| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ippei Morita, Keiichi Tanimoto, Nobuteru Akiyama, Noriyuki Naya, Kumiko Fujieda, Takanori Iwasaki, Hideo Yukiok. Chronic hyperinsulinemia contributes to insulin resistance under dietary restriction in association with altered lipid metabolism in Zucker diabetic fatty rats. American journal of physiology. Endocrinology and metabolism. vol 312. issue 4. 2017-06-26. PMID:28143857. |
notably, insulin sensitivity was significantly reduced in the dr group rather than the al group and inversely correlated with plasma levels of insulin and triglyceride but not glucose. |
2017-06-26 |
2023-08-13 |
rat |
| Ippei Morita, Keiichi Tanimoto, Nobuteru Akiyama, Noriyuki Naya, Kumiko Fujieda, Takanori Iwasaki, Hideo Yukiok. Chronic hyperinsulinemia contributes to insulin resistance under dietary restriction in association with altered lipid metabolism in Zucker diabetic fatty rats. American journal of physiology. Endocrinology and metabolism. vol 312. issue 4. 2017-06-26. PMID:28143857. |
these results suggest that chronic hyperinsulinemia may lead to the progression of insulin resistance under dr conditions in association with altered lipid metabolism in peripheral tissues in zdf rats. |
2017-06-26 |
2023-08-13 |
rat |
| Sarah E Wheeler, Nam Y Le. Emerging Roles of Transforming Growth Factor β Signaling in Diabetic Retinopathy. Journal of cellular physiology. vol 232. issue 3. 2017-05-15. PMID:27472503. |
to date, the pathogenesis of dr has been extensively characterized in the context of elevated glucose, insulin, and vegf signaling, although a growing number of other growth factors and molecules, including transforming growth factor β (tgf-β) are being recognized as important contributors and/or therapeutic targets. |
2017-05-15 |
2023-08-13 |
Not clear |
| Pavel Kotlarsky, Arkady Bolotin, Karina Dorfman, Boris Knyazer, Tova Lifshitz, Jaime Lev. Link between retinopathy and nephropathy caused by complications of diabetes mellitus type 2. International ophthalmology. vol 35. issue 1. 2016-12-13. PMID:25391917. |
dr is affected positively by diabetes duration, insulin treatment, glucose levels, and hba1c, and it is affected negatively by gfr, triglyceride levels, and bmi. |
2016-12-13 |
2023-08-13 |
Not clear |
| Sharmistha Roy Chowdhury, Rebecca L Thomas, Gareth J Dunseath, Rajesh Peter, D Aled Rees, Rachel V North, Stephen D Luzio, David R Owen. Diabetic Retinopathy in Newly Diagnosed Subjects With Type 2 Diabetes Mellitus: Contribution of β-Cell Function. The Journal of clinical endocrinology and metabolism. vol 101. issue 2. 2016-06-29. PMID:26652932. |
however, the association between β-cell responsiveness and insulin sensitivity leading to fasting and postprandial hyperglycemia with dr in newly diagnosed treatment-naïve t2dm subjects remain unreported. |
2016-06-29 |
2023-08-13 |
human |
| Ambrose A Dunn-Meynell, Christelle Le Foll, Miranda D Johnson, Thomas A Lutz, Matthew R Hayes, Barry E Levi. Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity. American journal of physiology. Regulatory, integrative and comparative physiology. vol 310. issue 4. 2016-06-29. PMID:26676252. |
after 6 wk on chow, vmh ctr-depleted dr rats ate and gained the equivalent amount of food and weight but had 18% heavier fat pads (relative to carcass weight), 144% higher leptin levels, and were insulin resistant compared with control aav dr rats. |
2016-06-29 |
2023-08-13 |
rat |
| Ambrose A Dunn-Meynell, Christelle Le Foll, Miranda D Johnson, Thomas A Lutz, Matthew R Hayes, Barry E Levi. Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity. American journal of physiology. Regulatory, integrative and comparative physiology. vol 310. issue 4. 2016-06-29. PMID:26676252. |
after 6 wk more on hfd, vmh ctr-depleted dr rats ate the same amount but gained 28% more weight, had 60% more carcass fat, 254% higher leptin levels, and 132% higher insulin areas under the curve during an oral glucose tolerance test than control dr rats. |
2016-06-29 |
2023-08-13 |
rat |
| Ambrose A Dunn-Meynell, Christelle Le Foll, Miranda D Johnson, Thomas A Lutz, Matthew R Hayes, Barry E Levi. Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity. American journal of physiology. Regulatory, integrative and comparative physiology. vol 310. issue 4. 2016-06-29. PMID:26676252. |
therefore, impairing endogenous vmh ctr-mediated signaling reduced leptin signaling and caused dr rats to become more obese and insulin resistant, both on chow and hfd. |
2016-06-29 |
2023-08-13 |
rat |
| Umarani Balakrishnan, Krishnamurthi Venkatachalapathy, Girirajkumar S Marimuth. A Hybrid PSO-DEFS Based Feature Selection for the Identification of Diabetic Retinopathy. Current diabetes reviews. vol 11. issue 3. 2016-02-17. PMID:25817547. |
diabetic retinopathy (dr) is an eye disease, which may cause blindness by the upsurge of insulin in blood. |
2016-02-17 |
2023-08-13 |
Not clear |
| Yue Zhang, Nana Meng, Zhiping Lv, Hao Li, Yi Q. The gene polymorphisms of UCP1 but not PPAR γ and TCF7L2 are associated with diabetic retinopathy in Chinese type 2 diabetes mellitus cases. Acta ophthalmologica. vol 93. issue 3. 2015-12-02. PMID:25274455. |
