| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Lane, S S Ball, D K Ingram, R G Cutler, J Engel, V Read, G S Rot. Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. The American journal of physiology. vol 268. issue 5 Pt 1. 1995-06-29. PMID:7762649. |
during the first 2-3 yr of this longitudinal study, glucose and insulin levels were not altered by diet restriction (dr). |
1995-06-29 |
2023-08-12 |
monkey |
| M A Lane, S S Ball, D K Ingram, R G Cutler, J Engel, V Read, G S Rot. Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. The American journal of physiology. vol 268. issue 5 Pt 1. 1995-06-29. PMID:7762649. |
several measures of the insulin response (baseline, maximum, and integrated areas under curve) increased with age and were lower in dr monkeys. |
1995-06-29 |
2023-08-12 |
monkey |
| B Ruhland, L Walker, C M Peterso. Human fetal islet response to interferon gamma. Annals of clinical and laboratory science. vol 24. issue 4. 1994-11-09. PMID:7944269. |
cells containing surface expression of dr and intracellular insulin by flow cytometry following depletion of phagocytic cells were also quantified and increased from 0 to 0.67 percent following exposure to ifn. |
1994-11-09 |
2023-08-12 |
human |
| B Ruhland, L Walker, C M Peterso. Human fetal islet response to interferon gamma. Annals of clinical and laboratory science. vol 24. issue 4. 1994-11-09. PMID:7944269. |
interferon gamma exposed, dr positive insulin containing cells contained one third the insulin of dr negative insulin containing cells (2.1 +/- 1.5 vs 6.6 +/- 3.4 microu/cell) but were nevertheless capable of stimulated insulin secretion. |
1994-11-09 |
2023-08-12 |
human |
| S Matsushita, K Takahashi, M Motoki, K Komoriya, S Ikagawa, Y Nishimur. Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome. The Journal of experimental medicine. vol 180. issue 3. 1994-09-22. PMID:8064238. |
although this fragment probably exists at a very low level under normal physiological conditions due to the disulfide bond between flanking cysteine residues (6cys-11cys), a reducing compound such as methimazole may cleave the disulfide bond in vivo and allow dr alpha-drb1*0406 complex on antigen-presenting cells to bind much of the linear fragment of insulin alpha chain, which may lead to the activation of self-insulin-specific t-helper cells. |
1994-09-22 |
2023-08-12 |
human |
| B E Levi. Diet cycling and age alter weight gain and insulin levels in rats. The American journal of physiology. vol 267. issue 2 Pt 2. 1994-09-21. PMID:8067464. |
plasma insulin levels were 70% higher in cycled vs. noncycled dio and dr rats, and both were higher than cf rats. |
1994-09-21 |
2023-08-12 |
rat |
| G D Cartee, D J Dea. Glucose transport with brief dietary restriction: heterogenous responses in muscles. The American journal of physiology. vol 266. issue 6 Pt 1. 1994-07-29. PMID:8023926. |
epitrochlearis glucose transport activity with 100 microu/ml insulin was increased by 38% after 5 days of dr (p < 0.05) despite no change in glucose transport activity with 0 or 20,000 microu/ml insulin. |
1994-07-29 |
2023-08-12 |
rat |
| G D Cartee, D J Dea. Glucose transport with brief dietary restriction: heterogenous responses in muscles. The American journal of physiology. vol 266. issue 6 Pt 1. 1994-07-29. PMID:8023926. |
the increase with 100 microu/ml insulin was not further enhanced by 20 days of dr. dr did not result in a significant increase in the glucose transport activity of the fdb with 0, 100, or 20,000 microu/ml insulin. |
1994-07-29 |
2023-08-12 |
rat |
| M Sh Shamkhalova, I A Abugova, P I Shishko, I I Dedov, L V Kozlov, V A Aleshkin, M N Rozin. [Effect of azathioprine on immunologic parameters in patients with newly diagnosed insulin-dependent diabetes mellitus]. Problemy endokrinologii. vol 39. issue 5. 1994-03-18. PMID:8108339. |
azathioprine immunosuppressive therapy prolongs remissions and stimulates residual beta-cell function, suppresses insulin antibody production, reduces the activity of the complement and ch50 components, reduces initially increased cellular immunity parameters (total t and b cell counts, t helper to t inductor ratio, and the count of dr carrier cells) in patients with newly detected insulin-dependent diabetes mellitus; this makes this drug effective at the first stages of the disease. |
1994-03-18 |
2023-08-12 |
Not clear |
| C Levy-Marchal, J Tichet, I Fajardy, F Dubois, P Czernicho. [Risk markers of insulin-dependent diabetes in the normal population]. Annales d'endocrinologie. vol 53. issue 3. 1993-04-15. PMID:1295436. |
several factors have been identified as the genetic background at the hla level (dr and dq regions) and autoantibodies like islet cells antibodies (ica) and insulin autoantibodies (iaa). |
1993-04-15 |
2023-08-11 |
Not clear |
| C Giordano, R De Maria, M Todaro, G Stassi, A Mattina, P Richiusa, G Galluzzo, F Pantó, A Galluzz. Study of T-cell activation in type I diabetic patients and pre-type I diabetic subjects by cytometric analysis: antigen expression defect in vitro. Journal of clinical immunology. vol 13. issue 1. 1993-04-08. PMID:8095271. |
