| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harold Kalan. Adverse effects of cannabis on health: an update of the literature since 1996. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 5. 2004-12-30. PMID:15363608. |
a causal role of acute cannabis intoxication in motor vehicle and other accidents has now been shown by the presence of measurable levels of delta(9)-tetrahydrocannabinol (thc) in the blood of injured drivers in the absence of alcohol or other drugs, by surveys of driving under the influence of cannabis, and by significantly higher accident culpability risk of drivers using cannabis. |
2004-12-30 |
2023-08-12 |
Not clear |
| Dorothea Gadzicki, Kirsten R Müller-Vahl, Daniela Heller, Sebastian Ossege, Markus M Nöthen, Johannes Hebebrand, Manfred Stuhrman. Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 127B. issue 1. 2004-11-02. PMID:15108190. |
involvement of the central cannabinoid (cb1) system is suggested because of therapeutic effects of marijuana (cannabis sativa l.) consumption and delta(9)-tetrahydrocannabinol (-thc) treatment in ts patients. |
2004-11-02 |
2023-08-12 |
Not clear |
| Supaart Sirikantaramas, Satoshi Morimoto, Yoshinari Shoyama, Yu Ishikawa, Yoshiko Wada, Yukihiro Shoyama, Futoshi Taur. The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. The Journal of biological chemistry. vol 279. issue 38. 2004-10-25. PMID:15190053. |
the gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of delta1-tetrahydrocannabinolic acid synthase from cannabis sativa l. delta(1)-tetrahydrocannabinolic acid (thca) synthase is the enzyme that catalyzes oxidative cyclization of cannabigerolic acid into thca, the precursor of delta(1)-tetrahydrocannabinol. |
2004-10-25 |
2023-08-12 |
Not clear |
| Luciano De Petrocellis, Maria Grazia Cascio, Vincenzo Di Marz. The endocannabinoid system: a general view and latest additions. British journal of pharmacology. vol 141. issue 5. 2004-10-14. PMID:14744801. |
after the discovery, in the early 1990s, of specific g-protein-coupled receptors for marijuana's psychoactive principle delta(9)-tetrahydrocannabinol, the cannabinoid receptors, and of their endogenous agonists, the endocannabinoids, a decade of investigations has greatly enlarged our understanding of this altogether new signalling system. |
2004-10-14 |
2023-08-12 |
Not clear |
| Yoonkyung Do, Robert J McKallip, Mitzi Nagarkatti, Prakash S Nagarkatt. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 4. 2004-09-28. PMID:15294950. |
addition of delta(9)-tetrahydrocannabinol (thc), a major psychoactive component found in marijuana or anandamide, an endogenous cannabinoid, to dc cultures induced apoptosis in dcs. |
2004-09-28 |
2023-08-12 |
mouse |
| Dirk W Lachenmeier, Lars Kroener, Frank Musshoff, Burkhard Made. Determination of cannabinoids in hemp food products by use of headspace solid-phase microextraction and gas chromatography-mass spectrometry. Analytical and bioanalytical chemistry. vol 378. issue 1. 2004-08-26. PMID:14598006. |
linearity was good for delta(9)-tetrahydrocannabinol (thc), cannabidiol, and cannabinol; regression coefficients were greater than 0.99. |
2004-08-26 |
2023-08-12 |
Not clear |
| Silvana Gaetani, Vincenzo Cuomo, Daniele Piomell. Anandamide hydrolysis: a new target for anti-anxiety drugs? Trends in molecular medicine. vol 9. issue 11. 2004-08-12. PMID:14604824. |
the major psychoactive constituent of cannabis, delta(9)-tetrahydrocannabinol, affects emotional states in humans and laboratory animals by activating brain cannabinoid receptors. |
2004-08-12 |
2023-08-12 |
rat |
| Natalya M Kogan, Ruth Rabinowitz, Paloma Levi, Dan Gibson, Peter Sandor, Michael Schlesinger, Raphael Mechoula. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. Journal of medicinal chemistry. vol 47. issue 15. 2004-08-12. PMID:15239658. |
three cannabis constituents, cannabidiol (1), delta(8)-tetrahydrocannabinol (3), and cannabinol (5), were oxidized to their respective para-quinones 2, 4, and 6. |
2004-08-12 |
2023-08-12 |
mouse |
| Zuzana Justinova, Gianluigi Tanda, Patrik Munzar, Steven R Goldber. The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys. Psychopharmacology. vol 173. issue 1-2. 2004-08-06. PMID:14668977. |
since delta(9)-tetrahydrocannabinol (thc), the natural psychoactive ingredient in marijuana, is actively and persistently self-administered by squirrel monkeys, this provides an opportunity to directly study involvement of opioid systems in the reinforcing effects of thc in non-human primates. |
2004-08-06 |
2023-08-12 |
monkey |
| Franjo Grotenherme. Pharmacology of cannabinoids. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159677. |
dronabinol (delta 9-tetrahydocannabinol, thc), the main source of the pharmacological effects caused by the use of cannabis, is an agonist to both the cb1 and the cb2 subtype of cannabinoid receptors. |
2004-08-03 |
2023-08-12 |
Not clear |
