| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Campbell, T C Foster, R E Hampson, S A Deadwyle. delta 9-Tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus. The Journal of pharmacology and experimental therapeutics. vol 239. issue 3. 1987-01-30. PMID:3025423. |
the results demonstrate that low doses of delta 9-thc distort behaviorally relevant sensory information converging on the dentate gyrus and support the hypothesis that the psychoactive effects of marijuana may be mediated by action within the hippocampus. |
1987-01-30 |
2023-08-11 |
rat |
| T U Järbe, A J Hiltunen, N Lander, R Mechoula. Cannabimimetic activity (delta 1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons. Pharmacology, biochemistry, and behavior. vol 25. issue 2. 1986-11-21. PMID:3020594. |
cannabimimetic activity (delta 1-thc cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons. |
1986-11-21 |
2023-08-11 |
rat |
| T U Järbe, A J Hiltunen, N Lander, R Mechoula. Cannabimimetic activity (delta 1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons. Pharmacology, biochemistry, and behavior. vol 25. issue 2. 1986-11-21. PMID:3020594. |
animals (rats and pigeons) trained to discriminate between the presence and absence of the effects of delta 1-tetrahydrocannabinol (delta 1-thc; 3 and 0.56 mg/kg, respectively) were tested for generalization with graded doses of delta 1-thc as well as with two 7-hydroxyhexahydrocannabinol epimers which differ in the stereochemistry at the c-1 position only, and a cannabidiol (cbd)-like compound, cannabidiol monomethyl ether (cbdm). |
1986-11-21 |
2023-08-11 |
rat |
| L L Murphy, L Tyre. Induction of luteinizing hormone release by electrochemical stimulation of the medial preoptic area in delta 9-tetrahydrocannabinol-blocked proestrous rats. Neuroendocrinology. vol 43. issue 4. 1986-10-06. PMID:3018608. |
the predominant psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol (thc), blocks the preovulatory luteinizing hormone (lh) surge and ovulation in rats treated with thc (10 mg/kg body weight) during the early afternoon of proestrus. |
1986-10-06 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järb. Cannabidiol attenuates delta 9-tetrahydrocannabinol-like discriminative stimulus effects of cannabinol. European journal of pharmacology. vol 125. issue 2. 1986-10-02. PMID:3017729. |
cannabidiol attenuates delta 9-tetrahydrocannabinol-like discriminative stimulus effects of cannabinol. |
1986-10-02 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järb. Cannabidiol attenuates delta 9-tetrahydrocannabinol-like discriminative stimulus effects of cannabinol. European journal of pharmacology. vol 125. issue 2. 1986-10-02. PMID:3017729. |
interaction effects of cannabidiol (cbd) and cannabinol (cbn) were examined using a drug discrimination procedure in which rats had been trained to discriminate between 3 mg/kg of delta 9-tetrahydrocannabinol (delta 9-thc) and vehicle (2 ml/kg). |
1986-10-02 |
2023-08-11 |
rat |
| C J Hillard, A S Bloom, M D Housla. Effects of delta 9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes. Biochemical pharmacology. vol 35. issue 16. 1986-09-17. PMID:3017362. |
delta-tetrahydrocannabinol (delta 9-thc), the principal psychoactive constituent of cannabis sativa, was found to increase glucagon activation of liver plasma membrane adenylate cyclase. |
1986-09-17 |
2023-08-11 |
rat |
| C J Hillard, A S Bloom, M D Housla. Effects of delta 9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes. Biochemical pharmacology. vol 35. issue 16. 1986-09-17. PMID:3017362. |
11-oh-delta 9-thc, a psychoactive metabolite of delta 9-thc, also increased glucagon activation of adenylate cyclase while two cannabinoids without marihuana-like psychoactive potency, cannabinol and cannabidiol, did not. |
1986-09-17 |
2023-08-11 |
rat |
| S Dalterio, P J Thomford, S D Michael, L DeAngelo, D Mayfiel. Perinatal cannabinoid exposure: effects on hepatic cytochrome P-450 and plasma protein levels in male mice. Teratology. vol 33. issue 2. 1986-09-16. PMID:3016935. |
maternal exposure to the major psychoactive delta 9-tetrahydrocannabinol (thc), or to the nonpsychoactive cannabinol (cbn) or cannabidiol (cbd) on day 12 of gestation, or on day 1 postpartum, affected the concentrations of hepatic cytochromes p-450 in adult male offspring. |
1986-09-16 |
2023-08-11 |
mouse |
| S Ferri, E Cavicchini, P Romualdi, E Speroni, G Murar. Possible mediation of catecholaminergic pathways in the antinociceptive effect of an extract of Cannabis sativa L. Psychopharmacology. vol 89. issue 2. 1986-08-14. PMID:3088644. |
