| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander F Hoffman, Nora Laaris, Masahito Kawamura, Susan A Masino, Carl R Lupic. Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 2. 2010-02-01. PMID:20071517. |
marijuana is a widely used drug that impairs memory through interaction between its psychoactive constituent, delta-9-tetrahydrocannabinol (delta(9)-thc), and cb(1) receptors (cb1rs) in the hippocampus. |
2010-02-01 |
2023-08-12 |
mouse |
| Elizabeth J Rahn, Andrea G Hohman. Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 6. issue 4. 2010-01-25. PMID:19789075. |
cannabinoids, drugs that share the same target as delta(9)-tetrahydrocannabinol (delta(9)-thc), the psychoactive ingredient in cannabis, have the potential to address this unmet need. |
2010-01-25 |
2023-08-12 |
human |
| Elizabeth J Rahn, Andrea G Hohman. Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 6. issue 4. 2010-01-25. PMID:19789075. |
in humans, effects of smoked marijuana, synthetic delta(9)-thc analogs (e.g., marinol, cesamet) and medicinal cannabis preparations containing both delta(9)-thc and cannabidiol (e.g., sativex, cannador) in neuropathic pain states are reviewed. |
2010-01-25 |
2023-08-12 |
human |
| Eugene W Schwilke, David M Schwope, Erin L Karschner, Ross H Lowe, William D Darwin, Deanna L Kelly, Robert S Goodwin, David A Gorelick, Marilyn A Huesti. Delta9-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC plasma pharmacokinetics during and after continuous high-dose oral THC. Clinical chemistry. vol 55. issue 12. 2009-12-28. PMID:19833841. |
delta(9)-tetrahydrocannabinol (thc) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. |
2009-12-28 |
2023-08-12 |
Not clear |
| M Gallant, F Odei-Addo, C L Frost, R-A Levenda. Biological effects of THC and a lipophilic cannabis extract on normal and insulin resistant 3T3-L1 adipocytes. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 16. issue 10. 2009-12-14. PMID:19345076. |
delta(9)-tetrahydrocannabinol (thc) is the primary psychoactive component of cannabis. |
2009-12-14 |
2023-08-12 |
cattle |
| Angelo A Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, Raphael Mechoula. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends in pharmacological sciences. vol 30. issue 10. 2009-12-11. PMID:19729208. |
however, the plant cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than delta(9)-tetrahydrocannabinol. |
2009-12-11 |
2023-08-12 |
Not clear |
| Angelo A Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, Raphael Mechoula. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends in pharmacological sciences. vol 30. issue 10. 2009-12-11. PMID:19729208. |
special emphasis is given to cannabidiol, the possible applications of which have recently emerged in inflammation, diabetes, cancer, affective and neurodegenerative diseases, and to delta(9)-tetrahydrocannabivarin, a novel cb(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity. |
2009-12-11 |
2023-08-12 |
Not clear |
| Laura E Wise, Andrew J Thorpe, Aron H Lichtma. Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 9. 2009-12-07. PMID:19322169. |
however, the degree to which cb(1) receptors in the hippocampus play a specific functional role in the memory disruptive effects of marijuana or its primary psychoactive constituent delta(9)-tetrahydrocannabinol (delta(9)-thc) is unknown. |
2009-12-07 |
2023-08-12 |
rat |
| M David Marks, Li Tian, Jonathan P Wenger, Stephanie N Omburo, Wilfredo Soto-Fuentes, Ji He, David R Gang, George D Weiblen, Richard A Dixo. Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa. Journal of experimental botany. vol 60. issue 13. 2009-12-03. PMID:19581347. |
rna isolated from the glands of a delta(9)-tetrahydrocannabinolic acid (thca)-producing strain of cannabis sativa was used to generate a cdna library containing over 100 000 expressed sequence tags (ests). |
2009-12-03 |
2023-08-12 |
Not clear |
| Aoife Gowran, Carrie E Murphy, Veronica A Campbel. Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain. FEBS letters. vol 583. issue 21. 2009-12-03. PMID:19819240. |
the phytocannabinoid delta(9)-tetrahydrocannabinol (delta(9)-thc), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. |
2009-12-03 |
2023-08-12 |
rat |
| Lamont Booker, Pattipati S Naidu, Raj K Razdan, Anu Mahadevan, Aron H Lichtma. Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception. Drug and alcohol dependence. vol 105. issue 1-2. 2009-11-30. PMID:19679411. |
considerable preclinical research has demonstrated the efficacy of delta(9)-tetrahydrocannabinol (delta(9)-thc), the primary psychoactive constituent of cannabis sativa, in a wide variety of animal models of pain, but few studies have examined other phytocannabinoids. |
