| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sílvia Cufí, Bruna Corominas-Faja, Eugeni Lopez-Bonet, Rosa Bonavia, Sonia Pernas, Isabel Álvarez López, Joan Dorca, Susana Martínez, Norberto Batista López, Severina Domínguez Fernández, Elisabet Cuyàs, Joana Visa, Esther Rodríguez-Gallego, Rosa Quirantes-Piné, Antonio Segura-Carretero, Jorge Joven, Begoña Martin-Castillo, Javier A Menende. Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin. Oncotarget. vol 4. issue 9. 2014-07-10. PMID:23986086. |
cancer cells expressing constitutively active phosphatidylinositol-3 kinase (pi3k) are proliferative regardless of the absence of insulin, and they form dietary restriction (dr)-resistant tumors in vivo. |
2014-07-10 |
2023-08-12 |
mouse |
| Manda L Orgeron, Kirsten P Stone, Desiree Wanders, Cory C Cortez, Nancy T Van, Thomas W Getty. The impact of dietary methionine restriction on biomarkers of metabolic health. Progress in molecular biology and translational science. vol 121. 2014-07-10. PMID:24373243. |
the link between the life-extending effects of dr and adiposity is the subject of an ongoing debate, but it is clear that decreased fat accumulation improves insulin sensitivity and produces beneficial effects on overall metabolic health. |
2014-07-10 |
2023-08-12 |
human |
| Li Hu, Dong-Hao L. Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China. International journal of ophthalmology. vol 7. issue 3. 2014-06-26. PMID:24967192. |
to explore the related risk factors for diabetic retinopathy (dr) in type 2 diabetes with insulin therapy. |
2014-06-26 |
2023-08-13 |
Not clear |
| Jacqueline M Crissey, Nathan T Jenkins, Kasey A Lansford, Pamela K Thorne, David S Bayless, Victoria J Vieira-Potter, R Scott Rector, John P Thyfault, M Harold Laughlin, Jaume Padill. Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 306. issue 8. 2014-06-06. PMID:24523340. |
wr and dr rats exhibited markedly lower adiposity (7.1 ± 0.4 and 15.7 ± 1.1% body fat, respectively) relative to sed (27 ± 1.2% body fat), as well as improved blood lipid profiles and systemic markers of insulin resistance. |
2014-06-06 |
2023-08-12 |
rat |
| Mohammad Shamsul Ol. Effect of hyperglycemia on insulin receptor signaling in the cultured retinal Müller glial cells. Biochemical and biophysical research communications. vol 444. issue 2. 2014-04-30. PMID:24462861. |
hyperglycemia and impaired insulin signaling are considered as major factors in the retinal pathology in diabetic retinopathy (dr). |
2014-04-30 |
2023-08-12 |
Not clear |
| Colin Selman, Sarah Hempenstal. Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice. Longevity & healthspan. vol 1. 2014-04-25. PMID:24764508. |
we examined a range of metabolic parameters (body mass, body composition (lean and fat mass), glucose tolerance, fed blood glucose, fasting plasma insulin and insulin-like growth factor 1 (igf-1), insulin sensitivity) in male c57bl/6 mice dietary switched from dr to al (dr-al) at 11 months of age (mid life). |
2014-04-25 |
2023-08-13 |
mouse |
| Kerry M Cameron, Satomi Miwa, Cornelia Walker, Thomas von Zglinick. Male mice retain a metabolic memory of improved glucose tolerance induced during adult onset, short-term dietary restriction. Longevity & healthspan. vol 1. 2014-04-25. PMID:24764509. |
chronic dietary restriction (dr) has been shown to have beneficial effects on glucose homeostasis and insulin sensitivity. |
2014-04-25 |
2023-08-13 |
mouse |
| Lauren T Robertson, James R Mitchel. Benefits of short-term dietary restriction in mammals. Experimental gerontology. vol 48. issue 10. 2014-03-11. PMID:23376627. |
here we review data on the ability of short-term dr to induce beneficial effects on clinically relevant endpoints including surgical stress, inflammation, chemotherapy and insulin resistance. |
2014-03-11 |
2023-08-12 |
Not clear |
| Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Masashige Takahashi, Mochamad A Sobirin, Taisuke Ono, Kagami Hirabayashi, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsu. Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice. Endocrinology. vol 155. issue 1. 2014-02-24. PMID:24189138. |
exercise training (ex) and diet restriction (dr) are essential for effective management of obesity and insulin resistance in diabetes mellitus. |
2014-02-24 |
2023-08-12 |
mouse |
| Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Masashige Takahashi, Mochamad A Sobirin, Taisuke Ono, Kagami Hirabayashi, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsu. Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice. Endocrinology. vol 155. issue 1. 2014-02-24. PMID:24189138. |
obesity and insulin resistance induced by a hfd were significantly but partially improved by ex or dr and completely reversed by ex+dr. |
2014-02-24 |
2023-08-12 |
mouse |
| Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Masashige Takahashi, Mochamad A Sobirin, Taisuke Ono, Kagami Hirabayashi, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsu. Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice. Endocrinology. vol 155. issue 1. 2014-02-24. PMID:24189138. |
