| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H H Szeto, D L Wu, J A Decena, Y Chen. Effects of single and repeated marijuana smoke exposure on fetal EEG. Pharmacology, biochemistry, and behavior. vol 40. issue 1. 1992-03-10. PMID:1780352. |
maternal inhalation of marijuana smoke (n = 9) resulted in a significant reduction in total power and power distribution in the delta (1-4 hz) band, and an increase in power distribution in the faster frequencies in the first h after smoke inhalation. |
1992-03-10 |
2023-08-11 |
Not clear |
| D R Compton, M R Johnson, L S Melvin, B R Marti. Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents. The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1309872. |
opening of the pyran ring of delta 9-tetrahydrocannabinol (thc) produces cannabidiol, a bicyclic cannabinoid devoid of many pharmacological properties produced by delta 8-thc or delta 9-thc. |
1992-02-18 |
2023-08-11 |
mouse |
| D R Compton, M R Johnson, L S Melvin, B R Marti. Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents. The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1309872. |
a series of 16 bicyclic analogs of vi and xiv were evaluated and compared with the pharmacological profile of cannabidiol, delta 8-thc and delta 9-thc. |
1992-02-18 |
2023-08-11 |
mouse |
| S Specter, G Lancz, D Goodfello. Suppression of human macrophage function in vitro by delta 9-tetrahydrocannabinol. Journal of leukocyte biology. vol 50. issue 5. 1992-01-23. PMID:1660911. |
the ability of macrophages to function in the presence of delta 9-tetrahydrocannabinol (thc), the major psychoactive component in marijuana, was evaluated. |
1992-01-23 |
2023-08-11 |
human |
| J C Eldridge, L L Murphy, P W Landfiel. Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance. Steroids. vol 56. issue 5. 1991-09-24. PMID:1652167. |
it has long been recognized that cannabinoids, including delta 9-tetrahydrocannabinol (thc), the major psychoactive substance of marijuana, bear structural similarities to steroid hormones. |
1991-09-24 |
2023-08-11 |
rat |
| T M Westlake, A C Howlett, S F Ali, M G Paule, A C Scallet, W Slikke. Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors. Brain research. vol 544. issue 1. 1991-08-29. PMID:1649662. |
the effects of chronic delta 9-tetrahydrocannabinol (delta 9-thc) and marijuana administration on the properties of brain cannabinoid receptor populations of the rat and monkey, respectively, were examined in this study. |
1991-08-29 |
2023-08-11 |
rat |
| H Schuel, D Berkery, R Schuel, M C Chang, A M Zimmerman, S Zimmerma. Reduction of the fertilizing capacity of sea urchin sperm by cannabinoids derived from marihuana. I. Inhibition of the acrosome reaction induced by egg jelly. Molecular reproduction and development. vol 29. issue 1. 1991-07-31. PMID:1647172. |
delta 9-tetrahydrocannabinol (thc) and two other major cannabinoids derived from marihuana--cannabidiol (cbd) and cannabinol (cbn)--inhibit fertilization in the sea urchin strongylocentrotus purpuratus by reducing the fertilizing capacity of sperm (schuel et al., 1987). |
1991-07-31 |
2023-08-11 |
Not clear |
| L L Murphy, F Rodriguez de Fonseca, R W Stege. delta 9-Tetrahydrocannabinol antagonism of the anterior pituitary response to estradiol in immature female rats. Steroids. vol 56. issue 2. 1991-05-30. PMID:1850566. |
the potential estrogenicity or antiestrogenicity of delta 9-tetrahydrocannabinol (thc), the chief psychoactive constituent of marijuana, was evaluated in immature female rats treated for 3 days with estradiol (e2; 1 microgram/kg), thc (10 mg/kg body weight), or e2 + thc. |
1991-05-30 |
2023-08-11 |
rat |
| S J Heishman, M A Huestis, J E Henningfield, E J Con. Acute and residual effects of marijuana: profiles of plasma THC levels, physiological, subjective, and performance measures. Pharmacology, biochemistry, and behavior. vol 37. issue 3. 1991-05-23. PMID:1965045. |
three experienced marijuana smokers participated in four 2-day experimental sessions in which they smoked either 0, 1, or 2 marijuana cigarettes containing 2.57% delta 9-tetrahydrocannabinol (thc) at two different times on the first day. |
1991-05-23 |
2023-08-11 |
human |
| J Chen, W Paredes, J H Lowinson, E L Gardne. Delta 9-tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex. European journal of pharmacology. vol 190. issue 1-2. 1991-04-22. PMID:1963849. |
these data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic da mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for delta 9-thc in particular. |
1991-04-22 |
2023-08-11 |
rat |
| J P Chen, W Paredes, J Li, D Smith, J Lowinson, E L Gardne. Delta 9-tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Psychopharmacology. vol 102. issue 2. 1991-02-26. PMID:2177204. |