| Anke Witting, Lisa Walter, Jennifer Wacker, Thomas Möller, Nephi Stell. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 9. 2004-06-17. PMID:14976257. |
endogenous cannabinoid ligands (endocannabinoids) produced by neurons, astrocytes, and microglial cells activate cannabinoid receptors, the molecular target for marijuana's bioactive ingredient delta(9)-tetrahydrocannabinol. |
2004-06-17 |
2023-08-12 |
Not clear |
| Nobuaki Egashira, Kenichi Mishima, Tomoko Uchida, Nobuyoshi Hasebe, Hiroshi Nagai, Ai Mizuki, Katsunori Iwasaki, Hisanori Ishii, Ryoji Nishimura, Yukihiro Shoyama, Michihiro Fujiwar. Anandamide inhibits the DOI-induced head-twitch response in mice. Psychopharmacology. vol 171. issue 4. 2004-05-25. PMID:14586538. |
recently, delta(9)-tetrahydrocannabinol (thc), the major psychoactive component of marijuana, and synthetic cannabinoid receptor agonists reportedly reduced the head-twitches induced by the 5-ht(2a/2c) receptor agonist 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (doi) in mice, which is mediated via the activation of 5-ht(2a) receptor. |
2004-05-25 |
2023-08-12 |
mouse |
| Emmanuel Contassot, Mirna Tenan, Valérie Schnüriger, Marie-Françoise Pelte, Pierre-Yves Dietric. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecologic oncology. vol 93. issue 1. 2004-05-20. PMID:15047233. |
delta(9)-tetrahydrocannabinol, the active agent of cannabis sativa, exhibits well-documented antitumor properties, but little is known about the possible effects mediated by endogenous cannabinoids on human tumors. |
2004-05-20 |
2023-08-12 |
human |
| P J McLaughlin, K Winston, L Swezey, A Wisniecki, J Aberman, D J Tardif, A J Betz, K Ishiwari, A Makriyannis, J D Salamon. The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats. Behavioural pharmacology. vol 14. issue 8. 2004-05-19. PMID:14665975. |
cannabinoid cb1 receptor agonists, including delta-9-tetrahydrocannabinol (delta 9-thc) (the main psychoactive ingredient in marijuana) have been shown to increase feeding in rats and humans. |
2004-05-19 |
2023-08-12 |
rat |
| María G Sánchez, Lidia Ruiz-Llorente, Ana M Sánchez, Inés Díaz-Laviad. Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cellular signalling. vol 15. issue 9. 2004-05-05. PMID:12834810. |
treatment of pc-3 cells with either delta(9)-tetrahydrocannabinol (thc), the major psychoactive ingredient of marijuana, or r-(+)-methanandamide (met), an analogue of the endogenous cannabinoid anandamide, increased phosphorylation of pkb in thr308 and ser473. |
2004-05-05 |
2023-08-12 |
human |
| S Akerman, H Kaube, P J Goadsb. Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. The Journal of pharmacology and experimental therapeutics. vol 309. issue 1. 2004-05-04. PMID:14718591. |
known behavioral effects of anandamide are antinociception, catalepsy, hypothermia, and depression of motor activity, similar to delta(9)-tetrahydocannanbinol, the psychoactive constituent of cannabis. |
2004-05-04 |
2023-08-12 |
Not clear |
| Christopher D Verrico, J David Jentsch, Robert H Roth, Jane R Taylo. Repeated, intermittent delta(9)-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attention. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 3. 2004-04-14. PMID:14694348. |
moreover, experimental investigations suggest that repeated, intermittent (subchronic) delta(9)-tetrahydrocannabinol (thc), the main psychoactive ingredient of marijuana, alters neurotransmission in the frontal cortex of rats and humans, a key neural site mediating attention and executive functions. |
2004-04-14 |
2023-08-12 |
rat |
| Thomas W Klein, Cathy Newton, Kellie Larsen, Joe Chou, Izabella Perkins, Lily Lu, Liang Nong, Herman Friedma. Cannabinoid receptors and T helper cells. Journal of neuroimmunology. vol 147. issue 1-2. 2004-03-15. PMID:14741435. |
we have reported that injection of marijuana cannabinoids, such as delta(9)-tetrahydrocannabinol (thc), into mice, followed by infection with legionella pneumophila (lp), suppresses the development of cell-mediated immunity t helper 1 (th1) activity. |
2004-03-15 |
2023-08-12 |
mouse |
| Franjo Grotenhermen, Kirsten Müller-Vah. IACM 2nd Conference on Cannabinoids in Medicine. Expert opinion on pharmacotherapy. vol 4. issue 12. 2004-03-12. PMID:14640935. |
the international association for cannabis as medicine 2nd conference on cannabinoids in medicine focused on new clinical research with cannabis and single cannabinoids (delta(9)-tetrahydrocannabinol, ct-3) and on animal research with possible therapeutic implications. |
2004-03-12 |
2023-08-12 |
Not clear |
| Diana L Cichewic. Synergistic interactions between cannabinoid and opioid analgesics. Life sciences. vol 74. issue 11. 2004-02-18. PMID:14706563. |
thus, a search for a better analgesic strategy led to the discovery that delta 9-tetrahydrocannabinol (thc), the major psychoactive constituent of marijuana, enhances the potency of opioids such as morphine in animal models. |
2004-02-18 |
2023-08-12 |
Not clear |