| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah J Paulsen, Jacob Jelsing, Andreas N Madsen, Gitte Hansen, Kirsten Lykkegaard, Leif K Larsen, Philip J Larsen, Barry E Levin, Niels Vran. Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats. Obesity (Silver Spring, Md.). vol 18. issue 2. 2010-02-22. PMID:19661956. |
to improve our understanding of the underlying cause for the deteriorating glucose and insulin parameters, we have investigated possible adaptive responses in dio and dr rats at the level of the insulin-producing beta-cells. |
2010-02-22 |
2023-08-12 |
human |
| Sarah J Paulsen, Jacob Jelsing, Andreas N Madsen, Gitte Hansen, Kirsten Lykkegaard, Leif K Larsen, Philip J Larsen, Barry E Levin, Niels Vran. Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats. Obesity (Silver Spring, Md.). vol 18. issue 2. 2010-02-22. PMID:19661956. |
at the time of weaning, dr rats were found to have a higher body weight and beta-cell mass compared to dio rats, and elevated insulin and glucose responses to an oral glucose load. |
2010-02-22 |
2023-08-12 |
human |
| Sarah J Paulsen, Jacob Jelsing, Andreas N Madsen, Gitte Hansen, Kirsten Lykkegaard, Leif K Larsen, Philip J Larsen, Barry E Levin, Niels Vran. Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats. Obesity (Silver Spring, Md.). vol 18. issue 2. 2010-02-22. PMID:19661956. |
however, at 2.5 months of age, and for the remaining study period, the effect of genotype became evident: the chow-fed dio rats steadily increased their body weight and beta-cell mass, as well as insulin and glucose levels compared to the dr rats. |
2010-02-22 |
2023-08-12 |
human |
| James R Mitchell, Mariëlle Verweij, Karl Brand, Marieke van de Ven, Natascha Goemaere, Sandra van den Engel, Timothy Chu, Flavio Forrer, Cristina Müller, Marion de Jong, Wilfred van IJcken, Jan N M IJzermans, Jan H J Hoeijmakers, Ron W F de Brui. Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging cell. vol 9. issue 1. 2010-02-09. PMID:19878145. |
protection by both short-term dr and fasting correlated with improved insulin sensitivity, increased expression of markers of antioxidant defense and reduced expression of markers of inflammation and insulin/insulin-like growth factor-1 signaling. |
2010-02-09 |
2023-08-12 |
mouse |
| Futoshi Anan, Masaki Takayuki, Naohiko Takahashi, Mikiko Nakagawa, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimats. Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients. Hypertension research : official journal of the Japanese Society of Hypertension. vol 32. issue 4. 2009-12-07. PMID:19262488. |
this preliminary study was therefore designed to test the hypothesis that dr is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients without insulin treatment. |
2009-12-07 |
2023-08-12 |
Not clear |
| Futoshi Anan, Masaki Takayuki, Naohiko Takahashi, Mikiko Nakagawa, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimats. Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients. Hypertension research : official journal of the Japanese Society of Hypertension. vol 32. issue 4. 2009-12-07. PMID:19262488. |
with respect to metabolic findings, dr patients had higher fasting plasma insulin concentration (p<0.0001) and higher homeostasis model assessment (homa) index (p<0.00001) than the ndr patients. |
2009-12-07 |
2023-08-12 |
Not clear |
| Futoshi Anan, Masaki Takayuki, Naohiko Takahashi, Mikiko Nakagawa, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimats. Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients. Hypertension research : official journal of the Japanese Society of Hypertension. vol 32. issue 4. 2009-12-07. PMID:19262488. |
our results suggest that dr is associated with depressed cardiovascular autonomic function and insulin resistance and that homa index and the percent wr of (123)i-mibg are independently associated with dr in japanese patients with type 2 diabetes mellitus. |
2009-12-07 |
2023-08-12 |
Not clear |
| Radu C Oita, Dawn J Mazzatti, Fei Ling Lim, Jonathan R Powell, Brian J Merr. Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats. Mechanisms of ageing and development. vol 130. issue 4. 2009-08-14. PMID:19150624. |
the mechanisms by which dr increases survival are controversial but are thought to include improvements in mitochondrial function concomitant with reductions in reactive oxygen species production and alterations in the insulin signalling pathway, resulting in global metabolic adaptation. |
2009-08-14 |
2023-08-12 |
rat |
| Alessio Donati, Gianluca Recchia, Gabriella Cavallini, Ettore Bergamin. Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 63. issue 6. 2008-09-05. PMID:18559627. |
both dr and eod maintain the sensitivity to glucagon at juvenile levels, whereas only eod can fully maintain response to insulin. |
2008-09-05 |
2023-08-12 |
rat |
