| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura E Wise, Roberta Cannavacciulo, Benjamin F Cravatt, Billy F Martin, Aron H Lichtma. Evaluation of fatty acid amides in the carrageenan-induced paw edema model. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17675189. |
while it has long been recognized that delta(9)-tetrahydrocannabinol (thc), the primary psychoactive constituent of cannabis, and other cannabinoid receptor agonists possess anti-inflammatory properties, their well known cns effects have dampened enthusiasm for therapeutic development. |
2008-04-18 |
2023-08-12 |
mouse |
| Roey Senn, Ora Keren, Aya Hefetz, Yosef Sarn. Long-term cognitive deficits induced by a single, extremely low dose of tetrahydrocannabinol (THC): behavioral, pharmacological and biochemical studies in mice. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17888506. |
we have previously reported that an injection of a single, extremely low dose (0.001 mg/kg) of delta 9-tetrahydrocannabinal (thc, the major psychoactive ingredient of marijuana) to mice deteriorated their performance in the morris water maze test 3 weeks later. |
2008-04-09 |
2023-08-12 |
mouse |
| Cristina Blázquez, María Salazar, Arkaitz Carracedo, Mar Lorente, Ainara Egia, Luis González-Feria, Amador Haro, Guillermo Velasco, Manuel Guzmá. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer research. vol 68. issue 6. 2008-04-09. PMID:18339876. |
local administration of delta(9)-tetrahydrocannabinol (thc), the major active ingredient of cannabis, down-regulated mmp-2 expression in gliomas generated in mice, as determined by western blot, immunofluorescence, and real-time quantitative pcr analyses. |
2008-04-09 |
2023-08-12 |
mouse |
| K Luan Phan, Mike Angstadt, Jamie Golden, Ikechukwu Onyewuenyi, Ana Popovska, Harriet de Wi. Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 10. 2008-04-07. PMID:18322078. |
the anxiolytic effects of delta(9)-tetrahydrocannabinol (thc), the primary psychoactive ingredient in cannabis, are believed to be mediated through direct and selective agonism of cb(1) receptors localized within the basolateral amygdala, a critical brain region for threat perception. |
2008-04-07 |
2023-08-12 |
Not clear |
| A A Boucher, G E Hunt, T Karl, J Micheau, I S McGregor, J C Arnol. Heterozygous neuregulin 1 mice display greater baseline and Delta(9)-tetrahydrocannabinol-induced c-Fos expression. Neuroscience. vol 149. issue 4. 2008-03-28. PMID:17905522. |
we have recently shown that nrg1 het mice are more sensitive to the behavioral effects of the main psychoactive constituent of cannabis, delta(9)-tetrahydrocannabinol (thc). |
2008-03-28 |
2023-08-12 |
mouse |
| Jane E Lauckner, Jill B Jensen, Huei-Ying Chen, Hui-Chen Lu, Bertil Hille, Ken Macki. GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 7. 2008-03-13. PMID:18263732. |
the cb(1) cannabinoid receptor mediates many of the psychoactive effects of delta(9)thc, the principal active component of cannabis. |
2008-03-13 |
2023-08-12 |
Not clear |
| Karin Woelkart, Outi M H Salo-Ahen, Rudolf Baue. CB receptor ligands from plants. Current topics in medicinal chemistry. vol 8. issue 3. 2008-03-07. PMID:18289087. |
cannabis sativa l. with the known plant cannabinoid, delta(9-)tetrahydrocannabinol (thc) and echinacea species with the cannabinoid (cb) receptor-binding lipophilic alkamides are the best known herbal cannabimimetics. |
2008-03-07 |
2023-08-12 |
Not clear |
| Georg Juckel, Patrik Roser, Thomas Nadulski, Andreas M Stadelmann, Jürgen Gallina. Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity. Schizophrenia research. vol 97. issue 1-3. 2008-03-04. PMID:17884351. |
this study investigated the effects of cannabis on mmn amplitude in 22 healthy volunteers (age 28+/-6 years, 11 male) by comparing delta(9)-tetrahydrocannabinol (delta(9)-thc) and standardized cannabis extract containing delta(9)-thc and cannabidiol (cbd) in a prospective, double-blind, placebo-controlled cross-over design. |
2008-03-04 |
2023-08-12 |
human |
| Georg Juckel, Patrik Roser, Thomas Nadulski, Andreas M Stadelmann, Jürgen Gallina. Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity. Schizophrenia research. vol 97. issue 1-3. 2008-03-04. PMID:17884351. |
significantly greater mmn amplitude values at central electrodes were found under cannabis extract, but not under delta(9)-thc. |
2008-03-04 |
2023-08-12 |
human |
| Georg Juckel, Patrik Roser, Thomas Nadulski, Andreas M Stadelmann, Jürgen Gallina. Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity. Schizophrenia research. vol 97. issue 1-3. 2008-03-04. PMID:17884351. |
