| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Navarro, P Rubio, F R de Fonsec. Behavioural consequences of maternal exposure to natural cannabinoids in rats. Psychopharmacology. vol 122. issue 1. 1996-09-11. PMID:8711059. |
behavioral consequences of maternal exposure to either cannabis preparations or to its main psychoactive component, delta 9-tetrahydrocannabinol (thc) in rat models are reviewed in this paper. |
1996-09-11 |
2023-08-12 |
rat |
| M Lepore, X Liu, V Savage, D Matalon, E L Gardne. Genetic differences in delta 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains. Life sciences. vol 58. issue 25. 1996-07-22. PMID:8649214. |
once reward thresholds were stable, rats were given 1.0 mg/kg delta 9-tetrahydrocannabinol (delta 9-thc), the psychoactive constituent in marijuana and hashish, or vehicle, by intraperitoneal injection. |
1996-07-22 |
2023-08-12 |
rat |
| V Bianchi, G Donzell. Rapid reversed-phase high-performance liquid chromatographic method for the assay of urinary 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid and confirmation of use of cannabis derivatives. Journal of chromatography. B, Biomedical applications. vol 675. issue 1. 1996-07-11. PMID:8634759. |
the main active cannabis (marijuana and hashish) derivative delta 9-tetrahydrocannabinol is, in vivo, transformed and excreted mainly as 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (thc-cooh) and its glucuronide. |
1996-07-11 |
2023-08-12 |
human |
| J Romero, E García-Palomero, S Y Lin, J A Ramos, A Makriyannis, J J Fernández-Rui. Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand. Life sciences. vol 58. issue 15. 1996-06-03. PMID:8614278. |
recent evidence has demonstrated that arachidonylethanolamide ("anandamide", aea), the major endogenous ligand of cb1 receptors, inhibits motor behavior in rats, as does (-)delta 9-tetrahydrocannabinol (thc), the prototypical tricyclic cannabinoid derived from cannabis sativa preparations. |
1996-06-03 |
2023-08-12 |
rat |
| G Pugh, M E Abood, S P Welc. Antisense oligodeoxynucleotides to the kappa-1 receptor block the antinociceptive effects of delta 9-THC in the spinal cord. Brain research. vol 689. issue 1. 1996-01-30. PMID:8528701. |
intrathecal pretreatment of mice with an antisense oligodeoxynucleotide directed against the kappa-1 receptor significantly reduced the antinociceptive effects of the kappa receptor agonist u50,488 as well as delta 9-thc, the major psychoactive ingredient found in cannabis. |
1996-01-30 |
2023-08-12 |
mouse |
| M D Aceto, S M Scates, J A Lowe, B R Marti. Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A. European journal of pharmacology. vol 282. issue 1-3. 1996-01-18. PMID:7498260. |
precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, sr 141716a (n-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1h-pyrazole carboxamide.hcl). |
1996-01-18 |
2023-08-12 |
rat |
| P M Kemp, I K Abukhalaf, J E Manno, B R Manno, D D Alford, M E McWilliams, F E Nixon, M J Fitzgerald, R R Reeves, M J Woo. Cannabinoids in humans. II. The influence of three methods of hydrolysis on the concentration of THC and two metabolites in urine. Journal of analytical toxicology. vol 19. issue 5. 1996-01-16. PMID:7500615. |
human volunteers (n = 8) each smoked one marijuana cigarette containing 3.58% delta 9-tetrahydrocannabinol (thc) and submitted urine samples prior to smoking, 5 min after smoking, and hourly for 8 h thereafter. |
1996-01-16 |
2023-08-12 |
human |
| M Szirmai, M M Halldi. A urinary metabolite of delta 1-tetrahydrocannabinol. The first synthesis of 4",5"-bisnor-delta 1-tetrahydrocannabinol-7,3"-dioic acid, and a deuterium labelled analogue. Bioorganic & medicinal chemistry. vol 3. issue 7. 1995-12-28. PMID:7582966. |
the first synthesis of unlabelled and [2h5]-labelled 4",5"-bisnor-delta 1-thc-7,3"-dioic acid, the major dicarboxylated urinary metabolite of delta 1-thc in man, is presented (preliminary results of this work have been presented in part at the melbourne symposium on cannabis, australia, september 1987, ref. |
1995-12-28 |
2023-08-12 |
Not clear |
| G Petri, S Nyiredy, P Veszki, P Oroszlán, G Turiá. [Gas chromatographic analysis of cannabinoids on tandem columns]. Acta pharmaceutica Hungarica. vol 65. issue 3. 1995-10-24. PMID:7572186. |
the psychotropic cannabinoids delta 1-tetrahydrocannabinol (delta 1-thc) and delta 1(6)-tetrahydrocannabionol (delta 1(6)-thc), as well as, their main metabolites cannabidiol (cbd) and cannabichromene (cbc) were baseline separated except the cannabigerol (cbg) and cannabinol (cbn) pair, however for these compounds the separation was also satisfactory for the quantitative determinations. |
