| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S J Heishman, M L Stitzer, G E Bigelo. Alcohol and marijuana: comparative dose effect profiles in humans. Pharmacology, biochemistry, and behavior. vol 31. issue 3. 1989-07-18. PMID:2855116. |
male subjects (n = 6) with histories of moderate alcohol and marijuana use received three doses of alcohol (0, 0.6, 1.2 g/kg) and three doses of marijuana (0, 1.3, 2.7% delta 9-thc) in a double-blind, randomized crossover design. |
1989-07-18 |
2023-08-11 |
human |
| R W Foltin, M W Fischman, J V Brady, R M Capriotti, C S Emuria. The regularity of smoked marijuana self-administration. Pharmacology, biochemistry, and behavior. vol 32. issue 2. 1989-07-12. PMID:2542995. |
subjects were instructed that up to five active marijuana cigarettes (1.84% delta 9 w/w thc) could be smoked on designated days between 0945 and 2200. |
1989-07-12 |
2023-08-11 |
human |
| W D Lyman, J R Sonett, C F Brosnan, R Elkin, M B Bornstei. Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 23. issue 1. 1989-06-26. PMID:2542370. |
delta 9-tetrahydrocannabinol (thc), an active component of marijuana, has been shown to be immunosuppressive. |
1989-06-26 |
2023-08-11 |
rat |
| J E Shook, T F Burk. Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. The Journal of pharmacology and experimental therapeutics. vol 249. issue 2. 1989-06-26. PMID:2542532. |
these data indicate that delta 9-thc, delta 9,11-thc, cannabinol and nabilone (but not cannabidiol) exert an inhibitory effect on gi transit and motility in rats. |
1989-06-26 |
2023-08-11 |
mouse |
| A J Hiltunen, T U Järbe, M R Kamkar, T Arche. Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination. Neuropharmacology. vol 28. issue 2. 1989-06-20. PMID:2541367. |
behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination. |
1989-06-20 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järbe, M R Kamkar, T Arche. Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination. Neuropharmacology. vol 28. issue 2. 1989-06-20. PMID:2541367. |
the animals were then tested with delta 1-tetrahydrocannabinol (delta 1-thc), cannabinol, and cannabidiol alone and in combination. |
1989-06-20 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järbe, M R Kamkar, T Arche. Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination. Neuropharmacology. vol 28. issue 2. 1989-06-20. PMID:2541367. |
tests with single doses of delta 1-thc (dose-range: 0.3-5.6 mg/kg) and cannabinol (dose-range: 1-56 mg/kg) but not cannabidiol (dose-range 3-100 mg/kg), yielded a dose-related biphasic effect on the response rate. |
1989-06-20 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järbe, M R Kamkar, T Arche. Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination. Neuropharmacology. vol 28. issue 2. 1989-06-20. PMID:2541367. |
cannabidiol (10 and 30 kg/kg), together with delta 1-thc (1 and 3 mg/kg), decreased the response output and increased the rate of reinforcement. |
1989-06-20 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järbe, M R Kamkar, T Arche. Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination. Neuropharmacology. vol 28. issue 2. 1989-06-20. PMID:2541367. |
hence the actions of delta 1-thc and cannabinol on behaviour in rats maintained by low rate differential reinforcement were similar (approximate difference in potency 1:10), whereas no stimulation of response rate was demonstrated with cannabidiol. |
1989-06-20 |
2023-08-11 |
rat |
| S Narimatsu, K Watanabe, I Yamamoto, H Yoshimur. Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver. Drug metabolism and disposition: the biological fate of chemicals. vol 16. issue 6. 1989-06-02. PMID:2907469. |
effects of four cannabinoids [cannabidiol (cbd), delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol, and cannabinol] on hepatic microsomal oxidation of testosterone (17 beta-hydroxy-androst-4-ene-3-one) were examined in adult male rats. |
1989-06-02 |
2023-08-11 |
rat |
