| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Luis Castañeda-Cabral, José Guadalupe López-Ortega, Blanca Fabiola Fajardo-Fregoso, Carlos Beas-Zárate, Mónica E Ureña-Guerrer. Glutamate induced neonatal excitotoxicity modifies the expression level of EAAT1 (GLAST) and EAAT2 (GLT-1) proteins in various brain regions of the adult rat. Neuroscience letters. vol 735. 2021-04-23. PMID:32645399. |
western blot analysis showed that neonatal msg-treatment decreased eaat1 expression levels in the cmc, striatum and hippocampus, while eaat2 levels were increased in the striatum and ec and decreased in the cmc. |
2021-04-23 |
2023-08-13 |
rat |
| Yan Wang, Meiling Lian, Xiaoyu Xiu, Zhiwen Zhang, Liping Song, Shengzhou W. Dicer1 promotes Aβ clearance via blocking B2 RNA-mediated repression of apolipoprotein E. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 2. 2021-04-23. PMID:33285223. |
with western blot, quantitative real-time pcr, fluorescence in situ hybridization, and northern blot,dicer1 overexpression increased apolipoprotein e (apoe) and concomitantly decreased b2 rna in the hippocampus of the ad mice and in astrocyte cultures whereas transfection of b2 mm2 rna decreased apoe mrna and protein levels in astrocyte cultures. |
2021-04-23 |
2023-08-13 |
mouse |
| Daniel Pérez-Pérez, José Luis Castañeda-Cabral, Sandra Orozco-Suárez, Julio Sotelo, Walter Besio, Luisa Roch. Noninvasive transcranial focal stimulation affects the convulsive seizure-induced P-glycoprotein expression and function in rats. Epilepsy & behavior : E&B. vol 115. 2021-04-19. PMID:33334719. |
p-glycoprotein expression was analyzed by western blot in the cerebral cortex and hippocampus of rats receiving 5 min of tfs (300 hz, 50 ma, 200 μs, biphasic charge-balanced squared pulses) using a tripolar concentric ring electrode (tcre) prior to administration of a single dose of mpa. |
2021-04-19 |
2023-08-13 |
rat |
| Leela Paladugu, Abeer Gharaibeh, Nivya Kolli, Cameron Learman, Tia C Hall, Lixin Li, Julien Rossignol, Panchanan Maiti, Gary L Dunba. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 2. 2021-04-07. PMID:33467075. |
the extent of neurodegeneration, aβ plaque load, and key proteins associated with the insulin signaling pathways were measured using western blot and neuroinflammation (via immunohistological assays) in the cortical and hippocampal regions of the brain were assessed following a series of behavioral tests used to measure cognitive function after lir or vehicle treatments. |
2021-04-07 |
2023-08-13 |
mouse |
| Hyejin Sim, Tae-Kyeong Lee, Yeon Ho Yoo, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Jae-Chul Lee, Joon Ha Park, Soon-Sung Lim, Jung-Seok Park, Il Jun Kang, Young-Myeong Kim, Myoung Cheol Shin, Jun Hwi Cho, Yoonsoo Park, Moo-Ho Wo. Increased Calbindin D28k Expression via Long-Term Alternate-Day Fasting Does Not Protect against Ischemia-Reperfusion Injury: A Focus on Delayed Neuronal Death, Gliosis and Immunoglobulin G Leakage. International journal of molecular sciences. vol 22. issue 2. 2021-04-06. PMID:33440708. |
cb expression was investigated in the cornu ammonis 1 (ca1) region of the hippocampus via western blot analysis and immunohistochemistry. |
2021-04-06 |
2023-08-13 |
Not clear |
| Lidong Sun, Donghao Bai, Maoguang Lin, Eerdenidalai, Li Zhang, Fengzhen Wang, Shangwu Ji. miR-96 Inhibits SV2C to Promote Depression-Like Behavior and Memory Disorders in Mice. Frontiers in behavioral neuroscience. vol 14. 2021-04-06. PMID:33815074. |
reverse transcription-quantitative polymerase chain reaction and western blot analysis evaluated the expression of mir-96 and sv2c expression in the ca1 hippocampal region of the mice. |
2021-04-06 |
2023-08-13 |
mouse |
