| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Corchero, J A Fuentes, J Manzanare. delta 9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus. European journal of pharmacology. vol 323. issue 2-3. 1997-06-16. PMID:9128838. |
delta 9-tetrahydrocannabinol, the main psychoactive component of cannabis, produces a large spectrum of pharmacological effects, many of which have been linked to interaction with the opioid system. |
1997-06-16 |
2023-08-12 |
rat |
| M C Sañudo-Peña, K Tsou, E R Delay, A G Hohman, M Force, J M Walke. Endogenous cannabinoids as an aversive or counter-rewarding system in the rat. Neuroscience letters. vol 223. issue 2. 1997-06-09. PMID:9089689. |
the results showed that animals failed to develop place conditioning at a low dose (1.5 mg/kg) and developed a place aversion at a high dose (15 mg/kg) of the active principle in marijuana, delta 9-tetrahydrocannabinol (delta 9-thc), a finding consistent with most previous studies. |
1997-06-09 |
2023-08-12 |
human |
| R A Wis. Addictive drugs and brain stimulation reward. Annual review of neuroscience. vol 19. 1997-05-12. PMID:8833446. |
cocaine, mu and delta opiates, nicotine, phencyclidine, and cannabis each have actions that summate with rewarding electrical stimulation of the medial forebrain bundle (mfb). |
1997-05-12 |
2023-08-12 |
Not clear |
| A Bonnin, R de Miguel, J G Castro, J A Ramos, J J Fernandez-Rui. Effects of perinatal exposure to delta 9-tetrahydrocannabinol on the fetal and early postnatal development of tyrosine hydroxylase-containing neurons in rat brain. Journal of molecular neuroscience : MN. vol 7. issue 4. 1997-04-07. PMID:8968950. |
the exposure of pregnant rats to delta 9-tetrahydrocannabinol (delta 9-thc), the main psychoactive constituent of cannabis sativa, during the perinatal period affects the gene expression and the activity of tyrosine hydroxylase (th) in the brains of their offspring at peripubertal and adult ages. |
1997-04-07 |
2023-08-12 |
rat |
| J S Poling, M A Rogawski, N Salem, S Vicin. Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels. Neuropharmacology. vol 35. issue 7. 1997-03-11. PMID:8938728. |
anandamide has been identified in porcine brain as an endogenous cannabinoid receptor ligand and is believed to be a counterpart to the psychoactive component of marijuana, delta 9-tetrahydrocannabinol (delta 9-thc). |
1997-03-11 |
2023-08-12 |
rat |
| M A Huestis, J M Mitchell, E J Con. Urinary excretion profiles of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol in humans after single smoked doses of marijuana. Journal of analytical toxicology. vol 20. issue 6. 1997-01-30. PMID:8889681. |
in this study, six subjects smoked a single marijuana cigarette (placebo, 1.75% delta 9-tetrahydrocannabinol [thc], or 3.55% thc) each week while residing on the clinical ward of the addiction research center. |
1997-01-30 |
2023-08-12 |
human |
| I B Adams, B R Marti. Cannabis: pharmacology and toxicology in animals and humans. Addiction (Abingdon, England). vol 91. issue 11. 1997-01-29. PMID:8972919. |
the psychoactive constituent of cannabis, delta 9-tetrahydrocannabinol (delta 9-thc), produces a myriad of pharmacological effects in animals and humans. |
1997-01-29 |
2023-08-12 |
Not clear |
| E C Nyoni, B R Sitaram, D A Taylo. Determination of delta 9-tetrahydrocannabinol levels in brain tissue using high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical applications. vol 679. issue 1-2. 1997-01-21. PMID:8998573. |
delta 9-tetrahydrocannabinol (delta 9-thc) is the major psychoactive component of cannabis. |
1997-01-21 |
2023-08-12 |
rat |
| K Watanabe, Y Kayano, T Matsunaga, I Yamamoto, H Yoshimur. Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids. Biological & pharmaceutical bulletin. vol 19. issue 8. 1997-01-09. PMID:8874830. |
cannabidiol (cbd), cannabinol (cbn) and delta 9-tetrahydrocannabinol (delta 9-thc) significantly inhibited the hydrolysis of the amide by mouse brain microsomes. |
1997-01-09 |
2023-08-12 |
mouse |
| M F Ruh, J A Taylor, A C Howlett, W V Welshon. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960061. |