1995-10-24 |
2023-08-12 |
Not clear |
| D Burnette-Curley, G A Cabra. Differential inhibition of RAW264.7 macrophage tumoricidal activity by delta 9tetrahydrocannabinol. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 210. issue 1. 1995-10-19. PMID:7675800. |
delta 9tetrahydrocannabinol (thc), the major psychoactive component of marijuana, has been shown to inhibit macrophage cell contact-dependent cytolysis of tumor cells. |
1995-10-19 |
2023-08-12 |
mouse |
| Y Daaka, T W Klein, H Friedma. Expression of cannabinoid receptor mRNA in murine and human leukocytes. Advances in experimental medicine and biology. vol 373. 1995-10-12. PMID:7545349. |
delta 9-tetrahydrocannabinol, the major psychoactive cannabinoid of marijuana modulates immune cells in vivo and in vitro. |
1995-10-12 |
2023-08-12 |
mouse |
| F R Rodríguez de Fonseca, M A Villanúa, R M Muñoz, O San-Martin-Clark, M Navarr. Differential effects of chronic treatment with either dopamine D1 or D2 receptor agonists on the acute neuroendocrine actions of the highly potent synthetic cannabinoid HU-210 in male rats. Neuroendocrinology. vol 61. issue 6. 1995-10-04. PMID:7659195. |
acute exposure to delta 9-tetrahydrocannabinol (thc), the main psychoactive constituent of marijuana, produces a well-characterized set of neuroendocrine effects. |
1995-10-04 |
2023-08-12 |
rat |
| J M Derocq, M Ségui, J Marchand, G Le Fur, P Casella. Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS letters. vol 369. issue 2-3. 1995-09-22. PMID:7544292. |
the two synthetic cannabinoids, cp55,940 and win55212-2, as well as delta 9-tetrahydrocannabinol (thc), the psychoactive component of marijuana, caused a dose-dependent increase of b-cell proliferation and displayed ec50 at low nanomolar concentrations. |
1995-09-22 |
2023-08-12 |
human |
| T W Klein, C Newton, W Zhu, Y Daaka, H Friedma. delta 9-Tetrahydrocannabinol, cytokines, and immunity to Legionella pneumophila. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 209. issue 3. 1995-07-13. PMID:7777582. |
the major psychoactive component of marijuana, delta 9-tetrahydrocannabinol (thc), has been shown to suppress the functions of various immune cells. |
1995-07-13 |
2023-08-12 |
Not clear |
| M Lepore, S R Vorel, J Lowinson, E L Gardne. Conditioned place preference induced by delta 9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward. Life sciences. vol 56. issue 23-24. 1995-07-11. PMID:7776834. |
the rewarding property of delta 9-tetrahydrocannabinol (thc), the psychoactive constituent of marijuana and hashish, was studied using the conditioned place preference paradigm, and compared to that of cocaine, morphine, and food reward. |
1995-07-11 |
2023-08-12 |
Not clear |
| S K Das, B C Paria, I Chakraborty, S K De. Cannabinoid ligand-receptor signaling in the mouse uterus. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 10. 1995-06-16. PMID:7753807. |
the psychoactive cannabinoid component of marijuana--delta 9-tetrahydrocannabinol (thc)--or anandamide, but not the inactive and nonpsychoactive cannabidiol (cbd), inhibited forskolin-stimulated cyclic amp formation in the mouse uterus, which was prevented by pertussis toxin pretreatment. |
1995-06-16 |
2023-08-12 |
mouse |
| T H Kelly, R W Foltin, M T Mayr, M W Fischma. Effects of delta 9-tetrahydrocannabinol and social context on marijuana self-administration by humans. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862735. |
effects of delta 9-tetrahydrocannabinol and social context on marijuana self-administration by humans. |
1995-03-22 |
2023-08-12 |
human |
| T H Kelly, R W Foltin, M T Mayr, M W Fischma. Effects of delta 9-tetrahydrocannabinol and social context on marijuana self-administration by humans. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862735. |
up to eight marijuana cigarettes (0.0% or 2.3% delta 9-thc) could be smoked each day. |
1995-03-22 |
2023-08-12 |
human |
| I Wirguin, R Mechoulam, A Breuer, E Schezen, J Weidenfeld, T Brenne. Suppression of experimental autoimmune encephalomyelitis by cannabinoids. Immunopharmacology. vol 28. issue 3. 1995-03-16. PMID:7852052. |
delta 8-thc is an analogue of delta 9-thc, the psychoactive component of marijuana. |
1995-03-16 |
2023-08-12 |
rat |
| J L Azorlosa, M K Greenwald, M L Stitze. Marijuana smoking: effects of varying puff volume and breathhold duration. The Journal of pharmacology and experimental therapeutics. vol 272. issue 2. 1995-03-15. PMID:7853169. |
each study also varied levels of delta 9-tetrahydro-cannabinol marijuana cigarette content (1.75% and 3.55%). |
1995-03-15 |
2023-08-12 |
human |