| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Roth, J A Marques-Magallanes, M Yuan, W Sun, D P Tashkin, O Hankinso. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. American journal of respiratory cell and molecular biology. vol 24. issue 3. 2001-04-19. PMID:11245634. |
these differences between marijuana and tobacco were primarily due to delta(9)-tetrahydrocannabinol (delta(9)-thc), the psychoactive component of marijuana. |
2001-04-19 |
2023-08-12 |
human |
| M D Roth, J A Marques-Magallanes, M Yuan, W Sun, D P Tashkin, O Hankinso. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. American journal of respiratory cell and molecular biology. vol 24. issue 3. 2001-04-19. PMID:11245634. |
this complex regulation of cyp1a1 by marijuana smoke and the delta(9)-thc that it contains has implications for the role of marijuana as a cancer risk factor. |
2001-04-19 |
2023-08-12 |
human |
| S K Mani, A Mitchell, B W O'Malle. Progesterone receptor and dopamine receptors are required in Delta 9-tetrahydrocannabinol modulation of sexual receptivity in female rats. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 3. 2001-04-12. PMID:11158625. |
we examined the effects of the active ingredient of cannabis, delta(9)-tetrahydrocannabinol (thc), on sexual behavior in female rats and its influence on steroid hormone receptors and neurotransmitters in the facilitation of sexual receptivity. |
2001-04-12 |
2023-08-12 |
rat |
| J T Kittler, E V Grigorenko, C Clayton, S Y Zhuang, S C Bundey, M M Trower, D Wallace, R Hampson, S Deadwyle. Large-scale analysis of gene expression changes during acute and chronic exposure to [Delta]9-THC in rats. Physiological genomics. vol 3. issue 3. 2001-03-08. PMID:11015613. |
a total of 24,456 cdna clones were randomly selected from a rat brain cdna library, amplified by pcr, and arrayed at high density to investigate differential gene expression profiles following acute (24 h), intermediate (7 days), and chronic (21 days) exposure to delta(9)-tetrahydrocannabinol (delta(9)-thc), the psychoactive ingredient of marijuana. |
2001-03-08 |
2023-08-12 |
rat |
| T Gómez del Pulgar, G Velasco, M Guzmá. The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. The Biochemical journal. vol 347. issue Pt 2. 2001-03-01. PMID:10749665. |
using chinese hamster ovary cells stably transfected with the cb(1) receptor cdna we show here that delta(9)-tetrahydrocannabinol (thc), the major active component of marijuana, induces the activation of protein kinase b/akt (pkb). |
2001-03-01 |
2023-08-12 |
human |
| S O Jacobsson, E Rongård, M Stridh, G Tiger, C J Fowle. Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability. Biochemical pharmacology. vol 60. issue 12. 2001-01-11. PMID:11108795. |
in the present study, the effects of the combination of tamoxifen ((z)-2[p-(1,2-diphenyl-1-butenyl)phenoxy]-n,n-dimethylamine citrate) and three cannabinoids (delta(9)-tetrahydrocannabinol [delta(9)-thc], cannabidiol, and anandamide [aea]) upon the viability of c6 rat glioma cells was assessed at different incubation times and using different culturing concentrations of foetal bovine serum (fbs). |
2001-01-11 |
2023-08-12 |
human |
| S O Jacobsson, E Rongård, M Stridh, G Tiger, C J Fowle. Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability. Biochemical pharmacology. vol 60. issue 12. 2001-01-11. PMID:11108795. |
delta(9)-thc and cannabidiol, but not aea, produced a modest reduction in cell viability after 6 days of incubation in serum-free medium, whereas no effects were seen in 10% fbs-containing medium. |
2001-01-11 |
2023-08-12 |
human |
| M Chiarotti, L Costamagn. Analysis of 11-nor-9-carboxy-delta(9)-tetrahydrocannabinol in biological samples by gas chromatography tandem mass spectrometry (GC/MS-MS). Forensic science international. vol 114. issue 1. 2000-11-13. PMID:10924845. |
the proposed method, using deuterated delta(9)-thc-cooh as an internal standard, is able to detect the major metabolite of cannabis derivatives at very low levels (picograms/millilitre) with high specificity. |
2000-11-13 |
2023-08-12 |
Not clear |
| D Rueda, I Galve-Roperh, A Haro, M Guzmá. The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase. Molecular pharmacology. vol 58. issue 4. 2000-10-31. PMID:10999952. |
using chinese hamster ovary cells stably transfected with the cb(1) receptor cdna, we show here that delta(9)-tetrahydrocannabinol (thc), the major active component of marijuana, induces the activation of c-jun n-terminal kinase (jnk). |
2000-10-31 |
2023-08-12 |
Not clear |
| A H Lichtman, J Peart, J L Poklis, D T Bridgen, R K Razdan, D M Wilson, A Poklis, Y Meng, P R Byron, B R Marti. Pharmacological evaluation of aerosolized cannabinoids in mice. European journal of pharmacology. vol 399. issue 2-3. 2000-09-22. PMID:10884513. |
