| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luciano De Petrocellis, Maria Grazia Cascio, Vincenzo Di Marz. The endocannabinoid system: a general view and latest additions. British journal of pharmacology. vol 141. issue 5. 2004-10-14. PMID:14744801. |
after the discovery, in the early 1990s, of specific g-protein-coupled receptors for marijuana's psychoactive principle delta(9)-tetrahydrocannabinol, the cannabinoid receptors, and of their endogenous agonists, the endocannabinoids, a decade of investigations has greatly enlarged our understanding of this altogether new signalling system. |
2004-10-14 |
2023-08-12 |
Not clear |
| Yoonkyung Do, Robert J McKallip, Mitzi Nagarkatti, Prakash S Nagarkatt. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 4. 2004-09-28. PMID:15294950. |
addition of delta(9)-tetrahydrocannabinol (thc), a major psychoactive component found in marijuana or anandamide, an endogenous cannabinoid, to dc cultures induced apoptosis in dcs. |
2004-09-28 |
2023-08-12 |
mouse |
| Dirk W Lachenmeier, Lars Kroener, Frank Musshoff, Burkhard Made. Determination of cannabinoids in hemp food products by use of headspace solid-phase microextraction and gas chromatography-mass spectrometry. Analytical and bioanalytical chemistry. vol 378. issue 1. 2004-08-26. PMID:14598006. |
linearity was good for delta(9)-tetrahydrocannabinol (thc), cannabidiol, and cannabinol; regression coefficients were greater than 0.99. |
2004-08-26 |
2023-08-12 |
Not clear |
| Silvana Gaetani, Vincenzo Cuomo, Daniele Piomell. Anandamide hydrolysis: a new target for anti-anxiety drugs? Trends in molecular medicine. vol 9. issue 11. 2004-08-12. PMID:14604824. |
the major psychoactive constituent of cannabis, delta(9)-tetrahydrocannabinol, affects emotional states in humans and laboratory animals by activating brain cannabinoid receptors. |
2004-08-12 |
2023-08-12 |
rat |
| Natalya M Kogan, Ruth Rabinowitz, Paloma Levi, Dan Gibson, Peter Sandor, Michael Schlesinger, Raphael Mechoula. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. Journal of medicinal chemistry. vol 47. issue 15. 2004-08-12. PMID:15239658. |
three cannabis constituents, cannabidiol (1), delta(8)-tetrahydrocannabinol (3), and cannabinol (5), were oxidized to their respective para-quinones 2, 4, and 6. |
2004-08-12 |
2023-08-12 |
mouse |
| Zuzana Justinova, Gianluigi Tanda, Patrik Munzar, Steven R Goldber. The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys. Psychopharmacology. vol 173. issue 1-2. 2004-08-06. PMID:14668977. |
since delta(9)-tetrahydrocannabinol (thc), the natural psychoactive ingredient in marijuana, is actively and persistently self-administered by squirrel monkeys, this provides an opportunity to directly study involvement of opioid systems in the reinforcing effects of thc in non-human primates. |
2004-08-06 |
2023-08-12 |
monkey |
| Franjo Grotenherme. Pharmacology of cannabinoids. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159677. |
dronabinol (delta 9-tetrahydocannabinol, thc), the main source of the pharmacological effects caused by the use of cannabis, is an agonist to both the cb1 and the cb2 subtype of cannabinoid receptors. |
2004-08-03 |
2023-08-12 |
Not clear |
| Anke Witting, Lisa Walter, Jennifer Wacker, Thomas Möller, Nephi Stell. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 9. 2004-06-17. PMID:14976257. |
endogenous cannabinoid ligands (endocannabinoids) produced by neurons, astrocytes, and microglial cells activate cannabinoid receptors, the molecular target for marijuana's bioactive ingredient delta(9)-tetrahydrocannabinol. |
2004-06-17 |
2023-08-12 |
Not clear |
| Nobuaki Egashira, Kenichi Mishima, Tomoko Uchida, Nobuyoshi Hasebe, Hiroshi Nagai, Ai Mizuki, Katsunori Iwasaki, Hisanori Ishii, Ryoji Nishimura, Yukihiro Shoyama, Michihiro Fujiwar. Anandamide inhibits the DOI-induced head-twitch response in mice. Psychopharmacology. vol 171. issue 4. 2004-05-25. PMID:14586538. |
recently, delta(9)-tetrahydrocannabinol (thc), the major psychoactive component of marijuana, and synthetic cannabinoid receptor agonists reportedly reduced the head-twitches induced by the 5-ht(2a/2c) receptor agonist 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (doi) in mice, which is mediated via the activation of 5-ht(2a) receptor. |
2004-05-25 |
2023-08-12 |
mouse |
| Emmanuel Contassot, Mirna Tenan, Valérie Schnüriger, Marie-Françoise Pelte, Pierre-Yves Dietric. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecologic oncology. vol 93. issue 1. 2004-05-20. PMID:15047233. |
delta(9)-tetrahydrocannabinol, the active agent of cannabis sativa, exhibits well-documented antitumor properties, but little is known about the possible effects mediated by endogenous cannabinoids on human tumors. |
