| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Balapal S Basavarajappa, Basalingappa L Hungun. Role of the endocannabinoid system in the development of tolerance to alcohol. Alcohol and alcoholism (Oxford, Oxfordshire). vol 40. issue 1. 2005-08-31. PMID:15550443. |
the identification of a g-protein-coupled receptor, namely, the cannabinoid receptor (cb(1) receptor), which was activated by delta(9)-tetrahydrocannabinol (delta(9)-thc), the major psychoactive component of marijuana, led to the discovery of endogenous cannabinoid agonists. |
2005-08-31 |
2023-08-12 |
mouse |
| Vincenzo Di Marzo, Isabel Matia. Endocannabinoid control of food intake and energy balance. Nature neuroscience. vol 8. issue 5. 2005-07-08. PMID:15856067. |
marijuana and its major psychotropic component, delta(9)-tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the cb(1) cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance. |
2005-07-08 |
2023-08-12 |
Not clear |
| Elena Butovsky, Ana Juknat, Igor Goncharov, Judith Elbaz, Raya Eilam, Abraham Zangen, Zvi Voge. In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol. Journal of neurochemistry. vol 93. issue 4. 2005-07-05. PMID:15857384. |
here we show that chronic administration of delta(9)-tetrahydrocannabinol (delta(9)-thc), the active psychotropic agent in marijuana and hashish, at 1.5 mg per kg per day intraperitoneally for 7 days, increases the expression, at both mrna and protein levels, of brain-derived neurotrophic factor (bdnf), in specific rat brain areas, notably in those involved in reward and addiction. |
2005-07-05 |
2023-08-12 |
rat |
| C H Ashton, P B Moore, P Gallagher, A H Youn. Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. Journal of psychopharmacology (Oxford, England). vol 19. issue 3. 2005-06-27. PMID:15888515. |
the cannabinoids delta(9)-tetrahydrocannabinol (thc) and cannabidiol (cbd) may exert sedative, hypnotic, anxiolytic, antidepressant, antipsychotic and anticonvulsant effects. |
2005-06-27 |
2023-08-12 |
Not clear |
| Sam Niedbala, Keith Kardos, Sal Salamone, Dean Fritch, Matth Bronsgeest, Edward J Con. Passive cannabis smoke exposure and oral fluid testing. Journal of analytical toxicology. vol 28. issue 7. 2005-06-06. PMID:15516313. |
oral fluid testing for delta(9)-tetrahydrocannabinol (thc) provides a convenient means of detection of recent cannabis usage. |
2005-06-06 |
2023-08-12 |
human |
| Jonathan S Berman, Catherine Symonds, Rolfe Birc. Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial. Pain. vol 112. issue 3. 2005-05-19. PMID:15561385. |
these were placebo and two whole plant extracts of cannabis sativa l.: gw-1000-02 (sativex), containing delta(9)tetrahydrocannabinol (thc):cannabidiol (cbd) in an approximate 1:1 ratio and gw-2000-02, containing primarily thc. |
2005-05-19 |
2023-08-12 |
human |
| S P Vickers, G A Kennet. Cannabinoids and the regulation of ingestive behaviour. Current drug targets. vol 6. issue 2. 2005-04-29. PMID:15777191. |
over past centuries, cannabis sativa (delta(9)-tetrahydrocannabinol being the principal active ingredient) has been used extensively for both medicinal and recreational uses, and one widely reported effect is the onset of a ravenous appetite and eating behaviour. |
2005-04-29 |
2023-08-12 |
Not clear |
| Carl R Lupica, Arthur C Riegel, Alexander F Hoffma. Marijuana and cannabinoid regulation of brain reward circuits. British journal of pharmacology. vol 143. issue 2. 2005-04-22. PMID:15313883. |
the psychoactive properties of marijuana are mediated by the active constituent, delta(9)-thc, interacting primarily with cb1 cannabinoid receptors in a large number of brain areas. |
2005-04-22 |
2023-08-12 |
Not clear |
| Carl R Lupica, Arthur C Riegel, Alexander F Hoffma. Marijuana and cannabinoid regulation of brain reward circuits. British journal of pharmacology. vol 143. issue 2. 2005-04-22. PMID:15313883. |
in addition, we compare the effects of delta(9)-thc with those of other commonly abused drugs on these reward circuits, and we discuss the roles that endogenous cannabinoids may play within these brain pathways, and their possible involvement in regulating ongoing brain function, independently of marijuana consumption. |
2005-04-22 |
2023-08-12 |
Not clear |
| Kazuhide Hayakawa, Kenichi Mishima, Kohji Abe, Nobuyoshi Hasebe, Fumie Takamatsu, Hiromi Yasuda, Tomoaki Ikeda, Keiichiro Inui, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. vol 15. issue 15. 2005-04-08. PMID:15640760. |
cannabidiol and delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. |