the goals of the present study were to: (1) develop and characterize the physical properties of an aerosolized form of delta(9)-tetrahydrocannabinol (delta(9)-thc), the major psychoactive constituent present in marijuana; and (2) assess the pharmacological effects of cannabinoid inhalation in mice. |
2000-09-22 |
2023-08-12 |
mouse |
| M A Bacigalupo, A Ius, G Meroni, G Grassi, A Moschell. Time-resolved fluoroimmunoassay for delta(9)-tetrahydrocannabinol as applied to early discrimination of Cannabis sativa plants. Journal of agricultural and food chemistry. vol 47. issue 7. 2000-08-30. PMID:10552557. |
time-resolved fluoroimmunoassay for delta(9)-tetrahydrocannabinol as applied to early discrimination of cannabis sativa plants. |
2000-08-30 |
2023-08-12 |
Not clear |
| M Egertová, M R Elphic. Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB. The Journal of comparative neurology. vol 422. issue 2. 2000-08-02. PMID:10842224. |
the cb(1)-type cannabinoid receptor mediates physiologic effects of delta(9)-tetrahydrocannabinol, the psychoactive ingredient of the drug marijuana. |
2000-08-02 |
2023-08-12 |
rat |
| T W Klein, C A Newton, N Nakachi, H Friedma. Delta 9-tetrahydrocannabinol treatment suppresses immunity and early IFN-gamma, IL-12, and IL-12 receptor beta 2 responses to Legionella pneumophila infection. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 12. 2000-07-20. PMID:10843702. |
the marijuana cannabinoid, delta 9-tetrahydrocannabinol (thc), suppresses immunity to legionella pneumophila and development of th1 activity and cell-mediated immunity. |
2000-07-20 |
2023-08-12 |
mouse |
| Y Chen, J Buc. Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism. The Journal of pharmacology and experimental therapeutics. vol 293. issue 3. 2000-07-14. PMID:10869379. |
we report that submicromolar concentrations of delta(9)-tetrahydrocannabinol (thc), delta(8)-thc, cannabinol, or cannabidiol, but not win 55,212-2, prevented serum-deprived cell death. |
2000-07-14 |
2023-08-12 |
Not clear |
| A J Hampson, M Grimaldi, M Lolic, D Wink, R Rosenthal, J Axelro. Neuroprotective antioxidants from marijuana. Annals of the New York Academy of Sciences. vol 899. 2000-07-13. PMID:10863546. |
the psychotropic cannabinoid receptor agonist delta 9-tetrahydrocannabinol (thc) and cannabidiol, (a non-psychoactive constituent of marijuana), both reduced nmda, ampa and kainate receptor mediated neurotoxicities. |
2000-07-13 |
2023-08-12 |
rat |
| P J Winsauer, P Lambert, J M Moerschbaeche. Cannabinoid ligands and their effects on learning and performance in rhesus monkeys. Behavioural pharmacology. vol 10. issue 5. 2000-05-18. PMID:10780256. |
to characterize the role of cb1 receptors in mediating the acquisition of new behavior or learning, delta 9-thc (delta 9-tetrahydrocannabinol), win 55,212-2 (r-(+)-(2,3-dihydro-5-methyl-3-[(4-morpho-linyl)methyl]pyrol - (1,2,3-de]-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonate), sr141716a (n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlor- phenyl)-4-methyl-1h-pyrazole-3-carboxamide hydrochloride) and cannabidiol were administered to monkeys responding under a multiple schedule of repeated acquisition and performance of conditional discriminations. |
2000-05-18 |
2023-08-12 |
human |
| P J Winsauer, P Lambert, J M Moerschbaeche. Cannabinoid ligands and their effects on learning and performance in rhesus monkeys. Behavioural pharmacology. vol 10. issue 5. 2000-05-18. PMID:10780256. |
in summary, cb1-receptor agonists such as delta 9-thc and win 55,212-2 were more disruptive to the rate and accuracy of learning in old-world monkeys than the cb1-receptor antagonist sr141716a or cannabidiol. |
2000-05-18 |
2023-08-12 |
human |
| F Rakhshan, T A Day, R D Blakely, E L Barke. Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. The Journal of pharmacology and experimental therapeutics. vol 292. issue 3. 2000-03-17. PMID:10688610. |
anandamide (n-arachidonylethanolamide) is an endogenous cannabinoid that mimics the pharmacologic effects of delta(9)-tetrahydrocannabinol, the major bioactive substance in marijuana. |
2000-03-17 |
2023-08-12 |
Not clear |
| F Sporkert, F Prags. Use of headspace solid-phase microextraction (HS-SPME) in hair analysis for organic compounds. Forensic science international. vol 107. issue 1-3. 2000-03-13. PMID:10689567. |
because of the phenolic hydroxyl group a change of ph after alkaline hair digestion (by adding excess orthophosphoric acid) was necessary for the detection of delta 9-tetrahydrocannabinol (delta 9-thc), cannabinol (cbn) and cannabidiol (cbd) by hs-spme. |
2000-03-13 |
2023-08-12 |
Not clear |
| S P Welch, M Ead. Synergistic interactions of endogenous opioids and cannabinoid systems. Brain research. vol 848. issue 1-2. 2000-02-25. PMID:10612710. |
delta(9)-thc, an active constituent in marijuana, releases endogenous dynorphin a and leucine enkephalin in the production of analgesia. |
2000-02-25 |
2023-08-12 |
Not clear |