| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R Compton, P J Little, B R Martin, J W Gilman, J K Saha, V S Jorapur, H P Sard, R K Razda. Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogues of 10-substituted cannabidiol and 11- or 12-substituted delta 8-tetrahydrocannabinol. Journal of medicinal chemistry. vol 33. issue 5. 1990-05-29. PMID:2158563. |
the synthesis of a variety of novel 10-substituted cannabidiol (cbd) and 11- or 12-substituted delta 8-tetrahydrocannabinol (delta 8-thc) analogues containing amino, alkylamino, azido, or a n,n-bis(2-chloroethyl)amino functional group is described, as well as their pharmacological evaluation in mice. |
1990-05-29 |
2023-08-11 |
mouse |
| C J Hillard, J J Pounds, D R Boyer, A S Bloo. Studies of the role of membrane lipid order in the effects of delta 9-tetrahydrocannabinol on adenylate cyclase activation in heart. The Journal of pharmacology and experimental therapeutics. vol 252. issue 3. 1990-05-03. PMID:2156989. |
cannabidiol, cannabinol and (+)-delta 9-thc were all without effect, indicating that this effect of delta 9-thc is stereoselective and specific for cannabinoids with psychoactive potency. |
1990-05-03 |
2023-08-11 |
rat |
| T H Kelly, R W Foltin, A J Rose, M W Fischman, J V Brad. Smoked marijuana effects on tobacco cigarette smoking behavior. The Journal of pharmacology and experimental therapeutics. vol 252. issue 3. 1990-05-03. PMID:2319477. |
under blind conditions, subjects smoked placebo and active marijuana cigarettes (0%, 1.3%, 2.3%, or 2.7% delta 9-tetrahydrocannabinol) four times daily (9:45 a.m., 1:30 p.m., 5:00 p.m. and 8:30 p.m.). |
1990-05-03 |
2023-08-11 |
human |
| R W Foltin, M W Fischman, J V Brady, T H Kelly, D J Bernstein, M J Nelli. Motivational effects of smoked marijuana: behavioral contingencies and high-probability recreational activities. Pharmacology, biochemistry, and behavior. vol 34. issue 4. 1990-03-27. PMID:2623040. |
one or two cigarettes containing active marijuana (1.3-2.7% delta 9-thc) or placebo were smoked during both the private work period and the period of access to social activities. |
1990-03-27 |
2023-08-11 |
human |
| R W Foltin, M W Fischman, J V Brady, D J Bernstein, R M Capriotti, M J Nellis, T H Kell. Motivational effects of smoked marijuana: behavioral contingencies and low-probability activities. Journal of the experimental analysis of behavior. vol 53. issue 1. 1990-03-15. PMID:2299291. |
two cigarettes containing active marijuana (2.7% delta 9-thc) or placebo were smoked during the private work period and the period of access to social activities. |
1990-03-15 |
2023-08-11 |
human |
| E Johansson, M M Halldin, S Agurell, L E Hollister, H K Gillespi. Terminal elimination plasma half-life of delta 1-tetrahydrocannabinol (delta 1-THC) in heavy users of marijuana. European journal of clinical pharmacology. vol 37. issue 3. 1990-03-01. PMID:2558889. |
terminal elimination plasma half-life of delta 1-tetrahydrocannabinol (delta 1-thc) in heavy users of marijuana. |
1990-03-01 |
2023-08-11 |
human |
| E Johansson, M M Halldin, S Agurell, L E Hollister, H K Gillespi. Terminal elimination plasma half-life of delta 1-tetrahydrocannabinol (delta 1-THC) in heavy users of marijuana. European journal of clinical pharmacology. vol 37. issue 3. 1990-03-01. PMID:2558889. |
the terminal elimination half-life of delta 1-tetrahydrocannabinol (delta 1-thc) was investigated in eight men who were heavy users of marijuana. |
1990-03-01 |
2023-08-11 |
human |
| J J Rachlinski, R W Foltin, M W Fischma. The effects of smoked Marijuana on interpersonal distances in small groups. Drug and alcohol dependence. vol 24. issue 3. 1990-02-22. PMID:2605993. |
four cigarettes containing active marijuana (0-2.7% delta 9 thc) were smoked daily, two prior to and two during the social access period. |
1990-02-22 |
2023-08-11 |
human |
| E A Formukong, A T Evans, F J Evan. The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation. The Journal of pharmacy and pharmacology. vol 41. issue 10. 1990-02-20. PMID:2575149. |
olivetol, cannabigerol (cbg), cannabidiol (cbd), cannabinol (cbn) and tetrahydrocannabinol (delta 1-thc) were assessed for their ability to inhibit agonist-induced platelet aggregation and [14c]5-ht release. |
1990-02-20 |
2023-08-11 |
human |
| F Lu, D W O. Cocaine or delta 9-tetrahydrocannabinol does not affect cellular cytotoxicity in vitro. International journal of immunopharmacology. vol 11. issue 7. 1990-02-01. PMID:2557290. |
cocaine or delta 9-tetrahydrocannabinol (thc), the major psychoactive component of marijuana, has no effect on in vitro cytotoxicity mediated by natural killer (nk) cells and cytotoxic t-lymphocytes (ctl) at concentrations similar to those observed in vivo. |
