| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Scherma, Leigh V Panlilio, Paola Fadda, Liana Fattore, Islam Gamaleddin, Bernard Le Foll, Zuzana Justinová, Eva Mikics, Jozsef Haller, Julie Medalie, Jessica Stroik, Chanel Barnes, Sevil Yasar, Gianluigi Tanda, Daniele Piomelli, Walter Fratta, Steven R Goldber. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. The Journal of pharmacology and experimental therapeutics. vol 327. issue 2. 2008-11-13. PMID:18725543. |
a more functionally selective way to alter endocannabinoid activity is to inhibit fatty acid amide hydrolase (faah), thereby magnifying and prolonging the effects of the endocannabinoid anandamide only when and where it is synthesized and released on demand. |
2008-11-13 |
2023-08-12 |
rat |
| Sabrina F Lisboa, Leonardo B M Resstel, Daniele C Aguiar, Francisco S Guimarãe. Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test. European journal of pharmacology. vol 593. issue 1-3. 2008-11-12. PMID:18691568. |
the animals received a first microinjection of vehicle (0.2 microl) or am251 (a cannabinoid cb(1) receptor antagonist; 100 pmol) followed, 5 min later, by a second microinjection of vehicle, anandamide (an endocannabinoid, 5 pmol), am404 (an inhibitor of anandamide uptake, 50 pmol) or urb597 (an inhibitor of fatty acid amide hydrolase, 0.01 or 0.1 nmol). |
2008-11-12 |
2023-08-12 |
rat |
| Matthew N Hill, Erica J Carrier, Ryan J McLaughlin, Anna C Morrish, Sarah E Meier, Cecilia J Hillard, Boris B Gorzalk. Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18643796. |
we determined the effects of cus, with or without concurrent treatment with the antidepressant imipramine (10 mg/kg), on cp55940 binding to the cannabinoid cb(1) receptor; whole tissue endocannabinoid content; and fatty acid amide hydrolase (faah) activity in the prefrontal cortex, hippocampus, hypothalamus, amygdala, midbrain and ventral striatum. |
2008-11-07 |
2023-08-12 |
rat |
| Maulik D Jhaveri, Denise Richardson, Ian Robinson, Michael J Garle, Annie Patel, Yan Sun, Devi R Sagar, Andrew J Bennett, Stephen P H Alexander, David A Kendall, David A Barrett, Victoria Chapma. Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18534634. |
inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain. |
2008-11-05 |
2023-08-12 |
Not clear |
| D de Filippis, T Iuvone, A d'amico, G Esposito, L Steardo, A G Herman, P A Pelckmans, B Y de Winter, J G de Ma. Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 8. 2008-10-27. PMID:18373655. |
cannabidiol also regulates the activity of fatty acid amide hydrolase (faah) which is the main enzyme involved in endocannabinoid breakdown and which modulates gastrointestinal motility. |
2008-10-27 |
2023-08-12 |
mouse |
| Parisa Hasanein, Siamak Shahidi, Alireza Komaki, Naser Miraz. Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis. European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18593578. |
considering the interaction that has been shown between the endogenous opioid and endocannabinoid systems in nociception processing, we studied the effects of urb597, a selective inhibitor of faah (fatty acid amide hydrolase), on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis. |
2008-10-15 |
2023-08-12 |
rat |
| Parisa Hasanein, Siamak Shahidi, Alireza Komaki, Naser Miraz. Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis. European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18593578. |
these data showed that urb597 as a faah inhibitor potentiates antinociception induced by cholestasis in tail-flick test and that the inhibitory effects of urb597 in this model are mediated by cannabinoid cb(1) and not cb(2) receptors. |
2008-10-15 |
2023-08-12 |
rat |
| Mauro Mileni, Douglas S Johnson, Zhigang Wang, Daniel S Everdeen, Marya Liimatta, Brandon Pabst, Keshab Bhattacharya, Richard A Nugent, Satwik Kamtekar, Benjamin F Cravatt, Kay Ahn, Raymond C Steven. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 35. 2008-10-06. PMID:18753625. |
the integral membrane enzyme fatty acid amide hydrolase (faah) hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. |
2008-10-06 |
2023-08-12 |
human |
| Juan Suárez, Francisco Javier Bermúdez-Silva, Ken Mackie, Catherine Ledent, Andreas Zimmer, Benjamin F Cravatt, Fernando Rodríguez de Fonsec. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. The Journal of comparative neurology. vol 509. issue 4. 2008-09-02. PMID:18521853. |
these proteins include the two main cannabinoid receptors (cb(1) and cb(2)), the enzymes involved in cannabinoid biosynthesis (dagl alpha, dagl beta, and nape-pld), and the endocannabinoid-degradating enzymes (faah and magl). |
2008-09-02 |
2023-08-12 |
rat |
| Juan Suárez, Francisco Javier Bermúdez-Silva, Ken Mackie, Catherine Ledent, Andreas Zimmer, Benjamin F Cravatt, Fernando Rodríguez de Fonsec. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. The Journal of comparative neurology. vol 509. issue 4. 2008-09-02. PMID:18521853. |
with regard to the cerebellar cortex, these data confirm several published reports on the distribution of cannabinoid cb(1) receptors, dagl alpha, magl, and faah, which suggests a role of endocannabinoids as retrograde messengers in the synapses of the purkinje cells by either parallel fibers of granule cells or climbing fibers from the inferior olive or gabaergic interneuron. |