2004-05-20 |
2023-08-12 |
human |
| P J McLaughlin, K Winston, L Swezey, A Wisniecki, J Aberman, D J Tardif, A J Betz, K Ishiwari, A Makriyannis, J D Salamon. The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats. Behavioural pharmacology. vol 14. issue 8. 2004-05-19. PMID:14665975. |
cannabinoid cb1 receptor agonists, including delta-9-tetrahydrocannabinol (delta 9-thc) (the main psychoactive ingredient in marijuana) have been shown to increase feeding in rats and humans. |
2004-05-19 |
2023-08-12 |
rat |
| María G Sánchez, Lidia Ruiz-Llorente, Ana M Sánchez, Inés Díaz-Laviad. Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cellular signalling. vol 15. issue 9. 2004-05-05. PMID:12834810. |
treatment of pc-3 cells with either delta(9)-tetrahydrocannabinol (thc), the major psychoactive ingredient of marijuana, or r-(+)-methanandamide (met), an analogue of the endogenous cannabinoid anandamide, increased phosphorylation of pkb in thr308 and ser473. |
2004-05-05 |
2023-08-12 |
human |
| S Akerman, H Kaube, P J Goadsb. Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. The Journal of pharmacology and experimental therapeutics. vol 309. issue 1. 2004-05-04. PMID:14718591. |
known behavioral effects of anandamide are antinociception, catalepsy, hypothermia, and depression of motor activity, similar to delta(9)-tetrahydocannanbinol, the psychoactive constituent of cannabis. |
2004-05-04 |
2023-08-12 |
Not clear |
| Christopher D Verrico, J David Jentsch, Robert H Roth, Jane R Taylo. Repeated, intermittent delta(9)-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attention. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 3. 2004-04-14. PMID:14694348. |
moreover, experimental investigations suggest that repeated, intermittent (subchronic) delta(9)-tetrahydrocannabinol (thc), the main psychoactive ingredient of marijuana, alters neurotransmission in the frontal cortex of rats and humans, a key neural site mediating attention and executive functions. |
2004-04-14 |
2023-08-12 |
rat |
| Thomas W Klein, Cathy Newton, Kellie Larsen, Joe Chou, Izabella Perkins, Lily Lu, Liang Nong, Herman Friedma. Cannabinoid receptors and T helper cells. Journal of neuroimmunology. vol 147. issue 1-2. 2004-03-15. PMID:14741435. |
we have reported that injection of marijuana cannabinoids, such as delta(9)-tetrahydrocannabinol (thc), into mice, followed by infection with legionella pneumophila (lp), suppresses the development of cell-mediated immunity t helper 1 (th1) activity. |
2004-03-15 |
2023-08-12 |
mouse |
| Franjo Grotenhermen, Kirsten Müller-Vah. IACM 2nd Conference on Cannabinoids in Medicine. Expert opinion on pharmacotherapy. vol 4. issue 12. 2004-03-12. PMID:14640935. |
the international association for cannabis as medicine 2nd conference on cannabinoids in medicine focused on new clinical research with cannabis and single cannabinoids (delta(9)-tetrahydrocannabinol, ct-3) and on animal research with possible therapeutic implications. |
2004-03-12 |
2023-08-12 |
Not clear |
| Diana L Cichewic. Synergistic interactions between cannabinoid and opioid analgesics. Life sciences. vol 74. issue 11. 2004-02-18. PMID:14706563. |
thus, a search for a better analgesic strategy led to the discovery that delta 9-tetrahydrocannabinol (thc), the major psychoactive constituent of marijuana, enhances the potency of opioids such as morphine in animal models. |
2004-02-18 |
2023-08-12 |
Not clear |
| Sven-Eric Jordt, Diana M Bautista, Huai-Hu Chuang, David D McKemy, Peter M Zygmunt, Edward D Högestätt, Ian D Meng, David Juliu. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. vol 427. issue 6971. 2004-02-02. PMID:14712238. |
here we show that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by delta(9)-tetrahydrocannabinol (thc), the psychoactive component of marijuana. |
2004-02-02 |
2023-08-12 |
Not clear |
| Albert D Fraser, David Wort. Urinary excretion profiles of 11-nor-9-carboxy-Delta9-tetrahydrocannabinol. Study III. A Delta9-THC-COOH to creatinine ratio study. Forensic science international. vol 137. issue 2-3. 2004-01-23. PMID:14609657. |
the objective of the present study was to evaluate whether creatinine corrected specimens could differentiate new marijuana or hashish use from the excretion of residual delta(9)-thc-cooh in chronic marijuana users based on the huestis 0.5 ratio. |
2004-01-23 |
2023-08-12 |
human |
| Wayne Hall, Louisa Degenhard. Medical marijuana initiatives : are they justified? How successful are they likely to be? CNS drugs. vol 17. issue 10. 2003-11-03. PMID:12873153. |
the principal constituent of cannabis, delta(9)-tetrahydrocannabinol (thc), is moderately effective in treating nausea and vomiting, appetite loss, and acute and chronic pain. |
2003-11-03 |
2023-08-12 |
Not clear |