Jesse Loverme, Giovanna La Rana, Timothy R Compton, Jeff Parrott, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Antonio Calignano, Daniele Piomell. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17412883. |
fatty acid amide hydrolase (faah) is an intracellular serine hydrolase that catalyzes the cleavage of bioactive fatty acid ethanolamides, such as the endogenous cannabinoid agonist anandamide. |
2007-08-30 |
2023-08-12 |
mouse |
| Roberto Russo, Jesse Loverme, Giovanna La Rana, Timothy R Compton, Jeff Parrott, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Antonio Calignano, Daniele Piomell. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17412883. |
the results provide new evidence for a role of the endocannabinoid system in pain modulation and reinforce the proposed role of faah as a target for analgesic drug development. |
2007-08-30 |
2023-08-12 |
mouse |
| Marcello Solinas, Maria Scherma, Gianluigi Tanda, Carrie E Wertheim, Walter Fratta, Steven R Goldber. Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17351107. |
in addition, when metabolic degradation of the endogenous cannabinoid anandamide was blocked by the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoylbiphenil-3-yl-ester (urb-597; 0.3 mg/kg i.p.) |
2007-07-30 |
2023-08-12 |
rat |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. |
2007-07-26 |
2023-08-12 |
human |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
in the present study, a series of analogues of ibuprofen and indomethacin have been investigated with respect to their ability to inhibit fatty acid amide hydrolase, the enzyme responsible for the hydrolysis of the endogenous cannabinoid anandamide. |
2007-07-26 |
2023-08-12 |
human |