| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Pinto, F Potié, K C Rice, D Boring, M R Johnson, D M Evans, G H Wilken, C H Cantrell, A C Howlet. Cannabinoid receptor binding and agonist activity of amides and esters of arachidonic acid. Molecular pharmacology. vol 46. issue 3. 1994-11-10. PMID:7935333. |
the cannabinoid receptor in brain (cb1) specifically binds delta 9-tetrahydrocannabinol, the predominant central nervous system-active component of marijuana. |
1994-11-10 |
2023-08-12 |
Not clear |
| R N Takahashi, G Singe. Cross self-administration of delta 9-tetrahydrocannabinol and D-amphetamine in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 14. issue 6. 1994-10-19. PMID:6153044. |
the small number of responses for delta 9-thc is in agreement with reports of the poor reinforcing capability of cannabis compounds in rats. |
1994-10-19 |
2023-08-12 |
rat |
| C A Newton, T W Klein, H Friedma. Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infection and immunity. vol 62. issue 9. 1994-09-21. PMID:8063421. |
in this report, delta 9-tetrahydrocannabinol (thc), the major psychoactive cannabinoid of marijuana and an immunomodulator, suppressed development of secondary immunity to l. pneumophila, which correlated with a reduction in th1 activity. |
1994-09-21 |
2023-08-12 |
mouse |
| T H Kelly, R W Foltin, C S Emurian, M W Fischma. Effects of delta 9-THC on marijuana smoking, dose choice, and verbal report of drug liking. Journal of the experimental analysis of behavior. vol 61. issue 2. 1994-06-02. PMID:8169569. |
effects of delta 9-thc on marijuana smoking, dose choice, and verbal report of drug liking. |
1994-06-02 |
2023-08-12 |
human |
| T H Kelly, R W Foltin, C S Emurian, M W Fischma. Effects of delta 9-THC on marijuana smoking, dose choice, and verbal report of drug liking. Journal of the experimental analysis of behavior. vol 61. issue 2. 1994-06-02. PMID:8169569. |
the effects of delta 9-tetrahydrocannabinol content of marijuana on cigarette smoking, dose choice, and verbal report of drug "liking" by adult males living in a residential laboratory were investigated. |
1994-06-02 |
2023-08-12 |
human |
| T H Kelly, R W Foltin, C S Emurian, M W Fischma. Effects of delta 9-THC on marijuana smoking, dose choice, and verbal report of drug liking. Journal of the experimental analysis of behavior. vol 61. issue 2. 1994-06-02. PMID:8169569. |
in the first study, placebo or active (2.3% delta 9-tetrahydrocannabinol) marijuana cigarettes were available for 1-, 2-, or 3-day intervals at varying times of day. |
1994-06-02 |
2023-08-12 |
human |
| S C Shivers, C Newton, H Friedman, T W Klei. delta 9-Tetrahydrocannabinol (THC) modulates IL-1 bioactivity in human monocyte/macrophage cell lines. Life sciences. vol 54. issue 17. 1994-05-20. PMID:8164509. |
we have previously observed that delta 9-tetrahydrocannabinol (thc), the major psychoactive component of marijuana, increased supernatant interleukin-1 (il-1) bioactivity in cultures of mouse resident peritoneal macrophages stimulated with lipopolysaccharide (lps). |
1994-05-20 |
2023-08-12 |
mouse |
| H S Greenberg, S A Werness, J E Pugh, R O Andrus, D J Anderson, E F Domin. Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers. Clinical pharmacology and therapeutics. vol 55. issue 3. 1994-04-29. PMID:8143398. |
smoking one marijuana cigarette containing 1.54% delta 9-tetrahydrocannabinol increased postural tracking error in both the patients and normal control subjects with both eyes open and closed; this untoward effect was greatest for the patients. |
1994-04-29 |
2023-08-12 |
human |
| D I Kusher, L O Dawson, A C Taylor, J Y Dje. Effect of the psychoactive metabolite of marijuana, delta 9-tetrahydrocannabinol (THC), on the synthesis of tumor necrosis factor by human large granular lymphocytes. Cellular immunology. vol 154. issue 1. 1994-04-06. PMID:8118892. |
effect of the psychoactive metabolite of marijuana, delta 9-tetrahydrocannabinol (thc), on the synthesis of tumor necrosis factor by human large granular lymphocytes. |
1994-04-06 |
2023-08-12 |
human |
| D I Kusher, L O Dawson, A C Taylor, J Y Dje. Effect of the psychoactive metabolite of marijuana, delta 9-tetrahydrocannabinol (THC), on the synthesis of tumor necrosis factor by human large granular lymphocytes. Cellular immunology. vol 154. issue 1. 1994-04-06. PMID:8118892. |
delta 9-tetrahydrocannabinol (thc), an active constituent of marijuana, has been reported to be immunosuppressive at concentrations that exceed attainable plasma levels. |
1994-04-06 |