2005-04-08 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Kohji Abe, Nobuyoshi Hasebe, Fumie Takamatsu, Hiromi Yasuda, Tomoaki Ikeda, Keiichiro Inui, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. vol 15. issue 15. 2005-04-08. PMID:15640760. |
the neuroprotective effects of delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by sr141716, a cannabinoid cb1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. |
2005-04-08 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Kenichi Mishima, Kohji Abe, Nobuyoshi Hasebe, Fumie Takamatsu, Hiromi Yasuda, Tomoaki Ikeda, Keiichiro Inui, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. vol 15. issue 15. 2005-04-08. PMID:15640760. |
these results surely show that the neuroprotective effect of delta(9)-tetrahydrocannabinol are via a cb1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of cb1 blockade and of hypothermia. |
2005-04-08 |
2023-08-12 |
mouse |
| Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono, Ikuo Yamamot. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology. vol 206. issue 3. 2005-02-24. PMID:15588936. |
the progesterone 17alpha-hydroxylase activity, which is one of the steroidogenic enzymes in rat testis microsomes, was significantly inhibited by crude marijuana extracts from delta(9)-tetrahydrocannabinolic acid (thca)- and cannabidiolic acid (cbda)-strains. |
2005-02-24 |
2023-08-12 |
rat |
| Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono, Ikuo Yamamot. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology. vol 206. issue 3. 2005-02-24. PMID:15588936. |
delta(9)-tetrahydrocannabinol, cannabidiol and cannabinol also inhibited the enzymatic activity with relatively higher concentration (100-1000 microm). |
2005-02-24 |
2023-08-12 |
rat |
| Paola Fadda, Lianne Robinson, Walter Fratta, Roger G Pertwee, Gernot Riede. Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. Neuropharmacology. vol 47. issue 8. 2005-02-10. PMID:15567426. |
here, we employed a delayed-matching-to-place (dmtp) task in the open-field water maze and examined the effects of cannabis plant extracts rich in either delta(9)-tetrahydrocannabinol (delta(9)-thc), or rich in cannabidiol (cbd), on spatial working and short-term memory formation in rats. |
2005-02-10 |
2023-08-12 |
rat |
| Marilyn A Huestis, Edward J Con. Relationship of Delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis. Journal of analytical toxicology. vol 28. issue 6. 2005-02-04. PMID:15516285. |
relationship of delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis. |
2005-02-04 |
2023-08-12 |
human |
| Eric S Lavins, Bethany D Lavins, Amanda J Jenkin. Cannabis (marijuana) contamination of United States and foreign paper currency. Journal of analytical toxicology. vol 28. issue 6. 2005-02-04. PMID:15516293. |
as is the case with cocaine, differentiating "background levels" of the various cannabinoid constituents of cannabis sativa l., namely, delta(9)-tetrahydrocannabinol (thc), cannabinol (cbn), and cannabidiol (cbd) contaminating currency found in the general circulation from currency associated with illegal drug activity is imperative if a legal nexus is to be established with the latter. |
2005-02-04 |
2023-08-12 |
Not clear |
| Christian Giroud, Katarzyna Michaud, Frank Sporkert, Chin Eap, Marc Augsburger, Pascal Cardinal, Patrice Mangi. A fatal overdose of cocaine associated with coingestion of marijuana, buprenorphine, and fluoxetine. Body fluid and tissue distribution of cocaine and its metabolites determined by hydrophilic interaction chromatography-mass spectrometry(HILIC-MS). Journal of analytical toxicology. vol 28. issue 6. 2005-02-04. PMID:15516297. |
a relatively high concentration of delta(9)-thc was measured both in peripheral blood (8.2 microg/l) and brain cortex (13.5 microg/kg), suggesting that the victim was under the influence of cannabis at the time of death. |
2005-02-04 |
2023-08-12 |
Not clear |
| Angelo A Izz. Cannabinoids and intestinal motility: welcome to CB2 receptors. British journal of pharmacology. vol 142. issue 8. 2005-01-26. PMID:15277313. |
delta(9)-tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, cb(1) receptors (expressed by central and peripheral neurons) and cb(2) receptors (that occur mainly in immune cells). |
2005-01-26 |
2023-08-12 |
rat |
| Nephi Stell. Cannabinoid signaling in glial cells. Glia. vol 48. issue 4. 2005-01-14. PMID:15390110. |
delta 9-tetrahydrocannabinol, the main psychoactive compound of marijuana, interacts with cb receptors, impinging on this communication and inducing profound behavioral effects such as memory impairment and analgesia. |
2005-01-14 |
2023-08-12 |
Not clear |