| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrzej Bartke, Michal M Masternak, Khalid A Al-Regaiey, Michael S Bonkowsk. Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. Interdisciplinary topics in gerontology. vol 35. 2006-12-06. PMID:17063033. |
moreover, the effects of dr on the expression of the examined genes in different insulin target organs were not identical. |
2006-12-06 |
2023-08-12 |
mouse |
| C Guja, Loreta Guja, Sarah Nutland, Helen Rance, J A Todd, C Ionescu-Tîrgovişt. Strong association of insulin gene INS-VNTR polymorphisms with type 1 diabetes in the Romanian population. Romanian journal of internal medicine = Revue roumaine de medecine interne. vol 42. issue 2. 2006-06-28. PMID:15529622. |
class ii hla dr and dq and insulin gene polymorphisms encode for most of the t1dm genetic susceptibility. |
2006-06-28 |
2023-08-12 |
Not clear |
| James Herrington, Yun-Ping Zhou, Randal M Bugianesi, Paula M Dulski, Yue Feng, Vivien A Warren, McHardy M Smith, Martin G Kohler, Victor M Garsky, Manuel Sanchez, Michael Wagner, Kristin Raphaelli, Priya Banerjee, Chinweze Ahaghotu, Denise Wunderler, Birgit T Priest, John T Mehl, Maria L Garcia, Owen B McManus, Gregory J Kaczorowski, Robert S Slaughte. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. vol 55. issue 4. 2006-06-26. PMID:16567526. |
delayed-rectifier k+ currents (i(dr)) in pancreatic beta-cells are thought to contribute to action potential repolarization and thereby modulate insulin secretion. |
2006-06-26 |
2023-08-12 |
mouse |
| James Herrington, Yun-Ping Zhou, Randal M Bugianesi, Paula M Dulski, Yue Feng, Vivien A Warren, McHardy M Smith, Martin G Kohler, Victor M Garsky, Manuel Sanchez, Michael Wagner, Kristin Raphaelli, Priya Banerjee, Chinweze Ahaghotu, Denise Wunderler, Birgit T Priest, John T Mehl, Maria L Garcia, Owen B McManus, Gregory J Kaczorowski, Robert S Slaughte. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. vol 55. issue 4. 2006-06-26. PMID:16567526. |
these data point to a mechanism for specific enhancement of glucose-dependent insulin secretion by applying blockers of the beta-cell i(dr), which may provide advantages over currently used therapies for the treatment of type 2 diabetes. |
2006-06-26 |
2023-08-12 |
mouse |
| C Alonso, M Proto, A Coviello, M Peral de Brun. Insulin improves the endothelium-independent relaxation and the contractile response in aorta from hypertensive diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 51. issue 6. 2006-03-02. PMID:16309581. |
we investigated the effect of insulin on basal tone and contractile response in isolated aorta from hypertensive streptozotocin-induced diabetic rats (dr) and the role of endothelium in this response. |
2006-03-02 |
2023-08-12 |
rat |
| C Alonso, M Proto, A Coviello, M Peral de Brun. Insulin improves the endothelium-independent relaxation and the contractile response in aorta from hypertensive diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 51. issue 6. 2006-03-02. PMID:16309581. |
the effect of insulin was tested in rings of control rats (cr) and dr in different protocols: in basal tone, in the plateau of norepinephrine (ne) or kcl contracted rings and in the response to ne or kcl preincubated with insulin. |
2006-03-02 |
2023-08-12 |
rat |
| C Alonso, M Proto, A Coviello, M Peral de Brun. Insulin improves the endothelium-independent relaxation and the contractile response in aorta from hypertensive diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 51. issue 6. 2006-03-02. PMID:16309581. |
we found in dr: a) an endothelium independent-vasorelaxant effect of insulin on basal tone; b) a decreased response to ne (without differences in the sensibility) and to kcl (20 mmol/l) and an improvement of this hyporeactivity by insulin pre-treatment, and c) a potentiated vasorelaxant response of insulin dependent of increased vascular tone. |
2006-03-02 |
2023-08-12 |
rat |
| C Alonso, M Proto, A Coviello, M Peral de Brun. Insulin improves the endothelium-independent relaxation and the contractile response in aorta from hypertensive diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 51. issue 6. 2006-03-02. PMID:16309581. |
furthermore, an additional action of insulin on endothelial response through no-release was observed in precontracted vessels from cr, not observed in dr. our results support that insulin plays a role in regulation of arterial basal tone from dr by a direct effect on smooth muscle vascular cells exposed to high blood pressure. |
2006-03-02 |
2023-08-12 |
rat |
| C Alonso, M Proto, A Coviello, M Peral de Brun. Insulin improves the endothelium-independent relaxation and the contractile response in aorta from hypertensive diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 51. issue 6. 2006-03-02. PMID:16309581. |
the vasorelaxant effect of insulin dependent of endothelium is blunted in dr by a reduced endothelial no production. |
2006-03-02 |
2023-08-12 |
rat |
| E Chantelau, J Frysty. Progression of diabetic retinopathy during improved metabolic control may be treated with reduced insulin dosage and/or somatostatin analogue administration -- a case report. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 15. issue 2. 2005-07-08. PMID:15809016. |