this study examined the effects of acute administration of delta-9-tetrahydrocannabinol (delta 9-thc), the psychoactive ingredient in marijuana, on extracellular efflux of dopamine (da) and its metabolites as measured by in vivo microdialysis in nucleus accumbens of conscious, freely-moving rats. |
1991-02-26 |
2023-08-11 |
rat |
| L L Murphy, R W Steger, M S Smith, A Bartk. Effects of delta-9-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combinations, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat. Neuroendocrinology. vol 52. issue 4. 1991-02-07. PMID:1979838. |
the acute effects of low oral doses of delta 9-tetrahydrocannabinol (thc), cannabinol (cbn) and cannabidiol (cbd) administered alone or in combinations on lh and prolactin (prl) secretion and on hypothalamic norepinephrine (ne), dopamine (da) and serotonin (5-ht) dynamics were examined in adult male rats. |
1991-02-07 |
2023-08-11 |
rat |
| V Rettori, M C Aguila, M F Gimeno, A M Franchi, S M McCan. In vitro effect of delta 9-tetrahydrocannabinol to stimulate somatostatin release and block that of luteinizing hormone-releasing hormone by suppression of the release of prostaglandin E2. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 24. 1991-02-07. PMID:1979873. |
previous in vivo studies have shown that delta 9-tetrahydrocannabinol (thc), the principal active ingredient in marijuana, can suppress both luteinizing hormone (lh) and growth hormone (gh) secretion after its injection into the third ventricle of conscious male rats. |
1991-02-07 |
2023-08-11 |
rat |
| E K Johansson, L E Hollister, M M Halldi. Urinary elimination half-life of delta-1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking. NIDA research monograph. vol 95. 1990-09-20. PMID:2561839. |
the urinary excretion of delta 1-tetrahydrocannabinol-7-oic acid (delta 1-thc-7-oic acid), the major urinary metabolite of delta 1-thc, and the total amount of thc metabolites was studied in heavy marijuana users after smoking using high-performance liquid chromatography and the emt-d.a.u. |
1990-09-20 |
2023-08-11 |
Not clear |
| D R Compton, W L Dewey, B R Marti. Cannabis dependence and tolerance production. Advances in alcohol & substance abuse. vol 9. issue 1-2. 1990-09-05. PMID:2165734. |
this may be due to the physiochemical characteristics of cannabis or delta 9-thc, which complicates this type of animal experimentation. |
1990-09-05 |
2023-08-11 |
Not clear |
| E Johansson, H K Gillespie, M M Halldi. Human urinary excretion profile after smoking and oral administration of [14C]delta 1-tetrahydrocannabinol. Journal of analytical toxicology. vol 14. issue 3. 1990-08-30. PMID:2165199. |
the urinary excretion profiles of delta 1-tetrahydrocannabinol (delta 1-thc) metabolites have been evaluated in two chronic and two naive marijuana users after smoking and oral administration of [14c]delta 1-thc. |
1990-08-30 |
2023-08-11 |
human |
| E Johansson, H K Gillespie, M M Halldi. Human urinary excretion profile after smoking and oral administration of [14C]delta 1-tetrahydrocannabinol. Journal of analytical toxicology. vol 14. issue 3. 1990-08-30. PMID:2165199. |
however, in the chronic users the excretion profiles of delta 1-thc-7-oic acid and emit readings did not resemble the radioactive excretion due to the heavy influence from previous cannabis use. |
1990-08-30 |
2023-08-11 |
human |
| E S Onaivi, M R Green, B R Marti. Pharmacological characterization of cannabinoids in the elevated plus maze. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:2162942. |
in contrast to the effects of delta 9-thc, mice treated with cannabidiol and nabilone spent a greater amount of time in the open arm of the maze, an effect similar to that produced by diazepam, the reference anxiolytic agent. |
1990-07-31 |
2023-08-11 |
mouse |
| R W Foltin, M W Fischma. The effects of combinations of intranasal cocaine, smoked marijuana, and task performance on heart rate and blood pressure. Pharmacology, biochemistry, and behavior. vol 36. issue 2. 1990-07-20. PMID:2162543. |
following the determination of baseline cardiovascular indexes, a one-gram marijuana cigarette (0-2.9% delta 9-thc w/w) was smoked, and cocaine hydrochloride (4-96 mg) was inhaled five minutes after completion of marijuana smoking. |
1990-07-20 |
2023-08-11 |
human |
| D R Compton, P J Little, B R Martin, J W Gilman, J K Saha, V S Jorapur, H P Sard, R K Razda. Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogues of 10-substituted cannabidiol and 11- or 12-substituted delta 8-tetrahydrocannabinol. Journal of medicinal chemistry. vol 33. issue 5. 1990-05-29. PMID:2158563. |
synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogues of 10-substituted cannabidiol and 11- or 12-substituted delta 8-tetrahydrocannabinol. |
1990-05-29 |
2023-08-11 |
mouse |