to confirm this hypothesis we investigated the t-cell activation trend, evaluating the surface expression of il-2 receptor (cd25), transferrin (cd71), hla class ii (dr), and cd69 phenotypes after in vitro stimulation with phytohemagglutinin (pha; 1 and 10 micrograms/ml) and concanavalin a (12.5 micrograms/ml) in six newly diagnosed type i diabetics and six islet cell- and insulin autoantibody-positive first-degree relatives. |
1993-04-08 |
2023-08-12 |
human |
| J Seissler, B Hering, W Richter, M Glück, N Yassin, R G Bretzel, B O Boehm, K Federlin, W A Scherbau. Antibodies to the M(r) 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired beta-cell function. Diabetologia. vol 35. issue 6. 1992-07-30. PMID:1612228. |
these subjects were typed for hla dr and dq alleles and investigated for the presence of antibodies to the m(r) 64,000 (64k) islet cell antigen, complement-fixing islet cell antibodies and radiobinding insulin autoantibodies to determine their potency in detecting subjects with impaired beta-cell function. |
1992-07-30 |
2023-08-11 |
human |
| S E Fineberg, A A Biegel, K L Durr, S Hufferd, N S Fineberg, J H Anderso. Presence of insulin autoantibodies as regular feature of nondiabetic repertoire of immunity. Diabetes. vol 40. issue 9. 1991-12-06. PMID:1936623. |
plasma and peripheral blood mononuclear cells were obtained from 50 nondiabetic whites for determination of insulin autoantibodies by elisa and radioimmunoassay (anti-insulin igg [ai-igg] and 125i-labeled insulin bound [%]), islet cell antibodies, anti-nuclear antibodies and rheumatoid factor, and hla class ii-type antigens (dr, drw, and dq). |
1991-12-06 |
2023-08-11 |
human |
| B E Levi. Defective cerebral glucose utilization in diet-induced obese rats. The American journal of physiology. vol 261. issue 4 Pt 2. 1991-11-20. PMID:1928425. |
dio rats had 159-219% heavier retroperitoneal fat pads and 158% higher plasma insulin levels than chow-fed and dr rats, but plasma glucose levels were equal. |
1991-11-20 |
2023-08-11 |
rat |
| G Soldevila, M Doshi, R James, S P Lake, R Sutton, D Gray, G F Bottazzo, R Pujol-Borrel. HLA DR, DP, DQ induction in human islet beta cells by the cytokine combination IFN-gamma + TNF-alpha. Autoimmunity. vol 6. issue 4. 1991-10-21. PMID:2129492. |
to assess whether or not they can be induced to express the products of the class ii subregions, dr, dp and dq, human islet cultures from 10 pancreas were supplemented with the combination of ifn-gamma + tnf-alpha using moabs specific for dr, dp and dq products, and antibodies to insulin and glucagon. |
1991-10-21 |
2023-08-11 |
human |
| S Bardet, V Rohmer, D Maugendre, A Valentin, Y Gallois, H Stetieh, M Marre, H Allannic, B Charbonnel, P Sa. Beta-cell cytoadherent lymphocytes in some subjects at risk for type 1 (insulin-dependent) diabetes: progression to diabetes within 2 years. The Journal of clinical endocrinology and metabolism. vol 71. issue 5. 1990-12-10. PMID:2146283. |
these diabetic rosettes were slightly associated with acute insulin response to iv glucose lower than the 5th percentile of controls (immunoreactive insulin at 1 +/- 3 min, 250 pmol/l; by chi 2, p = 0.04) and with hla dr 3/4 heterozygosity (by chi 2, p = 0.04). |
1990-12-10 |
2023-08-11 |
human |
| S Bardet, V Rohmer, D Maugendre, A Valentin, Y Gallois, H Stetieh, M Marre, H Allannic, B Charbonnel, P Sa. Beta-cell cytoadherent lymphocytes in some subjects at risk for type 1 (insulin-dependent) diabetes: progression to diabetes within 2 years. The Journal of clinical endocrinology and metabolism. vol 71. issue 5. 1990-12-10. PMID:2146283. |
a statistical association was detected between hla dr 3/4 heterozygosity and a low acute insulin response to iv glucose (by chi 2, p less than 0.003). |
1990-12-10 |
2023-08-11 |
human |
| S Bardet, V Rohmer, D Maugendre, A Valentin, Y Gallois, H Stetieh, M Marre, H Allannic, B Charbonnel, P Sa. ["Diabetic rosettes": a cellular immunity marker in subjects at risk for type I diabetes]. Annales de biologie clinique. vol 48. issue 2. 1990-06-26. PMID:2188535. |
"diabetic rosettes" were associated with hla dr 3/4 heterozygosity (p less than 0.04) and with a "low" acute insulin release to iv glucose (p = 0.05). |
1990-06-26 |
2023-08-11 |
human |
| C Baudouin, D Fredj-Reygrobellet, D Jambou, P Gastaud, P Lapalu. HLA DR and DQ expression on human retinal pigment epithelial cells in vitro. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 228. issue 1. 1990-04-26. PMID:2107128. |
confluent rpe-cell monolayers were supplemented with several biological or chemical reagents [recombinant interferon gamma, phytohemagglutinin a-p (pha-p), phorbol-myristate acetate (pma), recombinant interleukin-2, fibroblast growth factor (fgf), insulin], to investigate their ability to induce hla dr and dq expression. |
1990-04-26 |
2023-08-11 |
human |
| H K Driscoll, P A Gottlieb, J P Mordes, F M Matschinsky, A A Rossin. Plasma from BB/Wor rats increases insulin secretion by perfused rat pancreas. Endocrinology. vol 126. issue 2. 1990-03-05. PMID:2404744. |
we found that plasma dialyzed to remove molecules less than 14 kd from nondiabetic dr and dp bb rats significantly enhanced total insulin secretion [4806 +/- 711 ng (+/- sem; n = 6) and 4968 +/- 1235 ng (n = 7), respectively] from perfused pancreata when compared with the effects of either plasma from wistar-furth rats (2585 +/- 336 ng; n = 9) or medium containing no plasma (1862 +/- 92 ng; n = 38). |
1990-03-05 |
2023-08-11 |
rat |