| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadia Fucci, Nadia De Giovanni, Marcello Chiarott. Simultaneous detection of some drugs of abuse in saliva samples by SPME technique. Forensic science international. vol 134. issue 1. 2003-10-14. PMID:12842356. |
a simple method for the simultaneous determination of many drugs of abuse in saliva is referred [methadone, 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium perchlorate (eddp), cocaine, cocaethylene, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (mdma), 3,4-methylenedioxyethyl amphetamine (mdea), n-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (mbdb), cannabidiol (cbd), delta(9)-tetrahydrocannabinol (thc), cannabinol (cbn)]. |
2003-10-14 |
2023-08-12 |
Not clear |
| Olaf H Drummer, Jim Gerostamoulos, Helen Batziris, Mark Chu, John R M Caplehorn, Michael D Robertson, Philip Swan. The incidence of drugs in drivers killed in Australian road traffic crashes. Forensic science international. vol 134. issue 2-3. 2003-10-09. PMID:12850411. |
8.5% of all drivers tested positive for delta(9)-tetrahydrocannabinol (thc) and the balance of cannabis positive drivers were positive to only the 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid (carboxy-thc) metabolite. |
2003-10-09 |
2023-08-12 |
Not clear |
| Jennifer McDonald, Laura Schleifer, Jerry B Richards, Harriet de Wi. Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12784123. |
this study investigated the acute effects of delta(9)-tetrahydrocannabinol (thc) on four behavioral measures of impulsivity in recreational marijuana users. |
2003-09-02 |
2023-08-12 |
human |
| Jenny L Wiley, Billy R Marti. Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505690. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), the primary psychoactive constituent of marijuana (cannabis sativa), is known to bind to two cannabinoid receptors: cb(1) receptors, located primarily in the brain, and cb(2) receptors, located primarily in the periphery. |
2003-08-22 |
2023-08-12 |
mouse |
| Albert D Fraser, David Wort. Urinary excretion profiles of 11-nor-9-carboxy-Delta9-tetrahydrocannabinol: a Delta9-THC-COOH to creatinine ratio study #2. Forensic science international. vol 133. issue 1-2. 2003-07-29. PMID:12742686. |
the objective of the present study was to determine whether creatinine corrected urine specimens positive for cannabinoids could differentiate new marijuana use from the excretion of residual delta(9)-thc-cooh in chronic users of marijuana based on the huestis 0.5 ratio. |
2003-07-29 |
2023-08-12 |
human |
| Frank Musshoff, Dirk W Lachenmeier, Lars Kroener, Burkhard Made. Automated headspace solid-phase dynamic extraction for the determination of cannabinoids in hair samples. Forensic science international. vol 133. issue 1-2. 2003-07-29. PMID:12742687. |
the limit of detection was 0.14 ng/mg for delta(9)-tetrahydrocannabinol, 0.09 ng/mg for cannabidiol, and 0.12ng/mg for cannabinol. |
2003-07-29 |
2023-08-12 |
human |
| P Mura, P Kintz, B Ludes, J M Gaulier, P Marquet, S Martin-Dupont, F Vincent, A Kaddour, J P Goullé, J Nouveau, M Moulsma, S Tilhet-Coartet, O Pourra. Comparison of the prevalence of alcohol, cannabis and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. Forensic science international. vol 133. issue 1-2. 2003-07-29. PMID:12742692. |
all age groups confounded, the main active substance of cannabis, delta(9) tetrahydrocannabinol (thc), was found in 10% of drivers and 5% of controls. |
2003-07-29 |
2023-08-12 |
human |
| Demetris P Papahatjis, Spyros P Nikas, Thanos Andreou, Alexandros Makriyanni. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic & medicinal chemistry letters. vol 12. issue 24. 2003-07-16. PMID:12443781. |
1',1'-cyclopropyl side chain substituents enhance the affinities of delta(8)-tetrahydrocannabinol and respective cannabidiol analogues for the cb1 and cb2 cannabinoid receptors. |
2003-07-16 |
2023-08-12 |
Not clear |
| Leslie Iverse. Cannabis and the brain. Brain : a journal of neurology. vol 126. issue Pt 6. 2003-07-01. PMID:12764049. |
the active compound in herbal cannabis, delta(9)-tetrahydrocannabinol, exerts all of its known central effects through the cb(1) cannabinoid receptor. |
2003-07-01 |
2023-08-12 |
mouse |
| Franjo Grotenherme. Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical pharmacokinetics. vol 42. issue 4. 2003-06-11. PMID:12648025. |
delta(9)-tetrahydrocannabinol (thc) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. |
2003-06-11 |
2023-08-12 |
Not clear |
| Maurizio Bifulco, Vincenzo Di Marz. [The endocannabinoid system as a target for the development of new drugs for cancer therapy]. Recenti progressi in medicina. vol 94. issue 5. 2003-06-09. PMID:12723496. |
