| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Holland, J A Panetta, J M Hoskins, M Bebawy, B D Roufogalis, J D Allen, J C Arnol. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical pharmacology. vol 71. issue 8. 2006-04-25. PMID:16458258. |
unlike the known p-gp inhibitor, psc833, short 1h exposure to three plant-derived cannabinoids, cannabinol (cbn), cannabidiol (cbd) and delta(9)-tetrahydrocannabinol (thc) and the synthetic cannabinoid receptor agonist, win55, 212-2 (win) did not inhibit the efflux of the p-gp substrate rhodamine 123 (rh123) in either a drug-selected human t lymphoblastoid leukaemia cell line (cem/vlb(100)) or in a mouse fibroblast mdr1 transfected cell line (77.1). |
2006-04-25 |
2023-08-12 |
mouse |
| Keizo Wak. [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 126. issue 2. 2006-04-17. PMID:16462096. |
delta(9)-tetrahydrocannabinol, major psychoactive component of marijuana, has been shown to interact with specific cannabinoid receptors, thereby eliciting a variety of pharmacological responses in experimental animals and human. |
2006-04-17 |
2023-08-12 |
human |
| Janne Mannila, Tomi Järvinen, Kristiina Järvinen, Maarit Tarvainen, Pekka Jarh. Effects of RM-beta-CD on sublingual bioavailability of Delta9-tetrahydrocannabinol in rabbits. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 26. issue 1. 2006-04-07. PMID:15955678. |
complexation of model cannabinoids, delta(9)-tetrahydrocannabinol (thc) and cannabidiol (cbd), with randomly methylated beta-cyclodextrin (rm-beta-cd) and hydroxypropyl-beta-cyclodextrin (hp-beta-cd), were studied by the phase-solubility method. |
2006-04-07 |
2023-08-12 |
Not clear |
| Mauro Maccarron. Fatty acid amide hydrolase: a potential target for next generation therapeutics. Current pharmaceutical design. vol 12. issue 6. 2006-03-31. PMID:16472164. |
anandamide (n-arachidonoylethanolamine; aea) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of delta(9)-tetrahydrocannabinol, the active principle of cannabis sativa preparations like hashish and marijuana. |
2006-03-31 |
2023-08-12 |
human |
| Daniel Thomas Malone, David Alan Taylo. The effect of Delta9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats. Behavioural brain research. vol 166. issue 1. 2006-03-14. PMID:16143410. |
in this study, we investigate the effect of the major psychoactive constituent of cannabis and partial cannabinoid cb(1) receptor agonist delta(9)-tetrahydrocannabinol (thc) on prepulse inhibition (%ppi) of the acoustic startle reflex and on habituation in socially isolated and grouped rats. |
2006-03-14 |
2023-08-12 |
rat |
| Linda A Parker, Magdalena Kwiatkowska, Raphael Mechoula. Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Physiology & behavior. vol 87. issue 1. 2006-03-09. PMID:16197970. |
the expression of this conditioned retching reaction was completely suppressed by pretreatment with each of the principal cannabinoids found in marijuana, delta(9)-tetrahydrocannabinol or cannabidiol, at a dose that did not suppress general activity. |
2006-03-09 |
2023-08-12 |
Not clear |
| Zuzana Justinova, Marcello Solinas, Gianluigi Tanda, Godfrey H Redhi, Steven R Goldber. The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 23. 2006-02-17. PMID:15944392. |
anandamide, an endogenous ligand for brain cannabinoid cb(1) receptors, produces many behavioral effects similar to those of delta(9)-tetrahydrocannabinol (thc), the main psychoactive ingredient in marijuana. |
2006-02-17 |
2023-08-12 |
monkey |
| Paul Berghuis, Marton B Dobszay, Xinyu Wang, Sabrina Spano, Fernanda Ledda, Kyle M Sousa, Gunnar Schulte, Patrik Ernfors, Ken Mackie, Gustavo Paratcha, Yasmin L Hurd, Tibor Harkan. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 52. 2006-02-06. PMID:16357196. |
in utero exposure to delta(9)-tetrahydrocannabinol (delta(9)-thc), the active component from marijuana, induces cognitive deficits enduring into adulthood. |
2006-02-06 |
2023-08-12 |
Not clear |
| Jane E Lauckner, Bertil Hille, Ken Macki. The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 52. 2006-02-06. PMID:16365309. |
the calcium rise was win-specific, being essentially absent in cells treated with other classes of cannabinoid agonists, including delta(9)-tetrahydrocannabinol, hu-210, cp55,940, 2-arachidonoylglycerol, methanandamide, and cannabidiol. |
2006-02-06 |
2023-08-12 |
human |
| Marilyn A Huestis, Allan Barnes, Michael L Smit. Estimating the time of last cannabis use from plasma delta9-tetrahydrocannabinol and 11-nor-9-carboxy-delta9-tetrahydrocannabinol concentrations. Clinical chemistry. vol 51. issue 12. 2006-01-27. PMID:16223887. |
two models for predicting time of last cannabis use from single plasma cannabinoid concentrations-model i, using delta(9)-tetrahydrocannabinol (thc), and model ii, using the concentration ratio of 11-nor-9-carboxy-thc (thccooh) to thc-were developed and validated from controlled drug administration studies. |
2006-01-27 |
