| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xu. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042992. |
serum and hippocampal cytokines, namely tumor necrosis factor (tnf)-α, interleukin (il)-1β, il-6 and il-10, were quantified using elisas and protein levels of hippocampal brain-derived neurotrophic factor (bdnf), glucagon synthase kinase (gsk)-3β, glutamate receptor subunit 1 (glur1), postsynaptic density protein 95 (psd95) and synapsin i were quantified using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo-Ho Won, Choong-Hyun Le. Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils. Laboratory animal research. vol 33. issue 3. 2020-10-01. PMID:29046699. |
this study investigated age-related alterations in expression of myelin basic protein (mbp) in the hippocampal subregions (dentate gyrus, ca2/3 and ca1 areas) of gerbils of various ages; young (1 month), adult (6 months) and aged (24 months), using western blot and immunohistochemistry. |
2020-10-01 |
2023-08-13 |
human |
| Xuan Li, Kai Wei, Rong Hu, Bo Zhang, Li Li, Li Wan, Chuanhan Zhang, Wenlong Ya. Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:29218001. |
in this study, postnatal day-7 (p7) rat pups and primary hippocampal neurons were exposed to 2% isoflurane for 6 h. terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining was used to detect neuronal apoptosis, and the expression of proteins involved in apoptosis (cleaved caspase-3, bax and bcl-2) was assessed by western blot. |
2020-10-01 |
2023-08-13 |
rat |
| Xinjing Yang, Zhuo Guo, Jun Lu, Bingcong Zhao, Yutong Fei, Jing Li, Huili Jiang, Lan Sun, Yu Wang, Yang Sun, Tuya Ba. The Role of MAPK and Dopaminergic Synapse Signaling Pathways in Antidepressant Effect of Electroacupuncture Pretreatment in Chronic Restraint Stress Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:29234374. |
the protein levels of dat, th, mapt, and prkc in the hippocampus were examined by using western blot. |
2020-10-01 |
2023-08-13 |
rat |
| Musi Ji, Xiaohua Su, Jizhen Liu, Yi Zhao, Zhidong Li, Xun Xu, Huawen Li, Bayaer Nashu. Comparison of naturally aging and D-galactose induced aging model in beagle dogs. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285136. |
the expression levels of aging-associated factors in the hippocampus, including proliferating cell nuclear antigen (pcna), p16 and p21 were also determined through reverse transcription quantitative-polymerase chain reaction, and western blot analysis. |
2020-10-01 |
2023-08-13 |
dog |
| Shun Zou, Mingxiong Zhang, Limei Feng, Yuanfang Zhou, Li Li, Lili Ba. Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285151. |
hippocampal expression of brain-derived neurotrophic factor (bdnf) mrna, and bcl-2 and bax protein at the end of reperfusion were measured by rt-qpcr and western blot analysis, respectively. |
2020-10-01 |
2023-08-13 |
rat |
| Shun Zou, Mingxiong Zhang, Limei Feng, Yuanfang Zhou, Li Li, Lili Ba. Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285151. |
rt-qpcr and western blot analysis showed that at the end of reperfusion, higher levels of bdnf mrna and the anti-apoptotic factor, bcl-2, and lower levels of the pro-apoptotic factor, bax, in the hippocampus were found in the ngr1 and ndc groups compared with the cir group. |
2020-10-01 |
2023-08-13 |
rat |
| Lin Ru Wang, Seung-Soo Bae. Treadmill exercise activates PI3K/Akt signaling pathway leading to GSK-3β inhibition in the social isolated rat pups. Journal of exercise rehabilitation. vol 14. issue 1. 2020-10-01. PMID:29511646. |
the expression of phosphoinositide 3 kinase (pi3k), tyrosine kinase b (akt), and glycogen synthase kinase 3β (gsk-3β) in the hippocampus were determined by using western blot analysis. |
2020-10-01 |
2023-08-13 |
rat |
| Luping Wang, Hushan Wang, Zongsheng Duan, Jian Zhang, Wenwen Zhan. Mechanism of gastrodin in cell apoptosis in rat hippocampus tissue induced by desflurane. Experimental and therapeutic medicine. vol 15. issue 3. 2020-10-01. PMID:29541166. |
the hippocampus tissues were taken from the rat after the behavioral experiment; then the number of apoptotic cells was detected using the terminal deoxynucleotidyltransferase-mediated dutp nick end labelling (tunel) kit, and the mrna and protein expression levels of p38 and interleukin-1 (il-1) were detected via semi-quantitative polymerase chain reaction (pcr) and western blot analysis. |
2020-10-01 |
2023-08-13 |
rat |
| Xinlei Wang, Guoyou Ding, Wei Lai, Shiwen Liu, Jun Shua. MicroRNA-383 upregulation protects against propofol-induced hippocampal neuron apoptosis and cognitive impairment. Experimental and therapeutic medicine. vol 15. issue 4. 2020-10-01. PMID:29545833. |
