| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maryam Moosavi, Etrat Hooshmandi, Pegah Javadpour, Nader Maghsoudi, Hermann Katinger, Rasoul Ghasem. Effect of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats. Behavioural brain research. vol 384. 2021-05-20. PMID:32057828. |
western blot analysis revealed that stz prompted the cleavage of caspase-3 in the hippocampus while pretreatment with cepo-fc significantly reduced the cleavage of this protein. |
2021-05-20 |
2023-08-13 |
rat |
| Yinxia Ding, Ming Zhong, Bingjie Qiu, Chuanpeng Liu, Jinfeng Wang, Jie Lian. Abnormal expression of miR-135a in patients with depression and its possible involvement in the pathogenesis of the condition. Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-20. PMID:34007335. |
subsequently, reverse transcription-quantitative polymerase chain reaction and western blot analysis revealed that treatment with mir-135a mimic significantly inhibited the expression of toll-like receptor 4 in the mouse hippocampus. |
2021-05-20 |
2023-08-13 |
mouse |
| Fariba Khodagholi, Shima Zareh Shahamati, Mona Maleki Chamgordani, Maryam Alsadat Mousavi, Mehdi Moslemi, Mojtaba Salehpour, Shahrbanoo Rafiei, Forough Foola. Interval aerobic training improves bioenergetics state and mitochondrial dynamics of different brain regions in restraint stressed rats. Molecular biology reports. vol 48. issue 3. 2021-05-19. PMID:33723690. |
rats were then euthanized by decapitation and tricarboxylic acid (tca) cycle enzyme activity, antioxidant levels, and mitochondrial biogenesis factors were assessed in the frontal, hippocampus, parietal and temporal regions using spectrophotometer and western blot technique. |
2021-05-19 |
2023-08-13 |
rat |
| Qiuhe Chen, Yalin Tu, Shinghung Mak, Jingkao Chen, Junfeng Lu, Chen Chen, Xiaohong Yang, Shengnan Wang, Shijun Wen, Shanshan Ma, Mingtao Li, Yifan Han, Karl Wah-Keung Tsim, Rongbiao P. Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo. European journal of pharmacology. vol 883. 2021-05-18. PMID:32673674. |
in addition, invitro studies of immunofluorescent staining and western blot showed that pt109 might promote the neurogenesis of c17.2 cells and induce synaptogenesis in primary cultured rat hippocampal neurons. |
2021-05-18 |
2023-08-13 |
mouse |
| Wei-Li Gao, Xiang-Hua Li, Xin-Peng Dun, Xiao-Kuan Jing, Ke Yang, Yan-Kun L. Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities. Current medical science. vol 40. issue 3. 2021-05-18. PMID:32681248. |
furthermore, western blot results showed that gspe treatment could prevent the loss of akt and erk activities in the hippocampus and cerebral cortex induced by icv-stz. |
2021-05-18 |
2023-08-13 |
rat |
| Daniele Suzete Persike, Rebeca Padrão Amorim Puccinelli, Maria José da Silva Fernande. Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy. Pharmaceuticals (Basel, Switzerland). vol 14. issue 4. 2021-05-18. PMID:33919533. |
caspase-1 and caspase-3 activities were assayed using fluorimetry, and cathepsin d, hsp-70, and akt expression levels were assayed using western blot of hippocampal samples. |
2021-05-18 |
2023-08-13 |
rat |
| Haijin Huang, Cuicui Hu, Lin Xu, Xiaoping Zhu, Lili Zhao, Jia Mi. The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) Signaling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-17. PMID:32296010. |
hippocampal tissue homogenates underwent western blot for the quantification of markers of neuroinflammation and oxidative stress. |
2021-05-17 |
2023-08-13 |
rat |
| Junke Jia, Jinpiao Zhu, Qiuyue Yang, Yanlin Wang, Zongze Zhang, Chang Che. The Role of Histone Acetylation in the Sevoflurane-induced Inhibition of Neurogenesis in the Hippocampi of Young Mice. Neuroscience. vol 432. 2021-05-14. PMID:32109532. |
