| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cameron H Good, Carl R Lupic. Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534838. |
single injections with the main psychoactive ingredient of marijuana, delta(9)-tetrahydrocannabinol (delta(9)-thc), increased glur2-lacking ampa receptors and permitted ltd in only the ppn pathway, and these effects were prevented by in vivo pretreatment with the cannabinoid cb1 receptor antagonist am251. |
2010-08-24 |
2023-08-12 |
rat |
| Abir T El-Alfy, Kelly Ivey, Keisha Robinson, Safwat Ahmed, Mohamed Radwan, Desmond Slade, Ikhlas Khan, Mahmoud ElSohly, Samir Ros. Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology, biochemistry, and behavior. vol 95. issue 4. 2010-08-18. PMID:20332000. |
results of this study show that delta(9)-thc and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis. |
2010-08-18 |
2023-08-12 |
mouse |
| Paolo Fusar-Poli, Paul Allen, Sagnik Bhattacharyya, José A Crippa, Andrea Mechelli, Stefan Borgwardt, Rocio Martin-Santos, Marc L Seal, Colin O'Carrol, Zerrin Atakan, Antonio W Zuardi, Philip McGuir. Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. The international journal of neuropsychopharmacology. vol 13. issue 4. 2010-07-14. PMID:19775500. |
modulation of effective connectivity during emotional processing by delta 9-tetrahydrocannabinol and cannabidiol. |
2010-07-14 |
2023-08-12 |
human |
| Paolo Fusar-Poli, Paul Allen, Sagnik Bhattacharyya, José A Crippa, Andrea Mechelli, Stefan Borgwardt, Rocio Martin-Santos, Marc L Seal, Colin O'Carrol, Zerrin Atakan, Antonio W Zuardi, Philip McGuir. Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. The international journal of neuropsychopharmacology. vol 13. issue 4. 2010-07-14. PMID:19775500. |
in this study dynamic causal modelling (dcm) and bayesian model selection (bms) were used to explore the effects of pure compounds of c. sativa [600 mg of cannabidiol (cbd) and 10 mg delta 9-tetrahydrocannabinol (delta 9-thc)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fmri paradigm while viewing faces which elicited different levels of anxiety. |
2010-07-14 |
2023-08-12 |
human |
| Jennifer L Stewart, Lance R McMaho. Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs. The Journal of pharmacology and experimental therapeutics. vol 334. issue 1. 2010-07-13. PMID:20375197. |
to identify potential pharmacotherapies for marijuana withdrawal, this study first characterized rimonabant-induced delta(9)-tetrahydrocannabinol (delta(9)-thc) withdrawal in rhesus monkeys by using drug discrimination and directly observable signs. |
2010-07-13 |
2023-08-12 |
monkey |
| Jennifer L Stewart, Lance R McMaho. Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs. The Journal of pharmacology and experimental therapeutics. vol 334. issue 1. 2010-07-13. PMID:20375197. |
these results suggest that cannabinoid and noncannabinoid (alpha(2)-adrenergic) agonists are potentially useful therapeutics for marijuana dependence inasmuch as they attenuate the subjective experience of delta(9)-thc withdrawal. |
2010-07-13 |
2023-08-12 |
monkey |
| Erin L Karschner, Allan J Barnes, Ross H Lowe, Karl B Scheidweiler, Marilyn A Huesti. Validation of a two-dimensional gas chromatography mass spectrometry method for the simultaneous quantification of cannabidiol, Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in plasma. Analytical and bioanalytical chemistry. vol 397. issue 2. 2010-07-09. PMID:20306180. |
validation of a two-dimensional gas chromatography mass spectrometry method for the simultaneous quantification of cannabidiol, delta(9)-tetrahydrocannabinol (thc), 11-hydroxy-thc, and 11-nor-9-carboxy-thc in plasma. |
2010-07-09 |
2023-08-12 |
Not clear |
| Erin L Karschner, Allan J Barnes, Ross H Lowe, Karl B Scheidweiler, Marilyn A Huesti. Validation of a two-dimensional gas chromatography mass spectrometry method for the simultaneous quantification of cannabidiol, Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in plasma. Analytical and bioanalytical chemistry. vol 397. issue 2. 2010-07-09. PMID:20306180. |
a sensitive analytical method for simultaneous quantification of sub-nanogram concentrations of cannabidiol (cbd), delta(9)-tetrahydrocannabinol (thc), 11-hydroxy-thc (11-oh-thc), and 11-nor-9-carboxy-thc (thccooh) in plasma is presented for monitoring cannabinoid pharmacotherapy and illicit cannabis use. |
2010-07-09 |
2023-08-12 |
Not clear |
| Ute Mareck, Nadine Haenelt, Hans Geyer, Sven Guddat, Matthias Kamber, Rudolf Brenneisen, Mario Thevis, Wilhelm Schänze. Temporal indication of cannabis use by means of THC glucuronide determination. Drug testing and analysis. vol 1. issue 11-12. 2010-07-05. PMID:20355165. |
