| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Qin, Michael P Neeper, Yi Liu, Tasha L Hutchinson, Mary Lou Lubin, Christopher M Flore. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 24. 2008-07-10. PMID:18550765. |
among these, cannabidiol was found to be the most robust and potent (ec(50) = 3.7 microm), followed by delta(9)-tetrahydrocannabinol (ec(50) = 14 microm) and cannabinol (ec(50) = 77.7 microm). |
2008-07-10 |
2023-08-12 |
rat |
| Ziva D Cooper, Margaret Hane. Cannabis reinforcement and dependence: role of the cannabinoid CB1 receptor. Addiction biology. vol 13. issue 2. 2008-07-08. PMID:18279497. |
this paper will review data implicating the cannabinoid cb1 receptor in regulating the behavioral effects of delta(9)-tetrahydrocannobinol (thc), the primary psychoactive component of cannabis, across a range of species. |
2008-07-08 |
2023-08-12 |
Not clear |
| Fabrício A Moreira, Beat Lut. The endocannabinoid system: emotion, learning and addiction. Addiction biology. vol 13. issue 2. 2008-07-08. PMID:18422832. |
the identification of the cannabinoid receptor type 1 (cb1 receptor) was the milestone discovery in the elucidation of the behavioural and emotional responses induced by the cannabis sativa constituent delta(9)-tetrahydrocannabinol. |
2008-07-08 |
2023-08-12 |
Not clear |
| Roger G Pertwe. Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addiction biology. vol 13. issue 2. 2008-07-08. PMID:18482430. |
a major finding--that (-)-trans-delta(9)-tetrahydrocannabinol (delta(9)-thc) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, cb(1) and cb(2), and that delta(9)-thc and other compounds that target either or both of these receptors as agonists or antagonists have important therapeutic applications. |
2008-07-08 |
2023-08-12 |
Not clear |
| Robert E Vann, Thomas F Gamage, Jonathan A Warner, Ericka M Marshall, Nathan L Taylor, Billy R Martin, Jenny L Wile. Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol. Drug and alcohol dependence. vol 94. issue 1-3. 2008-06-27. PMID:18206320. |
divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of delta(9)-tetrahydrocannabinol. |
2008-06-27 |
2023-08-12 |
mouse |
| Robert E Vann, Thomas F Gamage, Jonathan A Warner, Ericka M Marshall, Nathan L Taylor, Billy R Martin, Jenny L Wile. Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol. Drug and alcohol dependence. vol 94. issue 1-3. 2008-06-27. PMID:18206320. |
cannabis sativa (marijuana plant) contains myriad cannabinoid compounds; yet, investigative attention has focused almost exclusively on delta(9)-tetrahydrocannabinol (thc), its primary psychoactive substituent. |
2008-06-27 |
2023-08-12 |
mouse |
| Luciano De Petrocellis, Vittorio Vellani, Aniello Schiano-Moriello, Pietro Marini, Pier Cosimo Magherini, Pierangelo Orlando, Vincenzo Di Marz. Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. The Journal of pharmacology and experimental therapeutics. vol 325. issue 3. 2008-06-16. PMID:18354058. |
the plant cannabinoids (phytocannabinoids), cannabidiol (cbd), and delta(9)-tetrahydrocannabinol (thc) were previously shown to activate transient receptor potential channels of both vanilloid type 1 (trpv1) and ankyrin type 1 (trpa1), respectively. |
2008-06-16 |
2023-08-12 |
rat |
| Alan W Jones, Anita Holmgren, Fredrik C Kugelber. Driving under the influence of cannabis: a 10-year study of age and gender differences in the concentrations of tetrahydrocannabinol in blood. Addiction (Abingdon, England). vol 103. issue 3. 2008-06-10. PMID:18190663. |
delta(9)-tetrahydrocannabinol (thc) is the major psychoactive constituent of cannabis and its various preparations. |
2008-06-10 |
2023-08-12 |
Not clear |
| L I Perrotti, R R Weaver, B Robison, W Renthal, I Maze, S Yazdani, R G Elmore, D J Knapp, D E Selley, B R Martin, L Sim-Selley, R K Bachtell, D W Self, E J Nestle. Distinct patterns of DeltaFosB induction in brain by drugs of abuse. Synapse (New York, N.Y.). vol 62. issue 5. 2008-06-03. PMID:18293355. |
we also extended previous research involving cocaine, morphine, and nicotine to two additional drugs of abuse, ethanol and delta(9)-tetrahydrocannabinol (delta(9)-thc, the active ingredient in marijuana). |
2008-06-03 |
2023-08-12 |
Not clear |
| Kazuhide Hayakawa, Kenichi Mishima, Mai Hazekawa, Kazunori Sano, Keiichi Irie, Kensuke Orito, Takashi Egawa, Yoshihisa Kitamura, Naoki Uchida, Ryoji Nishimura, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain research. vol 1188. 2008-06-02. PMID:18021759. |
cannabidiol potentiates pharmacological effects of delta(9)-tetrahydrocannabinol via cb(1) receptor-dependent mechanism. |