possible mediation of catecholaminergic pathways in the antinociceptive effect of an extract of cannabis sativa l. an extract of cannabis (5 and 15 mg/kg expressed as delta 9-thc) orally administered to rats caused an elevation of the nociceptive threshold (tail-flick latency and vocalization tests). |
1986-08-14 |
2023-08-11 |
rat |
| G Cortis, P Luchi, M Palma. Experimental cultivation of cannabis plants in the Mediterranean area. Bulletin on narcotics. vol 37. issue 4. 1986-07-15. PMID:3011161. |
in research carried out in 1982, which included the cultivation of cannabis plants with low, medium and high levels of delta 9-tetrahydrocannabinol (thc), the authors have determined the parameters for individualization and classification of cannabis plants according to their intoxicant potential. |
1986-07-15 |
2023-08-11 |
Not clear |
| S Felby, E Nielse. Cannabinoid content of cannabis grown on the Danish island of Bornholm. Bulletin on narcotics. vol 37. issue 4. 1986-07-15. PMID:3011164. |
the analysis in 1983 of representative samples taken from fruiting tops of seized cannabis plants illicitly grown in 19 localities on the danish island of bornholm showed that the average (mean) content of the total tetrahydrocannabinol (delta 9-tetrahydrocannabinol (thc) + delta 9-tetrahydrocannabinolic acid) was approximately 1.55 per cent, ranging from 0.1 to 4.2 per cent. |
1986-07-15 |
2023-08-11 |
Not clear |
| K Watanabe, K Hamajima, S Narimatsu, I Yamamoto, H Yoshimur. Effects of two cannabinoids on hepatic microsomal cytochrome P-450. Journal of pharmacobio-dynamics. vol 9. issue 1. 1986-07-02. PMID:3012058. |
the effects of cannabidiol (cbd) and delta 9-tetrahydrocannabinol (delta 9-thc) on the synthesis and degradation of hepatic microsomal cytochrome p-450 were studied in mice. |
1986-07-02 |
2023-08-11 |
mouse |
| M E Alburges, M A Pea. Profiles of delta 9-tetrahydrocannabinol metabolites in urine of marijuana users: preliminary observations by high performance liquid chromatography-radioimmunoassay. Journal of forensic sciences. vol 31. issue 2. 1986-06-27. PMID:3011957. |
profiles of delta 9-tetrahydrocannabinol metabolites in urine of marijuana users: preliminary observations by high performance liquid chromatography-radioimmunoassay. |
1986-06-27 |
2023-08-11 |
Not clear |
| L J McBurney, B A Bobbie, L A Sep. GC/MS and EMIT analyses for delta 9-tetrahydrocannabinol metabolites in plasma and urine of human subjects. Journal of analytical toxicology. vol 10. issue 2. 1986-05-23. PMID:3009969. |
ten male subjects smoked placebo marijuana cigarettes spiked with delta 9-tetrahydrocannabinol (thc) at 150 micrograms/kg body weight. |
1986-05-23 |
2023-08-11 |
human |
| A J Hiltunen, T U Järb. Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons. Neuropharmacology. vol 25. issue 2. 1986-05-23. PMID:3010159. |
interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons. |
1986-05-23 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järb. Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons. Neuropharmacology. vol 25. issue 2. 1986-05-23. PMID:3010159. |
the repeated tests procedure was then used to evaluate combinations of delta 9-thc and cannabidiol in both species. |
1986-05-23 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järb. Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons. Neuropharmacology. vol 25. issue 2. 1986-05-23. PMID:3010159. |
cannabidiol prolonged the cue effects of 1 mg/kg of delta 9-thc (intraperitoneal route of administration) in rats but did not change the time-effect curve for delta 9-thc in pigeons (dose range examined: 0.10--0.56 mg/kg); the challenge doses of cannabidiol were, respectively: 30.0 mg/kg (i.p.) |
1986-05-23 |
2023-08-11 |
rat |
| A J Hiltunen, T U Järb. Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons. Neuropharmacology. vol 25. issue 2. 1986-05-23. PMID:3010159. |
the rate of responding did not differ in tests with combinations of delta 9-thc and cannabidiol as compared to delta 9-thc given alone in pigeons. |
1986-05-23 |
2023-08-11 |
rat |
| G Nahas, R Trouv. Effects and interactions of natural cannabinoids on the isolated heart. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 180. issue 2. 1985-11-20. PMID:4048169. |
cardiac toxicity is observed with 3 x 10(-5) m. cannabidiol (cbd) at concentrations of 9 x 10(-6) m to 10(-4) m has limited effect on rate while increasing delta p and coronary flow. |
1985-11-20 |
2023-08-11 |
rat |