this study was designed to investigate the association between the polymorphisms in three insulin resistance-related genes, uncoupling protein-1 (ucp1), peroxisome proliferator-activated receptor γ (pparγ) and transcription factor 7-like 2 (tcf7l2) and the susceptibility to diabetic retinopathy (dr) in a chinese type 2 diabetes mellitus (t2dm) cohort. |
2015-12-02 |
2023-08-13 |
Not clear |
| Takuya Chiba, Yukari Tamashiro, Daeui Park, Tatsuya Kusudo, Ryoko Fujie, Toshimitsu Komatsu, Sang Eun Kim, Seongjoon Park, Hiroko Hayashi, Ryoichi Mori, Hitoshi Yamashita, Hae Young Chung, Isao Shimokaw. A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction. Scientific reports. vol 4. 2015-10-29. PMID:24682105. |
in contrast, the physiological processes activated during adaptation to dr, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of npy. |
2015-10-29 |
2023-08-12 |
mouse |
| Zhen Yu, Rong Wang, Wilson C Fok, Alexander Coles, Adam B Salmon, Viviana I Pére. Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 70. issue 4. 2015-06-12. PMID:24755936. |
to begin clarifying the mechanism(s) involved in insulin resistance induced by rapamycin, we compared several aspects of liver metabolism in mice treated with dr or rapamycin for 6 months. |
2015-06-12 |
2023-08-13 |
mouse |
| Marc Tatar, Stephanie Post, Kweon Y. Nutrient control of Drosophila longevity. Trends in endocrinology and metabolism: TEM. vol 25. issue 10. 2015-05-28. PMID:24685228. |
given that reduced insulin and/or insulin-like growth factor (igf) and target of rapamycin (tor) signaling increase drosophila lifespan, these pathways are candidate mediators of dr. |
2015-05-28 |
2023-08-12 |
drosophila_melanogaster |
| Rodolfo Mastropasqua, Lisa Toto, Francesco Cipollone, Donato Santovito, Paolo Carpineto, Leonardo Mastropasqu. Role of microRNAs in the modulation of diabetic retinopathy. Progress in retinal and eye research. vol 43. 2015-04-07. PMID:25128741. |
the purpose of this review is to describe the potential role of mirnas in diabetes and evaluate their implication in dr. mirnas involved in the modulation of glucose metabolism (insulin secretion and sensitivity) and mirnas playing a role in the pathogenesis of dr with their potential target genes are reviewed. |
2015-04-07 |
2023-08-13 |
Not clear |
| Zhenguo Chen, Jiayu Zhang, Chunjie Lu, Sisi Lin, Jiawei Chen, Hongliang Zhong, Bei Tian, Wenbin We. Visual function and morphological changes in the macular area of patients with type 2 diabetes mellitus after intensive insulin therapy. Chinese medical journal. vol 127. issue 4. 2015-04-06. PMID:24534218. |
intensive insulin therapy has been found to lessen the progress of diabetic retinopathy (dr) to some extent, while it has also been implicated to be responsible for decrease of dr. we investigated visual function and morphological changes in the macular area in short-term follow-up of patients with type 2 diabetes mellitus after intensive insulin therapy. |
2015-04-06 |
2023-08-12 |
Not clear |
| Chun Zhao, Weifang Wang, Ding Xu, Hui Li, Min Li, Fang Wan. Insulin and risk of diabetic retinopathy in patients with type 2 diabetes mellitus: data from a meta-analysis of seven cohort studies. Diagnostic pathology. vol 9. 2015-03-27. PMID:24972631. |
the association between insulin use and dr risk has also been reported in different studies. |
2015-03-27 |
2023-08-13 |
Not clear |
| Harri M Heikkilä, Benno Krachler, Rainer Rauramaa, Ursula S Schwa. Diet, insulin secretion and insulin sensitivity--the Dose-Responses to Exercise Training (DR's EXTRA) Study (ISRCTN45977199). The British journal of nutrition. vol 112. issue 9. 2015-02-23. PMID:25230681. |
diet, insulin secretion and insulin sensitivity--the dose-responses to exercise training (dr's extra) study (isrctn45977199). |
2015-02-23 |
2023-08-13 |
Not clear |
| M Usman Akram, Shehzad Khalid, Anam Tariq, Shoab A Khan, Farooque Aza. Detection and classification of retinal lesions for grading of diabetic retinopathy. Computers in biology and medicine. vol 45. 2014-09-15. PMID:24480176. |
diabetic retinopathy (dr) is an eye abnormality in which the human retina is affected due to an increasing amount of insulin in blood. |
2014-09-15 |
2023-08-12 |
human |
| Lorena Perrone, Carmela Matrone, Lalit P Sing. Epigenetic modifications and potential new treatment targets in diabetic retinopathy. Journal of ophthalmology. vol 2014. 2014-08-28. PMID:25165577. |
evidences have provided that after a period of poor glucose control insulin or diabetes drug treatment fails to prevent the development and progression of dr even when good glycemic control is reinstituted (glucose normalization), suggesting a metabolic memory phenomenon. |
2014-08-28 |
2023-08-13 |
Not clear |
| Charles E Egwuag. Chronic intraocular inflammation and development of retinal degenerative disease. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664726. |
this report discusses new developments in immunological and diabetic research that suggest that persistent secretion of pro-inflammatory cytokines during uveitis might induce insulin resistance and retinal degenerative changes that contribute to the pathogenesis of diabetic retinopathy (dr), a retinal dystrophy of significant public health importance. |
2014-07-24 |
2023-08-12 |
Not clear |