| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Rakhshan, T A Day, R D Blakely, E L Barke. Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. The Journal of pharmacology and experimental therapeutics. vol 292. issue 3. 2000-03-17. PMID:10688610. |
anandamide (n-arachidonylethanolamide) is an endogenous cannabinoid that mimics the pharmacologic effects of delta(9)-tetrahydrocannabinol, the major bioactive substance in marijuana. |
2000-03-17 |
2023-08-12 |
Not clear |
| F Sporkert, F Prags. Use of headspace solid-phase microextraction (HS-SPME) in hair analysis for organic compounds. Forensic science international. vol 107. issue 1-3. 2000-03-13. PMID:10689567. |
because of the phenolic hydroxyl group a change of ph after alkaline hair digestion (by adding excess orthophosphoric acid) was necessary for the detection of delta 9-tetrahydrocannabinol (delta 9-thc), cannabinol (cbn) and cannabidiol (cbd) by hs-spme. |
2000-03-13 |
2023-08-12 |
Not clear |
| S P Welch, M Ead. Synergistic interactions of endogenous opioids and cannabinoid systems. Brain research. vol 848. issue 1-2. 2000-02-25. PMID:10612710. |
delta(9)-thc, an active constituent in marijuana, releases endogenous dynorphin a and leucine enkephalin in the production of analgesia. |
2000-02-25 |
2023-08-12 |
Not clear |
| M A ElSohly, S Feng, T P Murphy, S A Ross, A Nimrod, Z Mehmedic, N Fortne. Delta 9-tetrahydrocannabivarin (delta 9-THCV) as a marker for the ingestion of cannabis versus Marinol. Journal of analytical toxicology. vol 23. issue 3. 1999-07-26. PMID:10369334. |
delta 9-tetrahydrocannabivarin (delta 9-thcv) as a marker for the ingestion of cannabis versus marinol. |
1999-07-26 |
2023-08-12 |
Not clear |
| C S Breivogel, S R Childer. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974175. |
the effects of the primary psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol, are mediated by cannabinoid receptors, cb1 and cb2. |
1999-05-06 |
2023-08-12 |
Not clear |
| R E Hampson, S A Deadwyle. Role of cannabinoid receptors in memory storage. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974179. |
studies have shown that delta 9-tetrahydrocannabinol, the principal psychoactive ingredient in marijuana, produces memory deficits similar to those produced by neurochemical lesions of the hippocampus. |
1999-05-06 |
2023-08-12 |
Not clear |
| H Kobayashi, T Suzuki, R Kamata, S Saito, I Sato, S Tsuda, N Matsusak. Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors. The Journal of toxicological sciences. vol 24. issue 1. 1999-04-22. PMID:10073332. |
nicotine in tobacco, tetrahydrocannabinol (delta 9-thc) in marijuana and morphine in opium are well known as drugs associated with dependence or addiction. |
1999-04-22 |
2023-08-12 |
Not clear |
| H Kobayashi, T Suzuki, R Kamata, S Saito, I Sato, S Tsuda, N Matsusak. Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors. The Journal of toxicological sciences. vol 24. issue 1. 1999-04-22. PMID:10073332. |
in this article we shall review recent findings related to the neurotoxicity of tobacco, marijuana and opium, and their toxic ingredients, nicotine, delta 9-thc and morphine in relation to their respective endogenous agents and receptors in the cns. |
1999-04-22 |
2023-08-12 |
Not clear |
| T Matsunaga, K Watanabe, H Yoshimura, I Yamamot. [Quantitative analysis and pharmaco-toxicity of cannabinoids in commercially available cannabis seeds]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 118. issue 9. 1999-01-22. PMID:9779001. |
delta 9-tetrahydrocannabinol (delta 9-thc), cannabinol, cannabidiol and cannabichromene were detected in commercially available cannabis seeds by silica gel tlc and gas chromatography. |
1999-01-22 |
2023-08-12 |
mouse |
| T Matsunaga, K Watanabe, H Yoshimura, I Yamamot. [Quantitative analysis and pharmaco-toxicity of cannabinoids in commercially available cannabis seeds]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 118. issue 9. 1999-01-22. PMID:9779001. |
when the suspension prepared from the benzene washing solution of cannabis seeds, benw, was administered at a dose of 3 mg/kg corresponding to delta 9-thc into a mouse, i.v., benw caused hypothermia, catalepsy, pentobarbital-induced sleep prolongation and suppression of locomotor activity. |
1999-01-22 |
2023-08-12 |
mouse |
