| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anindita Sarkar, Arianna Mei, Apua C M Paquola, Shani Stern, Cedric Bardy, Jason R Klug, Stacy Kim, Neda Neshat, Hyung Joon Kim, Manching Ku, Maxim N Shokhirev, David H Adamowicz, Maria C Marchetto, Roberto Jappelli, Jennifer A Erwin, Krishnan Padmanabhan, Matthew Shtrahman, Xin Jin, Fred H Gag. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell stem cell. vol 22. issue 5. 2019-09-05. PMID:29727680. |
this differentiation paradigm exhibits characteristics of neuronal network maturation, and rabies virus tracing revealed synaptic connections between stem cell-derived dentate gyrus (dg) and ca3 neurons in vitro recapitulating the neuronal connectivity within the hippocampus. |
2019-09-05 |
2023-08-13 |
human |
| Anindita Sarkar, Arianna Mei, Apua C M Paquola, Shani Stern, Cedric Bardy, Jason R Klug, Stacy Kim, Neda Neshat, Hyung Joon Kim, Manching Ku, Maxim N Shokhirev, David H Adamowicz, Maria C Marchetto, Roberto Jappelli, Jennifer A Erwin, Krishnan Padmanabhan, Matthew Shtrahman, Xin Jin, Fred H Gag. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell stem cell. vol 22. issue 5. 2019-09-05. PMID:29727680. |
because hippocampal dysfunction has been implicated in schizophrenia, we applied dg and ca3 differentiation paradigms to schizophrenia-patient-derived hipscs. |
2019-09-05 |
2023-08-13 |
human |
| Jonika Tannous, Henrique Amaral-Silva, Bo Cao, Mon-Ju Wu, Giovana B Zunta-Soares, Iram Kazimi, Cristian Zeni, Benson Mwangi, Jair C Soare. Hippocampal subfield volumes in children and adolescents with mood disorders. Journal of psychiatric research. vol 101. 2019-09-02. PMID:29550609. |
indeed, adult studies have reported smaller hippocampal subfield volumes in regions within the cornu ammonis (ca1 and ca4), dentate gyrus (dg), and hippocampal tails in both patients with major depressive disorder (mdd) and bipolar disorder (bd) compared to healthy controls. |
2019-09-02 |
2023-08-13 |
Not clear |
| Maryam Eslami, Bahman Sadeghi, Fatemeh Goshadro. Chronic ghrelin administration restores hippocampal long-term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease. Hippocampus. vol 28. issue 10. 2019-08-26. PMID:30009391. |
here, we investigated the neuroprotective and therapeutic effects of intracerebroventricular (icv) ghrelin infusion for 2 weeks on passive avoidance learning (pal), memory retention, and synaptic plasticity in the hippocampal dentate gyrus (dg) and ca1 of both normal rats and aβ1-42-induced neurotoxicity in ad model. |
2019-08-26 |
2023-08-13 |
human |
| Katherine G Akers, Yoan Chérasse, Yuki Fujita, Sakthivel Srinivasan, Takeshi Sakurai, Masanori Sakaguch. Concise Review: Regulatory Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional Function. Stem cells (Dayton, Ohio). vol 36. issue 7. 2019-08-20. PMID:29484772. |
one of these neurogenic regions is the dentate gyrus (dg) of the hippocampus, which plays an important role in cognition and emotion. |
2019-08-20 |
2023-08-13 |
Not clear |
| Maura Boldrini, Camille A Fulmore, Alexandria N Tartt, Laika R Simeon, Ina Pavlova, Verica Poposka, Gorazd B Rosoklija, Aleksandar Stankov, Victoria Arango, Andrew J Dwork, René Hen, J John Man. Human Hippocampal Neurogenesis Persists throughout Aging. Cell stem cell. vol 22. issue 4. 2019-08-14. PMID:29625071. |
aging humans are thought to exhibit waning neurogenesis and exercise-induced angiogenesis, with a resulting volumetric decrease in the neurogenic hippocampal dentate gyrus (dg) region, although concurrent changes in these parameters are not well studied. |
2019-08-14 |
2023-08-13 |
human |