the analysis of the glucuronide of the pharmacologically active delta 9-tetrahydrocannabinol (thc-gluc) may represent a complementary indicator for the detection of cannabis misuse in competition.an assay for the determination of thc-gluc in human urine was established. |
2010-07-05 |
2023-08-12 |
human |
| Patrik Roser, Franz X Vollenweider, Wolfram Kawoh. Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 2 Pt 2. 2010-06-14. PMID:20218784. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), the principal psychoactive constituent of the cannabis sativa plant, and other agonists at the central cannabinoid (cb(1)) receptor may induce characteristic psychomotor effects, psychotic reactions and cognitive impairment resembling schizophrenia. |
2010-06-14 |
2023-08-12 |
human |
| Patrik Roser, Franz X Vollenweider, Wolfram Kawoh. Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 2 Pt 2. 2010-06-14. PMID:20218784. |
these effects of delta(9)-thc can be reduced in animal and human models of psychopathology by two exogenous cannabinoids, cannabidiol (cbd) and sr141716. |
2010-06-14 |
2023-08-12 |
human |
| Balapal S Basavarajapp. Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity. Current neuropharmacology. vol 5. issue 2. 2010-06-10. PMID:18084639. |
endocannabinoids signal through the same cell surface receptors that are targeted by delta(9)-tetrahydrocannabinol (delta(9)thc), the active principles of cannabis sativa preparations like hashish and marijuana. |
2010-06-10 |
2023-08-12 |
Not clear |
| Angelo A Izzo, Keith A Sharke. Cannabinoids and the gut: new developments and emerging concepts. Pharmacology & therapeutics. vol 126. issue 1. 2010-06-04. PMID:20117132. |
the mechanistic basis of these treatments emerged after the discovery of delta(9)-tetrahydrocannabinol as the major constituent of cannabis. |
2010-06-04 |
2023-08-12 |
Not clear |
| Lianne Robinson, Anushka V Goonawardena, Roger Pertwee, Robert E Hampson, Bettina Platt, Gernot Riede. WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20079375. |
however, the identification of novel non-cb(1) receptors which are insensitive to the psychoactive ingredient of marijuana, delta(9)-tetrahydrocannabinol (delta(9)-thc) but sensitive to synthetic cannabinoids such as win55,212-2 (win-2) or endocannabinoids like anandamide lead us to question whether win-2 induced learning and memory deficits are indeed mediated by cb(1) receptor activation. |
2010-05-25 |
2023-08-12 |
rat |
| Satoshi Yamaori, Mika Kushihara, Ikuo Yamamoto, Kazuhito Watanab. Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes. Biochemical pharmacology. vol 79. issue 11. 2010-05-13. PMID:20117100. |
inhibitory effects of delta(9)-tetrahydrocannabinol (delta(9)-thc), cannabidiol (cbd), and cannabinol (cbn), the three major constituents in marijuana, on catalytic activities of human cytochrome p450 (cyp) 1 enzymes were investigated. |
2010-05-13 |
2023-08-12 |
human |
| Luciano De Petrocellis, Vincenzo Di Marz. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 5. issue 1. 2010-05-11. PMID:19847654. |
the molecular mechanism of action of delta(9)-tetrahydrocannabinol (thc), the psychotropic constituent of cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid cb1 and cb2 receptors. |
2010-05-11 |
2023-08-12 |
Not clear |
| Jenny L Wiley, James J Bursto. Chronic Delta9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats. Pharmacology, biochemistry, and behavior. vol 94. issue 4. 2010-04-29. PMID:19941884. |
this study examined the long-term effects of delta(9)-tetrahydrocannabinol (delta(9)-thc), the major psychoactive constituent of marijuana, in a delayed nonmatch-to-position task (dnmp). |
2010-04-29 |
2023-08-12 |
human |
| Cindy L Ehlers, Evelyn Phillips, Ian R Gizer, David A Gilder, Kirk C Wilhelmse. EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study. Drug and alcohol dependence. vol 106. issue 2-3. 2010-04-23. PMID:19748744. |
increases in spectral power in the delta frequency range, were significantly correlated with gender (p<0.001) and marijuana dependence (p<0.003). |
2010-04-23 |
2023-08-12 |
human |
| M G Cascio, L A Gauson, L A Stevenson, R A Ross, R G Pertwe. Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. British journal of pharmacology. vol 159. issue 1. 2010-04-23. PMID:20002104. |
the pharmacology of most of these has been little investigated, three notable exceptions being delta(9)-tetrahydrocannabinol, cannabidiol and delta(9)-tetrahydrocannabivarin. |
2010-04-23 |
2023-08-12 |
Not clear |
| Justin Fischedick, Frank Van Der Kooy, Robert Verpoort. Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor. Chemical & pharmaceutical bulletin. vol 58. issue 2. 2010-04-22. PMID:20118579. |
cannabis vapor and smoke was tested for cannabinoid receptor 1 (cb1) binding activity and compared to pure delta(9)-tetrahydrocannabinol (delta(9)-thc). |
2010-04-22 |
2023-08-12 |
Not clear |