| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Blanc, V A Manneh, R Ernst, D E Berger, S A de Keczer, C Chase, J M Centofanti, A J DeLizz. Adsorption losses from urine-based cannabinoid calibrators during routine use. Clinical chemistry. vol 39. issue 8. 1993-09-23. PMID:8394791. |
the major metabolite of cannabis found in urine, 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (delta 9-thc), is the compound most often used to calibrate cannabinoid immunoassays. |
1993-09-23 |
2023-08-12 |
Not clear |
| S Y Nah, D Saya, Z Voge. Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8102606. |
addition of cannabinoids, such as delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol or the psychoinactive cannabidiol inhibited formation of inositol phosphates evoked by carbachol, glutamate or norepinephrine by 55-90%. |
1993-09-17 |
2023-08-12 |
rat |
| S Y Nah, D Saya, Z Voge. Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8102606. |
ic50 values for delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol and cannabidiol were 9.6 +/- 1.0, 9.7 +/- 0.3 and 7.9 +/- 0.4 microm, respectively. |
1993-09-17 |
2023-08-12 |
rat |
| A S Freeman, B R Marti. Quantification of phencyclidine in mainstream smoke and identification of phenylcyclohex-1-ene as pyrolysis product. Journal of pharmaceutical sciences. vol 70. issue 9. 1993-04-21. PMID:6101140. |
the recovery of unchanged [3h]-delta 9-tetrahydrocannabinol from placebo marijuana cigarettes injected with a solution containing 3 mg of delta 9-tetrahydrocannabinol was 60%. |
1993-04-21 |
2023-08-12 |
Not clear |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana. Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338215. |
delta 9-tetrahydrocannabinol (thc), the primary psychoactive constituent of marijuana, is rapidly transferred from lungs to blood during smoking. |
1993-04-15 |
2023-08-11 |
human |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. II. Models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH) Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338216. |
models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (thc) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (thccooh) two mathematical models are described for the prediction of time of marijuana use from the analysis of a single plasma sample for cannabinoids. |
1993-04-15 |
2023-08-11 |
Not clear |
| D B Houston, A C Howlet. Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins. Molecular pharmacology. vol 43. issue 1. 1993-02-23. PMID:8423766. |
the order of potency for cannabinoid agonists in heterologous equilibrium binding studies was cp-55244 > or = desacetyllevonantradol > delta 9-tetrahydrocannabinol > cannabinol >> cannabidiol, consistent with the relative affinities for these agonists in brain membrane preparations. |
1993-02-23 |
2023-08-12 |
rat |
| R J Mathew, W H Wilson, D F Humphreys, J V Lowe, K E Wieth. Regional cerebral blood flow after marijuana smoking. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 12. issue 5. 1992-09-21. PMID:1324250. |
blood samples were drawn for quantification of plasma levels of delta 9-tetrahydrocannabinol (thc) before and during the 2 h after smoking marijuana or placebo. |
1992-09-21 |
2023-08-11 |
human |
| P Kelly, R T Jone. Metabolism of tetrahydrocannabinol in frequent and infrequent marijuana users. Journal of analytical toxicology. vol 16. issue 4. 1992-09-17. PMID:1323733. |
delta 9-tetrahydrocannabinol (thc), 11-nor-9-carboxy-delta 9- tetrahydrocannabinol (thc-cooh), and its o-ester glucuronide were measured in plasma by gc/ms and in urine by gc/ms and enzyme immunoassay after frequent and infrequent marijuana users were given 5 mg thc intravenously. |
1992-09-17 |
2023-08-11 |
Not clear |
| L D Chait, J P Zacn. Reinforcing and subjective effects of oral delta 9-THC and smoked marijuana in humans. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1319601. |
reinforcing and subjective effects of oral delta 9-thc and smoked marijuana in humans. |
1992-07-30 |