although obesity and insulin resistance were completely reversed by dr with an insulin-sensitizing drug or a long-term intervention, the exercise capacity and skeletal muscle function could not be normalized. |
2014-02-24 |
2023-08-12 |
mouse |
| Wayne H-H Sheu, Jane Z Kuo, I-Te Lee, Yi-Jen Hung, Wen-Jane Lee, Hin-Yeung Tsai, J-S Wang, Mark O Goodarzi, Ronald Klein, Barbara E K Klein, Eli Ipp, Shin-Yi Lin, Xiuqing Guo, Chang-Hsun Hsieh, Kent D Taylor, Chia-Po Fu, Jerome I Rotter, Yii-Der I Che. Genome-wide association study in a Chinese population with diabetic retinopathy. Human molecular genetics. vol 22. issue 15. 2014-01-31. PMID:23562823. |
these genes are still of particular interest because they are involved in insulin regulation, inflammation, lipid signaling and apoptosis pathways, all of which are possibly involved with dr. our finding nominates possible novel loci as potential dr susceptibility genes in the chinese that are independent of the level of hba1c and duration of diabetes and may provide insight into the pathophysiology of dr. |
2014-01-31 |
2023-08-12 |
human |
| Samuel E Schriner, Kevin Lee, Stephanie Truong, Kathyrn T Salvadora, Steven Maler, Alexander Nam, Thomas Lee, Mahtab Jafar. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PloS one. vol 8. issue 5. 2013-12-30. PMID:23704949. |
while the mechanism of dr itself is also unknown, three molecular pathways have been associated with it: the silent information regulator 2 (sir2) proteins, insulin and insulin-like growth factor signaling (iis), and the target of rapamycin (tor). |
2013-12-30 |
2023-08-12 |
human |
| Giovanni Sartore, Nino Cristiano Chilelli, Silvia Burlina, Annunziata Lapoll. Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes. Acta diabetologica. vol 50. issue 3. 2013-10-29. PMID:23417155. |
univariate analysis showed a close association between dr and duration of diabetes (or 1.11; 1.04-1.19), intensive insulin therapy (or 5.6, ci 1.14-27.30), sd (or 1.03; ci 1.01-1.06) and conga 2 (or 1.02; ci 1.00-1.04)-both indicators of variability and hbgi (or 1.1, ci 1.01-1.18)-a parameter reflecting acute hyperglycemia. |
2013-10-29 |
2023-08-12 |
Not clear |
| Andrew R Mendelsohn, James W Larric. Fibroblast growth factor-21 is a promising dietary restriction mimetic. Rejuvenation research. vol 15. issue 6. 2013-09-11. PMID:23173578. |
increased expression of fibroblast growth factor-21 (fgf21), a putative mammalian starvation master regulator, promotes many of the same beneficial physiological changes seen in dr animals, including decreased glucose levels, increased insulin sensitivity, and improved fatty acid/lipid profiles. |
2013-09-11 |
2023-08-12 |
mouse |
| Andrew R Mendelsohn, James W Larric. Dietary restriction: critical co-factors to separate health span from life span benefits. Rejuvenation research. vol 15. issue 5. 2013-07-12. PMID:22963324. |
several short-term studies show that humans may benefit from dr in as little as 6 months, by achieving lowered fasting insulin levels and improved cardiovascular health. |
2013-07-12 |
2023-08-12 |
mouse |
| R J Feuers, V G Desai, F X Chen, J D Hunter, P H Duffy, E T Oriak. Effects of dietary restriction on insulin resistance in obese mice. Journal of the American Aging Association. vol 23. issue 2. 2013-04-23. PMID:23604843. |
the effects of dr on blood glucose and insulin resistance were measured in yellow obese (a(vy)/a), lean black (a/a) mice and in another common inbred strain (b6c3f1) (at three different ages). |
2013-04-23 |
2023-08-12 |
mouse |
| R J Feuers, V G Desai, F X Chen, J D Hunter, P H Duffy, E T Oriak. Effects of dietary restriction on insulin resistance in obese mice. Journal of the American Aging Association. vol 23. issue 2. 2013-04-23. PMID:23604843. |
insulin responses and radioinsulin binding were assayed in yellow obese and lean black mice fed either ad libitum (al) or dr diets (yal, bal, ydr and yal, respectively) at four different circadian intervals. |
2013-04-23 |
2023-08-12 |
mouse |
| Jiarong Liu, Wei Zhang, Gin C Chuang, Helliner S Hill, Ling Tian, Yuchang Fu, Douglas R Moellering, W Timothy Garve. Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess. American journal of physiology. Endocrinology and metabolism. vol 303. issue 7. 2013-01-07. PMID:22850683. |
we have suggested previously that tribbles homolog 3 (trib3), a negative regulator of akt activity in insulin-sensitive tissues, could mediate glucose-induced insulin resistance in muscle under conditions of chronic hyperglycemia (liu j, wu x, franklin jl, messina jl, hill hs, moellering dr, walton rg, martin m, garvey wt. |
2013-01-07 |
2023-08-12 |
rat |
| M Usman Akram, Anam Tariq, M Almas Anjum, M Younus Jave. Automated detection of exudates in colored retinal images for diagnosis of diabetic retinopathy. Applied optics. vol 51. issue 20. 2012-11-16. PMID:22781265. |
diabetic retinopathy (dr) is an eye disease caused by the increase of insulin in blood and may cause blindness. |
2012-11-16 |
2023-08-12 |
Not clear |