| Pradeep Punnakkal, Deity Domini. NMDA Receptor GluN2 Subtypes Control Epileptiform Events in the Hippocampus. Neuromolecular medicine. vol 20. issue 1. 2019-08-13. PMID:29335819. |
epileptiform events (efes) were recorded from the ca1 and dg areas of hippocampus with or without subtype-specific antagonists. |
2019-08-13 |
2023-08-13 |
rat |
| Jawad Fares, Zeina Bou Diab, Sanaa Nabha, Youssef Fare. Neurogenesis in the adult hippocampus: history, regulation, and prospective roles. The International journal of neuroscience. vol 129. issue 6. 2019-08-12. PMID:30433866. |
abbreviations ahn adult hippocampal neurogenesis akt protein kinase b bmp bone morphogenic protein brdu bromodeoxyuridine cns central nervous system dg dentate gyrus disc1 disrupted-in-schizophrenia 1 fgf-2 fibroblast growth factor 2 gaba gamma-aminobutyric acid mbd1 methyl-cpg-binding domain protein 1 mecp2 methyl-cpg-binding protein 2 mtor mammalian target of rapamycin nscs neural stem cells ob olfactory bulb; p21: cyclin-dependent kinase inhibitor 1 rbpj recombination signal binding protein for immunoglobulin kappa j region rms rostral migratory stream sgz subgranular zone shh sonic hedgehog sox2 sry (sex determining region y)-box 2 svz subventricular zone wnt3 wingless-type mouse mammary tumor virus. |
2019-08-12 |
2023-08-13 |
mouse |
| Verónica Trujillo, Patricia Evelina Durando, Marta Magdalena Suáre. Maternal separation induces long-term changes in mineralocorticoid receptor in rats subjected to chronic stress and treated with tianeptine. The International journal of neuroscience. vol 129. issue 6. 2019-08-12. PMID:30485752. |
the aim of this study was to analyze whether early maternal separation would result in long-term, persistent alterations in stress response in adulthood, altering mineralocorticoid receptor immunoreactivity (mr-ir) in the dorsal hippocampal areas [ca1, ca2, ca3 and dentate gyrus (dg)], paraventricular nucleus of the hypothalamus and medial and central nucleus of the amygdala, key structures involved in stress response regulation. |
2019-08-12 |
2023-08-13 |
rat |
| Chong Zhang, Si-Jing Fan, An-Bang Sun, Zhen-Zhen Liu, Lian Li. Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30942466. |
the numbers of hippocampal neurons declined in the ca3 and dg regions. |
2019-08-01 |
2023-08-13 |
rat |
| Akram Sadeghi, Ebrahim Esfandiary, Javad Hami, Hossein Khanahmad, Zahra Hejazi, Mohammad Mardani, Shahnaz Razav. The effects of maternal diabetes and insulin treatment on neurogenesis in the developing hippocampus of male rats. Journal of chemical neuroanatomy. vol 91. 2019-07-29. PMID:29578075. |
our results showed a significant higher level of hippocampal dcx expression and an increase in the mean number of dcx positive cells in the dg of diabetic group male offspring (p < 0.05). |
2019-07-29 |
2023-08-13 |
rat |
| Naoya Murao, Shuzo Matsubara, Taito Matsuda, Hirofumi Noguchi, Tetsuji Mutoh, Masahiro Mutoh, Haruhiko Koseki, Masakazu Namihira, Kinichi Nakashim. Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain. Neuroscience research. vol 143. 2019-07-23. PMID:29859850. |
it is now generally known that adult neurogenesis in the hippocampal dentate gyrus (dg) and subventricular zone participates in various higher brain functions, such as learning and memory formation, olfactory discrimination and repair after brain injury. |
2019-07-23 |
2023-08-13 |
mouse |
| Naoya Murao, Shuzo Matsubara, Taito Matsuda, Hirofumi Noguchi, Tetsuji Mutoh, Masahiro Mutoh, Haruhiko Koseki, Masakazu Namihira, Kinichi Nakashim. Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain. Neuroscience research. vol 143. 2019-07-23. PMID:29859850. |