2023-08-11 |
human |
| K Fischer-Stenger, A W Updegrove, G A Cabra. Delta 9-tetrahydrocannabinol decreases cytotoxic T lymphocyte activity to herpes simplex virus type 1-infected cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 200. issue 3. 1992-07-24. PMID:1319584. |
the purpose of this study was to examine the effect of delta 9-tetrahydrocannabinol (delta 9-thc), the major psychoactive component of marijuana, on t lymphocyte functional competence against herpes simplex virus type 1 (hsv1) infection. |
1992-07-24 |
2023-08-11 |
mouse |
| K Mackie, B Hill. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 9. 1992-05-28. PMID:1315042. |
the psychoactive properties of cannabis sativa and its major biologically active constituent, delta 9-tetrahydrocannabinol, have been known for years. |
1992-05-28 |
2023-08-11 |
Not clear |
| D P Tashkin, F Gliederer, J Rose, P Chang, K K Hui, J L Yu, T C W. Tar, CO and delta 9THC delivery from the 1st and 2nd halves of a marijuana cigarette. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1666924. |
tar, co and delta 9thc delivery from the 1st and 2nd halves of a marijuana cigarette. |
1992-05-14 |
2023-08-11 |
human |
| E L Gardner, J H Lowinso. Marijuana's interaction with brain reward systems: update 1991. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806947. |
it is now clear, however, that delta 9-tetrahydrocannabinol (delta 9-thc), marijuana's principal psychoactive constituent, acts on these brain reward substrates in strikingly similar fashion to noncannabinoid drugs of abuse. |
1992-05-14 |
2023-08-11 |
Not clear |
| J L Azorlosa, S J Heishman, M L Stitzer, J M Mahaffe. Marijuana smoking: effect of varying delta 9-tetrahydrocannabinol content and number of puffs. The Journal of pharmacology and experimental therapeutics. vol 261. issue 1. 1992-05-12. PMID:1313866. |
marijuana smoking: effect of varying delta 9-tetrahydrocannabinol content and number of puffs. |
1992-05-12 |
2023-08-11 |
human |
| J L Azorlosa, S J Heishman, M L Stitzer, J M Mahaffe. Marijuana smoking: effect of varying delta 9-tetrahydrocannabinol content and number of puffs. The Journal of pharmacology and experimental therapeutics. vol 261. issue 1. 1992-05-12. PMID:1313866. |
the purpose of this study was to determine marijuana dose-effects on subjective and performance measures over a wider dosage range than previously reported using technology which allowed for specification of both the volume and delta 9-tetrahydrocannabinol (thc) content of smoke delivered, and to relate these effects to plasma thc levels. |
1992-05-12 |
2023-08-11 |
human |
| G Nahas, C Latou. The human toxicity of marijuana. The Medical journal of Australia. vol 156. issue 7. 1992-05-04. PMID:1313532. |
in animals, marijuana or delta 9-tetrahydrocannabinol (thc), the intoxicating material it contains, produces symptoms of neurobehavioural toxicity, disrupts all phases of gonadal or reproductive function, and is fetotoxic. |
1992-05-04 |
2023-08-11 |
human |
| R L Balster, W R Prescot. Delta 9-tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neuroscience and biobehavioral reviews. vol 16. issue 1. 1992-04-24. PMID:1313164. |
delta 9-tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. |
1992-04-24 |
2023-08-11 |
rat |
| R L Balster, W R Prescot. Delta 9-tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neuroscience and biobehavioral reviews. vol 16. issue 1. 1992-04-24. PMID:1313164. |
this concordance provides evidence for the validity of delta 9-thc discrimination in rats as an animal model of cannabis intoxication. |
1992-04-24 |
2023-08-11 |
rat |
| G A Cabral, R Vasque. delta 9-Tetrahydrocannabinol suppresses macrophage extrinsic antiherpesvirus activity. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 199. issue 2. 1992-03-24. PMID:1311105. |
the effect of delta 9-tetrahydrocannabinol (thc), the major psychoactive component of marijuana, on macrophage intrinsic and extrinsic antiherpesvirus activities was examined. |
1992-03-24 |
2023-08-11 |
Not clear |