| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C A Vercelli, J Aisemberg, S Billi, M Cervini, M L Ribeiro, M Farina, A M Franch. Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus. Reproductive biomedicine online. vol 18. issue 6. 2009-08-18. PMID:19490788. |
anandamide, a major endocannabinoid, mimics some of the psychotropic, hypnotic and analgesic effects of delta(9)-tetrahydrocannabinol, the psychoactive component of marijuana. |
2009-08-18 |
2023-08-12 |
Not clear |
| Ahmed M Galal, Desmond Slade, Waseem Gul, Abir T El-Alfy, Daneel Ferreira, Mahmoud A Elsohl. Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications. Recent patents on CNS drug discovery. vol 4. issue 2. 2009-08-18. PMID:19519560. |
naturally occurring cannabinoids (phytocannabinoids) are biosynthetically related terpenophenolic compounds uniquely produced by the highly variable plant, cannabis sativa l. natural and synthetic cannabinoids have been extensively studied since the discovery that the psychotropic effects of cannabis are mainly due to delta(9)-thc. |
2009-08-18 |
2023-08-12 |
Not clear |
| George Panagis, Styliani Vlachou, George G Nomiko. Behavioral pharmacology of cannabinoids with a focus on preclinical models for studying reinforcing and dependence-producing properties. Current drug abuse reviews. vol 1. issue 3. 2009-08-13. PMID:19630731. |
to this end, our knowledge and understanding of the way cannabis and its main psychoactive constituent, delta(9)-tetrahydrocannabinol (delta(9)-thc), act in the central nervous system to exert their reinforcing/rewarding effects is far from complete. |
2009-08-13 |
2023-08-12 |
Not clear |
| Joel E Schlosburg, Brittany L A Carlson, Divya Ramesh, Rehab A Abdullah, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. The AAPS journal. vol 11. issue 2. 2009-08-12. PMID:19430909. |
the only treatment currently shown consistently to alleviate cannabinoid withdrawal in both animals and humans is substitution therapy using the psychoactive constituent of marijuana, delta(9)-tetrahydrocannabinol (thc). |
2009-08-12 |
2023-08-12 |
mouse |
| Deepak Cyril D'Souza, Brian Pittman, Edward Perry, Arthur Sime. Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology. vol 202. issue 4. 2009-08-11. PMID:18807247. |
accordingly, we hypothesized that delta(9)-tetrahydrocannabinol (delta(9)-thc), the principal active component of cannabis, would alter bdnf levels in humans. |
2009-08-11 |
2023-08-12 |
Not clear |
| Joel E Schlosburg, Steven G Kinsey, Aron H Lichtma. Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation. The AAPS journal. vol 11. issue 1. 2009-07-23. PMID:19184452. |
faah-compromised animals reliably display antinociceptive and anti-inflammatory phenotypes with a similar efficacy as direct-acting cannabinoid receptor agonists, such as delta(9)-tetrahydrocannabinol (thc), the primary psychoactive constituent of cannabis sativa. |
2009-07-23 |
2023-08-12 |
mouse |
| Ester Fride, Datta Ponde, Aviva Breuer, Lumir Hanu. Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors. Neuropharmacology. vol 48. issue 8. 2009-07-17. PMID:15910887. |
delta-9 tetrahydrocannabinol (delta(9)-thc) and (-)-cannabidiol ((-)-cbd) are major constituents of the cannabis sativa plant with different pharmacological profiles: (delta(9)-thc activates cannabinoid cb(1) and cb(2) receptors and induces psychoactive and peripheral effects. |
2009-07-17 |
2023-08-12 |
mouse |
| J G Ramaekers, G Kauert, E L Theunissen, S W Toennes, M R Moelle. Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. Journal of psychopharmacology (Oxford, England). vol 23. issue 3. 2009-07-09. PMID:18719045. |
performance impairment during delta(9)-tetrahydrocannabinol (thc) intoxication has been well described in occasional cannabis users. |
2009-07-09 |
2023-08-12 |
human |
| Saoirse E O'Sullivan, Yan Sun, Andrew J Bennett, Michael D Randall, David A Kendal. Time-dependent vascular actions of cannabidiol in the rat aorta. European journal of pharmacology. vol 612. issue 1-3. 2009-07-09. PMID:19285060. |
we have shown that the major active agent of cannabis sativa, delta(9)-tetrahydrocannabinol, activates peroxisome proliferator-activated receptor gamma [ppargamma, o'sullivan, s.e., tarling, e.j., bennett, a.j., kendall, d.a., randall, m.d., 2005c. |
2009-07-09 |
2023-08-12 |
rat |
| Patrik Roser, Jürgen Gallinat, Gordon Weinberg, Georg Juckel, Inge Gorynia, Andreas M Stadelman. Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects. European archives of psychiatry and clinical neuroscience. vol 259. issue 5. 2009-07-01. PMID:19224107. |
this prospective, double-blind, placebo-controlled cross-over study investigated the acute effects of cannabinoids on psychomotor performance in 24 healthy right-handed volunteers (age 27.9 +/- 2.9 years, 12 male) by comparing delta(9)-tetrahydrocannabinol (delta(9)-thc) and standardized cannabis extract containing delta(9)-thc and cannabidiol. |
2009-07-01 |
2023-08-12 |
human |