2023-08-12 |
human |
| F Rodríguez de Fonseca, M A Gorriti, J J Fernández-Ruiz, T Palomo, J A Ramo. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment. Pharmacology, biochemistry, and behavior. vol 47. issue 1. 1994-03-25. PMID:8115426. |
in this work, we examined whether cannabinoid receptors exhibit downregulation as a consequence of the chronic exposure to delta 9-tetrahydrocannabinol (thc), which might explain certain tolerance phenomena observed in relation to motor and limbic effects of marijuana. |
1994-03-25 |
2023-08-12 |
rat |
| T H Kelly, R W Foltin, C S Emurian, M W Fischma. Performance-based testing for drugs of abuse: dose and time profiles of marijuana, amphetamine, alcohol, and diazepam. Journal of analytical toxicology. vol 17. issue 5. 1994-03-23. PMID:8107459. |
the time courses of the effects of acute doses of amphetamine (5 and 10 mg/70 kg), alcohol (0.3 and 0.6 g/kg), diazepam (5 and 10 mg/70 kg), and marijuana (2.0% and 3.5% delta 9-thc) on performance engendered by each of four computerized behavioral tasks were evaluated in six human subjects. |
1994-03-23 |
2023-08-12 |
human |
| K Fischer-Stenger, D A Dove Pettit, G A Cabra. Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-alpha: suppression of post-translational events. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263818. |
delta 9-tetrahydrocannabinol (delta 9-thc), the major psychoactive component of marijuana, has been shown to suppress macrophage soluble cytolytic activity. |
1994-01-27 |
2023-08-12 |
Not clear |
| J Chen, R Marmur, A Pulles, W Paredes, E L Gardne. Ventral tegmental microinjection of delta 9-tetrahydrocannabinol enhances ventral tegmental somatodendritic dopamine levels but not forebrain dopamine levels: evidence for local neural action by marijuana's psychoactive ingredient. Brain research. vol 621. issue 1. 1993-12-09. PMID:8221074. |
ventral tegmental microinjection of delta 9-tetrahydrocannabinol enhances ventral tegmental somatodendritic dopamine levels but not forebrain dopamine levels: evidence for local neural action by marijuana's psychoactive ingredient. |
1993-12-09 |
2023-08-12 |
rat |
| J Chen, R Marmur, A Pulles, W Paredes, E L Gardne. Ventral tegmental microinjection of delta 9-tetrahydrocannabinol enhances ventral tegmental somatodendritic dopamine levels but not forebrain dopamine levels: evidence for local neural action by marijuana's psychoactive ingredient. Brain research. vol 621. issue 1. 1993-12-09. PMID:8221074. |
microinjection of 12 micrograms or 24 micrograms delta 9-tetrahydrocannabinol (delta 9-thc), the psychoactive ingredient in marijuana and hashish, into the vta produced a dose-dependent increase in somatodendritic da levels in vta but failed to produce any simultaneous change in extracellular da in acb. |
1993-12-09 |
2023-08-12 |
rat |
| S Munro, K L Thomas, M Abu-Shaa. Molecular characterization of a peripheral receptor for cannabinoids. Nature. vol 365. issue 6441. 1993-09-30. PMID:7689702. |
the major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-thc), has been used as a psychoactive agent for thousands of years. |
1993-09-30 |
2023-08-12 |
Not clear |
| S Munro, K L Thomas, M Abu-Shaa. Molecular characterization of a peripheral receptor for cannabinoids. Nature. vol 365. issue 6441. 1993-09-30. PMID:7689702. |
marijuana, and delta 9-thc, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. |
1993-09-30 |
2023-08-12 |
Not clear |
| A Oviedo, J Glowa, M Herkenha. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain research. vol 616. issue 1-2. 1993-09-30. PMID:8395305. |
the active ingredient of marijuana is (-)-delta 9-tetrahydrocannabinol (delta 9-thc). |
1993-09-30 |
2023-08-12 |
rat |
| A Oviedo, J Glowa, M Herkenha. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain research. vol 616. issue 1-2. 1993-09-30. PMID:8395305. |
to test the hypothesis that tolerance is mediated by changes in cannabinoid receptor binding characteristics, we used quantitative in vitro autoradiography of [3h]cp-55,940 binding to striatal brain sections from rats treated either chronically or acutely with delta 9-thc, cp-55,940, or the inactive natural cannabinoid cannabidiol. |
1993-09-30 |
2023-08-12 |
rat |
| A Oviedo, J Glowa, M Herkenha. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain research. vol 616. issue 1-2. 1993-09-30. PMID:8395305. |
injections of delta 9-thc (10 mg/kg), cannabidiol (10 mg/kg), or cp-55,940 (1, 3, or 10 mg/kg) for 2 weeks and sacrificed 30 min after the last injection. |
1993-09-30 |
2023-08-12 |
rat |