| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Markus Kathmann, Karsten Flau, Agnes Redmer, Christian Tränkle, Eberhard Schlicke. Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 372. issue 5. 2007-06-13. PMID:16489449. |
the present study shows that cannabidiol is an allosteric modulator at mu and delta opioid receptors. |
2007-06-13 |
2023-08-12 |
rat |
| Stephen A Varvel, Laura E Wise, Floride Niyuhire, Benjamin F Cravatt, Aron H Lichtma. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 5. 2007-06-05. PMID:17047668. |
in contrast, the primary psychoactive constituent of marijuana, delta(9)-tetrahydrocannabinol, failed to affect extinction rates, suggesting that faah is a more effective target than a direct acting cb(1) receptor agonist in facilitating extinction. |
2007-06-05 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Ayumi Ogata, Mai Hazekawa, An-Xin Liu, Masayuki Fujioka, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. vol 52. issue 4. 2007-06-01. PMID:17320118. |
both delta(9)-tetrahydrocannabinol (delta(9)-thc) and cannabidiol are known to have a neuroprotective effect against cerebral ischemia. |
2007-06-01 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Ayumi Ogata, Mai Hazekawa, An-Xin Liu, Masayuki Fujioka, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. vol 52. issue 4. 2007-06-01. PMID:17320118. |
the neuroprotective effect of delta(9)-thc but not cannabidiol was inhibited by sr141716, cannabinoid cb(1) receptor antagonist. |
2007-06-01 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Ayumi Ogata, Mai Hazekawa, An-Xin Liu, Masayuki Fujioka, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. vol 52. issue 4. 2007-06-01. PMID:17320118. |
fourteen-day repeated treatment with delta(9)-thc, but not cannabidiol, led to tolerance of the neuroprotective and hypothermic effects. |
2007-06-01 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Ayumi Ogata, Mai Hazekawa, An-Xin Liu, Masayuki Fujioka, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. vol 52. issue 4. 2007-06-01. PMID:17320118. |
in addition, repeated treatment with delta(9)-thc reversed the increase in cerebral blood flow (cbf), while cannabidiol did not reverse that effect. |
2007-06-01 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Ayumi Ogata, Mai Hazekawa, An-Xin Liu, Masayuki Fujioka, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. vol 52. issue 4. 2007-06-01. PMID:17320118. |
cannabidiol exhibited stronger antioxidative power than delta(9)-thc in an in vitro study using the 1,1-diphenyl-2-picryhydrazyl (dpph) radical. |
2007-06-01 |
2023-08-12 |
mouse |
| Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kan. Endocannabinoids and synaptic function in the CNS. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 13. issue 2. 2007-05-25. PMID:17404373. |
marijuana affects neural functions through the binding of its active component (delta(9)-thc) to cannabinoid receptors in the cns. |
2007-05-25 |
2023-08-12 |
mouse |
| R G Pertwee, A Thomas, L A Stevenson, R A Ross, S A Varvel, A H Lichtman, B R Martin, R K Razda. The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo. British journal of pharmacology. vol 150. issue 5. 2007-05-10. PMID:17245367. |
to follow up in vitro evidence that delta(9)-tetrahydrocannabivarin extracted from cannabis (edelta(9)-thcv) is a cb(1) receptor antagonist by establishing whether synthetic delta(9)-tetrahydrocannabivarin (o-4394) and delta(8)-tetrahydrocannabivarin (o-4395) behave as cb(1) antagonists in vivo. |
2007-05-10 |
2023-08-12 |
mouse |
| Thomas Nadulski, Fritz Prags. Simple and sensitive determination of Delta(9)-tetrahydrocannabinol, cannabidiol and cannabinol in hair by combined silylation, headspace solid phase microextraction and gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 846. issue 1-2. 2007-04-02. PMID:16971195. |
simple and sensitive determination of delta(9)-tetrahydrocannabinol, cannabidiol and cannabinol in hair by combined silylation, headspace solid phase microextraction and gas chromatography-mass spectrometry. |
2007-04-02 |
2023-08-12 |
Not clear |
| Thomas Nadulski, Fritz Prags. Simple and sensitive determination of Delta(9)-tetrahydrocannabinol, cannabidiol and cannabinol in hair by combined silylation, headspace solid phase microextraction and gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 846. issue 1-2. 2007-04-02. PMID:16971195. |