the learning memory ability, hippocampal neuron apoptosis and expression of apoptosis-associated factors were detected using reverse transcription-quantitiative polymerase chain reaction and western blot analysis. |
2020-10-01 |
2023-08-13 |
rat |
| Yu Ri Kim, Min Young Kwon, Malk Eun Pak, So Hyun Park, Jin Ung Baek, Byung Tae Cho. Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:29670659. |
the cholinergic system activity and memory-related molecules were examined in the hippocampus by enzyme-linked immunosorbent, western blot, and immunofluorescence assays. |
2020-10-01 |
2023-08-13 |
mouse |
| Hong-Bin Luo, Nan Shang, Wen-Zhi Xie, De-Jian Wen, Min Qu, Sheng Huang, Sha-Sha Fan, Wei Chen, Nan-Qiao Mou, Xiang-Yu Liu, Qin Chen, Feng-Feng Xie, Jun-Xu L. Neural regeneration research. vol 13. issue 5. 2020-10-01. PMID:29863023. |
western blot assay was used to detect the levels of tau protein and other factors involved in tau phosphorylation in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Ting Wang, Qun Cai, Wen-Jie Yang, Hai-Hua Fan, Jian-Feng Yi, Feng X. MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase II gamma. Neural regeneration research. vol 13. issue 7. 2020-10-01. PMID:30028330. |
western blot assay and rescue experiments were also utilized to detect camkiiγ expression and further verify that mir-219 in hippocampal neurons exerted its effect through regulation of camkiiγ. |
2020-10-01 |
2023-08-13 |
rat |
| Yonghao Feng, Aiqun Chu, Qiong Luo, Men Wu, Xiaohong Shi, Yinghui Che. The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30042685. |
western blot showed that ast could upregulate nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase 1 (ho-1) expression and inhibit nuclear transcription factor kappa b (nf-κb) p65 activation in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yang Zhang, Rong Ding, Shanshan Wang, Zhiyun Ren, Lingyan Xu, Xunle Zhang, Jiahui Zhao, Yu Ding, Yu Wu, Yuesong Gon. Effect of intraperitoneal or intracerebroventricular injection of streptozotocin on learning and memory in mice. Experimental and therapeutic medicine. vol 16. issue 3. 2020-10-01. PMID:30186480. |
following morris water maze (mwm) test and fear-conditioning test, cerebral cortex and hippocampus tissues were collected and the levels of psd95 and shank3 proteins in these tissues were measured by western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Li Jin, Yi-Pei Li, Qiong Feng, Li Ren, Fang Wang, Guo-Jia Bo, Li Wan. Cognitive deficits and Alzheimer-like neuropathological impairments during adolescence in a rat model of type 2 diabetes mellitus. Neural regeneration research. vol 13. issue 11. 2020-10-01. PMID:30233075. |
western blot assay was used to determine expression levels of glutamate ionotropic receptor nmda type subunit 2a (glun2a) and glun2b in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Parisa Iloun, Zahra Abbasnejad, Mahyar Janahmadi, Abolhassan Ahmadiani, Rasoul Ghasem. Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment. EXCLI journal. vol 17. 2020-10-01. PMID:30233281. |
consequently, analysis of the amount of hippocampal phosphorylated forms of p38, jnk, erk, irs1 (ser307) and akt (ser473) were done by western blot. |
2020-10-01 |
2023-08-13 |
rat |
| Changhong Ren, Ning Li, Sijie Li, Rongrong Han, Qingjian Huang, Jiangnan Hu, Kunlin Jin, Xunming J. Limb Ischemic Conditioning Improved Cognitive Deficits via eNOS-Dependent Augmentation of Angiogenesis after Chronic Cerebral Hypoperfusion in Rats. Aging and disease. vol 9. issue 5. 2020-10-01. PMID:30271664. |
western blot analysis shows that lric therapy significantly increased p-enos expression in the hippocampus when compared with 2vo rats. |
2020-10-01 |
2023-08-13 |
rat |
| Jian Liu, Yu-Hong Wang, Wei Li, Lin Liu, Hui Yang, Pan Meng, Yuan-Shan Ha. Structural and functional damage to the hippocampal neurovascular unit in diabetes-related depression. Neural regeneration research. vol 14. issue 2. 2020-10-01. PMID:30531012. |
western blot assay was used to measure levels of structural proteins in the hippocampal neurovascular unit co-culture system. |
2020-10-01 |
2023-08-13 |
rat |
| Wen-Bo Zhou, Zong-Ning Miao, Bin Zhang, Wei Long, Fang-Xiu Zheng, Jing Kong, Bin Y. Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neural regeneration research. vol 14. issue 4. 2020-10-01. PMID:30632501. |
western blot assay was used to analyze the protein levels of brain-derived neurotrophic factor (bdnf) and phospho-extracellular signal-regulated kinase 1/2 (p-erk1/2) in the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |