| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David M Wilson, Stephan A Varvel, John P Harloe, Billy R Martin, Aron H Lichtma. SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16934319. |
finally, delta(9)-thc dose-dependently alleviated sr 141716-induced paw tremors in marijuana-dependent mice, but marijuana itself failed to reverse the precipitated withdrawal effect. |
2007-02-23 |
2023-08-12 |
mouse |
| David M Wilson, Stephan A Varvel, John P Harloe, Billy R Martin, Aron H Lichtma. SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16934319. |
it is likely that marijuana exposure generated insufficient delta(9)-thc brain levels (i.e., 203+/-19 ng/g) to reverse the withdrawal signs compared with the brain levels following intravenous injection (i.e., 1862+/-82 ng/g). |
2007-02-23 |
2023-08-12 |
mouse |
| David M Wilson, Stephan A Varvel, John P Harloe, Billy R Martin, Aron H Lichtma. SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16934319. |
these findings taken together indicate that mice exposed repeatedly to marijuana smoke exhibit similar precipitated withdrawal effects as delta(9)-thc-injected mice. |
2007-02-23 |
2023-08-12 |
mouse |
| David Day, David J Kuntz, Michael Feldman, Lance Presle. Detection of THCA in oral fluid by GC-MS-MS. Journal of analytical toxicology. vol 30. issue 9. 2007-01-25. PMID:17137523. |
detection of thca in oral fluid by gc-ms-ms. a major marijuana metabolite, 11-nor-9-carboxy-tetrahydrocannabinol (thca), has been identified in oral fluids from donors that previously tested positive for delta(9)-tetrahydrocannabinol (thc). |
2007-01-25 |
2023-08-12 |
Not clear |
| Duncan Ryan, Alison J Drysdale, Roger G Pertwee, Bettina Plat. Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia. Neuroscience letters. vol 408. issue 3. 2007-01-23. PMID:16997463. |
here, we investigated whether the main psychotropic constituent of cannabis, delta(9)-tetrahydrocannabinol (thc) alone or in combination with other cannabis constituents can cause similar responses, and whether thc affects the responses induced by cbd. |
2007-01-23 |
2023-08-12 |
Not clear |
| A Paradisi, S Oddi, M Maccarron. The endocannabinoid system in ageing: a new target for drug development. Current drug targets. vol 7. issue 11. 2007-01-04. PMID:17100593. |
anandamide (n-arachidonoylethanolamine; aea) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of delta(9)-tetrahydrocannabinol, the active principle of cannabis sativa preparations like hashish and marijuana. |
2007-01-04 |
2023-08-12 |
human |
| Linda J Kochman, Angela Amancio dos Santos, Casimir A Fornal, Barry L Jacob. Despite strong behavioral disruption, Delta9-tetrahydrocannabinol does not affect cell proliferation in the adult mouse dentate gyrus. Brain research. vol 1113. issue 1. 2006-12-13. PMID:16930565. |
we examined the effects of different doses and treatment regimens of delta(9)-tetrahydrocannabinol (thc), the main active ingredient in marijuana, on cell proliferation in the dentate gyrus of adult male mice. |
2006-12-13 |
2023-08-12 |
mouse |
| Lori M Lieving, Scott D Lane, Don R Cherek, Oleg V Tcheremissin. Effects of marijuana on temporal discriminations in humans. Behavioural pharmacology. vol 17. issue 2. 2006-12-06. PMID:16495725. |
administration of both low (1/2 placebo and 1/2 2.2% delta (9)-tetrahydrocannabinol cigarette) and high (3.89% delta(9)-tetrahydrocannabinol) potency marijuana cigarettes produced a bias of judging intervals as long, consistent with an interpretation that subjective time passes more quickly when an individual is intoxicated by marijuana. |
2006-12-06 |
2023-08-12 |
human |
| Marleen Laloup, Maria Del Mar Ramirez Fernandez, Michelle Wood, Gert De Boeck, Viviane Maes, Nele Samy. Correlation of Delta9-tetrahydrocannabinol concentrations determined by LC-MS-MS in oral fluid and plasma from impaired drivers and evaluation of the on-site Dräger DrugTest. Forensic science international. vol 161. issue 2-3. 2006-11-13. PMID:16842950. |
oral fluid (collected with the intercept((r)) device) and plasma samples were obtained from 139 individuals suspected of driving under the influence of drugs and analyzed for delta(9)-tetrahydrocannabinol (thc), the major psychoactive constituent of cannabis, using a validated quantitative lc-ms-ms method. |
2006-11-13 |
2023-08-12 |
Not clear |
| Hassan Z Khiabani, Jørgen G Bramness, Anders Bjørneboe, Jørg Mørlan. Relationship between THC concentration in blood and impairment in apprehended drivers. Traffic injury prevention. vol 7. issue 2. 2006-11-03. PMID:16854704. |
the most important psychoactive ingredient in cannabis, delta (9)-tetrahydrocannabinol (thc) is one of the most frequently detected substances in blood samples from suspected impaired drivers in norway. |
2006-11-03 |
2023-08-12 |
Not clear |