1990-02-01 |
2023-08-11 |
Not clear |
| D F Marks, M G MacAvo. Divided attention performance in cannabis users and non-users following alcohol and cannabis separately and in combination. Psychopharmacology. vol 99. issue 3. 1990-01-25. PMID:2594907. |
the effect of delta 9-tetrahydrocannabinol (delta 9-thc) and alcohol, singly and in combination, on divided attention performance was investigated in cannabis users and non-users who were matched for alcohol use. |
1990-01-25 |
2023-08-11 |
Not clear |
| A C Howlett, D K Scott, G H Wilke. Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies. Biochemical pharmacology. vol 38. issue 19. 1989-11-28. PMID:2554920. |
because cannabinoid drugs partition into membrane lipids and alter membrane fluidity parameters in a number of model systems, it was of interest to examine the influence of delta 9-tetrahydrocannabinol and cannabidiol on enzyme activity analyzed by the arrhenius plot. |
1989-11-28 |
2023-08-11 |
Not clear |
| A C Howlett, D K Scott, G H Wilke. Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies. Biochemical pharmacology. vol 38. issue 19. 1989-11-28. PMID:2554920. |
in summary, thermodynamic data suggest that cannabidiol can influence adenylate cyclase by increasing membrane fluidity, but that the inhibition of adenylate cyclase by delta 9-tetrahydrocannabinol is not related to membrane fluidization. |
1989-11-28 |
2023-08-11 |
Not clear |
| E Johansson, M M Halldi. Urinary excretion half-life of delta 1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking. Journal of analytical toxicology. vol 13. issue 4. 1989-10-17. PMID:2550702. |
urinary excretion half-life of delta 1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking. |
1989-10-17 |
2023-08-11 |
Not clear |
| E Johansson, M M Halldi. Urinary excretion half-life of delta 1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking. Journal of analytical toxicology. vol 13. issue 4. 1989-10-17. PMID:2550702. |
the urinary excretion of the total amount of delta 1-tetrahydrocannabinol (delta 1-thc) metabolites, with special emphasis on delta 1-tetrahydrocannabinol-7-oic acid (delta 1-thc-7-oic acid), was studied in thirteen heavy cannabis users after smoking administration of delta 1-thc, followed by a four week discontinuation period. |
1989-10-17 |
2023-08-11 |
Not clear |
| P J Anderson, J D Wilson, F C Hille. Particle size distribution of mainstream tobacco and marijuana smoke. Analysis using the electrical aerosol analyzer. The American review of respiratory disease. vol 140. issue 1. 1989-08-11. PMID:2751166. |
part of this disparity may be due tot he inefficiency to previous sizing methods in measuring ultrafine size range, to evaluate size distribution of smoke from standard research cigarettes, commercial filter cigarettes, and from marijuana cigarettes with different delta 9-tetrahydrocannabinol contents. |
1989-08-11 |
2023-08-11 |
Not clear |
| J M Ng Cheong Ton, G A Gerhardt, M Friedemann, A M Etgen, G M Rose, N S Sharpless, E L Gardne. The effects of delta 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study. Brain research. vol 451. issue 1-2. 1989-07-31. PMID:2855215. |
the effect of systemically administered delta 9-tetrahydrocannabinol (thc), the psychoactive ingredient in marijuana, on the potassium-evoked release of dopamine (da) was examined in the neostriatum of the chloral hydrate anesthetized rat. |
1989-07-31 |
2023-08-11 |
rat |
| S J Heishman, M L Stitzer, G E Bigelo. Alcohol and marijuana: comparative dose effect profiles in humans. Pharmacology, biochemistry, and behavior. vol 31. issue 3. 1989-07-18. PMID:2855116. |
male subjects (n = 6) with histories of moderate alcohol and marijuana use received three doses of alcohol (0, 0.6, 1.2 g/kg) and three doses of marijuana (0, 1.3, 2.7% delta 9-thc) in a double-blind, randomized crossover design. |
1989-07-18 |
2023-08-11 |
human |
| R W Foltin, M W Fischman, J V Brady, R M Capriotti, C S Emuria. The regularity of smoked marijuana self-administration. Pharmacology, biochemistry, and behavior. vol 32. issue 2. 1989-07-12. PMID:2542995. |
subjects were instructed that up to five active marijuana cigarettes (1.84% delta 9 w/w thc) could be smoked on designated days between 0945 and 2200. |
1989-07-12 |
2023-08-11 |
human |
| W D Lyman, J R Sonett, C F Brosnan, R Elkin, M B Bornstei. Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 23. issue 1. 1989-06-26. PMID:2542370. |
delta 9-tetrahydrocannabinol (thc), an active component of marijuana, has been shown to be immunosuppressive. |
1989-06-26 |
2023-08-11 |
rat |