| E L Gardner, W Paredes, D Smith, A Donner, C Milling, D Cohen, D Morriso. Facilitation of brain stimulation reward by delta 9-tetrahydrocannabinol. Psychopharmacology. vol 96. issue 1. 1989-04-05. PMID:2852376. |
the present experiment explored whether delta 9-tetrahydrocannabinol (delta 9-thc), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by electrical intracranial self-stimulation (icss). |
1989-04-05 |
2023-08-11 |
human |
| E L Gardner, W Paredes, D Smith, A Donner, C Milling, D Cohen, D Morriso. Facilitation of brain stimulation reward by delta 9-tetrahydrocannabinol. Psychopharmacology. vol 96. issue 1. 1989-04-05. PMID:2852376. |
delta 9-thc, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered icss thresholds, suggesting that marijuana acts on similar cns hedonic systems to most other drugs of abuse. |
1989-04-05 |
2023-08-11 |
human |
| R W Foltin, M W Fischman, M F Byrn. Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite. vol 11. issue 1. 1989-04-05. PMID:3228283. |
two cigarettes containing active marijuana (2.3% delta 9 thc) or placebo were smoked during both the private work period and the period of access to social activities. |
1989-04-05 |
2023-08-11 |
human |
| H N Bhargava, A Gulat. Selective inhibition of the binding of 3H-(3-MeHis2) thyrotropin releasing hormone to rat amygdala membranes by some naturally occurring cannabinoids. Peptides. vol 9. issue 4. 1989-04-04. PMID:2852360. |
the effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (thc), cannabinol (cbn) and cannabidiol (cbd), on the brain receptors for thyrotropin releasing hormone (trh) was investigated. |
1989-04-04 |
2023-08-11 |
rat |
| M Reichman, W Nen, L E Hoki. Delta 9-tetrahydrocannabinol increases arachidonic acid levels in guinea pig cerebral cortex slices. Molecular pharmacology. vol 34. issue 6. 1989-01-23. PMID:2849049. |
the relative rank-order of potencies in the cannabinoid series we examined were (-)-thc = (+)-thc greater than cannabinol greater than delta 8-thc greater than cannabidiol. |
1989-01-23 |
2023-08-11 |
Not clear |
| R M Capriotti, R W Foltin, J V Brady, M W Fischma. Effects of marijuana on the task-elicited physiological response. Drug and alcohol dependence. vol 21. issue 3. 1988-11-17. PMID:2844492. |
ten healthy male marijuana users smoked either a placebo or active (1.8% delta 9-thc) marijuana cigarette during five daily testing sessions. |
1988-11-17 |
2023-08-11 |
human |
| R W Foltin, M W Fischma. Effects of smoked marijuana on human social behavior in small groups. Pharmacology, biochemistry, and behavior. vol 30. issue 2. 1988-11-01. PMID:3174786. |
four cigarettes containing active marijuana (2.7% delta 9-thc w/w) or placebo were smoked daily: two during the work period, and two during the social access period. |
1988-11-01 |
2023-08-11 |
human |
| E Johansson, S Agurell, L E Hollister, M M Halldi. Prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users. The Journal of pharmacy and pharmacology. vol 40. issue 5. 1988-09-08. PMID:2899638. |
prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users. |
1988-09-08 |
2023-08-11 |
human |
| E Johansson, S Agurell, L E Hollister, M M Halldi. Prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users. The Journal of pharmacy and pharmacology. vol 40. issue 5. 1988-09-08. PMID:2899638. |
the aim of this study was to characterize the elimination half-life of delta 1-tetrahydrocannabinol in blood plasma in chronic marijuana users. |
1988-09-08 |
2023-08-11 |
human |
| E Johansson, S Agurell, L E Hollister, M M Halldi. Prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users. The Journal of pharmacy and pharmacology. vol 40. issue 5. 1988-09-08. PMID:2899638. |
albeit the present results are based upon a small sample, an elimination half-life of delta 1-tetrahydrocannabinol in blood plasma of about 4 days is more in line with apparent half-life excretion of delta 1-tetrahydrocannabinol metabolites in the urine of chronic marijuana smokers. |
1988-09-08 |
2023-08-11 |
human |