a new method for determination of delta(9)-tetrahydrocannabinol (thc), cannabidiol (cbd) and cannabinol (cbn) in hair based on alkaline hair hydrolysis, extraction by iso-octane, combined derivatization with n,o-bis-(trimethylsilyl)-trifluoroacetamide and headspace solid phase microextraction of the extract residue, and gas chromatography-mass spectrometry was developed and evaluated. |
2007-04-02 |
2023-08-12 |
Not clear |
| Roman Wachowiak, Bogna Strac. [Analysis of active components of evidence materials secured in the cases of drugs abuse associated with amphetamines and cannabis products]. Archiwum medycyny sadowej i kryminologii. vol 56. issue 4. 2007-03-20. PMID:17249374. |
the authors determined the conditions for qualitative and quantitative analysis of active components of the secured evidence materials containing amphetamine sulphate, methylamphetamine hydrochloride, 3,4-me-tylenedioxy-methamphetamine hydrochloride (mdma, ecstasy), as well as delta(9)-tetrahydrocannabinol (delta(9)-thc) as an active component of cannabis (marihuana, hashish). |
2007-03-20 |
2023-08-12 |
human |
| Christopher J Fowle. The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide. Fundamental & clinical pharmacology. vol 20. issue 6. 2007-03-15. PMID:17109648. |
although cannabis has been used both recreationally and for medicinal purposes since ancient times, it was not until the 1990s that the receptors responsible for many of the actions of delta(9)-tetrahydrocannabinol, the main psychoactive ingredient of cannabis, were cloned. |
2007-03-15 |
2023-08-12 |
Not clear |
| Hassan Z Khiabani, Jørg Mørlan. [Cannabis and cannabinoids as drugs]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 127. issue 5. 2007-03-14. PMID:17332810. |
delta (9)-tetrahydrocannabinol (thc) is the primary psychoactive component of cannabis. |
2007-03-14 |
2023-08-12 |
human |
| Hassan Z Khiabani, Asbjørg S Christophersen, Jørg Mørlan. [Cannabis affects driving skills]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 127. issue 5. 2007-03-14. PMID:17332811. |
delta (9)-tetrahydrocannabinol (thc), the most important psychoactive substance in cannabis, is frequently detected in blood from apprehended drivers suspected for drugged driving. |
2007-03-14 |
2023-08-12 |
human |
| Jürg Gertsch, Stefan Raduner, Karl-Heinz Altman. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118807. |
since the discovery that delta 9-tetrahydrocannabinol and related cannabinoids from cannabis sativa l. act on specific physiological receptors in the human body and the subsequent elucidation of the mammalian endogenous cannabinoid system, no other natural product class has been reported to mimic the effects of cannabinoids. |
2007-03-06 |
2023-08-12 |
human |
| Javier Fernandez-Solari, Juan P Prestifilippo, Stefan R Bornstein, Samuel M McCann, Valeria Rettor. Participation of the endocannabinoid system in the effect of TNF-alpha on hypothalamic release of gonadotropin-releasing hormone. Annals of the New York Academy of Sciences. vol 1088. 2007-03-05. PMID:17192570. |
it is known that delta(9)-tetrahydrocannabinol (thc), the major active ingredient of marijuana, can suppress reproductive function. |
2007-03-05 |
2023-08-12 |
rat |
| David M Wilson, Stephan A Varvel, John P Harloe, Billy R Martin, Aron H Lichtma. SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16934319. |
the goals of the present study were to: assess whether the cb(1) antagonist sr 141716 (rimonabant) precipitates withdrawal in mice that had been repeatedly exposed to marijuana smoke, and to compare these precipitated withdrawal effects to those elicited following intravenous administration of its chief psychoactive component delta(9)-tetrahydrocannabinol (delta(9)-thc). |
2007-02-23 |
2023-08-12 |
mouse |
| David M Wilson, Stephan A Varvel, John P Harloe, Billy R Martin, Aron H Lichtma. SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16934319. |
sr 141716 elicited a significant increase in paw tremors in mice that were repeatedly dosed with either marijuana or delta(9)-thc. |
2007-02-23 |
2023-08-12 |
mouse |
| David M Wilson, Stephan A Varvel, John P Harloe, Billy R Martin, Aron H Lichtma. SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16934319. |
unexpectedly, the blood and brain concentrations of delta(9)-thc following marijuana exposure were considerably lower than those found following delta(9)-thc injection when comparing an equivalent magnitude of paw tremors in both conditions. |
2007-02-23 |
2023-08-12 |
mouse |