| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A H Söderpalm, A Schuster, H de Wi. Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac. Pharmacology, biochemistry, and behavior. vol 69. issue 3-4. 2001-12-04. PMID:11509190. |
the present study examined the antiemetic effect of smoked marijuana cigarettes (8.4 and 16.9 mg delta(9)-tetrahydrocannabinol [thc]) compared to a highly potent antiemetic drug, ondansetron (8 mg) in 13 healthy volunteers. |
2001-12-04 |
2023-08-12 |
human |
| F Nava, G Carta, G Colombo, G L Gess. Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522331. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), the psychoactive ingredient of cannabis sativa, reduces both extracellular hippocampal acetylcholine concentration and correct alternation tasks in the t-maze. |
2001-12-04 |
2023-08-12 |
Not clear |
| T Yamaguchi, Y Hagiwara, H Tanaka, T Sugiura, K Waku, Y Shoyama, S Watanabe, T Yamamot. Endogenous cannabinoid, 2-arachidonoylglycerol, attenuates naloxone-precipitated withdrawal signs in morphine-dependent mice. Brain research. vol 909. issue 1-2. 2001-10-11. PMID:11478928. |
in the present study, we examined the effects of endogenous ligand 2-arachidonoylglycerol (2-ag) on naloxone-precipitated withdrawal in morphine-dependent mice, in comparison with that of two cannabinoid agonists, an ingredient of cannabis sativa delta(8)-tetrahydrocannabinol (delta(8)-thc) and the synthetic cannabinoid cb1 receptor agonist hu-210. |
2001-10-11 |
2023-08-12 |
mouse |
| E Valjent, C Pagès, M Rogard, M J Besson, R Maldonado, J Caboch. Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission. The European journal of neuroscience. vol 14. issue 2. 2001-10-11. PMID:11553284. |
it is now well established that central effects of delta 9-tetrahydrocannabinol (thc), the main psychoactive component of marijuana, are mediated by cb1 cannabinoid receptors. |
2001-10-11 |
2023-08-12 |
Not clear |
| A C Porter, C C Felde. The endocannabinoid nervous system: unique opportunities for therapeutic intervention. Pharmacology & therapeutics. vol 90. issue 1. 2001-10-04. PMID:11448725. |
the active principle in marijuana, delta(9)-tetrahydrocannabinol (thc), has been shown to have wide therapeutic application for a number of important medical conditions, including pain, anxiety, glaucoma, nausea, emesis, muscle spasms, and wasting diseases. |
2001-10-04 |
2023-08-12 |
Not clear |
| M van der Stelt, W B Veldhuis, P R Bär, G A Veldink, J F Vliegenthart, K Nicola. Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517236. |
here, we show in a longitudinal magnetic resonance imaging study that delta(9)-tetrahydrocannabinol (delta(9)-thc), the main active compound in marijuana, reduces neuronal injury in neonatal rats injected intracerebrally with the na(+)/k(+)-atpase inhibitor ouabain to elicit excitotoxicity. |
2001-09-20 |
2023-08-12 |
rat |
| T Maejima, T Ohno-Shosaku, M Kan. Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals. Neuroscience research. vol 40. issue 3. 2001-09-13. PMID:11448511. |
cannabinoid receptors are the molecular targets for the active component delta(9)-tetrahydrocannabinol of marijuana and hashish, and constitute a major family of g protein-coupled seven-transmembrane-domain receptors. |
2001-09-13 |
2023-08-12 |
Not clear |
| A H Lichtman, J L Poklis, A Poklis, D M Wilson, B R Marti. The pharmacological activity of inhalation exposure to marijuana smoke in mice. Drug and alcohol dependence. vol 63. issue 2. 2001-08-30. PMID:11376914. |
in order to determine dosimetry, blood levels of delta9-thc were obtained following either marijuana exposure or intravenous injection of delta(9)-thc. |
2001-08-30 |
2023-08-12 |
mouse |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
marijuana smoke and delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit fas-mediated apoptosis. |
2001-08-30 |
2023-08-12 |
Not clear |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