| Xinqiang Liu, Hongguang Ding, Xusheng Li, Yiyu Deng, Xiaoyu Liu, Kangrong Wang, Miaoyun Wen, Shenglong Chen, Wenqiang Jiang, Hongke Zen. Hypercapnia Exacerbates the Blood-Brain Barrier Disruption Via Promoting HIF-1a Nuclear Translocation in the Astrocytes of the Hippocampus: Implication in Further Cognitive Impairment in Hypoxemic Adult Rats. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32328929. |
western blot analysis was carried out to detect the protein expressions of total and nuclear hypoxia-inducible factor-1α (hif-1α), matrixmetalloproteinase-9 (mmp-9) and aquaporins-4 (aqp-4) in the hippocampus tissue. |
2021-03-29 |
2023-08-13 |
rat |
| Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong L. The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats. Frontiers in psychiatry. vol 12. 2021-03-23. PMID:33746787. |
synaptophysin (syn), postsynaptic density-95 (psd-95), and growth-associated protein-43 (gap-43) expressions in the hippocampus were detected by western blot. |
2021-03-23 |
2023-08-13 |
rat |
| Nannan Lan, Yongxin Liu, Zhaodong Juan, Rui Zhang, Baoyu Ma, Keliang Xie, Lina Sun, Hao Feng, Meng Sun, Jianfeng Li. The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy. Frontiers in pharmacology. vol 11. 2021-03-13. PMID:33708121. |
morris water maze (mwm), western blot, qrt-pcr, confocal microscopy and transmission electron microscopy (tem) were used to study the role of tspo-specific ligand pk11195 in lps-activated mitochondrial autophagy in rat hippocampus. |
2021-03-13 |
2023-08-13 |
rat |
| Jiayuan Chen, Li Gao, Yao Zhang, Ya Su, Zheng Kong, Dongqing Wang, Ming Ya. Acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism. Phytotherapy research : PTR. vol 35. issue 1. 2021-02-23. PMID:33029835. |
the acteoside induced increase in the protein expression of glucose transporters (glu t1, glu t3, and glu t4), glucose, and insulin levels in the hippocampus for maintaining normal learning and memory function were demonstrated by western blot. |
2021-02-23 |
2023-08-13 |
Not clear |
| Qingzhen Liu, Lidong Zhang, Junfeng Zhan. Induced pluripotent stem cell-derived neural progenitor cell transplantation promotes regeneration and functional recovery after post-traumatic stress disorder in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-23. PMID:33186796. |
moreover, western blot analysis suggested enhanced expression of brain-derived neurotrophic factor (bdnf) in hippocampus tissue of ipsc-npcs transplanted rats in comparison to the pbs group. |
2021-02-23 |
2023-08-13 |
human |
| Zhan-Qiang Zhuang, Zhe-Zhe Zhang, Yue-Ming Zhang, He-Hua Ge, Shi-Yu Sun, Ping Zhang, Gui-Hai Che. A Long-Term Enriched Environment Ameliorates the Accelerated Age-Related Memory Impairment Induced by Gestational Administration of Lipopolysaccharide: Role of Plastic Mitochondrial Quality Control. Frontiers in cellular neuroscience. vol 14. 2021-02-23. PMID:33613195. |
quantitative reverse transcription polymerase chain reaction and western blot were used to measure the messenber rna (mrna) and protein levels of mqc-related genes in the hippocampus, respectively. |
2021-02-23 |
2023-08-13 |
mouse |
| Qin Liu, Yuehong Li, Yong Zho. MicroRNA-489-3p plays a significant role in congenital hypothyroidism through regulating neuronal cell apoptosis via targeting translationally controlled tumor protein 1. Experimental and therapeutic medicine. vol 21. issue 3. 2021-02-20. PMID:33603838. |
additionally, rt-qpcr and western blot assays suggested that tpt1 was markedly downregulated in the hippocampal tissues of ch rats compared with control rats. |
2021-02-20 |
2023-08-13 |
rat |
| Qian Zhou, Ayumi Suzuki, Mitsuo Iinuma, Ke-Yong Wang, Kin-Ya Kubo, Kagaku Azum. Effects of Maternal Chewing on Prenatal Stress-Induced Cognitive Impairments in the Offspring via Multiple Molecular Pathways. International journal of molecular sciences. vol 21. issue 16. 2021-02-18. PMID:32781547. |
