| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Camila Scorticati, Claudia Mohn, Andrea De Laurentiis, Paula Vissio, Javier Fernández Solari, Adriana Seilicovich, Samuel M McCann, Valeria Rettor. The effect of anandamide on prolactin secretion is modulated by estrogen. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 4. 2003-04-01. PMID:12578974. |
recent research has revealed that endogenous cannabinoid receptors (cb1 and cb2) react with the active ingredient of marijuana, delta(9)-tetrahydrocannabinol. |
2003-04-01 |
2023-08-12 |
rat |
| J Ludovic Croxfor. Therapeutic potential of cannabinoids in CNS disease. CNS drugs. vol 17. issue 3. 2003-03-31. PMID:12617697. |
the major psychoactive constituent of cannabis sativa, delta(9)-tetrahydrocannabinol (delta(9)-thc), and endogenous cannabinoid ligands, such as anandamide, signal through g-protein-coupled cannabinoid receptors localised to regions of the brain associated with important neurological processes. |
2003-03-31 |
2023-08-12 |
Not clear |
| Giulia Di Carlo, Angelo A Izz. Cannabinoids for gastrointestinal diseases: potential therapeutic applications. Expert opinion on investigational drugs. vol 12. issue 1. 2003-03-26. PMID:12517253. |
delta(9)-tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, cb(1) and cb(2) receptors. |
2003-03-26 |
2023-08-12 |
Not clear |
| Ethan B Russo, John M McPartlan. Cannabis is more than simply delta(9)-tetrahydrocannabinol. Psychopharmacology. vol 165. issue 4. 2003-03-20. PMID:12491031. |
cannabis is more than simply delta(9)-tetrahydrocannabinol. |
2003-03-20 |
2023-08-12 |
Not clear |
| Satish Kathuria, Silvana Gaetani, Darren Fegley, Fernando Valiño, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Giovanna La Rana, Antonio Calignano, Arcangela Giustino, Maria Tattoli, Maura Palmery, Vincenzo Cuomo, Daniele Piomell. Modulation of anxiety through blockade of anandamide hydrolysis. Nature medicine. vol 9. issue 1. 2003-03-18. PMID:12461523. |
the psychoactive constituent of cannabis, delta(9)-tetrahydrocannabinol, produces in humans subjective responses mediated by cb1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion. |
2003-03-18 |
2023-08-12 |
rat |
| Maurice R Elphick, Yutaka Satou, Nori Sato. The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalis. Gene. vol 302. issue 1-2. 2003-03-14. PMID:12527200. |
the g-protein coupled cannabinoid receptors cb(1) and cb(2) are activated by delta(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, and mediate physiological effects of endogenous cannabinoids ('endocannabinoids'). |
2003-03-14 |
2023-08-12 |
human |
| Herbert Schuel, Lani J Burkman, Jack Lippes, Kent Crickard, Mary C Mahony, Andrea Giuffrida, Robert P Picone, Alexandros Makriyanni. Evidence that anandamide-signaling regulates human sperm functions required for fertilization. Molecular reproduction and development. vol 63. issue 3. 2003-03-10. PMID:12237954. |
r-methanandamide [am-356], a potent and metabolically stable aea analog, and (-)delta(9) tetrahydrocannabinol (thc), the major psychoactive constituent of cannabis, modulated capacitation and fertilizing potential of human sperm in vitro. |
2003-03-10 |
2023-08-12 |
human |
| b' Mauro Maccarrone, Alessandro Finazzi-Agr\\xc3\\xb. Endocannabinoids and their actions. Vitamins and hormones. vol 65. 2003-01-10. PMID:12481549.' |
anandamide (i) and 2-arachidonoylglycerol (ii) are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of delta 9-tetrahydrocannabinol (iii), the active principle of cannabis sativa preparations such as hashish and marijuana. |
2003-01-10 |
2023-08-12 |
human |
| H Valerie Curran, Catherine Brignell, Sally Fletcher, Paul Middleton, John Henr. Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis users. Psychopharmacology. vol 164. issue 1. 2003-01-07. PMID:12373420. |
cognitive and subjective dose-response effects of acute oral delta 9-tetrahydrocannabinol (thc) in infrequent cannabis users. |
2003-01-07 |
2023-08-12 |
Not clear |
