| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the model of perimenopausal depression was established by ovx and cus; the level of anxiety and depression was evaluated by open field test; the levels of interleukin-1β(il-1β) and interleukin-6(il-6) mrna in rat hippocampus were detected by real-time qpcr; double staining immunofluorescence was used to detect the expression of ionized calcium binding adaptor molecule-1(iba-1) and inducible nitric oxide synthase(inos) in microglia of rat dentate gyrus(dg); western blot was used to detect the protein expression of iba-1 and inos of microglia in dg region of rat hippocampus. |
2020-12-23 |
2023-08-13 |
rat |
| Xin Wang, Zhao-Xiang Meng, Ying-Zhu Chen, Yu-Ping Li, Hong-Yu Zhou, Man Yang, Ting-Ting Zhao, Yu-Lai Gong, Yi Wu, Tao Li. Enriched environment enhances histone acetylation of NMDA receptor in the hippocampus and improves cognitive dysfunction in aged mice. Neural regeneration research. vol 15. issue 12. 2020-12-22. PMID:32594057. |
furthermore, quantitative real-time polymerase chain reaction and western blot assays were used to detect right hippocampal glun2b mrna as well as protein expression of glun2b and creb binding protein in all mice. |
2020-12-22 |
2023-08-13 |
mouse |
| Luciano Román-Albasini, Gabriela Díaz-Véliz, Felipe Antonio Olave, Felipe Ignacio Aguayo, Gonzalo García-Rojo, Wladimir Antonio Corrales, Juan Pablo Silva, Ana María Ávalos, Paulina S Rojas, Esteban Aliaga, Jenny Lucy Fiedle. Antidepressant-relevant behavioral and synaptic molecular effects of long-term fasudil treatment in chronically stressed male rats. Neurobiology of stress. vol 13. 2020-12-22. PMID:33344690. |
24 hr after treatments, rats were either evaluated for behavioral tests (active avoidance, anxiety-like behavior and object location) or euthanized for western blot analyses of hippocampal whole extract and synaptoneurosome-enriched fractions. |
2020-12-22 |
2023-08-13 |
rat |
| Shao-Wei Yin, Yuan Wang, Yi-Lin Meng, Cai-Xia Li. Effects of mild intrauterine hypoperfusion in the second trimester on memory and learning function in rat offspring. Neural regeneration research. vol 15. issue 11. 2020-12-11. PMID:32394966. |
immunofluorescence double staining and western blot assays demonstrated that hippocampal nestin and ki67 (both cell-proliferation-related proteins) expression was significantly downregulated in the miuh group compared with the sham group. |
2020-12-11 |
2023-08-13 |
rat |
| Nagisa Sada, Shogo Suto, Mana Suzuki, Shoichiro Usui, Tsuyoshi Inou. Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy. Epilepsia. vol 61. issue 5. 2020-11-30. PMID:32202309. |
using western blot analyses, we found that ldha expression was increased in the hippocampus of the chronic seizure model, whereas ldhb expression was not. |
2020-11-30 |
2023-08-13 |
mouse |
| Shanshan Zou, Zheng Zachory Wei, Yun Yue, Hui Zheng, Michael Qize Jiang, Anshi W. Desflurane and Surgery Exposure During Pregnancy Decrease Synaptic Integrity and Induce Functional Deficits in Juvenile Offspring Mice. Neurochemical research. vol 45. issue 2. 2020-11-23. PMID:31858378. |
hippocampal tissues of both fetal (g14) and offspring mice (postnatal day 31) were collected and analyzed by real-time qpcr and western blot. |
2020-11-23 |
2023-08-13 |
mouse |
| Zhenjie Zhu, Min Ge, Chunlei Li, Liqiang Yu, Yudan Gu, Yuming Hu, Zhilong Ca. Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 78. 2020-11-17. PMID:32360159. |
twenty-four hours after modeling, the expression of p-p38 mapk protein and apoptosis related genes in rat hippocampal tissues was detected by tunel staining, qrt-pcr and western blot. |
2020-11-17 |
2023-08-13 |
rat |
| Xuan Gao, Han Wang, Yong-Yue Gao, Xiao-Ming Zhou, Tao Tao, Guang-Jie Liu, Yan Zhou, Wei Li, Chun-Hua Han. Elevated hippocampal CD24 in astrocytes participates in neural regeneration possibly via activating SHP2/ERK pathway after experimental traumatic brain injury in mice. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194038. |
therefore, we detected the cd24 expression in the ipsilateral hippocampus via western blot and quantitative real-time pcr. |
2020-11-17 |
2023-08-13 |
mouse |
| Rahim Ullah, Gowhar Ali, Nisar Ahmad, Muhammad Akram, Geeta Kumari, Muhammad Usman Amin, Muhammad Naveed Uma. Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative. Pharmaceuticals (Basel, Switzerland). vol 13. issue 10. 2020-11-03. PMID:33086500. |
furthermore, the hippocampal expression of inflammatory cytokines was observed via rt-pcr and western blot. |
2020-11-03 |
2023-08-13 |
mouse |
| Yuting Song, Xiuxiu Li, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Green tea polyphenols improve isoflurane-induced cognitive impairment via modulating oxidative stress. The Journal of nutritional biochemistry. vol 73. 2020-10-16. PMID:31704346. |
protein expression levels of right hippocampus p-camkii, p-creb and bdnf were examined by western blot. |
2020-10-16 |
2023-08-13 |
mouse |