2009-11-30 |
2023-08-12 |
Not clear |
| Lamont Booker, Pattipati S Naidu, Raj K Razdan, Anu Mahadevan, Aron H Lichtma. Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception. Drug and alcohol dependence. vol 105. issue 1-2. 2009-11-30. PMID:19679411. |
in contrast, tetrahydrocannabivarin (thcv), another component of cannabis, antagonizes the pharmacological effects of delta(9)-thc. |
2009-11-30 |
2023-08-12 |
Not clear |
| Lamont Booker, Pattipati S Naidu, Raj K Razdan, Anu Mahadevan, Aron H Lichtma. Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception. Drug and alcohol dependence. vol 105. issue 1-2. 2009-11-30. PMID:19679411. |
these data raise the intriguing possibility that other constituents of cannabis can be used to modify the pharmacological effects of delta(9)-thc by either eliciting antinociceptive effects (i.e., cbn) or antagonizing (i.e., thcv) the actions of delta(9)-thc. |
2009-11-30 |
2023-08-12 |
Not clear |
| Piotr Kupczyk, Adam Reich, Jacek C Szepietowsk. Cannabinoid system in the skin - a possible target for future therapies in dermatology. Experimental dermatology. vol 18. issue 8. 2009-11-16. PMID:19664006. |
the major agent of exogenous cannabinoids is delta(9)-tetrahydrocannabinol (delta(9)-thc), natural psychoactive ingredient of marijuana. |
2009-11-16 |
2023-08-12 |
Not clear |
| Stefania Petrosino, Alessia Ligresti, Vincenzo Di Marz. Endocannabinoid chemical biology: a tool for the development of novel therapies. Current opinion in chemical biology. vol 13. issue 3. 2009-09-30. PMID:19457702. |
the identification of the major psychoactive constituent of cannabis and marijuana, delta(9)-tetrahydrocannabinol, opened the way first to the cloning of the g-protein-coupled cannabinoid cb(1) and cb(2) receptors, and then to the isolation and characterisation of their endogenous agonists, the endocannabinoids. |
2009-09-30 |
2023-08-12 |
Not clear |
| Anna Mazur, Cheryl F Lichti, Paul L Prather, Agnieszka K Zielinska, Stacie M Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P Miller, Anna Radomińska-Pandya, Jeffery H Mora. Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids. Drug metabolism and disposition: the biological fate of chemicals. vol 37. issue 7. 2009-09-28. PMID:19339377. |
tetrahydrocannabinol (delta(9)-thc), the primary psychoactive ingredient in marijuana, is subject to cytochrome p450 oxidation and subsequent udp-glucuronosyltransferase (ugt)-dependent glucuronidation. |
2009-09-28 |
2023-08-12 |
human |
| Giuseppe Astarita, Jennifer Geaga, Faizy Ahmed, Daniele Piomell. Targeted lipidomics as a tool to investigate endocannabinoid function. International review of neurobiology. vol 85. 2009-09-10. PMID:19607960. |
they bind and activate the membrane receptors that are targeted by delta(9)-tetrahydrocannabinol, the main psychoactive principle in marijuana (cannabis). |
2009-09-10 |
2023-08-12 |
Not clear |
| Riccardo Pierantoni, Gilda Cobellis, Rosaria Meccariello, Giovanna Cacciola, Rosanna Chianese, Teresa Chioccarelli, Silvia Fasan. CB1 activity in male reproduction: mammalian and nonmammalian animal models. Vitamins and hormones. vol 81. 2009-09-10. PMID:19647119. |
since the isolation of the main active compound of cannabis sativa, delta(9)-thc, several lines of research have evidenced the basic roles of this signaling system mainly considering its high conservation during evolution. |
2009-09-10 |
2023-08-12 |
Not clear |
| Claudine C Hunault, Tjeert T Mensinga, Koen B E Böcker, C Maarten A Schipper, Maaike Kruidenier, Marianne E C Leenders, Irma de Vries, Jan Meulenbel. Cognitive and psychomotor effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg delta-9-tetrahydrocannabinol (THC). Psychopharmacology. vol 204. issue 1. 2009-09-02. PMID:19099294. |
delta(9)-tetrahydrocannabinol (thc) is the main active constituent of cannabis. |
2009-09-02 |
2023-08-12 |
Not clear |
| Vincenzo Di Marz. The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacological research. vol 60. issue 2. 2009-09-02. PMID:19559360. |
the endocannabinoid signalling system includes: (1) at least two g-protein-coupled receptors, known as the cannabinoid cb(1) and cb(2) receptors and discovered following studies on the mechanism of action of delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant cannabis sativa; (2) the endogenous agonists at these receptors, known as endocannabinoids, of which anandamide and 2-arachidonoylglycerol are the best known; and (3) proteins and enzymes for the regulation of endocannabinoid levels and action at receptors. |
2009-09-02 |
2023-08-12 |
Not clear |