| Patrik Roser, Jürgen Gallinat, Gordon Weinberg, Georg Juckel, Inge Gorynia, Andreas M Stadelman. Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects. European archives of psychiatry and clinical neuroscience. vol 259. issue 5. 2009-07-01. PMID:19224107. |
cannabis extract, but not delta(9)-thc, revealed a significant reduction of right-hand tapping frequencies that was also found in schizophrenia. |
2009-07-01 |
2023-08-12 |
human |
| C Balducci, G Nervegna, A Cecinat. Evaluation of principal cannabinoids in airborne particulates. Analytica chimica acta. vol 641. issue 1-2. 2009-06-30. PMID:19393371. |
the determination of delta(9)-tetrahydrocannabinol (delta9-thc), cannabidiol (cnd) and cannabinol (cnb), primary active components in cannabis preparation, was carried out on airborne particulates by applying a specific procedure consisting of soot extraction by ultrasonic bath, purification by solvent partitioning, derivatization with n-(t-butyldimethylsilyl)-n-methyl-trifluoroacetamide, and separation/detection through gas chromatography coupled with tandem mass spectrometry. |
2009-06-30 |
2023-08-12 |
human |
| Balapal S Basavarajappa, Ralph A Nixon, Ottavio Aranci. Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini reviews in medicinal chemistry. vol 9. issue 4. 2009-06-23. PMID:19356123. |
thus, aea and 2-ag mimic several pharmacological effects of the exogenous cannabinoid delta9-tetrahydrocannabinol (delta(9)-thc), the psychoactive principle of cannabis sativa preparations like hashish and marijuana. |
2009-06-23 |
2023-08-12 |
human |
| R Andrew Sewell, James Poling, Mehmet Sofuogl. The effect of cannabis compared with alcohol on driving. The American journal on addictions. vol 18. issue 3. 2009-06-16. PMID:19340636. |
cannabis and alcohol acutely impair several driving-related skills in a dose-related fashion, but the effects of cannabis vary more between individuals than they do with alcohol because of tolerance, differences in smoking technique, and different absorptions of delta(9)-tetrahydrocannabinol (thc), the active ingredient in marijuana. |
2009-06-16 |
2023-08-12 |
Not clear |
| María Salazar, Arkaitz Carracedo, Iñigo J Salanueva, Sonia Hernández-Tiedra, Mar Lorente, Ainara Egia, Patricia Vázquez, Cristina Blázquez, Sofía Torres, Stephane García, Jonathan Nowak, Gian María Fimia, Mauro Piacentini, Francesco Cecconi, Pier Paolo Pandolfi, Luis González-Feria, Juan L Iovanna, Manuel Guzmán, Patricia Boya, Guillermo Velasc. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. The Journal of clinical investigation. vol 119. issue 5. 2009-06-08. PMID:19425170. |
here we demonstrate that delta(9)-tetrahydrocannabinol (thc), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. |
2009-06-08 |
2023-08-12 |
mouse |
| Shuso Takeda, Ikuo Yamamoto, Kazuhito Watanab. Modulation of Delta9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase. Toxicology. vol 259. issue 1-2. 2009-06-02. PMID:19428940. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), a major constituent of marijuana, has been shown to stimulate the growth of mcf-7 breast cancer cells through cannabinoid receptor-independent signaling [takeda, s., yamaori, s., motoya, e., matsunaga, t., kimura, t., yamamoto, i., watanabe, k., 2008. |
2009-06-02 |
2023-08-12 |
Not clear |
| Luciano De Petrocellis, Vincenzo Di Marz. An introduction to the endocannabinoid system: from the early to the latest concepts. Best practice & research. Clinical endocrinology & metabolism. vol 23. issue 1. 2009-05-26. PMID:19285257. |
a rather complex and pleiotropic endogenous signalling system was discovered in the late 1990s, starting from studies on the mechanism of action of delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant cannabis sativa. |
2009-05-26 |
2023-08-12 |
Not clear |
| Roger G Pertwe. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. British journal of pharmacology. vol 156. issue 3. 2009-05-08. PMID:19226257. |
these are cesamet (nabilone), marinol (dronabinol; delta(9)-tetrahydrocannabinol) and sativex (delta(9)-tetrahydrocannabinol with cannabidiol). |
2009-05-08 |
2023-08-12 |
Not clear |
| Alan M Roloff, Stanley A Thaye. Modulation of excitatory synaptic transmission by Delta 9-tetrahydrocannabinol switches from agonist to antagonist depending on firing rate. Molecular pharmacology. vol 75. issue 4. 2009-04-23. PMID:19118122. |
delta(9)-tetrahydrocannabinol (thc), the principal psychoactive ingredient in marijuana, acts as a partial agonist on presynaptic cannabinoid type 1 (cb1) receptors to inhibit neurotransmitter release. |
2009-04-23 |
2023-08-12 |
rat |
| Gregory L Gerdeman, Jason B Schechter, Edward D Frenc. Context-specific reversal of cocaine sensitization by the CB1 cannabinoid receptor antagonist rimonabant. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 11. 2009-04-22. PMID:18059436. |
consistent with previous reports, the induction of locomotor sensitization following repeated daily cocaine was not prevented by systemic pretreatment of either rimonabant, delta(9)-tetrahydrocannabinol (thc), or a 1:1 mixture of thc and cannabidiol (cbd). |
2009-04-22 |
2023-08-12 |
mouse |