| Yingying Huang, Yingjun Liao, Huijun Zhang, Shuyun L. Lead exposure induces cell autophagy via blocking the Akt/mTOR signaling in rat astrocytes. The Journal of toxicological sciences. vol 45. issue 9. 2020-10-09. PMID:32879255. |
the expression levels of gfap, lc3, and p62 in the rat hippocampus were detected by immunofluorescence and western blot after lead exposure. |
2020-10-09 |
2023-08-13 |
human |
| Tao Han, Zhonghua Hu, Yongzhong Tang, Alisha Shrestha, Wen Ouyang, Qin Lia. Inhibiting Rho kinase 2 reduces memory dysfunction in adult rats exposed to sevoflurane at postnatal days 7-9. Biomedical reports. vol 3. issue 3. 2020-10-01. PMID:26137236. |
the protein levels of rhoa, rock2 and cleaved caspase-3 (cl-csp3) in the adult hippocampus were assessed by western blot analysis. |
2020-10-01 |
2023-08-13 |
rat |
| Xiuqin Li, Yong Gao, Zhaoyun Meng, Cui Zhang, Qinde Q. Regulatory role of microRNA-30b and plasminogen activator inhibitor-1 in the pathogenesis of cognitive impairment. Experimental and therapeutic medicine. vol 11. issue 5. 2020-10-01. PMID:27168840. |
the protein expression levels of pai-1 in the hippocampus and blood were determined using western blot analysis and enzyme-linked immunosorbent assays. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiuqin Li, Yong Gao, Zhaoyun Meng, Cui Zhang, Qinde Q. Regulatory role of microRNA-30b and plasminogen activator inhibitor-1 in the pathogenesis of cognitive impairment. Experimental and therapeutic medicine. vol 11. issue 5. 2020-10-01. PMID:27168840. |
furthermore, western blot analysis and enzyme-linked immunosorbent assay demonstrated that the protein expression levels of pai-1 were significantly elevated in the hippocampus and blood in the model group, in comparison with the control group (p<0.05). |
2020-10-01 |
2023-08-13 |
mouse |
| Jun Gu, Yifeng Bao, Jian Chen, Chuanjun Huang, Xinghua Zhang, Rui Jiang, Qianqian Liu, Yonghua Liu, Xide Xu, Wei Sh. The Expression of NP847 and Sox2 after TBI and Its Influence on NSCs. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28066182. |
western blot results demonstrated that the expression of np847 and sox2 in the hippocampus is up-regulated after tbi, and they both peak 3 days after brain injury. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jianping Wei, Qingmei Nie, Feng L. Lamotrigine decreases MRP8 and IL-7 in rat models of intractable epilepsy secondary to focal cortical dysplasia. Experimental and therapeutic medicine. vol 12. issue 6. 2020-10-01. PMID:28105099. |
expression quantities of mrp8 and il-7 in the hippocampus sample tissues of mice in the control group, observation group i, and observation group ii were measured via fluorescence quantitative polymerase chain reaction assay, western blot analysis, enzyme-linked immunosorbent assay, and immunohistochemistry 48 h later. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiao-Ming Jiang, Jing-Hai Hu, Lu-Lu Wang, Chi Ma, Xu Wang, Xiao-Liang Li. Effects of ulinastatin on global ischemia via brain pro-inflammation signal. Translational neuroscience. vol 7. issue 1. 2020-10-01. PMID:28123836. |
elisa and western blot analysis were employed to determine pics and their receptors in the neocortex and hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Xiu-Fang Ding, Yan Liu, Zhi-Yi Yan, Xiao-Juan Li, Qing-Yu Ma, Zhong-Ye Jin, Yan Liu, Yue-Hua Li, Yue-Yun Liu, Zhe Xue, Jia-Xu Chen, Zhi-Ping L. Involvement of Normalized Glial Fibrillary Acidic Protein Expression in the Hippocampi in Antidepressant-Like Effects of Xiaoyaosan on Chronically Stressed Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:28348623. |
the protein and mrna expressions and the immunoreactivities of glial fibrillary acidic protein (gfap) and neuronal nuclei (neun) in mouse hippocampus were detected using a western blot, qrt-pcr, and immunohistochemical staining, respectively. |
2020-10-01 |
2023-08-13 |
mouse |
| Hwayoung Lee, Jiyun Im, Hansol Won, Wooyoung Nam, Young Ock Kim, Sang Won Lee, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Ki. Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 21. issue 4. 2020-10-01. PMID:28706449. |
western blot and immunohistochemical analyses of medial prefrontal cortex (mpfc) and hippocampus showed downregulation of bdnf and p-creb proteins in the fm group compared to the control group. |
2020-10-01 |
2023-08-13 |
mouse |
| Hiroko Miyagishi, Minoru Tsuji, Atsumi Saito, Kazuya Miyagawa, Hiroshi Taked. Inhibitory effect of yokukansan on the decrease in the hippocampal excitatory amino acid transporter EAAT2 in stress-maladaptive mice. Journal of traditional and complementary medicine. vol 7. issue 4. 2020-10-01. PMID:29034181. |
western blot analysis revealed that the expression level of eaat2 was specifically decreased in the hippocampus of stress-maladaptive mice while there were no changes in the level of gfap, and this change was inhibited by chronic treatment with yks. |
2020-10-01 |
2023-08-13 |
mouse |