immunohistochemistry and western blot findings revealed that maternal chewing alleviated hippocampal neurogenesis impairment and increased the expression of hippocampal brain-derived neurotrophic factor in the offspring. |
2021-02-18 |
2023-08-13 |
mouse |
| Indrani Poddar, Patrick M Callahan, Caterina M Hernandez, Anilkumar Pillai, Xiangkun Yang, Michael G Bartlett, Alvin V Terr. Oral quetiapine treatment results in time-dependent alterations of recognition memory and brain-derived neurotrophic factor-related signaling molecules in the hippocampus of rats. Pharmacology, biochemistry, and behavior. vol 197. 2021-02-08. PMID:32702397. |
multiple cohorts of adult rats were treated with quetiapine (25.0 mg/kg/day) for 30 or 90 days in their drinking water then evaluated for drug effects on motor function in a catalepsy assessment, recognition memory in a spontaneous novel object recognition (nor) task, and bdnf-related signaling molecules in the post mortem hippocampus via western blot. |
2021-02-08 |
2023-08-13 |
rat |
| Yong Zuo, Bowen Li, Jinhong Xie, Zhao Ma, Anand Thirupathi, Peng Yu, Guofen Gao, Jinjuan Zhou, Changhao Zhou, Hongmeng Xu, Yanzhong Chang, Zhenhua Sh. Sevoflurane anesthesia during pregnancy in mice induces cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis. Neurochemistry international. vol 135. 2021-01-25. PMID:32035889. |
hippocampus and cortex tissues or cerebral microvascular endothelial cells of offspring mice (postnatal day 35) were harvested and subjected to western blot and/or immunhistochemistry to assess ferritin, transferrin receptor 1(tfr1), ferroportin-1 (fpn1), myelin basic protein (mbp), tight junction protein zo-1, occludin, and claudin-5 levels. |
2021-01-25 |
2023-08-13 |
mouse |
| Asli Aykac, Ahmet Özer Şehirli, M Zafer Göre. Evaluation of the Effect of Prazosin Treatment on α-2c Adrenoceptor and Apoptosis Protein Levels in the Predator Scent-Induced Rat Model of Post-Traumatic Stress Disorder. Journal of molecular neuroscience : MN. vol 70. issue 7. 2021-01-21. PMID:32133592. |
we used western blot analysis to determine the effect of prazosin (0.5 mg/kg/ip) on α-2c-ar and apoptotic protein expression changes in the frontal cortex, hippocampus, and amygdala. |
2021-01-21 |
2023-08-13 |
rat |
| Lou-Yan Ma, Song-Fang Liu, Jun-Hui Du, Yu Niu, Peng-Fei Hou, Qing Shu, Ran-Ran Ma, Song-Di Wu, Qiu-Min Qu, Ya-Li L. Chronic ghrelin administration suppresses IKK/NF-κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ-diabetic rats. Neurobiology of learning and memory. vol 169. 2021-01-19. PMID:31904547. |
western blot analysis showed that diabetic rats exhibited significantly decreased levels of ghsr-1a and protein phosphatase 1 (pp1) in the hippocampus and increased activation of the ikk/nf-κb/bace1 pathway. |
2021-01-19 |
2023-08-13 |
rat |
| Utcharaporn Kamsrijai, Prapimpun Wongchitrat, Chutikorn Nopparat, Jutamaad Satayavivad, Piyarat Govitrapon. Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats. Neurochemistry international. vol 132. 2021-01-07. PMID:31726088. |
morris water maze, western blot and immunohistochemistry analysis of proteins in the hippocampus were measured. |
2021-01-07 |
2023-08-13 |
rat |
| Yunfei Tan, Yuko Fujita, Youge Qu, Lijia Chang, Yaoyu Pu, Siming Wang, Xingming Wang, Kenji Hashimot. Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31866390. |
western blot analysis showed decreased levels of brain-derived neurotrophic factor (bdnf) and decreased ratio of phosphorylated-trkb (p-trkb) to trkb in the prefrontal cortex (pfc) and hippocampus of pcp-treated mice. |
2020-12-31 |
2023-08-13 |
mouse |