2023-08-12 |
Not clear |
| Thomas Nadulski, Frank Sporkert, Martin Schnelle, Andreas M Stadelmann, Patrik Roser, Tom Schefter, Fritz Prags. Simultaneous and sensitive analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in plasma after oral application of small doses of THC and cannabis extract. Journal of analytical toxicology. vol 29. issue 8. 2006-01-18. PMID:16356335. |
besides the psychoactive delta(9)-tetrahydrocannabinol (thc), hashish and marijuana as well as cannabis-based medicine extracts contain varying amounts of cannabidiol (cbd) and of the degradation product cannabinol (cbn). |
2006-01-18 |
2023-08-12 |
Not clear |
| Patrick Weydt, Soyon Hong, Anke Witting, Thomas Möller, Nephi Stella, Michel Klio. Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. vol 6. issue 3. 2006-01-04. PMID:16183560. |
however, delta(9)-tetrahydrocannabinol (delta(9)-thc), the predominant cannabinoid in marijuana, induces mind-altering effects and is partially addictive, compromising its clinical usefulness. |
2006-01-04 |
2023-08-12 |
mouse |
| Ganesh A Thakur, Richard I Duclos, Alexandros Makriyanni. Natural cannabinoids: templates for drug discovery. Life sciences. vol 78. issue 5. 2005-12-22. PMID:16242157. |
structure-activity relationship (sar) studies performed on delta(9)-tetrahydrocannabinol (delta(9)-thc), the key psychoactive ingredient of cannabis, and its synthetic analogues have identified the c-3 side chain as the key pharmacophore for ligand affinity and selectivity for the known cannabinoid receptors and for pharmacological potency. |
2005-12-22 |
2023-08-12 |
Not clear |
| Perras . Sativex for the management of multiple sclerosis symptoms. Issues in emerging health technologies. issue 72. 2005-12-12. PMID:16317825. |
sativex (r) is a cannabis-based pharmaceutical product containing delta 9-tetrahydrocannabinol (thc) and cannabidiol (cbd) in a 1:1 ratio, delivered in an oromucosal (mouth) spray. |
2005-12-12 |
2023-08-12 |
Not clear |
| Natalia Battista, Filomena Fezza, Mauro Maccarron. Endocannabinoids and their involvement in the neurovascular system. Current neurovascular research. vol 1. issue 2. 2005-12-05. PMID:16185189. |
anandamide (n-arachidonoylethanolamine; aea) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of delta(9)-tetrahydrocannabinol, the active principle of cannabis sativa preparations like hashish and marijuana. |
2005-12-05 |
2023-08-12 |
Not clear |
| Alice Egerton, Ros R Brett, Judith A Prat. Acute delta9-tetrahydrocannabinol-induced deficits in reversal learning: neural correlates of affective inflexibility. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 10. 2005-11-29. PMID:15812570. |
we therefore examined the ability of rats to perform affective and attentional shifts following acute administration of delta(9)-tetrahydrocannabinol (thc), the primary psychoactive marijuana constituent. |
2005-11-29 |
2023-08-12 |
rat |
| Zizhong Li, Andrew Gifford, Qian Liu, Rajesh Thotapally, Yu-Shin Ding, Alexandros Makriyannis, S John Gatle. Candidate PET radioligands for cannabinoid CB1 receptors: [18F]AM5144 and related pyrazole compounds. Nuclear medicine and biology. vol 32. issue 4. 2005-10-18. PMID:15878505. |
the mammalian brain contains abundant g protein-coupled cannabinoid cb(1) receptors that respond to delta(9)-tetrahydrocannabinol, the active ingredient of cannabis. |
2005-10-18 |
2023-08-12 |
Not clear |
| Balapal S Basavarajappa, Basalingappa L Hungun. Role of the endocannabinoid system in the development of tolerance to alcohol. Alcohol and alcoholism (Oxford, Oxfordshire). vol 40. issue 1. 2005-08-31. PMID:15550443. |
the identification of a g-protein-coupled receptor, namely, the cannabinoid receptor (cb(1) receptor), which was activated by delta(9)-tetrahydrocannabinol (delta(9)-thc), the major psychoactive component of marijuana, led to the discovery of endogenous cannabinoid agonists. |
2005-08-31 |
2023-08-12 |
mouse |
| Vincenzo Di Marzo, Isabel Matia. Endocannabinoid control of food intake and energy balance. Nature neuroscience. vol 8. issue 5. 2005-07-08. PMID:15856067. |
marijuana and its major psychotropic component, delta(9)-tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the cb(1) cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance. |
2005-07-08 |
2023-08-12 |
Not clear |
| Elena Butovsky, Ana Juknat, Igor Goncharov, Judith Elbaz, Raya Eilam, Abraham Zangen, Zvi Voge. In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol. Journal of neurochemistry. vol 93. issue 4. 2005-07-05. PMID:15857384. |
here we show that chronic administration of delta(9)-tetrahydrocannabinol (delta(9)-thc), the active psychotropic agent in marijuana and hashish, at 1.5 mg per kg per day intraperitoneally for 7 days, increases the expression, at both mrna and protein levels, of brain-derived neurotrophic factor (bdnf), in specific rat brain areas, notably in those involved in reward and addiction. |
2005-07-05 |
2023-08-12 |
rat |