| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H K Driscoll, P A Gottlieb, J P Mordes, F M Matschinsky, A A Rossin. Plasma from BB/Wor rats increases insulin secretion by perfused rat pancreas. Endocrinology. vol 126. issue 2. 1990-03-05. PMID:2404744. |
the enhancement of insulin secretion by bb rat plasma, both diabetic and nondiabetic (dr and dp), was characterized by preservation of first and second phase hormone release. |
1990-03-05 |
2023-08-11 |
rat |
| M Glerum, B H Robinson, J M Marti. Could bovine serum albumin be the initiating antigen ultimately responsible for the development of insulin dependent diabetes mellitus? Diabetes research (Edinburgh, Scotland). vol 10. issue 3. 1989-12-04. PMID:2553321. |
analysis of the amino-acid homology in relation to the dr/dq allotypes found in the human population gave a strong correlation between the combined dr and dq homology score with bovine serum albumin and the incidence of insulin dependent diabetes mellitus. |
1989-12-04 |
2023-08-11 |
human |
| B E Levin, A C Sulliva. Glucose-induced sympathetic activation in obesity-prone and resistant rats. International journal of obesity. vol 13. issue 2. 1989-08-15. PMID:2744935. |
intravenous glucose infusion (lg/kg) also produced greater insulin release in dio rats associated with a 25 percent reduction in glucose disposal rates; areas under the insulin curve were 273 and 51 percent higher than chow-fed and dr rats, respectively. |
1989-08-15 |
2023-08-11 |
rat |
| B E Levin, A C Sulliva. Glucose-induced sympathetic activation in obesity-prone and resistant rats. International journal of obesity. vol 13. issue 2. 1989-08-15. PMID:2744935. |
dr rats, on the other hand, showed normal glucose disposal rates but increased insulin release to a glucose load (148 percent greater area under the curve than chow-fed rats). |
1989-08-15 |
2023-08-11 |
rat |
| R Fimmers, M Neugebauer, J Dennert, T Wienker, M P Bau. Association and sibpair analysis for the HLA, Gm, Km, and insulin polymorphisms in multiplex IDDM families. Genetic epidemiology. vol 6. issue 1. 1989-07-25. PMID:2567252. |
an extended sibpair analysis was applied to the hla-b,dr loci and to the gm, km, and insulin gene polymorphisms. |
1989-07-25 |
2023-08-11 |
Not clear |
| W Klitz, M K Kuhner, W Robinson, M Esposito, G Thomso. Clues to IDDM pathogenesis from genetic and serological traits in multiply affected families. Genetic epidemiology. vol 6. issue 1. 1989-07-25. PMID:2567254. |
a scheme is outlined for analyzing the genotypic contributions of two unlinked loci in producing a disease, using dr and the 5' insulin locus (ins) in insulin-dependent diabetes mellitus (iddm) as examples. |
1989-07-25 |
2023-08-11 |
Not clear |
| N J Cox, R S Spielma. The insulin gene and susceptibility to IDDM. Genetic epidemiology. vol 6. issue 1. 1989-07-25. PMID:2567260. |
this is also true when insulin gene sharing is conditioned on hla sharing, on the particular hla dr types in asps, or on the parents' insulin allele classes. |
1989-07-25 |
2023-08-11 |
Not clear |
| B Newman, J Selby, M Lee, M C Kin. Genetic epidemiology of persistent islet cell antibodies among IDDM patients. Genetic epidemiology. vol 6. issue 1. 1989-07-25. PMID:2659427. |
persistence of ica was not significantly associated with hla dr type, immunoglobulin genotype, insulin allele class, sex, history of viral diseases, or prior vaccinations. |
1989-07-25 |
2023-08-11 |
Not clear |
| W E Plehwe, M A Sleightholm, E M Kohne. Does vitreous fluorophotometry reflect severity of early diabetic retinopathy? The British journal of ophthalmology. vol 73. issue 4. 1989-06-16. PMID:2653418. |
to determine the relationship between vitreous fluorophotometry (vf) and severity of diabetic retinopathy (dr) 13 patients with mild to moderate background dr starting continuous subcutaneous insulin infusion were followed up serially for 12 months. |
1989-06-16 |
2023-08-11 |
human |
| O H Perurena, B W Festof. Environmental influence on altered receptor function in a genetic disease: insulin and glucose affect insulin receptors in myotonic dystrophy. Journal of the neurological sciences. vol 89. issue 1. 1989-05-05. PMID:2647909. |
confirming our previous studies and those of others, the present results show that the glucose infusion rate (dr), an estimate of in vivo insulin sensitivity, was significantly diminished in myd. |
