| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haibin Zhang, Hongxuan Kuang, Yifan Luo, Shuhua Liu, Lingxue Meng, Qihua Pang, Ruifang Fa. Low-dose bisphenol A exposure impairs learning and memory ability with alterations of neuromorphology and neurotransmitters in rats. The Science of the total environment. vol 697. 2020-02-20. PMID:31476513. |
additionally, rats after low- or high-exposure to bpa exhibited decreased dg dendritic complexity and reduced ca1 and dg dendritic spine densities in the hippocampus. |
2020-02-20 |
2023-08-13 |
rat |
| Karolina Kołosowska, Aleksandra Gawryluk, Aleksandra Wisłowska-Stanek, Monika Liguz-Lęcznar, Katarzyna Hetmańczyk, Agnieszka Ługowska, Alicja Sobolewska, Anna Skórzewska, Marek Gryz, Małgorzata Lehne. Stress changes amphetamine response, D2 receptor expression and epigenetic regulation in low-anxiety rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:31022425. |
the contrasting changes were observed in the dentate gyrus (dg) of the hippocampus - the lr rats presented a decrease, but the hr rats showed an increase in h3k9 trimethylation. |
2020-02-14 |
2023-08-13 |
rat |
| Natalie M Zahr, Kilian M Pohl, Manojkumar Saranathan, Edith V Sullivan, Adolf Pfefferbau. Hippocampal subfield CA2+3 exhibits accelerated aging in Alcohol Use Disorder: A preliminary study. NeuroImage. Clinical. vol 22. 2020-01-17. PMID:30904825. |
freesurfer 6.0 hippocampal subfield analysis produced 12 subfields: parasubiculum; presubiculum; subiculum; ca1; ca2+3; ca4; gc-ml-dg (granule cell (gc) and molecular layer (ml) of the dentate gyrus (dg)); molecular layer; hippocampus-amygdala-transition-area (hata); fimbria; hippocampal tail; hippocampal fissure; and whole volume for left and right hippocampi. |
2020-01-17 |
2023-08-13 |
human |
| Haiyu Mu, Zhifei Wang, Xianjuan Zhang, Dongmeng Qian, Yuyang Wang, Shasha Jiang, Shuzhen Liang, Bin Wan. HCMV-encoded IE2 induces anxiety-depression and cognitive impairment in UL122 genetically-modified mice. International journal of clinical and experimental pathology. vol 12. issue 11. 2020-01-17. PMID:31933804. |
level of fibroblast growth factor 2 (fgf2) protein in the hippocampus cornu ammonia areas (ca1, ca3) and dentate gyrus (dg) of the experimental group was significantly lower, consistent with immunohistochemical staining and western blot for neuron-specific nuclear protein (neun) and glial fibrillary acidic protein (gfap). |
2020-01-17 |
2023-08-13 |
mouse |
| Feixue Wang, Peng Wan, Weiyao Wang, Bin Xiao, Hua Jin, Qinghua Ji. Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors. Brain research bulletin. vol 144. 2020-01-16. PMID:30472150. |
as the entry structure of the hippocampal formation, the hippocampal dentate gyrus (dg) is critically involved in spatial learning and memory. |
2020-01-16 |
2023-08-13 |
rat |
| Feixue Wang, Peng Wan, Weiyao Wang, Bin Xiao, Hua Jin, Qinghua Ji. Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors. Brain research bulletin. vol 144. 2020-01-16. PMID:30472150. |
our results suggest that da activation of d1rs in the hippocampal dg promotes spatial learning and memory, in part by modulating the responses of eaas during spatial learning. |
2020-01-16 |
2023-08-13 |
rat |
| Barbara Pijet, Marzena Stefaniuk, Leszek Kaczmare. MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury. Neural plasticity. vol 2019. 2020-01-14. PMID:31198417. |
decreased spine density was also observed in the dentate gyrus of the hippocampus; however, in contrast to the cerebral cortex, spines in the dg became more filopodia-like. |
2020-01-14 |
2023-08-13 |
mouse |
| Wan Long Pan, Michael Chopp, Baoyan Fan, Ruilan Zhang, Xinli Wang, Jiani Hu, Xiao Ming Zhang, Zheng Gang Zhang, Xian Shuang Li. Ablation of the microRNA-17-92 cluster in neural stem cells diminishes adult hippocampal neurogenesis and cognitive function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 4. 2020-01-13. PMID:30668139. |
compared with wild-type mice, ablation of the mir-17-92 cluster significantly reduced the number of proliferating nscs and neuroblasts and neuronal differentiation in the dentate gyrus (dg) of the hippocampus and significantly impaired hippocampal-dependent learning and memory, as assayed by social recognition memory, novel object recognition, and morris water-maze tests. |
2020-01-13 |
2023-08-13 |
mouse |
| Karim A Alkadh. Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus. Molecular neurobiology. vol 56. issue 9. 2020-01-13. PMID:30874972. |
a distinct feature of the hippocampus of the brain is its unidirectional tri-synaptic pathway originating from the entorhinal cortex and projecting to the dentate gyrus (dg) then to area ca3 and subsequently, area ca1 of the ammon's horn. |
2020-01-13 |
2023-08-13 |
Not clear |
| Bangrong Cai, Kyung-Joo Seong, Sun-Woong Bae, Min Suk Kook, Changju Chun, Jin Ho Lee, Won-Seok Choi, Ji-Yeon Jung, Won-Jae Ki. Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30740619. |
microglia-mediated neuroinflammatory responses are well known to inhibit neurogenesis in the dentate gyrus (dg) of the adult hippocampus, and growing evidence indicates that therapeutic intervention to suppress microglial activation could be an effective strategy for restoring the impaired neurogenesis and memory performance. |