2008-09-02 |
2023-08-12 |
rat |
| Lisa L Merritt, B R Martin, C Walters, A H Lichtman, M Imad Dama. The endogenous cannabinoid system modulates nicotine reward and dependence. The Journal of pharmacology and experimental therapeutics. vol 326. issue 2. 2008-08-12. PMID:18451315. |
in contrast, genetic deletion, or pharmacological inhibition of fatty acid amide hydrolase (faah), the enzyme responsible for catabolism of the endocannabinoid anandamide, enhanced the expression of nicotine cpp. |
2008-08-12 |
2023-08-12 |
mouse |
| Filomena Fezza, Sergio Oddi, Monia Di Tommaso, Chiara De Simone, Cinzia Rapino, Nicoletta Pasquariello, Enrico Dainese, Alessandro Finazzi-Agrò, Mauro Maccarron. Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation. Journal of lipid research. vol 49. issue 6. 2008-08-05. PMID:18316795. |
conversely, b-aea does not interact or interfere with the other components of the endocannabinoid system, such as type-1 and type-2 cannabinoid receptors, vanilloid receptor, aea synthetase (n-acylphosphatidylethanolamine-hydrolyzing phospholipase d), or aea hydrolase (fatty acid amide hydrolase). |
2008-08-05 |
2023-08-12 |
Not clear |
| Venkatesh L Hegde, Shweta Hegde, Benjamin F Cravatt, Lorne J Hofseth, Mitzi Nagarkatti, Prakash S Nagarkatt. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Molecular pharmacology. vol 74. issue 1. 2008-07-25. PMID:18388242. |
in addition, deficiency or inhibition of endocannabinoid hydrolyzing enzyme fatty acid amide hydrolase (faah), which leads to increased levels of endogenous cannabinoids, resulted in decreased liver injury upon cona challenge. |
2008-07-25 |
2023-08-12 |
mouse |
| Venkatesh L Hegde, Shweta Hegde, Benjamin F Cravatt, Lorne J Hofseth, Mitzi Nagarkatti, Prakash S Nagarkatt. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Molecular pharmacology. vol 74. issue 1. 2008-07-25. PMID:18388242. |
our data demonstrate that targeting cannabinoid receptors using exogenous or endogenous cannabinoids and use of faah inhibitors may constitute novel therapeutic modalities to treat immune-mediated liver inflammation. |
2008-07-25 |
2023-08-12 |
mouse |
| M Dalle Carbonare, E Del Giudice, A Stecca, D Colavito, M Fabris, A D'Arrigo, D Bernardini, M Dam, A Leo. A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story... Journal of neuroendocrinology. vol 20 Suppl 1. 2008-07-18. PMID:18426496. |
a saturated n-acylethanolamine other than n-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story... n-acylethanolamines, which include the endocannabinoid anandamide and the cannabinoid receptor-inactive saturated compounds n-palmitoyl ethanolamine and n-stearoyl ethanolamine, are ethanolamines of long-chain fatty acids degraded by fatty acid amide hydrolase (faah) known to accumulate in degenerating tissues and cells. |
2008-07-18 |
2023-08-12 |
Not clear |
| S Engel. Dysregulation of the endocannabinoid system in obesity. Journal of neuroendocrinology. vol 20 Suppl 1. 2008-07-18. PMID:18426509. |
for example, most data show decreased fatty acid amide hydrolase (faah) expression and/or activity as a result of obesity or high-fat intake, but the endocannabinoid predominantly increased in tissues is 2-arachidonoylglycerol (2-ag), which is not degraded by faah in vivo. |
2008-07-18 |
2023-08-12 |
human |
| E Cottone, A Guastalla, K Mackie, M F Franzon. Endocannabinoids affect the reproductive functions in teleosts and amphibians. Molecular and cellular endocrinology. vol 286. issue 1-2 Suppl 1. 2008-07-11. PMID:18343023. |
the fact that cb1-li-ir was found indeed in the fsh gonadotrophs of the xenopus pituitary gland and cb1 receptors together with the fatty acid amide hydrolase, the degradative enzyme of the endocannabinoid anandamide, were demonstrated in both bonyfish and frog gonads, strongly suggests that endocannabinoids are involved in central and peripheral gonadotropic functions of teleosts and amphibians. |
2008-07-11 |
2023-08-12 |
xenopus_laevis |
| Palmiero Monteleone, Alfonso Tortorella, Vassilis Martiadis, Carmela Di Filippo, Benedetta Canestrelli, Mario Ma. The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. Psychoneuroendocrinology. vol 33. issue 4. 2008-07-01. PMID:18295974. |
the cdna 385c to a missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. |
2008-07-01 |
2023-08-12 |
human |
| E Núñez, C Benito, R M Tolón, C J Hillard, W S T Griffin, J Romer. Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. Neuroscience. vol 151. issue 1. 2008-04-22. PMID:18068305. |
glial expression of cannabinoid cb(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in down's syndrome. |
2008-04-22 |
2023-08-12 |
human |
| E Núñez, C Benito, R M Tolón, C J Hillard, W S T Griffin, J Romer. Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. Neuroscience. vol 151. issue 1. 2008-04-22. PMID:18068305. |
specifically, data obtained in human brain tissue sections from alzheimer's disease patients showed that the expression of cannabinoid receptors of the cb(2) type is induced in activated microglial cells while fatty acid amide hydrolase (faah) expression is increased in reactive astrocytes. |
2008-04-22 |
2023-08-12 |
human |