| S A Varvel, J L Wiley, R Yang, D T Bridgen, K Long, A H Lichtman, B R Marti. Interactions between THC and cannabidiol in mouse models of cannabinoid activity. Psychopharmacology. vol 186. issue 2. 2006-10-20. PMID:16572263. |
interest persists in characterizing potential interactions between delta(9)-tetrahydocannabinol (thc) and other marijuana constituents such as cannabidiol (cbd). |
2006-10-20 |
2023-08-12 |
mouse |
| Evelyne Célérier, Therese Ahdepil, Helena Wikander, Fernando Berrendero, Fred Nyberg, Rafael Maldonad. Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence. Neuropharmacology. vol 50. issue 7. 2006-10-06. PMID:16443242. |
here, we examined in mice whether the exposure to the anabolic-androgenic steroid nandrolone would affect the pharmacological and motivational effects induced by delta(9)-tetrahydrocannabinol (thc), the principal psychoactive component of cannabis sativa. |
2006-10-06 |
2023-08-12 |
mouse |
| Annick Ménétrey, Marc Augsburger, Bernard Favrat, Marie A Pin, Laura E Rothuizen, Monique Appenzeller, Thierry Buclin, Patrice Mangin, Christian Girou. Assessment of driving capability through the use of clinical and psychomotor tests in relation to blood cannabinoids levels following oral administration of 20 mg dronabinol or of a cannabis decoction made with 20 or 60 mg Delta9-THC. Journal of analytical toxicology. vol 29. issue 5. 2006-09-22. PMID:16105257. |
delta(9)-tetrahydrocannabinol (thc) is frequently found in the blood of drivers suspected of driving under the influence of cannabis or involved in traffic crashes. |
2006-09-22 |
2023-08-12 |
human |
| Eric Murillo-Rodríguez, Diana Millán-Aldaco, Marcela Palomero-Rivero, Raphael Mechoulam, René Drucker-Colí. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS letters. vol 580. issue 18. 2006-09-19. PMID:16844117. |
delta(9)-tetrahydrocannabinol (delta(9)-thc) and cannabidiol (cbd) are two major constituents of cannabis sativa. |
2006-09-19 |
2023-08-12 |
rat |
| Theodore A Sarafian, Nancy Habib, Michael Oldham, Navindra Seeram, Ru-Po Lee, Laura Lin, Donald P Tashkin, Michael D Rot. Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo. American journal of physiology. Lung cellular and molecular physiology. vol 290. issue 6. 2006-08-11. PMID:16414979. |
we hypothesized that delta(9)-tetrahydrocannabinol (thc), the primary psychoactive component of marijuana, might contribute to these findings by impairing cellular energetics and mitochondrial function. |
2006-08-11 |
2023-08-12 |
rat |
| Manuela Licata, Patrizia Verri, Giovanni Bedusch. Delta9 THC content in illicit cannabis products over the period 1997-2004 (first four months). Annali dell'Istituto superiore di sanita. vol 41. issue 4. 2006-08-11. PMID:16569917. |
the aim of this study is to determine delta 9 tetrahydrocannabinol (delta9 thc) content in 5227 seizures of cannabis products over the period 1997-2004 (first four months). |
2006-08-11 |
2023-08-12 |
Not clear |
| Hao-Jie Zhu, Jun-Sheng Wang, John S Markowitz, Jennifer L Donovan, Bryan B Gibson, Holly A Gefroh, C Lindsay Devan. Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16439618. |
the purpose of this study was to investigate the possible interaction of p-gp with each of four major marijuana constituents: delta(9)-tetrahydrocannabinol (thc), 11-nor-delta(9)-tetrahydrocannabinol-carboxylic acid (thc-cooh), cannabinol (cbn), and cannabidiol (cbd). |
2006-06-09 |
2023-08-12 |
rat |
| Ronald I Herning, Warren Better, Kimberly Tate, Jean L Cade. Neuropsychiatric alterations in MDMA users: preliminary findings. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179502. |
absolute log delta power in the eeg of mdma abusers at central electrode sites was significantly higher than that of the mdma/marijuana, marijuana abusers, and control subjects. |
2006-06-06 |
2023-08-12 |
human |
| Saoirse E O'Sullivan, David A Kendall, Michael D Randal. Further characterization of the time-dependent vascular effects of delta9-tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16352700. |
we have previously shown that over time (2 h), the active ingredient of cannabis, delta(9)-tetrahydrocannabinol (thc), produces peroxisome proliferator-activated receptor (ppar) gamma-mediated vasorelaxation of conduit arteries. |
2006-05-25 |
2023-08-12 |
rat |
| Kitty C M Verhoeckx, Henrie A A J Korthout, A P van Meeteren-Kreikamp, Karl A Ehlert, Mei Wang, Jan van der Greef, Richard J T Rodenburg, Renger F Witkam. Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways. International immunopharmacology. vol 6. issue 4. 2006-04-26. PMID:16504929. |
the present paper describes the potential immuno-modulating activity of unheated cannabis sativa extracts and its main non-psychoactive constituent delta(9)-tetrahydrocanabinoid acid (thca). |
2006-04-26 |
2023-08-12 |
Not clear |