2008-06-02 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Mai Hazekawa, Kazunori Sano, Keiichi Irie, Kensuke Orito, Takashi Egawa, Yoshihisa Kitamura, Naoki Uchida, Ryoji Nishimura, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain research. vol 1188. 2008-06-02. PMID:18021759. |
cannabidiol, a non-psychoactive component of cannabis, has been reported to have interactions with delta(9)-tetrahydrocannabinol (delta(9)-thc). |
2008-06-02 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Mai Hazekawa, Kazunori Sano, Keiichi Irie, Kensuke Orito, Takashi Egawa, Yoshihisa Kitamura, Naoki Uchida, Ryoji Nishimura, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain research. vol 1188. 2008-06-02. PMID:18021759. |
in the present study, we investigated whether cannabidiol modulates the pharmacological effects of delta(9)-thc on locomotor activity, catalepsy-like immobilisation, rectal temperature and spatial memory in the eight-arm radial maze task in mice. |
2008-06-02 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Mai Hazekawa, Kazunori Sano, Keiichi Irie, Kensuke Orito, Takashi Egawa, Yoshihisa Kitamura, Naoki Uchida, Ryoji Nishimura, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain research. vol 1188. 2008-06-02. PMID:18021759. |
however, higher dose of cannabidiol (10 or 50 mg/kg) exacerbated pharmacological effects of lower dose of delta(9)-thc, such as hypoactivity, hypothermia and impairment of spatial memory. |
2008-06-02 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Mai Hazekawa, Kazunori Sano, Keiichi Irie, Kensuke Orito, Takashi Egawa, Yoshihisa Kitamura, Naoki Uchida, Ryoji Nishimura, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain research. vol 1188. 2008-06-02. PMID:18021759. |
moreover, cannabidiol (50 mg/kg) with delta(9)-thc (1 mg/kg) enhanced the expression level of cb(1) receptor expression in hippocampus and hypothalamus. |
2008-06-02 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Mai Hazekawa, Kazunori Sano, Keiichi Irie, Kensuke Orito, Takashi Egawa, Yoshihisa Kitamura, Naoki Uchida, Ryoji Nishimura, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain research. vol 1188. 2008-06-02. PMID:18021759. |
cannabidiol potentiated pharmacological effects of delta(9)-thc via cb(1) receptor-dependent mechanism. |
2008-06-02 |
2023-08-12 |
mouse |
| Tiina J Kauppila, Ville Arvola, Markus Haapala, Jaroslav Pól, Laura Aalberg, Ville Saarela, Sami Franssila, Tapio Kotiaho, Risto Kostiaine. Direct analysis of illicit drugs by desorption atmospheric pressure photoionization. Rapid communications in mass spectrometry : RCM. vol 22. issue 7. 2008-05-29. PMID:18320545. |
3,4-methylenedioxymethamphetamine (mdma), amphetamine, phenazepam, and buprenorphine were detected from the analyzed tablets, lysergic acid diethylamide (lsd) and bromobenzodifuranylisopropylamine (bromo-dragonfly, abdf) from blotter paper, and delta(9)-tetrahydrocannabinol (thc) and cannabinol from cannabis sativa bloom and resin. |
2008-05-29 |
2023-08-12 |
Not clear |
| B Bindukumar, S D Mahajan, J L Reynolds, Z Hu, D E Sykes, R Aalinkeel, S A Schwart. Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain research. vol 1191. 2008-05-19. PMID:18163980. |
delta-9-tetrahydrocannabinol (delta(9)-thc), the main psychoactive component of marijuana, is known to dysregulate various immune responses. |
2008-05-19 |
2023-08-12 |
human |
| David J Potter, Peter Clark, Marc B Brow. Potency of delta 9-THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology. Journal of forensic sciences. vol 53. issue 1. 2008-05-08. PMID:18279244. |
potency of delta 9-thc and other cannabinoids in cannabis in england in 2005: implications for psychoactivity and pharmacology. |
2008-05-08 |
2023-08-12 |
Not clear |
| M E Page, V C Oropeza, E J Van Bockstael. Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex. Neuroscience letters. vol 431. issue 1. 2008-05-01. PMID:18055114. |
delta(9)-tetrahydrocannabinol, the main psychoactive ingredient in marijuana, activates specific cannabinoid (cb) receptors to exert complex actions on modulatory neurotransmitters involved in attention and cognition. |
2008-05-01 |
2023-08-12 |
rat |
| Cristina Blázquez, Arkaitz Carracedo, María Salazar, Mar Lorente, Ainara Egia, Luis González-Feria, Amador Haro, Guillermo Velasco, Manuel Guzmá. Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17675107. |
local administration of delta(9)-tetrahydrocannabinol (thc), the major active ingredient of cannabis, down-regulated timp-1 expression in mice bearing subcutaneous gliomas, as determined by western blot and immunofluorescence analyses. |
2008-04-18 |
2023-08-12 |
mouse |