| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stéphanie Larose, Christopher Filliter, Robert W Platt, Oriana H Y Yu, Kristian B Filio. Long-acting insulin analogues and the risk of diabetic retinopathy among patients with type 2 diabetes: A population-based cohort study. Diabetes, obesity & metabolism. 2023-05-11. PMID:37165960. |
to determine whether the use of long-acting insulin analogues is associated with an increased risk of incident diabetic retinopathy (dr) among patients with type 2 diabetes. |
2023-05-11 |
2023-08-14 |
Not clear |
| H Liu, J-T Zhang, S-H Xin, W-N Ren, Q-K L. Comprehensive review of glucagon-like peptide 1 receptor agonist treatment on the risk of cardiovascular outcomes and retinopathy as diabetic complications. European review for medical and pharmacological sciences. vol 27. issue 6. 2023-04-04. PMID:37013752. |
accumulating evidence indicates that glp-1ras may provide a greater reduction in the risk of dr in patients with diabetes compared to dpp-4 inhibitors, sulfonylureas, or insulin. |
2023-04-04 |
2023-08-14 |
Not clear |
| Chengjun Zhu, Jiaxi Zhu, Lei Wang, Shizheng Xiong, Yijian Zou, Jing Huang, Huimin Xie, Wenye Zhang, Huiqun Wu, Yun Li. Development and validation of a risk prediction model for diabetic retinopathy in type 2 diabetic patients. Scientific reports. vol 13. issue 1. 2023-03-28. PMID:36977687. |
after retrieving, eight meta-analyses with a total of 15,654 cases and 12 risk factors associated with the onset of dr in t2dm, including weight loss surgery, myopia, lipid-lowing drugs, intensive glucose control, course of t2dm, glycated hemoglobin (hba1c), fasting plasma glucose, hypertension, gender, insulin treatment, residence, and smoking were included for lr modeling. |
2023-03-28 |
2023-08-14 |
Not clear |
| Hassan Barakat, Khaled Al-Roug, Raya Algonaiman, Sami A Althwab, Hani A Alfheeaid, Raghad M Alhomaid, Mona S Almujaydil, Taqwa Bushnaq, Tarek A Ebei. Biological Assessment of Stevioside and Sucralose as Sucrose Substitutes for Diabetics on STZ-Induced Diabetes in Rats. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770608. |
a significant improvement in total bilirubin (tbili) was observed when insulin was injected with st or su in dr groups. |
2023-02-11 |
2023-08-14 |
human |
| Latika Matai, Thalyana Stathis, Jonathan D Lee, Christine Parsons, Tanvi Saxena, Kovi Shlomchik, Frank J Slac. The conserved microRNA-229 family controls low-insulin signaling and dietary restriction induced longevity through interactions with SKN-1/NRF2. Aging cell. 2023-02-07. PMID:36748780. |
mir-229-66 is also critical for lifespan extension observed under dr and reduced insulin signaling (iis) and by constitutive nuclear skn-1. |
2023-02-07 |
2023-08-14 |
caenorhabditis_elegans |
| Koyo Takase, Harumasa Yokota, Akira Ohno, Masahisa Watanabe, Akifumi Kushiyama, Sakura Kushiyama, Satoru Yamagami, Taiji Nagaok. A pilot study of diabetic retinopathy in a porcine model of maturity onset diabetes of the young type 3 (MODY3). Experimental eye research. 2023-01-07. PMID:36608813. |
thus, attempts have been made to establish porcine models of dr by surgical, pharmaceutical or genetical induction of insulin deficiency, and dietary intervention. |
2023-01-07 |
2023-08-14 |
human |
| Hugo Martin, Sébastien Bullich, Maud Martinat, Mathilde Chataigner, Mathieu Di Miceli, Vincent Simon, Samantha Clark, Jasmine Butler, Mareike Schell, Simran Chopra, Francis Chaouloff, Andre Kleinridders, Daniela Cota, Philippe De Deurwaerdere, Luc Pénicaud, Sophie Layé, Bruno P Guiard, Xavier Fioramont. Insulin modulates emotional behavior through a serotonin-dependent mechanism. Molecular psychiatry. 2022-10-07. PMID:36207585. |
our results show that insulin directly modulates the activity of dorsal raphe (dr) 5-ht neurons to dampen 5-ht neurotransmission through a 5-ht |
2022-10-07 |
2023-08-14 |
Not clear |
| Malita A Jones, Ravirajsinh N Jadeja, Orneika Flandrin, Ammar A Abdelrahman, Menaka C Thounojam, Shakera Thomas, Caihong Dai, Haiyan Xiao, Jian-Kang Chen, Sylvia B Smith, Manuela Bartoli, Pamela M Martin, Folami L Powel. Autonomous regulation of retinal insulin biosynthesis in diabetes. Neuropeptides. vol 94. 2022-06-06. PMID:35660758. |
the expression of insulin in the retina was altered with the progression of diabetes in stz mice and donors with dr. |
2022-06-06 |
2023-08-14 |
mouse |
| Samanta Taurone, Chiara De Ponte, Dante Rotili, Elena De Santis, Antonello Mai, Francesco Fiorentino, Susanna Scarpa, Marco Artico, Alessandra Micer. Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409409. |
sirt1, 3, 5, and 6 are key enzymes in dr since they modulate glucose metabolism, insulin sensitivity, and inflammation. |
2022-04-12 |
2023-08-13 |
Not clear |
| Eli Ip. Diabetic Retinopathy and Insulin Insufficiency: Beta Cell Replacement as a Strategy to Prevent Blindness. Frontiers in endocrinology. vol 12. 2021-12-16. PMID:34912295. |
this perspective article will provide evidence for insufficient endogenous insulin secretion as an important factor in the development of dr. |
2021-12-16 |
2023-08-13 |
Not clear |
