| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roger G Pertwe. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. British journal of pharmacology. vol 156. issue 3. 2009-05-08. PMID:19226257. |
these are cesamet (nabilone), marinol (dronabinol; delta(9)-tetrahydrocannabinol) and sativex (delta(9)-tetrahydrocannabinol with cannabidiol). |
2009-05-08 |
2023-08-12 |
Not clear |
| Alan M Roloff, Stanley A Thaye. Modulation of excitatory synaptic transmission by Delta 9-tetrahydrocannabinol switches from agonist to antagonist depending on firing rate. Molecular pharmacology. vol 75. issue 4. 2009-04-23. PMID:19118122. |
delta(9)-tetrahydrocannabinol (thc), the principal psychoactive ingredient in marijuana, acts as a partial agonist on presynaptic cannabinoid type 1 (cb1) receptors to inhibit neurotransmitter release. |
2009-04-23 |
2023-08-12 |
rat |
| Gregory L Gerdeman, Jason B Schechter, Edward D Frenc. Context-specific reversal of cocaine sensitization by the CB1 cannabinoid receptor antagonist rimonabant. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 11. 2009-04-22. PMID:18059436. |
consistent with previous reports, the induction of locomotor sensitization following repeated daily cocaine was not prevented by systemic pretreatment of either rimonabant, delta(9)-tetrahydrocannabinol (thc), or a 1:1 mixture of thc and cannabidiol (cbd). |
2009-04-22 |
2023-08-12 |
mouse |
| Hassan Z Khiabani, Jørg Mørland, Jørgen G Bramnes. Frequency and irregularity of heart rate in drivers suspected of driving under the influence of cannabis. European journal of internal medicine. vol 19. issue 8. 2009-04-02. PMID:19046727. |
delta 9-tetrahydrocannabinol (thc) is the major active component of cannabis. |
2009-04-02 |
2023-08-12 |
Not clear |
| Matthijs G Bossong, Bart N M van Berckel, Ronald Boellaard, Lineke Zuurman, Robert C Schuit, Albert D Windhorst, Joop M A van Gerven, Nick F Ramsey, Adriaan A Lammertsma, René S Kah. Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 3. 2009-03-30. PMID:18754005. |
here we show that delta 9-tetrahydrocannabinol (thc), the main psychoactive component in cannabis, induces dopamine release in the human striatum. |
2009-03-30 |
2023-08-12 |
human |
| Laurence Bonhomme-Faivre, Amine Benyamina, Michel Reynaud, Robert Farinotti, Chadi Abbar. Disposition of Delta tetrahydrocannabinol in CF1 mice deficient in mdr1a P-glycoprotein. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18331373. |
being lipophilic, delta(9) tetrahydrocannabinol (thc), the main cannabis component, could be a potential p-gp substrate. |
2009-03-05 |
2023-08-12 |
mouse |
| Zuzana Justinova, Patrik Munzar, Leigh V Panlilio, Sevil Yasar, Godfrey H Redhi, Gianluigi Tanda, Steven R Goldber. Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 12. 2009-02-20. PMID:18305459. |
therefore, we studied intravenous self-administration of delta(9)-tetrahydrocannabinol (thc), the main psychoactive constituent of marijuana, using a second-order schedule of drug seeking. |
2009-02-20 |
2023-08-12 |
monkey |
| Michel A Steiner, Carsten T Wotja. Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis. Progress in brain research. vol 170. 2009-02-13. PMID:18655899. |
accordingly, exogenous cannabinoids such as the major active component of marijuana, delta(9)-tetrahydrocannabinol, have long been known to activate the major neuroendocrine stress response system of mammals, the hypothalamic-pituitary-adrenocortical (hpa) axis. |
2009-02-13 |
2023-08-12 |
Not clear |
| Paolo Fusar-Poli, José A Crippa, Sagnik Bhattacharyya, Stefan J Borgwardt, Paul Allen, Rocio Martin-Santos, Marc Seal, Simon A Surguladze, Colin O'Carrol, Zerrin Atakan, Antonio W Zuardi, Philip K McGuir. Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Archives of general psychiatry. vol 66. issue 1. 2009-01-16. PMID:19124693. |
distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. |
2009-01-16 |
2023-08-12 |
Not clear |
| Jean-Christian Maillet, Yun Zhang, Xuesheng Li, Xia Zhan. PTEN-5-HT2C coupling: a new target for treating drug addiction. Progress in brain research. vol 172. 2009-01-15. PMID:18772044. |
systemic or intra-amygdaloid application of the interfering peptide tat-3l4f is able to disrupt pten coupling with 5-ht2cr in the rat vta, resulting both in a suppression of the increased firing rate of vta dopaminergic neurons induced by delta 9-tetrahydrocannabinol (thc), the psychoactive ingredient of marijuana, and in a blockade of the conditioned place preference induced by thc and nicotine [ji, s.p. |
2009-01-15 |
2023-08-12 |
rat |
| Giovanni Appendino, Simon Gibbons, Anna Giana, Alberto Pagani, Gianpaolo Grassi, Michael Stavri, Eileen Smith, M Mukhlesur Rahma. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Journal of natural products. vol 71. issue 8. 2008-12-05. PMID:18681481. |