studies on the main bioactive components of cannabis sativa, the cannabinoids, and particularly delta 9-tetrahydrocannabinol (thc), led to the discovery of a new endogenous signalling system that controls several physiological and pathological conditions: the endocannabinoid system. |
2003-06-09 |
2023-08-12 |
Not clear |
| Carl L Hart, Amie S Ward, Margaret Haney, Sandra D Comer, Richard W Foltin, Marian W Fischma. Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans. Psychopharmacology. vol 164. issue 4. 2003-04-23. PMID:12457271. |
comparison of smoked marijuana and oral delta(9)-tetrahydrocannabinol in humans. |
2003-04-23 |
2023-08-12 |
Not clear |
| Carl L Hart, Amie S Ward, Margaret Haney, Sandra D Comer, Richard W Foltin, Marian W Fischma. Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans. Psychopharmacology. vol 164. issue 4. 2003-04-23. PMID:12457271. |
although smoked marijuana contains at least 60 cannabinoids, delta(9)-tetrahydrocannabinol (delta(9)-thc) is presumed to be the cannabinoid primarily responsible for many marijuana-related effects, including increased food intake and subjective effects. |
2003-04-23 |
2023-08-12 |
Not clear |
| Carl L Hart, Amie S Ward, Margaret Haney, Sandra D Comer, Richard W Foltin, Marian W Fischma. Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans. Psychopharmacology. vol 164. issue 4. 2003-04-23. PMID:12457271. |
yet, there has been no systematic comparison of repeated doses of oral delta(9)-thc with repeated doses of smoked marijuana in the same individuals. |
2003-04-23 |
2023-08-12 |
Not clear |
| Kirsten R Müller-Vahl, Heidrun Prevedel, Karen Theloe, Hans Kolbe, Hinderk M Emrich, Udo Schneide. Treatment of Tourette syndrome with delta-9-tetrahydrocannabinol (delta 9-THC): no influence on neuropsychological performance. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589392. |
previous studies provide evidence that marijuana (cannabis sativa) and delta-9-tetrahydrocannabinol (delta(9)-thc), the major psychoactive ingredient of marijuana, respectively, are effective in the treatment of tics and behavioral problems in tourette syndrome (ts). |
2003-04-21 |
2023-08-12 |
Not clear |
| V Seuti. [Effects of nicotine and cannabinoids on the central nervous system]. Revue medicale de Liege. vol 58. issue 1. 2003-04-18. PMID:12647593. |
we describe the molecular mechanisms of action of nicotine and delta 9-tetrahydrocannabinol, the most potent component of cannabis. |
2003-04-18 |
2023-08-12 |
Not clear |
| D Cota, G Marsicano, B Lutz, V Vicennati, G K Stalla, R Pasquali, U Pagott. Endogenous cannabinoid system as a modulator of food intake. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 27. issue 3. 2003-04-17. PMID:12629555. |
the ability of cannabis sativa (marijuana) to increase hunger has been noticed for centuries, although intensive research on its molecular mode of action started only after the characterization of its main psychoactive component delta(9)-tetrahydrocannabinol in the late 1960s. |
2003-04-17 |
2023-08-12 |
human |
| Roger G Pertwe. Cannabinoids and multiple sclerosis. Pharmacology & therapeutics. vol 95. issue 2. 2003-04-03. PMID:12182963. |
these trials have shown that cannabis, delta(9)-tetrahydrocannabinol, and nabilone can produce objective and/or subjective relief from spasticity, pain, tremor, and nocturia in patients with multiple sclerosis (8 trials) or spinal cord injury (1 trial). |
2003-04-03 |
2023-08-12 |
mouse |
| Albert D Fraser, Lawrence Coffin, David Wort. Drug and chemical metabolites in clinical toxicology investigations: the importance of ethylene glycol, methanol and cannabinoid metabolite analyses. Clinical biochemistry. vol 35. issue 7. 2003-04-02. PMID:12493577. |
serial monitoring of the major urinary cannabinoid metabolite (delta(9)-thc-cooh) to creatinine ratios in paired urine specimens (collected at least 24 h apart) could differentiate new marijuana or hashish use from residual cannabinoid metabolite excretion in urine after drug use according to huestis. |
2003-04-02 |
2023-08-12 |
human |
| Albert D Fraser, Lawrence Coffin, David Wort. Drug and chemical metabolites in clinical toxicology investigations: the importance of ethylene glycol, methanol and cannabinoid metabolite analyses. Clinical biochemistry. vol 35. issue 7. 2003-04-02. PMID:12493577. |
the second objective is to demonstrate that creatinine corrected urine specimens positive for cannabinoids may help differentiate new marijuana use from the excretion of residual delta(9) -thc-cooh in chronic users of marijuana or hashish. |
2003-04-02 |
2023-08-12 |
human |