| Eli Ip. Diabetic Retinopathy and Insulin Insufficiency: Beta Cell Replacement as a Strategy to Prevent Blindness. Frontiers in endocrinology. vol 12. 2021-12-16. PMID:34912295. |
the areas of evidence discussed are: (a) presence of insulin receptors in the retina, (b) clinical studies that show an association of beta cell insufficiency with dr, (c) treatment with insulin in type 2 diabetes, a marker for endogenous insulin deficiency, is an independent risk factor for dr, (d) recent clinical studies that link dr with an insulin deficient form of type 2 diabetes, and (e) beta cell replacement studies that demonstrate endogenous insulin prevents progression of dr. |
2021-12-16 |
2023-08-13 |
Not clear |
| Hossein Khaleghzadeh-Ahangar, Shaghayegh Khandan, Saeideh Khosrav. Intraventricular insulin adjacent to the arcuate nucleus reduced the formalin-induced pain through dorsal raphe nucleus opioid receptors in the STZ-induced diabetic rats. Behavioural brain research. vol 418. 2021-12-11. PMID:34774584. |
so it was tried to investigate the influence of insulin within the arcuate nucleus with/without dr opioid receptors blockade on the nociception in the formalin test paradigm. |
2021-12-11 |
2023-08-13 |
rat |
| Hossein Khaleghzadeh-Ahangar, Shaghayegh Khandan, Saeideh Khosrav. Intraventricular insulin adjacent to the arcuate nucleus reduced the formalin-induced pain through dorsal raphe nucleus opioid receptors in the STZ-induced diabetic rats. Behavioural brain research. vol 418. 2021-12-11. PMID:34774584. |
a possible suggested mechanism for this observation is that insulin reinforces the pomc and endorphin release from the arcuate nucleus and decreases pain through dr. |
2021-12-11 |
2023-08-13 |
rat |
| Elizabeth Seaquis. Celebrating 100 years of insulin with Dr Elizabeth Seaquist. Disease models & mechanisms. vol 14. issue 11. 2021-11-17. PMID:34762125. |
celebrating 100 years of insulin with dr elizabeth seaquist. |
2021-11-17 |
2023-08-13 |
Not clear |
| Stephanie A Eid, Phillipe D O'Brien, Lucy M Hinder, John M Hayes, Faye E Mendelson, Hongyu Zhang, Samanthi Narayanan, Steven F Abcouwer, Frank C Brosius, Subramaniam Pennathur, Masha G Savelieff, Eva L Feldma. Differential effects of minocycline on microvascular complications in murine models of type 1 and type 2 diabetes. Journal of translational science. vol 7. issue 1. 2021-06-06. PMID:33868719. |
minocycline partially ameliorated dr and dkd in t1d and t2d animals, but was less effective than insulin or pioglitazone, and failed to improve dpn in either model. |
2021-06-06 |
2023-08-13 |
Not clear |
| Marcella Nebbioso, Alessandro Lambiase, Marta Armentano, Giosuè Tucciarone, Marta Sacchetti, Antonio Greco, Ludovico Alis. Diabetic retinopathy, oxidative stress, and sirtuins: an in depth look in enzymatic patterns and new therapeutic horizons. Survey of ophthalmology. 2021-05-12. PMID:33864872. |
in dr sirtuins 1,3,5, and 6 play an important role as they regulate the activation of the inflammatory response, insulin sensibility, and both glycolysis and gluconeogenesis. |
2021-05-12 |
2023-08-13 |
Not clear |
| Jamila Hammoudi, Nour El Houda Bouanani, El Habri Chelqi, Yassamine Bentata, Hamid Nouayti, Abdelkhaleq Legssyer, Abderrahim Ziyya. Diabetic retinopathy in the Eastern Morocco: Different stage frequencies and associated risk factors. Saudi journal of biological sciences. vol 28. issue 1. 2021-01-12. PMID:33424367. |
the determinants of dr were insulin therapy, high blood pressure, poor glycemic control and duration of diabetes. |
2021-01-12 |
2023-08-13 |
Not clear |
| Ritika Verma, K S Day. Understanding the decay of proteins: A method to study time dependent response of pM concentration of insulin at microwave frequencies. MethodsX. vol 4. 2020-10-01. PMID:28116247. |
this study presents an experimental analysis of the decay pattern of pm concentration of insulin using whispering gallery mode (wgm) dielectric resonator (dr) method. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ahmadou M Jingi, Jean Jacques N Noubiap, Mickael Essouma, Jean Joel R Bigna, Jobert Richie N Nansseu, Augustin Ellong, Côme Ebana Mvog. Association of insulin treatment versus oral hypoglycaemic agents with diabetic retinopathy and its severity in type 2 diabetes patients in Cameroon, sub-Saharan Africa. Annals of translational medicine. vol 4. issue 20. 2020-09-30. PMID:27867947. |
recent literature has reported an increased risk of dr with insulin use. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yun-Yun Li, Xiu-Fen Yang, Hong Gu, Torkel Snellingen, Xi-Pu Liu, Ning-Pu Li. The relationship between insulin resistance/β-cell dysfunction and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus: the Desheng Diabetic Eye Study. International journal of ophthalmology. vol 11. issue 3. 2020-09-30. PMID:29600185. |
to investigate the relationship between insulin resistance (ir)/β-cell dysfunction and diabetic retinopathy (dr) in chinese patients with type 2 diabetes mellitus (t2dm), and to explore further whether there were differences in the relationship among diabetic patients with higher and lower body mass index (bmi). |
2020-09-30 |
2023-08-13 |
Not clear |