all five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), delta (9)-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant staphylococcus aureus (mrsa) strains of current clinical relevance. |
2008-12-05 |
2023-08-12 |
Not clear |
| A Weinstein, O Brickner, H Lerman, M Greemland, M Bloch, H Lester, R Chisin, Y Sarne, R Mechoulam, R Bar-Hamburger, N Freedman, E Even-Sapi. A study investigating the acute dose-response effects of 13 mg and 17 mg Delta 9- tetrahydrocannabinol on cognitive-motor skills, subjective and autonomic measures in regular users of marijuana. Journal of psychopharmacology (Oxford, England). vol 22. issue 4. 2008-12-03. PMID:18635724. |
a study investigating the acute dose-response effects of 13 mg and 17 mg delta 9- tetrahydrocannabinol on cognitive-motor skills, subjective and autonomic measures in regular users of marijuana. |
2008-12-03 |
2023-08-12 |
human |
| A Weinstein, O Brickner, H Lerman, M Greemland, M Bloch, H Lester, R Chisin, Y Sarne, R Mechoulam, R Bar-Hamburger, N Freedman, E Even-Sapi. A study investigating the acute dose-response effects of 13 mg and 17 mg Delta 9- tetrahydrocannabinol on cognitive-motor skills, subjective and autonomic measures in regular users of marijuana. Journal of psychopharmacology (Oxford, England). vol 22. issue 4. 2008-12-03. PMID:18635724. |
the aim of this study was to investigate the acute effects of 13 mg and 17 mg delta 9-tetrahydrocannabinol (thc) on skills important for coordinated movement and driving and on subjective and autonomic measures in regular users of marijuana. |
2008-12-03 |
2023-08-12 |
human |
| Nina L Cluny, Robert J Naylor, Brian A Whittle, Farideh A Javi. The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus. Basic & clinical pharmacology & toxicology. vol 103. issue 2. 2008-11-12. PMID:18816298. |
suncus murinus were injected intraperitoneally with either cannabidiol (cbd) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), delta(9)-tetrahydrocannabinol (delta(9)-thc; 0.5, 3, 5 and 10 mg/kg) or vehicle 45 min. |
2008-11-12 |
2023-08-12 |
Not clear |
| Wai M Liu, Katherine A Scott, Jonathan Shamash, Simon Joel, Thomas B Powle. Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach. Leukemia & lymphoma. vol 49. issue 9. 2008-11-04. PMID:18608861. |
delta(9)-tetrahydrocannabinol (thc) is the active metabolite of cannabis, which has demonstrable cytotoxic activity in vitro. |
2008-11-04 |
2023-08-12 |
Not clear |
| Nobuaki Egashira, Tomomi Matsuda, Emi Koushi, Fuminori Higashihara, Kenichi Mishima, Shozo Chidori, Nobuyoshi Hasebe, Katsunori Iwasaki, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwar. Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18565508. |
in the present study, we investigated the effect of delta(9)-tetrahydrocannabinol (thc), the principal psychoactive component of marijuana, on immobility time during the forced swim test. |
2008-10-24 |
2023-08-12 |
mouse |
| Michelle L Holland, John D Allen, Jonathon C Arnol. Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18619955. |
indeed, the cannabinoids enhanced the intracellular accumulation of two abcc1 substrates, fluo3 and vincristine, in ovarian carcinoma cells over-expressing abcc1 (2008/mrp1) with a rank order of potency: cannabidiol>cannabinol>delta(9)-tetrahydrocannabinol. |
2008-10-15 |
2023-08-12 |
Not clear |
| Daniel K Nomura, Jacqueline L Blankman, Gabriel M Simon, Kazutoshi Fujioka, Roger S Issa, Anna M Ward, Benjamin F Cravatt, John E Casid. Activation of the endocannabinoid system by organophosphorus nerve agents. Nature chemical biology. vol 4. issue 6. 2008-09-10. PMID:18438404. |
delta(9)-tetrahydrocannabinol (thc), the psychoactive ingredient of marijuana, has useful medicinal properties but also undesirable side effects. |
2008-09-10 |
2023-08-12 |
Not clear |
| V Kiran Vemuri, David R Janero, Alexandros Makriyanni. Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome. Physiology & behavior. vol 93. issue 4-5. 2008-07-31. PMID:18155257. |
endogenous signaling lipids ("endocannabinoids") functionally related to delta(9)-tetrahydrocannabinol, the psychoactive ingredient of marijuana (cannabis), are important biomediators and metabolic regulators critical to mammalian (patho)physiology. |
2008-07-31 |
2023-08-12 |
Not clear |
| T Bisogn. Endogenous cannabinoids: structure and metabolism. Journal of neuroendocrinology. vol 20 Suppl 1. 2008-07-18. PMID:18426492. |
the finding of specific binding sites for delta(9)-tetrahydrocannabinol, the psychoactive component of cannabis sativa, has led to the discovery of the endocannabinoid system and has emphasised the physiological and pathological relevance of endocannabidoid lipid signalling. |
2008-07-18 |
2023-08-12 |
Not clear |