| H Valerie Curran, Catherine Brignell, Sally Fletcher, Paul Middleton, John Henr. Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis users. Psychopharmacology. vol 164. issue 1. 2003-01-07. PMID:12373420. |
although some aspects of memory functions are known to be acutely impaired by delta(9)-tetrahydrocannabinol (delta(9)-thc; the main active constituent of marijuana), effects on other aspects of memory are not known and the time course of functional impairments is unclear. |
2003-01-07 |
2023-08-12 |
Not clear |
| S R Wachtel, M A ElSohly, S A Ross, J Ambre, H de Wi. Comparison of the subjective effects of Delta(9)-tetrahydrocannabinol and marijuana in humans. Psychopharmacology. vol 161. issue 4. 2002-12-23. PMID:12073159. |
comparison of the subjective effects of delta(9)-tetrahydrocannabinol and marijuana in humans. |
2002-12-23 |
2023-08-12 |
Not clear |
| S R Wachtel, M A ElSohly, S A Ross, J Ambre, H de Wi. Comparison of the subjective effects of Delta(9)-tetrahydrocannabinol and marijuana in humans. Psychopharmacology. vol 161. issue 4. 2002-12-23. PMID:12073159. |
there has been controversy about whether the subjective, behavioral or therapeutic effects of whole plant marijuana differ from the effects of its primary active ingredient, delta(9)-tetrahydrocannabinol (thc). |
2002-12-23 |
2023-08-12 |
Not clear |
| B S Basavarajappa, B L Hungun. Neuromodulatory role of the endocannabinoid signaling system in alcoholism: an overview. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052043. |
the identification of a g-protein-coupled receptor, namely, the cannabinoid receptor (cb1 receptor) that was activated by delta(9)-tetrahydrocannabinol (delta(9)-thc), the major psychoactive component of marijuana, led to the discovery of endogenous cannabinoid agonists. |
2002-12-06 |
2023-08-12 |
mouse |
| T Cherlet, J E Scot. Tetrahydrocannabinol (THC) alters synthesis and release of surfactant-related material in isolated fetal rabbit type II cells. Drug and chemical toxicology. vol 25. issue 2. 2002-11-07. PMID:12024801. |
the present study was undertaken to determine the effects of delta 9-tetrahydrocannabinol (thc), the major psychoactive component in marijuana on fetal lung development specifically related to surfactant production. |
2002-11-07 |
2023-08-12 |
rabbit |
| David M Wilson, Joanne Peart, Billy R Martin, D Troy Bridgen, Peter R Byron, Aron H Lichtma. Physiochemical and pharmacological characterization of a Delta(9)-THC aerosol generated by a metered dose inhaler. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127197. |
further development of a delta(9)-thc mdi could provide an appropriate delivery device for the therapeutic use of cannabinoids, thereby reducing the need for medicinal marijuana. |
2002-10-22 |
2023-08-12 |
mouse |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
studies have shown that the delta(9)-tetrahydrocannabinol (delta(9)-thc) concentration in marijuana cigarettes is an important factor for the maintenance of marijuana self-administration. |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
yet, the impact of oral delta(9)-thc treatment on marijuana self-administration is unknown. |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
because other agonist therapies have been demonstrated to be effective for the treatment of substance use disorders, the objective of this study was to evaluate the influence of oral delta(9)-thc maintenance on choice to self-administer smoked marijuana. |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
each morning, except on days 6, 12, and 18, participants smoked the 'sample' marijuana cigarette (1.8% delta(9)-thc w/w) and received a $2 voucher (redeemable for cash at study's end). |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
relative to placebo delta(9)-thc maintenance, participants' choice to self-administer marijuana was not significantly altered by either of the two active delta(9)-thc maintenance conditions. |
2002-10-22 |
2023-08-12 |
human |