| Sergiy Libert, Yufang Chao, Jessica Zwiener, Scott D Pletche. Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction. Molecular immunology. vol 45. issue 3. 2008-02-15. PMID:17681604. |
we investigated the efficiency of the innate immune system in drosophila carrying the longevity extending mutations puc (jnk signaling pathway, stress response) and chico (insulin signaling pathway), as well as animals subjected to dietary restriction (dr), which also extends lifespan. |
2008-02-15 |
2023-08-12 |
drosophila_melanogaster |
| Min-Heui Yoo, Young Hee Yoon, Hyewon Chung, Kyung Sook Cho, Jae-Young Ko. Insulin increases retinal hemorrhage in mild oxygen-induced retinopathy in the rat: inhibition by riluzole. Investigative ophthalmology & visual science. vol 48. issue 12. 2008-01-29. PMID:18055818. |
although hyperglycemia is likely the main stimulus for vegf induction in diabetic retinopathy (dr), a switch from oral hypoglycemic therapy to parenteral insulin injection, despite producing better glucose control, sometimes paradoxically aggravates dr. |
2008-01-29 |
2023-08-12 |
rat |
| Tao-Hsin Tung, Hui-Chuan Shih, Shih-Tzer Tsai, Pesus Chou, Shih-Jen Chen, Fenq-Lih Lee, Shao-Yuan Chuang, Jorn-Hon Li. A community-based study of the relationship between insulin resistance/beta-cell dysfunction and diabetic retinopathy among type II diabetics in Kinmen, Taiwan. Ophthalmic epidemiology. vol 14. issue 3. 2007-08-21. PMID:17613850. |
to explore whether insulin resistance and beta-cell dysfunction are both related to diabetic retinopathy (dr) in type ii diabetics by using a community-based study in kinmen, taiwan. |
2007-08-21 |
2023-08-12 |
Not clear |
| Judith N Gorski, Ambrose A Dunn-Meynell, Barry E Levi. Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 292. issue 5. 2007-07-02. PMID:17218441. |
in rats selectively bred to develop diet-induced obesity (dio) or to be diet-resistant (dr), dio maternal obesity selectively enhances the development of obesity and insulin resistance in their adult offspring. |
2007-07-02 |
2023-08-12 |
rat |
| Judith N Gorski, Ambrose A Dunn-Meynell, Barry E Levi. Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 292. issue 5. 2007-07-02. PMID:17218441. |
maternal obesity in the current studies led to increased body and fat pad weights and higher leptin and insulin levels in postnatal day 16 offspring of both dio and dr dams. |
2007-07-02 |
2023-08-12 |
rat |
| Judith N Gorski, Ambrose A Dunn-Meynell, Barry E Levi. Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 292. issue 5. 2007-07-02. PMID:17218441. |
however, by 6 wk of age, most of these intergroup differences disappeared and offspring of obese dio dams had unexpected increases in arcuate nucleus leptin receptor mrna, peripheral insulin sensitivity, diet- and leptin-induced brown adipose temperature increase and 24-h anorectic response compared with offspring of lean dio, but not lean dr dams. |
2007-07-02 |
2023-08-12 |
rat |
| Seong Jin Lee, Moon Gi Cho. Association of manganese superoxide dismutase gene polymorphism (V16A) with diabetic macular edema in Korean type 2 diabetic patients. Metabolism: clinical and experimental. vol 55. issue 12. 2007-02-20. PMID:17142144. |
hypertension, diabetic duration, and insulin therapy were related to dr. |
2007-02-20 |
2023-08-12 |
human |
| Boman G Irani, Ambrose A Dunn-Meynell, Barry E Levi. Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology. vol 148. issue 1. 2007-02-13. PMID:17023527. |
however, he diet intake lowered lateral hypothalamic melanocortin-3 and melanocortin-4 receptor and hippocampal insulin binding of both dio and dr rats and hypothalamic paraventricular nucleus melanocortin-4 receptor binding only in dr rats. |
2007-02-13 |
2023-08-12 |
rat |
| Mohamed M Jahromi, George S Eisenbart. Genetic determinants of type 1 diabetes across populations. Annals of the New York Academy of Sciences. vol 1079. 2007-01-10. PMID:17130568. |
the main genetic determinants map to the major histocompatibility complex (mhc), and in particular dr and dq, although, genes outside the mhc contribute, including the insulin gene, ptpn22, and ctla-4. |
2007-01-10 |
2023-08-12 |
Not clear |
| Andrzej Bartke, Michal M Masternak, Khalid A Al-Regaiey, Michael S Bonkowsk. Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. Interdisciplinary topics in gerontology. vol 35. 2006-12-06. PMID:17063033. |
interestingly, dr leads to further increases in insulin sensitivity and longevity in ames dwarfs but not in ghrko mice. |
2006-12-06 |
2023-08-12 |
mouse |
| Andrzej Bartke, Michal M Masternak, Khalid A Al-Regaiey, Michael S Bonkowsk. Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. Interdisciplinary topics in gerontology. vol 35. 2006-12-06. PMID:17063033. |
the effects of dr partially overlapped but did not duplicate the effects of ames dwarfism or ghr deletion on the expression of genes related to insulin signaling and cell responsiveness to insulin. |
2006-12-06 |
2023-08-12 |
mouse |