we assessed the effect of repeated sevoflurane exposure on histone acetylation and the expression of brain-derived neurotropic factor (bdnf) and its receptor, tropomyosin-related kinase receptor b (trkb), in the hippocampus by western blot (wb). |
2021-05-14 |
2023-08-13 |
mouse |
| Yanan Shen, Ling Jing, Yuan Zhang, Hongguang Bao, Akbar Vohra, Yanna Si, Cailong Pan, Yan Xin. CXCR5 Knockdown Attenuates Hippocampal Neurogenesis Deficits and Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy. Neuroscience. vol 433. 2021-05-14. PMID:32194226. |
hippocampal expression of cxcr5, interleukin (il)-1β and il-6 were measured by western blot. |
2021-05-14 |
2023-08-13 |
mouse |
| Ying Cai, Baoshan Qiu, Mengshi Liao, Xiaolu Liu, Jing Lin, Linfang Lan, Guangqing Xu, Yuhua Fa. Intermittent Theta Burst Stimulation Improves the Spatial Cognitive Function of Rats with Chronic Hypertension-induced Cerebral Small Vessel Disease. Neuroscience. vol 437. 2021-05-14. PMID:32353458. |
the expression of the n-methyl-d-aspartate receptor (nmdar) subunits nr1, nr2a and nr2b, calcium/calmodulin-dependent protein kinase iiα (camkiiα), p-camkiiα and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit 1 (glur1) in the hippocampus were evaluated by western blot analysis. |
2021-05-14 |
2023-08-13 |
rat |
| Hua Li, Li-Ying Lin, Yan Zhang, Yoon Lim, Mehreen Rahman, Andrew Beck, Mohammed Al-Hawwas, Shiqing Feng, Larisa Bobrovskaya, Xin-Fu Zho. Pro-BDNF Knockout Causes Abnormal Motor Behaviours and Early Death in Mice. Neuroscience. vol 438. 2021-05-14. PMID:32413397. |
abnormal morphologic changes were found in the dentate gyrus (dg) of the hippocampus in pro-bdnf ko mice, and western blot confirmed significant cell apoptosis in pro-bdnf ko mice brains. |
2021-05-14 |
2023-08-13 |
mouse |
| Ayyub Babaei, Maryam Nourshahi, Maryam Fani, Zahra Entezari, Seyed Behnamedin Jameie, Abbas Haghparas. The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway. Journal of psychiatric research. vol 136. 2021-05-14. PMID:33607579. |
hippocampal pgc-1α, fndc5, and bdnf protein expression by western blot and serum corticosterone by elisa were detected. |
2021-05-14 |
2023-08-13 |
rat |
| Yue Yang, Lei Yang, Yu Wu, Jun Yua. [Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 2. 2021-05-11. PMID:33966704. |
methods sixty 7-day-old sd rats were assigned into five groups:control group(without any intervention),dex group(intraperitoneal injection of 25 μg/kg dex),sevoflurane group(3% sevoflurane treatment for 4 hours),sevoflurane+dex group(inhalation of 3% sevoflurane after injection of 25 μg/kg dex for 4 hours),and sevoflurane+dex+wnt inhibitor group(wnt inhibitor xav393 and 25 μg/kg dex were injected and 3% sevoflurane was inhaled for 4 hours).three weeks later,morris water maze was used to detect the cognitive function;tdt-mediated dutp nick end labeling(tunel)staining was performed to detect the apoptosis of hippocampal neurons;neuronal nuclei (neun) staining was conducted to detect the survival of hippocampal neurons;western blot was carried out to detect the expression of apoptosis-related proteins.the expression of the factors involved in wnt/gsk-3β/β-catenin signaling pathway was detected by fluorescence quantitative polymerase chain reaction,and western blot. |
2021-05-11 |
2023-08-13 |
rat |
| Mohammad-Bagher Almaspour, Mohammad Nasehi, Solmaz Khalifeh, Mohammad-Reza Zarrindas. The effect of fish oil on social interaction memory in total sleep-deprived rats with respect to the hippocampal level of stathmin, TFEB, synaptophysin and LAMP-1 proteins. Prostaglandins, leukotrienes, and essential fatty acids. vol 157. 2021-05-10. PMID:32388317. |