| M Haney, S D Comer, A S Ward, R W Foltin, M W Fischma. Factors influencing marijuana self-administration by humans. Behavioural pharmacology. vol 8. issue 2-3. 1998-12-29. PMID:9833006. |
each day at 10.00 h, participants "sampled" a marijuana cigarette containing the delta 9-thc concentration available that day, and selected the number of snack items available that day. |
1998-12-29 |
2023-08-12 |
human |
| M Haney, S D Comer, A S Ward, R W Foltin, M W Fischma. Factors influencing marijuana self-administration by humans. Behavioural pharmacology. vol 8. issue 2-3. 1998-12-29. PMID:9833006. |
these data demonstrate that: (a) delta 9-thc is an essential reinforcing component of marijuana; (b) marijuana use may be manipulated by monetary contingencies; and (c) tolerance may develop more readily to marijuana's subjective effects than its reinforcing effects. |
1998-12-29 |
2023-08-12 |
human |
| A S Ward, S D Comer, M Haney, R W Foltin, M W Fischma. The effects of a monetary alternative on marijuana self-administration. Behavioural pharmacology. vol 8. issue 4. 1998-12-15. PMID:9832987. |
three female and four male participants performed computer tasks (baseline) in the morning before smoking a sample marijuana cigarette (0.0, 1.8, or 3.9% delta 9-tetrahydrocannabinol (thc) and receiving the sample alternative ($5.00 voucher). |
1998-12-15 |
2023-08-12 |
human |
| C C Felder, M Glas. Cannabinoid receptors and their endogenous agonists. Annual review of pharmacology and toxicology. vol 38. 1998-07-14. PMID:9597153. |
both receptor types selectively bind delta 9-thc, the active principle in marijuana, and anandamide (arachidonylethanolamide), an endogenous cannabimimetic eicosanoid. |
1998-07-14 |
2023-08-12 |
mouse |
| B J Hall, M Satterfield-Doerr, A R Parikh, J S Brodbel. Determination of cannabinoids in water and human saliva by solid-phase microextraction and quadrupole ion trap gas chromatography/mass spectrometry. Analytical chemistry. vol 70. issue 9. 1998-06-16. PMID:9599579. |
solid-phase microextraction (spme) is applied to the determination of cannabidiol, delta 8-tetrahydrocannabinol (delta 8-thc), delta 9-tetrahydrocannabinol (delta 9-thc), and cannabinol in pure water and human saliva. |
1998-06-16 |
2023-08-12 |
human |
| T Lehmann, F Sager, R Brenneise. Excretion of cannabinoids in urine after ingestion of cannabis seed oil. Journal of analytical toxicology. vol 21. issue 5. 1997-12-29. PMID:9288590. |
gas chromatographic-mass spectrometric (gc-ms) quantitation of 25 cannabis sed oils determined delta 9-tetrahydrocannabinol (thc) concentrations from 3 to 1500 micrograms/g oil. |
1997-12-29 |
2023-08-12 |
human |
| M E Brewster, E Pop, R L Foltz, S Reuschel, W Griffith, S Amselem, A Biego. Clinical pharmacokinetics of escalating i.v. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers. International journal of clinical pharmacology and therapeutics. vol 35. issue 9. 1997-11-18. PMID:9314087. |
these data are similar to those reported for naturally occurring cannabinoids such as delta 9-tetrahydrocannabinol and cannabidiol. |
1997-11-18 |
2023-08-12 |
human |
| J P Goullé, P Kint. [Hair: a powerful biological marker for exposure to xenobiotics]. Annales de biologie clinique. vol 55. issue 5. 1997-11-18. PMID:9347010. |
measurement of metabolites from endogenous metabolism sign the exposure (6-monoacetylmorphine and morphine for heroin, benzoylecgonine for cocaine, delta 9-tetrahydrocannabinol carboxylic by-product for cannabis). |
1997-11-18 |
2023-08-12 |
human |
| S J Heishman, K Arasteh, M L Stitze. Comparative effects of alcohol and marijuana on mood, memory, and performance. Pharmacology, biochemistry, and behavior. vol 58. issue 1. 1997-09-30. PMID:9264076. |
male volunteers (n = 5) with histories of moderate alcohol and marijuana use were administered three doses of alcohol (0.25, 0.5, or 1.0 g/kg), three doses of marijuana [4.8, or 16 puffs of 3.55% delta 9-tetrahydrocannabinol (thc)], and placebo in random order under double blind conditions in seven separate sessions. |
1997-09-30 |
2023-08-12 |
human |
| T H Kelly, R W Foltin, C S Emurian, M W Fischma. Are choice and self-administration of marijuana related to delta 9-THC content? Experimental and clinical psychopharmacology. vol 5. issue 1. 1997-09-12. PMID:9234042. |
are choice and self-administration of marijuana related to delta 9-thc content? |
1997-09-12 |
2023-08-12 |
Not clear |