| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
because other agonist therapies have been demonstrated to be effective for the treatment of substance use disorders, the objective of this study was to evaluate the influence of oral delta(9)-thc maintenance on choice to self-administer smoked marijuana. |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
each morning, except on days 6, 12, and 18, participants smoked the 'sample' marijuana cigarette (1.8% delta(9)-thc w/w) and received a $2 voucher (redeemable for cash at study's end). |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
relative to placebo delta(9)-thc maintenance, participants' choice to self-administer marijuana was not significantly altered by either of the two active delta(9)-thc maintenance conditions. |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
some 'positive' subjective drug-effect ratings following the sample marijuana cigarette were reduced: by day 3 of active oral delta(9)-thc maintenance, participants' rating of 'good drug effect' and 'high' were significantly decreased. |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
finally, the effects of smoked marijuana on psychomotor task performance were only minimally affected by oral delta(9)-thc maintenance. |
2002-10-22 |
2023-08-12 |
human |
| Carl L Hart, Margaret Haney, Amie S Ward, Marian W Fischman, Richard W Folti. Effects of oral THC maintenance on smoked marijuana self-administration. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127201. |
these data indicate that participants' choice to self-administer marijuana was unaltered by the oral delta(9)-thc dosing regimen used in the present investigation. |
2002-10-22 |
2023-08-12 |
human |
| Maria João Baptista, Paula Verâncio Monsanto, Estela Gouveia Pinho Marques, Ana Bermejo, Sofia Avila, Alice Martelo Castanheira, Cláudia Margalho, Mário Barroso, Duarte Nuno Vieir. Hair analysis for delta(9)-THC, delta(9)-THC-COOH, CBN and CBD, by GC/MS-EI. Comparison with GC/MS-NCI for delta(9)-THC-COOH. Forensic science international. vol 128. issue 1-2. 2002-10-18. PMID:12208025. |
a sensitive analytical method was developed for quantitative analysis of delta(9)-tetrahydrocannabinol (delta(9)-thc), 11-nor-delta(9)-tetrahydrocannabinol-carboxylic acid (delta(9)-thc-cooh), cannabinol (cbn) and cannabidiol (cbd) in human hair. |
2002-10-18 |
2023-08-12 |
human |
| Maria João Baptista, Paula Verâncio Monsanto, Estela Gouveia Pinho Marques, Ana Bermejo, Sofia Avila, Alice Martelo Castanheira, Cláudia Margalho, Mário Barroso, Duarte Nuno Vieir. Hair analysis for delta(9)-THC, delta(9)-THC-COOH, CBN and CBD, by GC/MS-EI. Comparison with GC/MS-NCI for delta(9)-THC-COOH. Forensic science international. vol 128. issue 1-2. 2002-10-18. PMID:12208025. |
the identification of delta(9)-thc-cooh in hair would document cannabis use more effectively than the detection of parent drug (delta(9)-thc) which might have come from environmental exposure. |
2002-10-18 |
2023-08-12 |
human |
| Sophie Parmentier-Batteur, Kunlin Jin, Lin Xie, Xiao Ou Mao, David A Greenber. DNA microarray analysis of cannabinoid signaling in mouse brain in vivo. Molecular pharmacology. vol 62. issue 4. 2002-10-11. PMID:12237329. |
to identify novel genes involved in cannabinoid receptor-mediated signaling, we used cdna microarrays to detect changes in mrna expression in the forebrains of mice 12 h after they were given a single intraperitoneal dose of the naturally-occurring cannabis sativa alkaloid delta(9)-tetrahydrocannabinol (delta(9)-thc) or the synthetic cannabinoid receptor agonist (r)-(+)-2,3-dihydro-5-methyl-3-[(morpholinyl)methyl] pyrrolo[1,2,3-de]-1,4-benzoxazin-yl-1-naphtalenylmethanone mesylate [r(+)-win 55,212-2]. |
2002-10-11 |
2023-08-12 |
mouse |
| K R Müller-Vahl, U Schneider, A Koblenz, M Jöbges, H Kolbe, T Daldrup, H M Emric. Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial. Pharmacopsychiatry. vol 35. issue 2. 2002-09-25. PMID:11951146. |
anecdotal reports in tourette's syndrome (ts) have suggested that marijuana (cannabis sativa) and delta-9-tetrahydrocannabinol (delta(9)-thc), the major psychoactive ingredient of marijuana, reduce tics and associated behavioral disorders. |
2002-09-25 |
2023-08-12 |
Not clear |
| Anna Porcella, Giorgio Marchese, Maria Antonietta Casu, Antonio Rocchitta, Maria Letizia Lai, Gian Luigi Gessa, Luca Pan. Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid. European journal of endocrinology. vol 147. issue 2. 2002-09-24. PMID:12153749. |