marijuana smoke shares many components in common with tobacco smoke except for the presence of delta(9)-tetrahydrocannabinol (delta(9)-thc), the psychotropic compound found only in cannibis sativa. |
2001-08-30 |
2023-08-12 |
Not clear |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
however, particulate-phase smoke (tar) was a potent inhibitor of fas-induced caspase-3 activity, with marijuana tar being more potent than either tobacco or placebo marijuana tar (lacking delta(9)-thc). |
2001-08-30 |
2023-08-12 |
Not clear |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
flow cytometry was used to measure the percentage of cells undergoing apoptosis (staining for annexin v) versus necrosis (staining for propidium iodide) and confirmed that both marijuana tar extract and synthetic delta(9)-thc inhibit fas-induced apoptosis while promoting necrosis. |
2001-08-30 |
2023-08-12 |
Not clear |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
these observations suggest that the delta(9)-thc contained in marijuana smoke disrupts elements of the apoptotic pathway, thereby shifting the balance between apoptotic and necrotic cell death. |
2001-08-30 |
2023-08-12 |
Not clear |
| V A Campbel. Tetrahydrocannabinol-induced apoptosis of cultured cortical neurones is associated with cytochrome c release and caspase-3 activation. Neuropharmacology. vol 40. issue 5. 2001-07-12. PMID:11311898. |
delta(9)-tetrahydrocannabinol (thc), the principal psychoactive component of marijuana, is associated with impaired cognition and altered cortical function. |
2001-07-12 |
2023-08-12 |
Not clear |
| Y H Chang, S T Lee, W W Li. Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. Journal of cellular biochemistry. vol 81. issue 4. 2001-06-28. PMID:11329626. |
delta(9)-tetrahydrocannabinol (delta(9)-thc) is the major psychoactive component of marijuana and elicits pharmacological actions via cannabinoid receptors. |
2001-06-28 |
2023-08-12 |
Not clear |
| b' M R Elphick, M Egertov\\xc3\\xa. The neurobiology and evolution of cannabinoid signalling. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 356. issue 1407. 2001-06-21. PMID:11316486.' |
the major psychoactive ingredient of cannabis is delta(9)-tetrahydrocannabinol, which exerts effects in the brain by binding to a g-protein-coupled receptor known as the cb1 cannabinoid receptor. |
2001-06-21 |
2023-08-12 |
caenorhabditis_elegans |
| D Kim, S A Thaye. Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11319244. |
the principal psychoactive ingredient in marijuana, delta(9)-tetrahydrocannabinol, has been shown to inhibit adenylyl cyclase activity in vitro and can lead to impairment of memory in vivo. |
2001-06-21 |
2023-08-12 |
rat |
| C Sánchez, D Rueda, B Ségui, I Galve-Roperh, T Levade, M Guzmá. The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan. Molecular pharmacology. vol 59. issue 5. 2001-05-17. PMID:11306675. |
in this article, we report that delta(9)-tetrahydrocannabinol (thc), the major active component of marijuana, induces sphingomyelin hydrolysis in primary astrocytes but not in other cells expressing the cb(1) receptor, such as primary neurons, u373 mg astrocytoma cells, and chinese hamster ovary cells transfected with the cb(1) receptor cdna. |
2001-05-17 |
2023-08-12 |
Not clear |
| S C Azad, G Marsicano, I Eberlein, J Putzke, W Zieglgänsberger, R Spanagel, B Lut. Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse. The European journal of neuroscience. vol 13. issue 3. 2001-04-26. PMID:11168564. |
this study investigated whether the nitric oxide pathway was involved in the central effects of delta(9)-tetrahydrocannabinol (delta(9)-thc), the major psychoactive constituent of cannabis sativa. |
2001-04-26 |
2023-08-12 |
mouse |
| M D Roth, J A Marques-Magallanes, M Yuan, W Sun, D P Tashkin, O Hankinso. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. American journal of respiratory cell and molecular biology. vol 24. issue 3. 2001-04-19. PMID:11245634. |
induction and regulation of the carcinogen-metabolizing enzyme cyp1a1 by marijuana smoke and delta (9)-tetrahydrocannabinol. |
2001-04-19 |
2023-08-12 |
human |