specific ablation of np95 in adult ns/pcs (ans/pcs) led to a decrease in their proliferation and an impairment of neuronal differentiation and to suppression of neuronal maturation associated with the impairment of dendritic formation in the hippocampal dg. |
2019-07-23 |
2023-08-13 |
mouse |
| Mary Youssef, Varsha S Krish, Greer S Kirshenbaum, Piray Atsak, Tamara J Lass, Sophie R Lieberman, E David Leonardo, Alex Dranovsk. Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis. Hippocampus. vol 28. issue 8. 2019-07-16. PMID:29742815. |
environmental exposures during early life, but not during adolescence or adulthood, lead to persistent reductions in neurogenesis in the adult hippocampal dentate gyrus (dg). |
2019-07-16 |
2023-08-13 |
Not clear |
| Mary Youssef, Varsha S Krish, Greer S Kirshenbaum, Piray Atsak, Tamara J Lass, Sophie R Lieberman, E David Leonardo, Alex Dranovsk. Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis. Hippocampus. vol 28. issue 8. 2019-07-16. PMID:29742815. |
these findings contribute to our understanding of the relationship between dg development and adult neurogenesis, as well as suggest a possible mechanism by which early life experiences may lead to lasting deficits in adult hippocampal neurogenesis. |
2019-07-16 |
2023-08-13 |
Not clear |
| Xiao-Feng Zhao, Rafi Kohen, Rachel Parent, Yuntao Duan, Grace L Fisher, Matthew J Korn, Lingchao Ji, Guoqiang Wan, Jing Jin, Andreas W Püschel, David F Dolan, Jack M Parent, Gabriel Corfas, Geoffrey G Murphy, Roman J Gige. PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors. Cell reports. vol 22. issue 2. 2019-07-15. PMID:29320740. |
dentate gyrus (dg) development requires specification of granule cell (gc) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial dg. |
2019-07-15 |
2023-08-13 |
Not clear |
| Jiali Xu, Yongli Zhang, de Wu, Rui Zho. [Changes and mechanisms of corticosteroid receptors in the subhippocampal region of offspring of pregnant SD rats exposed to lipopolysaccharide]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 7. 2019-07-15. PMID:30381125. |
the neurons in the regions of ca1 and dg of the hippocampus were arranged disorderly. |
2019-07-15 |
2023-08-13 |
rat |
| Inmaculada Pereda-Pérez, Azucena Valencia, Shishir Baliyan, Ángel Núñez, Ancor Sanz-García, Berta Zamora, Raquel Rodríguez-Fernández, José Antonio Esteban, César Vener. Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. Neurobiology of aging. vol 78. 2019-07-08. PMID:30928883. |
moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (dg) and ca1, as well as a specific reduction in the volume of the stratum oriens and spine density in ca1. |
2019-07-08 |
2023-08-13 |
rat |
| Li-Juan Zhu, Huan-Yu Ni, Rong Chen, Lei Chang, Hu-Jiang Shi, Dan Qiu, Zhan Zhang, Dan-Lian Wu, Zhao-Chun Jiang, Hong-Liang Xin, Qi-Gang Zhou, Dong-Ya Zh. Hippocampal nuclear factor kappa B accounts for stress-induced anxiety behaviors via enhancing neuronal nitric oxide synthase (nNOS)-carboxy-terminal PDZ ligand of nNOS-Dexras1 coupling. Journal of neurochemistry. vol 146. issue 5. 2019-06-26. PMID:29858554. |
microinjection of pdtc into the hippocampus reversed cms-induced up-regulation of neuronal nitric oxide synthase (nnos), carboxy-terminal pdz ligand of nnos (capon), and dexamethasone-induced ras protein 1 (dexras1) and dendritic spine loss of dentate gyrus (dg) granule cells. |
2019-06-26 |
2023-08-13 |
mouse |
| Meng Jia, Xuewei Wang, Haolin Zhang, Can Ye, Hui Ma, Mingda Yang, Yijing Li, Cailian Cu. MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells. Neuroscience bulletin. vol 35. issue 3. 2019-06-26. PMID:30721395. |
similarly, specific overexpression of mir-132 in nscs of the adult hippocampal dentate gyrus (dg) during the acquisition stage of msa potentiated morphine-seeking behavior. |
2019-06-26 |
2023-08-13 |
rat |