1989-05-05 |
2023-08-11 |
Not clear |
| O H Perurena, B W Festof. Environmental influence on altered receptor function in a genetic disease: insulin and glucose affect insulin receptors in myotonic dystrophy. Journal of the neurological sciences. vol 89. issue 1. 1989-05-05. PMID:2647909. |
at the same per cent of ideal body weight dr in myd patients was considerably less than controls suggesting that obesity could not solely account for decreased insulin sensitivity in myd. |
1989-05-05 |
2023-08-11 |
Not clear |
| B E Levin, S Hogan, A C Sulliva. Initiation and perpetuation of obesity and obesity resistance in rats. The American journal of physiology. vol 256. issue 3 Pt 2. 1989-04-12. PMID:2646957. |
after 14 wk, dio rats were neither hyperinsulinemic nor insulin resistant, whereas dr rats had 64% reduced areas under their insulin curves after intravenous glucose (1 g/kg) compared with controls. |
1989-04-12 |
2023-08-11 |
rat |
| T W Hodge, B O Barger, R T Acto. DR beta Taq I restriction fragment length polymorphism (RFLP) associated with insulin dependent diabetes mellitus (IDDM). Disease markers. vol 5. issue 2. 1988-11-03. PMID:2901932. |
dr beta taq i restriction fragment length polymorphism (rflp) associated with insulin dependent diabetes mellitus (iddm). |
1988-11-03 |
2023-08-11 |
Not clear |
| A Schiffrin, S Suissa, P Poussier, R Guttmann, G Weitzne. Prospective study of predictors of beta-cell survival in type I diabetes. Diabetes. vol 37. issue 7. 1988-08-08. PMID:3290010. |
we conducted a prospective study to describe the course of the pancreatic beta-cell function from the time of clinical diagnosis of insulin-dependent (type i) diabetes to determine whether dr type, presence of islet cell antibodies (ica), presence of insulin antibodies (ia), age at onset, and sex could help in the prediction of residual endogenous insulin secretion. |
1988-08-08 |
2023-08-11 |
human |
| A Orren, D Taljaard, E de Toi. HLA-A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (black) and Cape coloured people. Tissue antigens. vol 26. issue 5. 1986-02-28. PMID:3867179. |
hla-a, b, c and dr antigen associations in insulin dependent diabetes mellitus (iddm) in south african negro (black) and cape coloured people. |
1986-02-28 |
2023-08-11 |
Not clear |
| A Orren, D Taljaard, E de Toi. HLA-A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (black) and Cape coloured people. Tissue antigens. vol 26. issue 5. 1986-02-28. PMID:3867179. |
hla-a, b, c and dr antigen frequencies were determined in south african negro (black) (50) and cape coloured (57) patients with insulin dependent diabetes mellitus (iddm) and in appropriate controls. |
1986-02-28 |
2023-08-11 |
Not clear |
| L O Almér, G Ekberg, S Fankhauser, P D Home, R Worth, S Sailer, A B Kurtz, M Christ. A prospective study of the immunogenicity of porcine insulin in HLA-typed new insulin-treated diabetics. Diabetes research (Edinburgh, Scotland). vol 2. issue 5. 1986-01-23. PMID:3905185. |
in 43 patients the insulin antibody response was correlated with hla a, b, and dr antigens. |
1986-01-23 |
2023-08-11 |
Not clear |
| P MacKay, A Boulton, A Rabinovitc. Lymphoid cells of BB/W diabetic rats are cytotoxic to islet beta cells in vitro. Diabetes. vol 34. issue 7. 1985-08-02. PMID:3891476. |
splenic lymphoid cells from diabetic (d), diabetes-prone (dp), and diabetes-resistant (dr) bb/w rats were incubated for 2 days with monolayer cultures of major histocompatibility complex (mhc)-compatible wistar-furth (wf) rat islet cells or a rat islet cell line (rin), and islet beta cell survival was determined by measuring insulin content in the cultures. |
1985-08-02 |
2023-08-11 |
rat |
| P MacKay, A Boulton, A Rabinovitc. Lymphoid cells of BB/W diabetic rats are cytotoxic to islet beta cells in vitro. Diabetes. vol 34. issue 7. 1985-08-02. PMID:3891476. |
dp cells also significantly reduced the insulin content in wf rat islet (-20%) and rin cultures (-63%), whereas dr cells had no significant effect. |
1985-08-02 |
2023-08-11 |
rat |
| J B Roullet, B Lacour, J P Yvert, J J Prat, T Druek. Factors of increase in serum triglyceride-rich lipoproteins in uremic rats. Kidney international. vol 27. issue 2. 1985-06-19. PMID:3886997. |
serum insulin concentration was significantly decreased in u rats as compared to c and dr rats in both series. |
1985-06-19 |
2023-08-11 |
rat |