hippocampal level of proteins was assessed using western blot. |
2021-05-10 |
2023-08-13 |
rat |
| Christopher G Sinon, Amy Ottensmeyer, Austin N Slone, Dan C Li, Rachael S Allen, Machelle T Pardue, Paul S Garcí. Prehabilitative exercise hastens recovery from isoflurane in diabetic and non-diabetic rats. Neuroscience letters. vol 751. 2021-05-10. PMID:33705936. |
postsynaptic density protein-95 (psd-95), an important scaffolding protein required for synaptic plasticity, protein levels were quantified from hippocampus using western blot. |
2021-05-10 |
2023-08-13 |
rat |
| Genmeng Yang, Liu Liu, Ruilin Zhang, Juan Li, Chi-Kwan Leung, Jian Huang, Yuanyuan Li, Baoyu Shen, Xiaofeng Zeng, Dongxian Zhan. Cannabidiol attenuates methamphetamine-induced conditioned place preference via the Sigma1R/AKT/GSK-3β/CREB signaling pathway in rats. Toxicology research. vol 9. issue 3. 2021-05-09. PMID:32670551. |
the protein expression levels of sigma1r, akt, p-akt, gsk-3β, p-gsk-3β, creb, and p-creb in the rats' prefrontal cortex, nucleus accumbens, and hippocampus and ventral tegmental were detected using western blot analysis. |
2021-05-09 |
2023-08-13 |
rat |
| Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang Cu. Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling. Neuroscience research. vol 157. 2021-04-28. PMID:31348997. |
we treated tbi and sham operated mice with dha, and investigated the effects of dha on jnk and tau phosphorylation, hippocampal long term potentiation (ltp), learning and memory, and motor function by western blot analysis, electrophysiology recording and behavioral assessments including morris water maze test, beam-balance test, beam-walk test and rotarod test. |
2021-04-28 |
2023-08-13 |
mouse |
| Yolanda Campos-Jurado, Lucía Martí-Prats, Jose A Morón, Ana Polache, Luis Granero, Lucía Hipólit. Dose-dependent induction of CPP or CPA by intra-pVTA ethanol: Role of mu opioid receptors and effects on NMDA receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:31978422. |
finally, modifications of the expression of nmda receptor subunits in the nucleus accumbens (nac) and hippocampus after ethanol-induced cpp were analyzed at the proteomic and transcriptomic levels by western blot and in situ hybridation rnascope techniques, respectively. |
2021-04-28 |
2023-08-13 |
Not clear |
| Fernanda Medina-Flores, Gabriela Hurtado-Alvarado, Arturo Contis-Montes de Oca, Stefanie Paola López-Cervantes, Mina Konigsberg, Maria A Deli, Beatriz Gómez-Gonzále. Sleep loss disrupts pericyte-brain endothelial cell interactions impairing blood-brain barrier function. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32485292. |
at the end of the sleep restriction, brain microvessels (mvs) were isolated from cerebral cortex and hippocampus and processed for western blot and immunocytochemistry to evaluate markers of pericyte-endothelial cell interaction (connexin 43, pdgfr-β), tight junction proteins, and proinflammatory mediator proteins (mmp9, a |
2021-04-27 |
2023-08-13 |
rat |
| Olga E Zubareva, Tatyana Y Postnikova, Alexandra V Grifluk, Alexander P Schwarz, Ilya V Smolensky, Anton A Karepanov, Dmitry S Vasilev, Ekaterina A Veniaminova, Alexander Y Rotov, Sergey V Kalemenev, Aleksey V Zaitse. Exposure to bacterial lipopolysaccharidein early life affects the expression of ionotropic glutamate receptor genes and is accompanied by disturbances in long-term potentiation and cognitive functions in young rats. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32726683. |
we revealed a substantial decrease of glun2b subunit expression in the hippocampus at p23 using western blot analysis and real-time polymerase chain reaction assay. |
2021-04-27 |
2023-08-13 |
rat |