since the main difference between delta(9)-thc and standardized cannabis extract is cbd, which seems to have neuroprotective and anti-psychotic properties, it can be speculated whether the greater mmn amplitude that may imply higher cortical activation and cognitive performance is related to the positive effects of cbd. |
2008-03-04 |
2023-08-12 |
human |
| M L Holland, D T T Lau, J D Allen, J C Arnol. The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17906686. |
here we address the interaction of cannabinol (cbn), cannabidiol (cbd) and delta 9-tetrahydrocannabinol (thc) with the related multidrug transporter, abcg2. |
2008-02-25 |
2023-08-12 |
Not clear |
| A Preet, R K Ganju, J E Groopma. Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene. vol 27. issue 3. 2008-02-15. PMID:17621270. |
delta(9)-tetrahydrocannabinol (thc) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis. |
2008-02-15 |
2023-08-12 |
mouse |
| Marilyn A Huestis, Karl B Scheidweiler, Takeshi Saito, Neil Fortner, Tsadik Abraham, Richard A Gustafson, Michael L Smit. Excretion of Delta9-tetrahydrocannabinol in sweat. Forensic science international. vol 174. issue 2-3. 2008-02-05. PMID:17481836. |
we evaluated delta(9)-tetrahydrocannabinol (thc) excretion in 11 daily cannabis users after cessation of drug use. |
2008-02-05 |
2023-08-12 |
human |
| Eric J Downer, Aoife Gowran, Veronica A Campbel. A comparison of the apoptotic effect of Delta(9)-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex. Brain research. vol 1175. 2008-01-25. PMID:17884022. |
the data provide evidence which supports the hypothesis that the neonatal rat brain is more vulnerable to the neurotoxic influence of delta(9)-tetrahydrocannabinol, suggesting that the cognitive deficits that are observed in humans exposed to marijuana during gestation may be due, in part, to abnormal engagement of the apoptotic cascade during brain development. |
2008-01-25 |
2023-08-12 |
rat |
| Krisztina Monory, Heike Blaudzun, Federico Massa, Nadine Kaiser, Thomas Lemberger, Günther Schütz, Carsten T Wotjak, Beat Lutz, Giovanni Marsican. Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS biology. vol 5. issue 10. 2007-12-06. PMID:17927447. |
marijuana and its main psychotropic ingredient delta(9)-tetrahydrocannabinol (thc) exert a plethora of psychoactive effects through the activation of the neuronal cannabinoid receptor type 1 (cb1), which is expressed by different neuronal subpopulations in the central nervous system. |
2007-12-06 |
2023-08-12 |
mouse |
| A H Taylor, C Ang, S C Bell, J C Konj. The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy. Human reproduction update. vol 13. issue 5. 2007-11-13. PMID:17584820. |
maternal use of marijuana, in which the exocannabinoid delta(9)-tetrahydrocannabinol is the most active psychoactive ingredient, is known to have adverse effects on various aspects of reproduction including ovulation, spermatogenesis, implantation and pregnancy duration. |
2007-11-13 |
2023-08-12 |
human |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Mai Hazekawa, Keiichi Irie, Masayuki Fujioka, Kensuke Orito, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17437545. |
we examined the neuroprotective mechanism of cannabidiol, non-psychoactive component of marijuana, on the infarction in a 4 h mouse middle cerebral artery (mca) occlusion model in comparison with delta(9)-tetrahydrocannabinol (delta(9)-thc). |
2007-11-06 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Mai Hazekawa, Keiichi Irie, Masayuki Fujioka, Kensuke Orito, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17437545. |
both pre- and post-ischemic treatment with cannabidiol resulted in potent and long-lasting neuroprotection, whereas only pre-ischemic treatment with delta(9)-thc reduced the infarction. |
2007-11-06 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Mai Hazekawa, Keiichi Irie, Masayuki Fujioka, Kensuke Orito, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17437545. |
unlike delta(9)-thc, cannabidiol did not affect the excess release of glutamate in the cortex after occlusion. |
2007-11-06 |
2023-08-12 |
mouse |
| Floride Niyuhire, Stephen A Varvel, Billy R Martin, Aron H Lichtma. Exposure to marijuana smoke impairs memory retrieval in mice. The Journal of pharmacology and experimental therapeutics. vol 322. issue 3. 2007-10-19. PMID:17586723. |
marijuana (cannabis sativa) and its primary psychoactive component, delta-9-tetrahydrocannabinol (delta(9)-thc), have long been known to disrupt cognition in humans. |
2007-10-19 |
2023-08-12 |
mouse |