previous reports have shown that the delta(9)-tetrahydrocannabinol (delta(9)tch), the major psychoactive cannabinoid components of marijuana, is able [corrected] to inhibit thyroid hormonal activity. |
2002-09-24 |
2023-08-12 |
rat |
| Marco Pistis, Anna Lisa Muntoni, Giuliano Pillolla, Gian Luigi Gess. Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study. The European journal of neuroscience. vol 15. issue 11. 2002-09-04. PMID:12081659. |
or the psychoactive principle of cannabis delta(9)-tetrahydrocannabinol (1.0 mg/kg, i.v.). |
2002-09-04 |
2023-08-12 |
rat |
| Robert J McKallip, Catherine Lombard, Billy R Martin, Mitzi Nagarkatti, Prakash S Nagarkatt. Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 302. issue 2. 2002-08-29. PMID:12130702. |
delta(9)-tetrahydrocannabinol (thc), the main psychoactive component of marijuana has been shown to suppress the immune response. |
2002-08-29 |
2023-08-12 |
mouse |
| Maria Cristina Tomasini, Luca Ferraro, Berta Wonjie Bebe, Sergio Tanganelli, Tommaso Cassano, Vincenzo Cuomo, Tiziana Antonell. Delta(9)-tetrahydrocannabinol increases endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons: involvement of CB(1) receptors. Journal of neuroscience research. vol 68. issue 4. 2002-07-18. PMID:11992471. |
the effects of the principal psychoactive component of marijuana, delta(9)-tetrahydrocannabinol (delta(9)-thc), on endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons were investigated. |
2002-07-18 |
2023-08-12 |
rat |
| J Killestein, E L J Hoogervorst, M Reif, N F Kalkers, A C Van Loenen, P G M Staats, R W Gorter, B M J Uitdehaag, C H Polma. Safety, tolerability, and efficacy of orally administered cannabinoids in MS. Neurology. vol 58. issue 9. 2002-05-24. PMID:12011290. |
the authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with ms who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral delta(9)-tetrahydrocannabinol (thc) and cannabis sativa plant extract. |
2002-05-24 |
2023-08-12 |
human |
| Jenny L Wiley, Irina D Beletskaya, Edward W Ng, Zongmin Dai, Peter J Crocker, Anu Mahadevan, Raj K Razdan, Billy R Marti. Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists. The Journal of pharmacology and experimental therapeutics. vol 301. issue 2. 2002-05-13. PMID:11961073. |
the role of the oxygen of the benzopyran substituent of delta(9)-tetrahydrocannabinol in defining affinity for brain cannabinoid (cb(1)) receptors is not well understood; however, it is known that opening the pyran ring can result in either increased potency and affinity, as in cp 55,940 [(-)-cis-3-[2-hydroxy-4(1,1- dimethyl-heptyl)phenyl]-trans-4-(3-hydroxy-propyl)cyclohexanol], or in an inactive cannabinoid, as in cannabidiol. |
2002-05-13 |
2023-08-12 |
Not clear |
| Scott D Lane, Don R Chere. Marijuana effects on sensitivity to reinforcement in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 4. 2002-05-09. PMID:11927176. |
under controlled laboratory conditions, eight adult subjects smoked placebo and three different potencies of marijuana cigarettes ranging in delta(9) thc content. |
2002-05-09 |
2023-08-12 |
human |
| E Downer, B Boland, M Fogarty, V Campbel. Delta 9-tetrahydrocannabinol induces the apoptotic pathway in cultured cortical neurones via activation of the CB1 receptor. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742222. |
delta 9-tetrahydrocannabinol, the principal psychoactive component of marijuana, exerts a variety of effects on the cns, including impaired cognitive function and neurobehavioural deficits. |
2002-03-18 |
2023-08-12 |
Not clear |
| C Giroud, A Ménétrey, M Augsburger, T Buclin, P Sanchez-Mazas, P Mangi. Delta(9)-THC, 11-OH-Delta(9)-THC and Delta(9)-THCCOOH plasma or serum to whole blood concentrations distribution ratios in blood samples taken from living and dead people. Forensic science international. vol 123. issue 2-3. 2002-02-14. PMID:11728742. |
in this respect, the delta(9)-thc, 11-oh-delta(9)-thc and delta(9)-thccooh concentrations were measured in plasma and whole blood taken from eight volunteers who smoke cannabis on a regular basis. |
2002-02-14 |
2023-08-12 |
human |
| Tong-Rong Jan, Gautham K Rao, Norbert E Kaminsk. Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809870. |
enhancement of il-2 was also demonstrated with cp55940, delta(9)-tetrahydrocannabinol, and cannabidiol, thus suggesting that the phenomenon is not unique to cbn. |
2002-02-07 |
2023-08-12 |
Not clear |