delta 9-tetrahydrocannabinol (thc), the primary active compound in cannabis sativa (marihuana), and other cannabinoid receptor agonists exert potent effects on luteinizing hormone and prolactin release in animal models and humans. |
1997-01-09 |
2023-08-12 |
Not clear |
| M F Ruh, J A Taylor, A C Howlett, W V Welshon. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960061. |
compounds possessing the tricyclic cannabinoid structure, including delta 9-thc and cannabidiol, have been reported to interact with rodent uterine estrogen receptors in ligand binding assays. |
1997-01-09 |
2023-08-12 |
Not clear |
| M F Ruh, J A Taylor, A C Howlett, W V Welshon. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960061. |
neither delta 9-thc, desacetyllevonantradol, nor cannabidiol stimulated transcriptional activity. |
1997-01-09 |
2023-08-12 |
Not clear |
| E Snella, S Pross, H Friedma. Relationship of aging and cytokines to the immunomodulation by delta-9-tetrahydrocannabinol on murine lymphoid cells. International journal of immunopharmacology. vol 17. issue 12. 1996-12-17. PMID:8964654. |
the effect of delta 9-tetrahydrocannabinol, the major psychoactive component of marijuana, was investigated utilizing lymphoid cells from 2-week, 2-month, and 18-month-old mice. |
1996-12-17 |
2023-08-12 |
mouse |
| E S Onaivi, A Chakrabarti, G Chaudhur. Cannabinoid receptor genes. Progress in neurobiology. vol 48. issue 4-5. 1996-12-05. PMID:8804112. |
cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-thc). |
1996-12-05 |
2023-08-12 |
mouse |
| V Cirimele, H Sachs, P Kintz, P Mangi. Testing human hair for Cannabis. III. rapid screening procedure for the simultaneous identification of delta 9-tetrahydrocannabinol, cannabinol, and cannabidiol. Journal of analytical toxicology. vol 20. issue 1. 1996-12-05. PMID:8837945. |
rapid screening procedure for the simultaneous identification of delta 9-tetrahydrocannabinol, cannabinol, and cannabidiol. |
1996-12-05 |
2023-08-12 |
human |
| V Cirimele, H Sachs, P Kintz, P Mangi. Testing human hair for Cannabis. III. rapid screening procedure for the simultaneous identification of delta 9-tetrahydrocannabinol, cannabinol, and cannabidiol. Journal of analytical toxicology. vol 20. issue 1. 1996-12-05. PMID:8837945. |
delta 9-tetrahydrocannabinol (thc), cannabidiol (cbd), and cannabinol (cbn) are three constituents of the 16 that can be currently isolated from some cannabis spp plants. |
1996-12-05 |
2023-08-12 |
human |
| N D Volkow, H Gillespie, N Mullani, L Tancredi, C Grant, A Valentine, L Holliste. Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication. Psychiatry research. vol 67. issue 1. 1996-11-22. PMID:8797240. |
brain glucose metabolism with and without delta 9 tetrahydrocannabinol (thc) (main psychoactive component of marijuana) was evaluated in eight normal subjects and eight chronic marijuana abusers with positron emission tomography. |
1996-11-22 |
2023-08-12 |
human |
| R G Coffey, Y Yamamoto, E Snella, S Pros. Tetrahydrocannabinol inhibition of macrophage nitric oxide production. Biochemical pharmacology. vol 52. issue 5. 1996-09-23. PMID:8765472. |
the effectiveness of various thc analogues, in decreasing order of potency, was delta 8-thc > delta 9-thc > cannabidiol > or = 11-oh-thc > cannabinol. |
1996-09-23 |
2023-08-12 |
mouse |
| J L Wiley, J W Huffman, R L Balster, B R Marti. Pharmacological specificity of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rhesus monkeys. Drug and alcohol dependence. vol 40. issue 1. 1996-09-19. PMID:8746928. |
delta 9-tetrahydrocannabinol (delta 9-thc) discrimination has been used as an animal model of cannabis intoxication in humans. |
1996-09-19 |
2023-08-12 |
rat |
| V Kircher, H Parla. Determination of delta 9-tetrahydrocannabinol from human saliva by tandem immunoaffinity chromatography--high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. vol 677. issue 2. 1996-09-12. PMID:8704928. |
in this paper a novel liquid chromatographic assay for the selective quantification of delta 9-tetrahydrocannabinol, the major indicator of a present cannabis intoxication in saliva, is described. |
1996-09-12 |
2023-08-12 |
human |