it is well known that intensified insulin treatment of poorly controlled type 1 diabetic patients may worsen an existing diabetic retinopathy (dr). |
2005-07-08 |
2023-08-12 |
Not clear |
| E Chantelau, J Frysty. Progression of diabetic retinopathy during improved metabolic control may be treated with reduced insulin dosage and/or somatostatin analogue administration -- a case report. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 15. issue 2. 2005-07-08. PMID:15809016. |
here, we report on three cases, where the progression of dr during intensified metabolic control was treated with manipulation of insulin therapy and/or by administration of octreotide. |
2005-07-08 |
2023-08-12 |
Not clear |
| E Chantelau, J Frysty. Progression of diabetic retinopathy during improved metabolic control may be treated with reduced insulin dosage and/or somatostatin analogue administration -- a case report. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 15. issue 2. 2005-07-08. PMID:15809016. |
in conclusion, in poorly controlled type 1 diabetic patients, intensified insulin therapy is able to cause florid dr with acute macular edema. |
2005-07-08 |
2023-08-12 |
Not clear |
| Robert S Rosenso. Cholesterol lowering in diabetes. New evidence supports aggressive LDL-C targets. Postgraduate medicine. vol 117. issue 4. 2005-05-05. PMID:15842129. |
in this article, dr rosenson discusses the rationale for cholesterol lowering in patients with diabetes, the lipoprotein abnormalities that accompany insulin resistance, and the prognostic significance of high ldl particle numbers. |
2005-05-05 |
2023-08-12 |
Not clear |
| Deborah J Clegg, Stephen C Benoit, Jacquelyn A Reed, Stephen C Woods, Ambrose Dunn-Meynell, Barry E Levi. Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. American journal of physiology. Regulatory, integrative and comparative physiology. vol 288. issue 4. 2005-04-15. PMID:15604298. |
before the he diet, iv3t insulin reduced 4-h and 24-h chow intake by 53% and 69% in dr rats but by only 17% and 27% in dio rats, respectively. |
2005-04-15 |
2023-08-12 |
rat |
| Deborah J Clegg, Stephen C Benoit, Jacquelyn A Reed, Stephen C Woods, Ambrose Dunn-Meynell, Barry E Levi. Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. American journal of physiology. Regulatory, integrative and comparative physiology. vol 288. issue 4. 2005-04-15. PMID:15604298. |
similarly, in selectively bred (sb) chow-fed dr rats, 8 mu iv3t insulin reduced 4-h and 24-h intake by 21% and 22%, respectively, but had no significant effect in sb dio rats. |
2005-04-15 |
2023-08-12 |
rat |
| Deborah J Clegg, Stephen C Benoit, Jacquelyn A Reed, Stephen C Woods, Ambrose Dunn-Meynell, Barry E Levi. Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. American journal of physiology. Regulatory, integrative and comparative physiology. vol 288. issue 4. 2005-04-15. PMID:15604298. |
reduced insulin responsiveness was unassociated with differences in arcuate nucleus insulin receptor mrna expression between dio and dr rats or between rats fed chow or he diet. |
2005-04-15 |
2023-08-12 |
rat |
| Deborah J Clegg, Stephen C Benoit, Jacquelyn A Reed, Stephen C Woods, Ambrose Dunn-Meynell, Barry E Levi. Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. American journal of physiology. Regulatory, integrative and comparative physiology. vol 288. issue 4. 2005-04-15. PMID:15604298. |
however, since the he diet reduced central insulin sensitivity in dr rats but did not make them obese, it is likely that other brain areas are involved in insulin's anorectic action or that other pathways contribute to the development and maintenance of obesity. |
2005-04-15 |
2023-08-12 |
rat |
| Jeroen Visser, Flip Klatter, Jan-Luuk Hillebrands, Ar Jansen, Lucas Vijfschaft, Jan Rozin. Thymectomy should be the first choice in the protection of diabetes-prone BB rats for breeding purposes. Laboratory animals. vol 38. issue 4. 2004-11-09. PMID:15479551. |
since dp-bb rats develop diabetes before or at the time of breeding, such rats used for breeding need to be protected against diabetes development by the transfer of regulatory t cells obtained from diabetes-resistant (dr)-bb rats, by insulin treatment or by thymectomy. |
2004-11-09 |
2023-08-12 |
rat |
| William I Sivit. Understanding insulin resistance. What are the clinical implications? Postgraduate medicine. vol 116. issue 1. 2004-08-12. PMID:15274287. |
in this concise review, dr sivitz discusses the underlying mechanisms involved in insulin resistance, the issues surrounding assessment, and the implications for management in patients in whom insulin resistance is either detected or suspected. |
2004-08-12 |
2023-08-12 |
Not clear |
| Theresa A Gresl, Ricki J Colman, Thomas C Havighurst, Lauri O Byerley, David B Allison, Dale A Schoeller, Joseph W Kemnit. Insulin sensitivity and glucose effectiveness from three minimal models: effects of energy restriction and body fat in adult male rhesus monkeys. American journal of physiology. Regulatory, integrative and comparative physiology. vol 285. issue 6. 2004-01-07. PMID:12842866. |
body fat, in part, statistically mediated the effect of dr to enhance insulin sensitivity indexes. |
2004-01-07 |
2023-08-12 |
monkey |