2020-01-09 |
2023-08-13 |
mouse |
| Bangrong Cai, Kyung-Joo Seong, Sun-Woong Bae, Min Suk Kook, Changju Chun, Jin Ho Lee, Won-Seok Choi, Ji-Yeon Jung, Won-Jae Ki. Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30740619. |
the impaired neurogenesis in the hippocampal dg triggered the cognitive function, and that treatment of arg-dg led to the recovery of cognitive decline. |
2020-01-09 |
2023-08-13 |
mouse |
| Bangrong Cai, Kyung-Joo Seong, Sun-Woong Bae, Min Suk Kook, Changju Chun, Jin Ho Lee, Won-Seok Choi, Ji-Yeon Jung, Won-Jae Ki. Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30740619. |
arg-dg also suppressed the production of lps-induced pro-inflammatory cytokines in hippocampal dg by blocking microglial activation. |
2020-01-09 |
2023-08-13 |
mouse |
| Mahshid Hosseinzadeh, Hamid Gholami Pourbadie, Fariba Khodagholi, Mahtab Daftari, Nima Naderi, Fereshteh Motamed. Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy. Neuroscience. vol 408. 2020-01-09. PMID:31026566. |
24 h after seizure induction, the hippocampal level of pro/anti-inflammatory mediators and electrophysiological properties of the dentate gyrus (dg) granular cells were investigated by western blot and whole cell patch clamp techniques, respectively. |
2020-01-09 |
2023-08-13 |
rat |
| Chrysoula Dioli, Patrícia Patrício, Nuno Sousa, Nikolaos Kokras, Christina Dalla, Sara Guerreiro, Miguel A Santos-Silva, Ana Cristina Rego, Luísa Pinto, Elisabete Ferreiro, Ioannis Sotiropoulo. Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields. Translational psychiatry. vol 9. issue 1. 2020-01-09. PMID:31028242. |
these findings suggest that the neuroplastic effects of chronic stress on dendritic maturation and complexity of dcx+ immature neurons vary based on the different maturation stage of dcx-positive cells and the different dg sublayer, highlighting the complex and dynamic stress-driven neuroplasticity of immature neurons in the adult hippocampus. |
2020-01-09 |
2023-08-13 |
Not clear |
| Véronique Deroche-Gamonet, Jean-Michel Revest, Jean-François Fiancette, Eric Balado, Muriel Koehl, Noëlle Grosjean, Djoher Nora Abrous, Pier-Vincenzo Piazz. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Molecular psychiatry. vol 24. issue 2. 2020-01-06. PMID:29507372. |
the hippocampus is the main locus for adult dentate gyrus (dg) neurogenesis. |
2020-01-06 |
2023-08-13 |
mouse |
| Yoo Jin Shin, Yeon Tae Chun, Sun Woo Lim, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Jiyeong Lee, Seongno Hong, Mun Yong Lee, Hee Gyoo Kang, Chul Woo Yan. Influence of Tacrolimus on Depressive-Like Behavior in Diabetic Rats Through Brain-Derived Neurotrophic Factor Regulation in the Hippocampus. Neurotoxicity research. vol 36. issue 2. 2020-01-02. PMID:31201731. |
bdnf expression in the hippocampus was examined in the dentate gyrus (dg) and ca3 region using immunohistochemistry. |
2020-01-02 |
2023-08-13 |
rat |
| Rebecca K West, Jessica I Wooden, Emily A Barton, J Leigh Leasur. Recurrent binge ethanol is associated with significant loss of dentate gyrus granule neurons in female rats despite concomitant increase in neurogenesis. Neuropharmacology. vol 148. 2019-12-27. PMID:30659841. |
using stereology, we quantified the number and/or size of neurons in the medial prefrontal cortex (mpfc) and hippocampal dentate gyrus (dg), as well as the number and activation state of microglia. |
2019-12-27 |
2023-08-13 |
rat |
| James E Delorme, Varna Kodoth, Sara J Ato. Sleep loss disrupts Arc expression in dentate gyrus neurons. Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29635031. |
using in situ hybridization (together with behavioral observation to quantify sleep amounts), we find that in the dorsal hippocampus, sd minimally affects arc mrna expression, and decreases the number of dentate gyrus (dg) granule cells expressing arc. |
2019-12-24 |
2023-08-13 |
mouse |
| Claire E Manning, Andrew L Eagle, Christine C Kwiatkowski, Ridouane Achargui, Hillary Woodworth, Emily Potter, Yoshinori Ohnishi, Gina M Leinninger, A J Robiso. Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning. Neuroscience. vol 406. 2019-12-24. PMID:30902680. |
here, we crossed neurotensin receptor-2 (ntsr2) cre mice, which express cre within the subgranular zone (sgz) of dhpc dg, with floxed fosb mice to show that knockout of Δfosb in hippocampal sgz neurons reduces antidepressant-induced neurogenesis and impedes hippocampus-dependent learning in the novel object recognition task. |
2019-12-24 |
2023-08-13 |
mouse |
| Stanislau Hrybouski, Melanie MacGillivray, Yushan Huang, Christopher R Madan, Rawle Carter, Peter Seres, Nikolai V Malykhi. Involvement of hippocampal subfields and anterior-posterior subregions in encoding and retrieval of item, spatial, and associative memories: Longitudinal versus transverse axis. NeuroImage. vol 191. 2019-12-20. PMID:30742981. |
the hippocampus can be segmented into three major anteroposterior sections, called head, body and tail, and into the cornu ammonis (ca), dentate gyrus (dg), and subiculum (sub) subfields based on its transverse axis. |
2019-12-20 |
2023-08-13 |
human |